Alpha-interferon does not increase the efficacy of 5-fluorouracil in advanced colorectal cancer.

abstract：:The aim of this study was to evaluate the expression of CC chemokine receptor 7 (CCR7) in squamous cell cancer of the tonsil with respect to patterns of spread, relapse-free, overall and disease-specific survival. Eighty-four patients with squamous cell cancer of the tonsil were identified. There was a male predominan...

journal_title：British journal of cancer

authors： Pitkin L,Luangdilok S,Corbishley C,Wilson PO,Dalton P,Bray D,Mady S,Williamson P,Odutoye T,Rhys Evans P,Syrigos KN,Nutting CM,Barbachano Y,Eccles S,Harrington KJ

更新日期：2007-09-03 00:00:00

abstract：:In recent years, large discrepancies were described in the success rate of the tyrosinase reverse transcription polymerase chain reaction (RT-PCR) for detecting melanoma cells in the peripheral blood of melanoma patients. We present a quality control study in which we analysed the reproducibility of detection of tyros...

journal_title：British journal of cancer

authors： de Vries TJ,Fourkour A,Punt CJ,van de Locht LT,Wobbes T,van den Bosch S,de Rooij MJ,Mensink EJ,Ruiter DJ,van Muijen GN

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:The risk and prognosis of ovarian cancer have not been well established in women with endometriosis. Thus, we investigated the impact of endometriosis on the risk and prognosis for ovarian cancer, and evaluated clinicopathologic characteristics of endometriosis-associated ovarian cancer (EAOC) in comparison ...

journal_title：British journal of cancer

authors： Kim HS,Kim TH,Chung HH,Song YS

更新日期：2014-04-02 00:00:00

abstract：BACKGROUND:Most oestrogen receptor (ER)-positive early breast cancer diagnosed today is highly curable with multimodality treatment. Systemic adjuvant treatments including endocrine therapy and chemotherapy have made a significant contribution to the increasing cure rates over the past three decades. However not all wo...

journal_title：British journal of cancer

authors： Yeo B,Zabaglo L,Hills M,Dodson A,Smith I,Dowsett M

更新日期：2015-07-28 00:00:00

abstract：BACKGROUND:Metabolomics has shown promise in gastric cancer (GC) detection. This research sought to identify whether GC has a unique urinary metabolomic profile compared with benign gastric disease (BN) and healthy (HE) patients. METHODS:Urine from 43 GC, 40 BN, and 40 matched HE patients was analysed using (1)H nucle...

journal_title：British journal of cancer

authors： Chan AW,Mercier P,Schiller D,Bailey R,Robbins S,Eurich DT,Sawyer MB,Broadhurst D

更新日期：2016-01-12 00:00:00

abstract：:Expression of both P-glycoprotein (P-gp) and mutant p53 have recently been reported to be associated with poor prognosis of breast cancer. The expression of P-gp is associated in vitro and in vivo with cross-resistance to several anti-cancer drugs. p53 plays a regulatory role in apoptosis, and mutant p53 has been sugg...

journal_title：British journal of cancer

authors： Linn SC,Honkoop AH,Hoekman K,van der Valk P,Pinedo HM,Giaccone G

更新日期：1996-07-01 00:00:00

abstract：:Expression of the tumour suppressor gene p53 was examined in squamous cell carcinoma of the head and neck using two p53 antibodies, PAb 421 and PAb 1801. Elevated p53 expression was found in 67% of the 73 patients investigated. P53 expression was not found to correlate with whether the patient had been previously trea...

journal_title：British journal of cancer

authors： Field JK,Spandidos DA,Malliri A,Gosney JR,Yiagnisis M,Stell PM

更新日期：1991-09-01 00:00:00

abstract：:A sequential, quantitative loss of Peanut agglutinin (PNA) binding with progression of mouse mammary cells from normal to preneoplastic to neoplastic phenotypes was observed. Normal mammary epithelium, preneoplastic mammary lesions designated D2HAN (D2-type hyperplastic alveolar nodules) and a series of nine spontaneo...

journal_title：British journal of cancer

authors： Rak JW,McEachern D,Miller FR

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:The role of chemotherapy for neuroendocrine tumours remains controversial and there is no standard regimen. METHOD:We report the outcome for a consecutive series of chemonaive patients with metastatic or locally advanced neuroendocrine tumours treated with a combination of 5-fluorouracil (500 mg m(-2)), cis...

journal_title：British journal of cancer

authors： Turner NC,Strauss SJ,Sarker D,Gillmore R,Kirkwood A,Hackshaw A,Papadopoulou A,Bell J,Kayani I,Toumpanakis C,Grillo F,Mayer A,Hochhauser D,Begent RH,Caplin ME,Meyer T

更新日期：2010-03-30 00:00:00

abstract：BACKGROUND:Human papillomavirus (HPV) testing in oropharyngeal squamous cell carcinoma (OPSCC) is now advocated. Demonstration of transcriptionally active high-risk HPV (HR-HPV) in fresh tumour tissue is considered to be the analytical 'gold standard'. Clinical testing has focused on formalin-fixed paraffin-embedded (F...

journal_title：British journal of cancer

authors： Schache AG,Liloglou T,Risk JM,Jones TM,Ma XJ,Wang H,Bui S,Luo Y,Sloan P,Shaw RJ,Robinson M

更新日期：2013-04-02 00:00:00

abstract：BACKGROUND:Cervical cancer screening coverage remains insufficient in most countries. Our objective was to assess whether in-home vaginal self-sampling with a dry swab for high-risk human papillomavirus (HR-HPV) testing is effective and cost-effective in increasing participation in cervical cancer screening. METHODS:I...

journal_title：British journal of cancer

authors： Haguenoer K,Sengchanh S,Gaudy-Graffin C,Boyard J,Fontenay R,Marret H,Goudeau A,Pigneaux de Laroche N,Rusch E,Giraudeau B

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:The development of practical patient-reported outcome measures (PROM) to assess the user view of health programmes is increasingly important. Valid, shorter instruments are more likely to be used and completed than extensive questionnaires. METHODS:Consecutive adult outpatient attendees who were long-term s...

journal_title：British journal of cancer

authors： Phillips R,Absolom K,Stark D,Glaser A

更新日期：2010-11-09 00:00:00

abstract：BACKGROUND:The small stress heat shock protein 27 (Hsp27) has recently turned as a promising target for cancer treatment. Hsp27 upregulation is associated with tumour growth and resistance to chemo- and radio-therapeutic treatments, and several ongoing drugs inhibiting Hsp27 expression are under clinical trial. Hsp27 i...

journal_title：British journal of cancer

authors： Gibert B,Eckel B,Gonin V,Goldschneider D,Fombonne J,Deux B,Mehlen P,Arrigo AP,Clézardin P,Diaz-Latoud C

更新日期：2012-06-26 00:00:00

abstract：:Serial transplantation of an HCG-producing human testicular teratoma in immune-deprived mice is described. The xenografted tumour was compared to the tumour of origin in histology, immunohistochemistry (using an immune peroxidase technique to localize HCG) autoradiography, marker production and growth rate. It is conc...

journal_title：British journal of cancer

authors： Selby PJ,Heyderman E,Gibbs J,Peckham MJ

更新日期：1979-05-01 00:00:00

abstract：:To design hybrid tumour necrosis factor-alpha (TNF-alpha) applicable to systemic anti-tumour therapeutic use, we assessed the relationships among the molecular size of hybrid TNF-alpha, in vitro bioactivity and in vivo anti-tumour potency. Natural human TNF-alpha was covalently modified with polyethylene glycol (PEG) ...

journal_title：British journal of cancer

authors： Tsutsumi Y,Tsunoda S,Kamada H,Kihira T,Nakagawa S,Kaneda Y,Kanamori T,Mayumi T

更新日期：1996-10-01 00:00:00

abstract：:In a meta-analysis of testicular cancer in twins, twins had a 30% increased risk (estimate 1.31, 95% CI 1.1-1.6), providing indirect support for the hypothesis that in utero hormone variations influence risk of testicular cancer. The summary-estimate for dizygotic twins was 1.3 (1.0-1.7) and for monozygotic or same se...

journal_title：British journal of cancer

authors： Neale RE,Carrière P,Murphy MF,Baade PD

更新日期：2008-01-15 00:00:00

abstract：:Although CD133 has been shown to be a marker for cancer stem cells in various tumours, its expression in pancreatic cancer has not yet been clinically reported. In this study, we investigated the relationship between CD133 expression and clinicopathological factors in pancreatic cancer. Pancreatic head carcinoma speci...

journal_title：British journal of cancer

authors： Maeda S,Shinchi H,Kurahara H,Mataki Y,Maemura K,Sato M,Natsugoe S,Aikou T,Takao S

更新日期：2008-04-22 00:00:00

abstract：:Local infiltrates of eosinophilic leucocytes and macrophages and the deposition of acid mucopolysaccharides (AMPS) in 72 operable primary lung cancers and 17 isolated pulmonary metastases of known origin were correlated to tumour stage (radically or non-radically operable) and clinical course, by following the patient...

journal_title：British journal of cancer

authors： Kolb E,Müller E

更新日期：1979-09-01 00:00:00

abstract：BACKGROUND:Epithelial ovarian cancer (EOC) cells are prone to metastasise throughout the peritoneal cavity. The epithelial-to-mesenchymal transition (EMT) is a necessary step towards metastatic tumour progression. CA125/MUC16 mucin is a high-molecular-weight glycoprotein overexpressed in the majority of serous carcinom...

journal_title：British journal of cancer

authors： Comamala M,Pinard M,Thériault C,Matte I,Albert A,Boivin M,Beaudin J,Piché A,Rancourt C

更新日期：2011-03-15 00:00:00

abstract：:The effects of steroid hormones are pleiotropic. Similarly, non-steroidal oestrogen receptor antagonists such as tamoxifen exert partial agonistic effects with a species- and tissue-specific pattern. Conversely, little is known of the biological effects of non-steroidal anti-androgens, whose role has been investigated...

journal_title：British journal of cancer

authors： Decensi A,Torrisi R,Fontana V

更新日期：1994-03-01 00:00:00

abstract：:Although the presence of axillary node metastases in breast cancer is a key prognostic indicator and may influence treatment decisions, a significant proportion of patients diagnosed as axillary node negative (ANN) using standard histopathological techniques may have occult nodal metastases (OMs). A combination of lim...

journal_title：British journal of cancer

authors： McGuckin MA,Cummings MC,Walsh MD,Hohn BG,Bennett IC,Wright RG

更新日期：1996-01-01 00:00:00

abstract：:An extensive analysis of the reliability of positron emission tomography (PET) after induction treatment in patients with Hodgkin's disease (HD) or aggressive non-Hodgkin's lymphoma (NHL). In all, 75 untreated patients with HD (n=41) or aggressive NHL (n=34) were studied with both PET and CT scans following standard c...

journal_title：British journal of cancer

authors： Zinzani PL,Fanti S,Battista G,Tani M,Castellucci P,Stefoni V,Alinari L,Farsad M,Musuraca G,Gabriele A,Marchi E,Nanni C,Canini R,Monetti N,Baccarani M

更新日期：2004-08-31 00:00:00

abstract：:The reactivation of U.V.-irradiated adenovirus 2 in HeLa cells is enhanced 8-9 fold if the cells are given a brief hyperthermic shock before infection. Maximum reactivation is achieved by heating for 10 min at 45.5 degrees C and with a delay of 36 h between heating and infection. The induction process requires protein...

journal_title：British journal of cancer

authors： Piperakis SM,McLennan AG

更新日期：1984-02-01 00:00:00

abstract：BACKGROUND:Gram-negative bacteria mediated gemcitabine resistance in pre-clinical models. We determined if intratumoural lipopolysaccharide (LPS) detection by immunohistochemistry is associated with outcome in advanced pancreatic ductal adenocarcinoma (PDAC) treated with gemcitabine and non-gemcitabine containing 1st-l...

journal_title：British journal of cancer

authors： Guenther M,Haas M,Heinemann V,Kruger S,Westphalen CB,von Bergwelt-Baildon M,Mayerle J,Werner J,Kirchner T,Boeck S,Ormanns S

更新日期：2020-10-01 00:00:00

abstract：:Secretary component (SC) is expressed basolaterally as a transmembrane protein (pIg receptor) on secretory epithelial cells. As pIg receptor it plays a central role in humoral immunity by mediating the external translocation of dimeric IgA and pentameric IgM. A few case reports have suggested that reduced or absent SC...

journal_title：British journal of cancer

authors： Krajci P,Meling GI,Andersen SN,Hofstad B,Vatn MH,Rognum TO,Brandtzaeg P

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Despite recent advances in cancer therapy, the 5-year survival rate for Ewing's sarcoma is still very low, and new therapeutic approaches are necessary. It was found previously that melatonin induces cell death in the Ewing's sarcoma cell line, SK-N-MC, by activating the extrinsic apoptotic pathway. METHODS...

journal_title：British journal of cancer

authors： García-Santos G,Martin V,Rodríguez-Blanco J,Herrera F,Casado-Zapico S,Sánchez-Sánchez AM,Antolín I,Rodríguez C

更新日期：2012-03-27 00:00:00

abstract：:The matrix metalloprotease MMP-9 localizes to tumour-associated macrophages in human ovarian cancer but little is known of its regulation. Co-culture of human ovarian cancer cells (PEO-1) and a monocytic cell line (THP-1) led to production of 92-kDa proMMP-9. PEO-1-conditioned medium (CM) also stimulated THP-1 cells o...

journal_title：British journal of cancer

authors： Leber TM,Balkwill FR

更新日期：1998-09-01 00:00:00

abstract：:Testicular germ cell tumour (GCT) is not an AIDS-defining illness despite an increased incidence in men with HIV infection. We performed a matched case-control study comparing outcomes in HIV-positive men and the general population with GCT, using three age and stage matched controls for each case. There was no differ...

journal_title：British journal of cancer

authors： Powles T,Bower M,Shamash J,Stebbing J,Ong J,Daugaard G,De Ruiter A,Johnson M,Fisher M,Anderson J,Nelson M,Gazzard B,Oliver T

更新日期：2004-04-19 00:00:00

abstract：:The tumour suppressor gene CDKN2A, located on chromosome 9p21, encodes the cell cycle regulatory protein p16. Inactivation of the CDKN2A gene could lead to uncontrolled cell growth. In order to determine the role of CDKN2A in the development of sporadic ovarian cancer, loss of heterozygosity at 9p21-22, homozygous del...

journal_title：British journal of cancer

authors： Niederacher D,Yan HY,An HX,Bender HG,Beckmann MW

更新日期：1999-08-01 00:00:00

abstract：:Pancreatic cancer is the fifth most common cause of cancer death. Identification of defined patient groups based on a prognostic index may improve the prediction of survival and selection of therapy. Many prognostic factors have been identified often based on retrospective, underpowered studies with unclear analyses. ...

journal_title：British journal of cancer

authors： Stocken DD,Hassan AB,Altman DG,Billingham LJ,Bramhall SR,Johnson PJ,Freemantle N

更新日期：2008-09-16 00:00:00