The role of dendritic cell precursors in tumour vasculogenesis.

abstract：:Local recurrence of glioblastomas is a major cause of patient mortality after definitive treatment. This review discusses the roles of the chemokine stromal cell-derived factor-1 and its receptor CXC chemokine receptor 4 (CXCR4) in affecting the sensitivity of glioblastomas to irradiation. Blocking these molecules pre...

journal_title：British journal of cancer

authors： Tseng D,Vasquez-Medrano DA,Brown JM

更新日期：2011-06-07 00:00:00

abstract：:Antibody-dependent cellular cytotoxicity (ADCC) is considered to be the major mechanism through which tumour cells, upon treatment with anti-tumour MAbs, are eliminated in vivo. However, the relative importance of various parameters that influence the efficacy of ADCC is unclear. Here we present in vitro data on the i...

journal_title：British journal of cancer

authors： Velders MP,van Rhijn CM,Oskam E,Fleuren GJ,Warnaar SO,Litvinov SV

更新日期：1998-08-01 00:00:00

abstract：:Two meta-analyses were conducted to quantify the benefit of combining alpha-IFN to 5FU in advanced colorectal cancer in terms of tumour response and survival. Analyses were based on a total of 3254 individual patient data provided by principal investigators of each trial. The meta-analysis of 5FU +/- LV vs. 5FU +/- LV...

journal_title：British journal of cancer

authors： Thirion P,Piedbois P,Buyse M,O'Dwyer PJ,Cunningham D,Man A,Greco FA,Colucci G,Köhne CH,Di Constanzo F,Piga A,Palmeri S,Dufour P,Cassano A,Pajkos G,Pensel RA,Aykan NF,Marsh J,Seymour MT,Meta-Analysis Group in Cancer.

更新日期：2001-03-02 00:00:00

abstract：:To determine the maximum-tolerated dose (MTD), dose-limiting toxicities and pharmacokinetic of semisynthetic homoharringtonine (ssHHT), given as a twice daily subcutaneous (s.c.) injections for 9 days, in patients with advanced acute leukaemia, 18 patients with advanced acute myeloid leukaemia were included in this se...

journal_title：British journal of cancer

authors： Lévy V,Zohar S,Bardin C,Vekhoff A,Chaoui D,Rio B,Legrand O,Sentenac S,Rousselot P,Raffoux E,Chast F,Chevret S,Marie JP

更新日期：2006-08-07 00:00:00

abstract：BACKGROUND:Epithelial ovarian cancer (EOC) cells are prone to metastasise throughout the peritoneal cavity. The epithelial-to-mesenchymal transition (EMT) is a necessary step towards metastatic tumour progression. CA125/MUC16 mucin is a high-molecular-weight glycoprotein overexpressed in the majority of serous carcinom...

journal_title：British journal of cancer

authors： Comamala M,Pinard M,Thériault C,Matte I,Albert A,Boivin M,Beaudin J,Piché A,Rancourt C

更新日期：2011-03-15 00:00:00

abstract：:To examine the hypothesis that colorectal carcinomas with and without TP53 mutations may be characterised by aetiological heterogeneity, we analysed a group of 107 patients with primary Dukes' C colorectal cancer seen at the Memorial Sloan-Kettering Cancer Center (MSKCC) from 1986 to 1990. We assessed p53 overexpressi...

journal_title：British journal of cancer

authors： Zhang ZF,Zeng ZS,Sarkis AS,Klimstra DS,Charytonowicz E,Pollack D,Vena J,Guillem J,Marshall JR,Cordon-Cardo C

更新日期：1995-04-01 00:00:00

abstract：:The cytotoxicity of three platinum complexes, cis-diamminedichloroplatinum(II) (cis-platin), cis-dichloro-trans-dihydroxy-cis-bis (isopropylamine) platinum(IV), (CHIP) and diammine (1, 1-cyclobutane-dicarboxylato) platinum(II) (carboplatin) on Chinese Hamster ovary (CHO) and mouse sarcoma RIF-1 cells cultured in vitro...

journal_title：British journal of cancer

authors： Smith E,Brock AP

更新日期：1988-06-01 00:00:00

abstract：:Increased fibre intake has been shown to reduce serum oestrogen concentrations. We hypothesized that fibre exerts this effect by decreasing the time available for reabsorption of oestrogens in the colon. We tested this in volunteers by measuring changes in serum oestrogen levels in response to manipulation of intestin...

journal_title：British journal of cancer

authors： Lewis SJ,Heaton KW,Oakey RE,McGarrigle HH

更新日期：1997-01-01 00:00:00

abstract：:Combinations of dacarbazine (DTIC) and other cytotoxic agents or alpha-interferon were given to 136 patients in five different regimens. The total response rate was 32% (95% confidence interval 24-40%); 13% had a complete remission. Female patients had a significantly higher chance of response than male patients: 46% ...

journal_title：British journal of cancer

authors： Mulder NH,van der Graaf WT,Willemse PH,Koops HS,de Vries EG,Sleijfer DT

更新日期：1994-10-01 00:00:00

abstract：:Circulating anti-p53 antibodies have been described and used as tumoural markers in patients with various cancers and strongly correlate with the p53 mutated status of the tumours. No study has yet looked at the prevalence of such antibodies in skin carcinoma patients although these tumours have been shown to be frequ...

journal_title：British journal of cancer

authors： Moch C,Moysan A,Lubin R,de la Salmonière P,Soufir N,Galisson F,Vilmer C,Venutolo E,Le Pelletier F,Janin A,Basset-Séguin N

更新日期：2001-12-14 00:00:00

abstract：BACKGROUND:Several tyrosine kinase inhibitors (TKIs) can decrease docetaxel clearance in patients by an unknown mechanism. We hypothesised that these interactions are mediated by the hepatic uptake transporter OATP1B1. METHODS:The influence of 16 approved TKIs on transport was studied in vitro using HEK293 cells expre...

journal_title：British journal of cancer

authors： Hu S,Mathijssen RH,de Bruijn P,Baker SD,Sparreboom A

更新日期：2014-02-18 00:00:00

abstract：BACKGROUND:The current analysis was performed to evaluate the impact of PIK3CA hotspot mutations on everolimus efficacy in BOLERO-2 participants, using cell-free DNA (cfDNA) from plasma samples collected at the time of patient randomisation. METHODS:PIK3CA H1047R, E545K, and E542K mutations in plasma-derived cfDNA wer...

journal_title：British journal of cancer

authors： Moynahan ME,Chen D,He W,Sung P,Samoila A,You D,Bhatt T,Patel P,Ringeisen F,Hortobagyi GN,Baselga J,Chandarlapaty S

更新日期：2017-03-14 00:00:00

abstract：:The matrix metalloprotease MMP-9 localizes to tumour-associated macrophages in human ovarian cancer but little is known of its regulation. Co-culture of human ovarian cancer cells (PEO-1) and a monocytic cell line (THP-1) led to production of 92-kDa proMMP-9. PEO-1-conditioned medium (CM) also stimulated THP-1 cells o...

journal_title：British journal of cancer

authors： Leber TM,Balkwill FR

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:BRCAness is defined as shared tumour characteristics between sporadic and BRCA-mutated cancers. However, how to exactly measure BRCAness and its frequency in breast cancer is not known. Assays to establish BRCAness would be extremely valuable for the clinical management of these tumours. We assessed BRCAness...

journal_title：British journal of cancer

authors： Lips EH,Mulder L,Oonk A,van der Kolk LE,Hogervorst FB,Imholz AL,Wesseling J,Rodenhuis S,Nederlof PM

更新日期：2013-05-28 00:00:00

abstract：:'de novo' carcinogenesis has been advocated besides 'adenoma carcinoma sequence' as another dominant pathway leading to colorectal carcinoma. Our recent study has demonstrated that the distribution of brain (fetal)-type glycogen phosphorylase (BGP) positive foci (BGP foci) has a close relationship with the location of...

journal_title：British journal of cancer

authors： Shimada S,Shiomori K,Tashima S,Tsuruta J,Ogawa M

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:A dose-dense strategy has been considered to improve results of adjuvant chemotherapy for breast cancer. This randomised phase II trial investigated the feasibility of this approach with sequential anthracyclines and taxanes-based chemotherapy. METHODS:Patients with high-risk node-positive breast cancer wer...

journal_title：British journal of cancer

authors： Brain E,Levy C,Serin D,Roché H,Spielmann M,Delva R,Veyret C,Mauriac L,Rios M,Martin AL,Jimenez M,Asselain B,Gauthier M,Bonnetain F,Fumoleau P

更新日期：2011-11-08 00:00:00

abstract：:In addition to hypoxia, acidic extracellular pH (pH(e)) is recognised as one of the microenvironmental characteristics of solid tumours. A number of studies have examined ways to increase tumour acidity in order to improve tumour-specific targeting of certain drugs and the effectiveness of hyperthermia. However, previ...

journal_title：British journal of cancer

authors： Kalliomäki T,Hill RP

更新日期：2004-05-04 00:00:00

abstract：:Immunoreactive and bioassayable plasma fibronectin (opsonic α(2) surface-binding (SB) glycoprotein) was measured during experimental Sarcoma-180 tumour growth in mice. Male C57BL/6 mice were challenged s.c. with 2 × 10(6) viable Sarcoma-180 tumour cells and evaluated sequentially in parallel with saline-injected contr...

journal_title：British journal of cancer

authors： Saba TM,Gregory TJ,Blumenstock FA

更新日期：1980-06-01 00:00:00

abstract：:Forty-two patients with small cell lung cancer were treated with a combination of carboplatin, ifosfamide and etoposide. Vincristine was given on day 14 of each course, the courses being repeated every 28 days for a maximum of six. Thoracic radiotherapy was given 4 weeks after the last course of chemotherapy but no pr...

journal_title：British journal of cancer

authors： Thatcher N,Lind M,Stout R,Payne C,Carroll KB,Campbell C,Moussalli H

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:RSPO ligands, activators of the Wnt/β-catenin pathway, are overexpressed in different cancers. The objective of this study was to investigate the role of RSPOs in breast cancer (BC). METHODS:Expression of RSPO and markers of various cancer pathways were measured in breast tumours and cell lines by qRT-PCR. ...

journal_title：British journal of cancer

authors： Coussy F,Lallemand F,Vacher S,Schnitzler A,Chemlali W,Caly M,Nicolas A,Richon S,Meseure D,El Botty R,De-Plater L,Fuhrmann L,Dubois T,Roman-Roman S,Dangles-Marie V,Marangoni E,Bièche I

更新日期：2017-06-06 00:00:00

abstract：:Estimation of FGF-3 oncogene amplification in DNA samples extracted from paraffin embedded sections of 136 ovarian cancer samples was carried out by a quantitative PCR method. The aim of this study was to elucidate a possible association of FGF-3 copy numbers with established prognostic factors such as age, histology,...

journal_title：British journal of cancer

authors： Rosen A,Sevelda P,Klein M,Dobianer K,Hruza C,Czerwenka K,Hanak H,Vavra N,Salzer H,Leodolter S

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Circulating total cytokeratin 18 (tCK18) and/or caspase cleaved cytokeratin 18 (cCK18) (measured by M65 and M30 enzyme-linked immunosorbent assays (ELISAs), respectively) are used as pharmacodynamic (PD) biomarkers of epithelial cell death in clinical trials. Having validated these ELISAs, we assessed their ...

journal_title：British journal of cancer

authors： Greystoke A,Dean E,Saunders MP,Cummings J,Hughes A,Ranson M,Dive C,Renehan AG

更新日期：2012-10-23 00:00:00

abstract：:The cellular pharmacology of a series of C8-linked pyrrolobenzodiazepine dimers with polymethylene linkers of n = 3-6 (compounds 1-4) has been studied in a range of human tumour cell lines. The four compounds showed the same pattern of relative activity in five ovarian carcinoma cell lines and one cervical carcinoma c...

journal_title：British journal of cancer

authors： Smellie M,Kelland LR,Thurston DE,Souhami RL,Hartley JA

更新日期：1994-07-01 00:00:00

abstract：:Interferon-alpha (IFN-alpha) is a clinically useful cytokine for treatment of a variety of cancers, including chronic myelocytic leukaemia (CML). Most CML cells are sensitive to IFN-alpha; however, its biological effects on leukaemic cells are incompletely characterized. Here, we provide evidence that IFN-alpha induce...

journal_title：British journal of cancer

authors： Miyachi T,Adachi M,Hinoda Y,Imai K

更新日期：1999-03-01 00:00:00

abstract：:Selection of cytostatic agents for intrathecal administration is the subject of this paper.Both the toxic side effects-destruction of blood-brain barrier and change of body weight-and the cytostatic effects on intracranially transplanted Yoshida ascites sarcoma were investigated of intrathecal administration of variou...

journal_title：British journal of cancer

authors： Hayakawa T,Yamada R,Kanai N,Kuroda R,Ushio Y,Higashi H,Mogami H

更新日期：1970-09-01 00:00:00

abstract：:Hybrid Capture II (HC-II) is a commercial human papillomavirus (HPV) detection test designed to detect 18 HPV types divided into high-risk and low-risk groups. We have tested 1647 scrapes from 1518 unselected women attending routine cytological screening by this assay for the detection of histologically proven high-gr...

journal_title：British journal of cancer

authors： Clavel C,Masure M,Bory JP,Putaud I,Mangeonjean C,Lorenzato M,Gabriel R,Quereux C,Birembaut P

更新日期：1999-07-01 00:00:00

abstract：:Recently, apoptosis has been implicated as one of the end points of cells exposed to chemotherapeutic agents. The p53 and Bcl-2 family of proteins are involved in chemotherapy-induced apoptosis, but in a cell type-dependent manner. We sought to determine the roles played by the p53 and Bcl-2 family of proteins in 5-fl...

journal_title：British journal of cancer

authors： Nita ME,Nagawa H,Tominaga O,Tsuno N,Fujii S,Sasaki S,Fu CG,Takenoue T,Tsuruo T,Muto T

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:To report the long-term outcomes of a phase III trial designed to test two hypotheses: (1) elective nodal irradiation (ENI) is superior to conventional field irradiation (CFI), and (2) chemoradiotherapy plus erlotinib is superior to chemoradiotherapy in locally advanced oesophageal squamous cell cancer (ESCC...

journal_title：British journal of cancer

authors： Xie C,Jing Z,Luo H,Jiang W,Ma L,Hu W,Zheng A,Li D,Ding L,Zhang H,Xie C,Lian X,Du D,Chen M,Bian X,Tan B,Xia B,Xie R,Liu Q,Wang L,Wu S

更新日期：2020-11-01 00:00:00

abstract：:The presence of a mononuclear cell reaction to 41 gestational choriocarcinomata, 10 invasive moles and 13 malignant trophoblastic teratomata has been investigated. The intensity of the reaction was graded; there was a significantly better response to therapy and survival rate in those with a "severe" cellular reaction...

journal_title：British journal of cancer

authors： Elston CW,Bagshawe KD

更新日期：1973-09-01 00:00:00

abstract：:A study involving the measurement of glutathione S-transferase activities and isoenzyme distributions in human ovarian tumours has been carried out. These tumours have been obtained either at initial debulking surgery, prior to cytotoxic chemotherapy, or at second look laparotomy following chemotherapy. The response r...

journal_title：British journal of cancer

authors： Murphy D,McGown AT,Hall A,Cattan A,Crowther D,Fox BW

更新日期：1992-11-01 00:00:00