当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Bacterial lipopolysaccharide as negative predictor of gemcitabine efficacy in advanced pancreatic cancer - translational results from the AIO-PK0104 Phase 3 study.

Bacterial lipopolysaccharide as negative predictor of gemcitabine efficacy in advanced pancreatic cancer - translational results from the AIO-PK0104 Phase 3 study.

Abstract：

BACKGROUND:Gram-negative bacteria mediated gemcitabine resistance in pre-clinical models. We determined if intratumoural lipopolysaccharide (LPS) detection by immunohistochemistry is associated with outcome in advanced pancreatic ductal adenocarcinoma (PDAC) treated with gemcitabine and non-gemcitabine containing 1st-line chemotherapy. METHODS:We examined LPS on tumour tissue from 130 patients treated within the randomised AIO-PK0104 trial and a validation cohort (n = 113) and analysed the association of LPS detection to patient outcome according to treatment subgroups. RESULTS:In 24% of samples from the AIO-PK0104 study LPS was detected; in LPS-positive patients median OS was 4.4 months, compared to 7.3 months with LPS negative tumours (HR 1.732, p = 0.010). A difference in OS was detected in 1st-line gemcitabine-treated patients (n = 71; HR 2.377, p = 0.002), but not in the non-gemcitabine treatment subgroup (n = 59; HR 1.275, p = 0.478). Within the validation cohort, the LPS positivity rate was 23%, and LPS detection was correlated with impaired OS in the gemcitabine subgroup (n = 94; HR 1.993, p = 0.008) whereas no difference in OS was observed in the non-gemcitabine subgroup (n = 19; HR 2.596, p = 0.219). CONCLUSIONS:The detection of intratumoural LPS as surrogate marker for gram-negative bacterial colonisation may serve as a negative predictor for gemcitabine efficacy in advanced PDAC. CLINICAL TRIAL REGISTRY:The Clinical trial registry identifier is NCT00440167.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Guenther M,Haas M,Heinemann V,Kruger S,Westphalen CB,von Bergwelt-Baildon M,Mayerle J,Werner J,Kirchner T,Boeck S,Ormanns S

doi

10.1038/s41416-020-01029-7

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

1370-1376

issue

9

eissn

0007-0920

issn

1532-1827

pii

10.1038/s41416-020-01029-7

journal_volume

123

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Targeting SDF-1/CXCR4 to inhibit tumour vasculature for treatment of glioblastomas.

    abstract：:Local recurrence of glioblastomas is a major cause of patient mortality after definitive treatment. This review discusses the roles of the chemokine stromal cell-derived factor-1 and its receptor CXC chemokine receptor 4 (CXCR4) in affecting the sensitivity of glioblastomas to irradiation. Blocking these molecules pre...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/bjc.2011.169

    authors： Tseng D,Vasquez-Medrano DA,Brown JM

    更新日期：2011-06-07 00:00:00

  • Diagnostic accuracy systematic review of rectal bleeding in combination with other symptoms, signs and tests in relation to colorectal cancer.

    abstract：BACKGROUND:Rectal bleeding is a recognised early symptom of colorectal cancer. This study aimed to assess the diagnostic accuracy of symptoms, signs and diagnostic tests in patients with rectal bleeding in relation to risk of colorectal cancer in primary care. METHODS:Diagnostic accuracy systematic review. Medline (19...

    journal_title：British journal of cancer

    pub_type： 杂志文章,meta分析,评审

    doi：10.1038/sj.bjc.6605426

    authors： Olde Bekkink M,McCowan C,Falk GA,Teljeur C,Van de Laar FA,Fahey T

    更新日期：2010-01-05 00:00:00

  • Telomerase activity in benign and malignant human thyroid tissues.

    abstract：:Telomerase is a specialized ribonucleoprotein polymerase that directs the synthesis of telomerase repeats at chromosome ends. Accumulating evidence has indicated that telomerase is stringently repressed in normal human somatic tissues but reactivated in cancers and immortal cells, suggesting that activation of telomer...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.363

    authors： Cheng AJ,Lin JD,Chang T,Wang TC

    更新日期：1998-06-01 00:00:00

  • Measurement of prostate-specific antigen in detection of benign or malignant breast disease in women.

    abstract：:Using a highly sensitive chemiluminescent enzyme immunoassay, we have evaluated the measurement of serum prostate-specific antigen (PSA) as a potential diagnostic test for differentiation between women with breast cancer and those with benign breast disease. In a controlled study consisting of 284 women with well-docu...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690252

    authors： Romppanen J,Keskikuru R,Kataja V,Eskelinen M,Kosma VM,Savolainen K,Uusitupa M,Mononen I

    更新日期：1999-03-01 00:00:00

  • Combined oral contraceptive use before the first birth and epithelial ovarian cancer risk.

    abstract：BACKGROUND:Combined oral contraceptive (COC) use reduces epithelial ovarian cancer (EOC) risk. However, little is known about risk with COC use before the first full-term pregnancy (FFTP). METHODS:This Canadian population-based case-control study (2001-2012) included 854 invasive cases/2139 controls aged ⩾40 years who...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.400

    authors： Cook LS,Pestak CR,Leung AC,Steed H,Nation J,Swenerton K,Gallagher R,Magliocco A,Köbel M,Brooks-Wilson A,Le N

    更新日期：2017-01-17 00:00:00

  • Genetic alterations on chromosome 17p associated with response to radiotherapy in bulky cervical cancer.

    abstract：:Chromosome 17 alterations are found in more cancers than those of any other chromosome, and frequently involve the p53 gene on 17p13. The aim of this study was to identify the correlations between the presence of loss of heterozygosity (LOH) and microsatellite instability (MI) on chromosome 17p13 in patients with cerv...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690658

    authors： Harima Y,Shirahama S,Harima K,Aoki S,Ohnishi T,Tanaka Y

    更新日期：1999-09-01 00:00:00

  • Anti-Her-2/neu antibody induces apoptosis in Her-2/neu overexpressing breast cancer cells independently from p53 status.

    abstract：:Anti-Her-2/neu antibody is known to induce apoptosis in HER-2/neu overexpressing breast cancer cells. However, exact regulatory mechanisms mediating and controlling this phenomenon are still unknown. In the present study, we have investigated the effect of anti-Her-2/neu antibody on apoptosis of HER-2/neu overexpressi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2001.2197

    authors： Brodowicz T,Kandioler D,Tomek S,Ludwig C,Rudas M,Kunstfeld R,Koestler W,Hejna M,Budinsky A,Wiltschke C,Zielinski CC

    更新日期：2001-11-30 00:00:00

  • The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer.

    abstract：:Many kallikrein genes were found to be differentially expressed in various malignancies, and prostate specific antigen (encoded by the KLK3 gene) is the best tumour marker for prostate cancer. Prostate specific antigen has recently been shown to be an independent favourable prognostic marker for breast cancer. KLK15 i...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600590

    authors： Yousef GM,Scorilas A,Magklara A,Memari N,Ponzone R,Sismondi P,Biglia N,Abd Ellatif M,Diamandis EP

    更新日期：2002-11-18 00:00:00

  • A recurrent pattern of chromosomal aberrations and immunophenotypic appearance defines anal squamous cell carcinomas.

    abstract：:Squamous cell carcinomas of the anus are rare neoplasias that account for about 3% of large bowel tumours. Infections with human papillomaviruses are frequently detected in these cancers, suggesting that pathogenic pathways in anal carcinomas and in carcinomas of the uterine cervix are similar. Little is known regardi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.547

    authors： Heselmeyer K,du Manoir S,Blegen H,Friberg B,Svensson C,Schröck E,Veldman T,Shah K,Auer G,Ried T

    更新日期：1997-01-01 00:00:00

  • Clinical and economic benefit of HPV-load testing in follow-up and management of women postcone biopsy for CIN2-3.

    abstract：:This study aimed to evaluate the clinical and economic implications of integrating human papilloma virus (HPV) load testing into the follow-up and management protocol of women postconisation for high-grade cervical intraepithelial neoplasia (CIN2-3). We evaluated 130 suitable women: 63 were screened biannually by Pap ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601032

    authors： Almog B,Gamzu R,Bornstein J,Levin I,Fainaru O,Niv J,Lessing JB,Bar-Am A

    更新日期：2003-07-07 00:00:00

  • Resistance to alkylating agents and tumour differentiation in xenografts of small cell lung cancer.

    abstract：:Small cell bronchial carcinoma (SCC) xenografts with differing sensitivity to cyclophosphamide (CY) were investigated using a variety of techniques. Two xenografts (HX78 and HX88) were relatively sensitive to CY, one xenograft (HX72) was inherently resistant to CY and a fourth xenograft (HX78Cy) was a CY induced resis...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1985.98

    authors： Berman R,Gusterson B,Steel GG

    更新日期：1985-05-01 00:00:00

  • Applications of array technology: identification of molecular targets in bladder cancer.

    abstract：:High-throughput microarrays are being used in expression profiling analyses with the objectives of gene and pathway discovery, functional characterization of genes, and tumor subclassification. This review summarizes bladder cancer studies dealing with both in vitro models and clinical specimens, using distinct microa...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/sj.bjc.6601406

    authors： Sánchez-Carbayo M,Cordon-Cardo C

    更新日期：2003-12-15 00:00:00

  • Comorbid conditions delay diagnosis of colorectal cancer: a cohort study using electronic primary care records.

    abstract：BACKGROUND:Pre-existing non-cancer conditions may complicate and delay colorectal cancer diagnosis. METHOD:Incident cases (aged ⩾40 years, 2007-2009) with colorectal cancer were identified in the Clinical Practice Research Datalink, UK. Diagnostic interval was defined as time from first symptomatic presentation of col...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2017.127

    authors： Mounce LTA,Price S,Valderas JM,Hamilton W

    更新日期：2017-06-06 00:00:00

  • Rab25 as a tumour suppressor in colon carcinogenesis.

    abstract：:Recent investigations have increasingly focussed attention on the roles of intracellular vesicle trafficking in the regulation of epithelial polarity and transformation. Rab25, an epithelial-specific member of the Rab family of small GTPases, has been associated with several epithelial cancers. Whereas Rab25 overexpre...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/sj.bjc.6605983

    authors： Goldenring JR,Nam KT

    更新日期：2011-01-04 00:00:00

  • A human testicular teratoma serially transplanted in immune-deprived mice.

    abstract：:Serial transplantation of an HCG-producing human testicular teratoma in immune-deprived mice is described. The xenografted tumour was compared to the tumour of origin in histology, immunohistochemistry (using an immune peroxidase technique to localize HCG) autoradiography, marker production and growth rate. It is conc...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1979.104

    authors： Selby PJ,Heyderman E,Gibbs J,Peckham MJ

    更新日期：1979-05-01 00:00:00

  • Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells.

    abstract：:Cimetidine has been shown to have beneficial effects in colorectal cancer patients. In this study, a total of 64 colorectal cancer patients who received curative operation were examined for the effects of cimetidine treatment on survival and recurrence. The cimetidine group was given 800 mg day(-1) of cimetidine orall...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1038/sj.bjc.6600048

    authors： Matsumoto S,Imaeda Y,Umemoto S,Kobayashi K,Suzuki H,Okamoto T

    更新日期：2002-01-21 00:00:00

  • Prognostic/predictive value of 207 serum factors in colorectal cancer treated with cediranib and/or chemotherapy.

    abstract：BACKGROUND:The prognostic and predictive value of multiple serum biomarkers was evaluated using samples from a randomised phase III study (HORIZON II) investigating chemotherapy with or without cediranib in metastatic colorectal cancer (mCRC). METHODS:Baseline levels of 207 protein markers were measured in serum sampl...

    journal_title：British journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/bjc.2013.649

    authors： Spencer SK,Pommier AJ,Morgan SR,Barry ST,Robertson JD,Hoff PM,Jürgensmeier JM

    更新日期：2013-11-26 00:00:00

  • Assessment of 1183 screen-detected, category 3B, circumscribed masses by cytology and core biopsy with long-term follow up data.

    abstract：:Discrete masses are commonly detected during mammographic screening and most such lesions are benign. For lesions without pathognomonically benign imaging features that are still regarded likely to be non-malignant (Tabar grade 3) reliable biopsy results would be a clinically useful alternative to mammographic surveil...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604296

    authors： Farshid G,Downey P,Gill P,Pieterse S

    更新日期：2008-04-08 00:00:00

  • Declining mortality from breast cancer in Yorkshire, 1983-1998: extent and causes.

    abstract：:Incidence and mortality data, stage of disease and treatment information for female breast cancer were obtained for the years 1975-1999 for the former Yorkshire Regional Health Authority area, from the Northern and Yorkshire Cancer Registry and Information Service. Deaths by age group and 3-year calendar period were s...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601614

    authors： Pisani P,Forman D

    更新日期：2004-02-09 00:00:00

  • The prognostic significance of transforming growth factors in human breast cancer.

    abstract：:Transforming growth factor alpha (TGF alpha) and Transforming growth factor beta-1 (TGF-beta 1) are growth regulatory for breast cancer cell lines in vitro and several studies have suggested that levels of the receptor for TGF alpha, the epidermal growth factor (EGFR) in tumour biopsies predict relapse and survival. W...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1993.261

    authors： Murray PA,Barrett-Lee P,Travers M,Luqmani Y,Powles T,Coombes RC

    更新日期：1993-06-01 00:00:00

  • Increased level of exhaled nitric oxide and up-regulation of inducible nitric oxide synthase in patients with primary lung cancer.

    abstract：:Monocyte-macrophage series have an important role in host surveillance against cancer. The cytotoxic/cytostatic activity of macrophages is, to a great extent, attributed to the up-regulation of inducible nitric oxide synthase (iNOS) and production of nitric oxide (NO). Here, in 28 patients with primary lung cancer and...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.528

    authors： Liu CY,Wang CH,Chen TC,Lin HC,Yu CT,Kuo HP

    更新日期：1998-08-01 00:00:00

  • A retrospective study of the cancer patterns among hospital in-patients in Botswana 1960-72.

    abstract：:Records of approximately 310,000 patients admitted to the 10 hospitals in Botswana between 1960 and 1972 have been studied and details of 1445 patients with malignant tumours abstracted. For the 894 tumours for which there was some supporting evidence--at best histological proof and minimally a clinical description of...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1975.138

    authors： Macrae SM,Cook BV

    更新日期：1975-07-01 00:00:00

  • TMPRSS4: an emerging potential therapeutic target in cancer.

    abstract：:Altered expression and activity of proteases is a key event in cancer, particularly in relation to invasion, modification of the extracellular matrix and metastasis. The transmembrane protease, serine 4 (TMPRSS4) is closely related to other cancer-associated proteases, such as hepsin, TMPRSS2 and matriptase. We review...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/bjc.2014.403

    authors： de Aberasturi AL,Calvo A

    更新日期：2015-01-06 00:00:00

  • Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers.

    abstract：:We have previously reported that supplementation with folic acid (1.2 mg day(-1) for 12 week) elicited a significant improvement in the folate status of 61 healthy volunteers. We have examined effects of this supplement on markers of genomic stability. Little is known about the effect of folate supplementation on DNA ...

    journal_title：British journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/sj.bjc.6603197

    authors： Basten GP,Duthie SJ,Pirie L,Vaughan N,Hill MH,Powers HJ

    更新日期：2006-06-19 00:00:00

  • Intake of wholegrain products and risk of colorectal cancers in the Diet, Cancer and Health cohort study.

    abstract：BACKGROUND:Consumption of wholegrain (WG) products may protect against colon and rectal cancer. METHODS:The associations between total and individual WG product consumption and colon and rectal cancer risk were prospectively examined using data on 461 incident cases of colon cancer and 283 incident cases of rectal can...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605806

    authors： Egeberg R,Olsen A,Loft S,Christensen J,Johnsen NF,Overvad K,Tjønneland A

    更新日期：2010-08-24 00:00:00

  • Evidence for characteristic vascular patterns in solid tumours: quantitative studies using corrosion casts.

    abstract：:The vascular architecture of four different tumour cell lines (CaX, CaNT, SaS, HEC-1B) transplanted subcutaneously in mice was examined by means of microvascular corrosion casting in order to determine whether there is a characteristic vascular pattern for different tumour types and whether it differs significantly fr...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690416

    authors： Konerding MA,Malkusch W,Klapthor B,van Ackern C,Fait E,Hill SA,Parkins C,Chaplin DJ,Presta M,Denekamp J

    更新日期：1999-05-01 00:00:00

  • Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2-· production in cancer cells.

    abstract：BACKGROUND:The TP53 tumor suppressor gene is the most frequently altered gene in tumors and mutant p53 gain-of-function isoforms actively promote cancer malignancy. METHODS:A panel of wild-type and mutant p53 cancer cell lines of different tissues, including pancreas, breast, skin, and lung were used, as well as chron...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-018-0288-2

    authors： Cordani M,Butera G,Dando I,Torrens-Mas M,Butturini E,Pacchiana R,Oppici E,Cavallini C,Gasperini S,Tamassia N,Nadal-Serrano M,Coan M,Rossi D,Gaidano G,Caraglia M,Mariotto S,Spizzo R,Roca P,Oliver J,Scupoli MT,Donad

    更新日期：2018-10-01 00:00:00

  • Loss of heterozygosity on the long arm of chromosome 11 in colorectal tumours.

    abstract：:We have examined a series of human colorectal adenomas, carcinomas and cell lines derived from human colorectal cancer for loss of heterozygosity (LOH) on chromosome 11q22-23 by polymerase chain reaction (PCR) amplification of a microsatellite polymorphism of the dopamine D2 receptor (DRD2) locus. LOH was demonstrated...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1994.315

    authors： Gustafson CE,Young J,Leggett B,Searle J,Chenevix-Trench G

    更新日期：1994-09-01 00:00:00

  • Serine protease-induced enhancement of blood-borne metastasis of rat ascites tumour cells and its prevention with deoxyribonuclease.

    abstract：:Serine proteases, such as alpha-chymotrypsin or elastase, caused an aggregation of rat ascites tumour cell lines, AH-130, AH-109A and YS, in a protein free medium which preserved the cell viability. This aggregation, which was monitored spectrophotometrically, was dependent upon the protease activities and was resista...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1990.339

    authors： Sugihara S,Yamamoto T,Tsuruta J,Tanaka J,Kambara T,Hiraoka T,Miyauchi Y

    更新日期：1990-10-01 00:00:00

  • A study of ovarian cancer patients treated with dose-intensive chemotherapy supported with peripheral blood progenitor cells mobilised by filgrastim and cyclophosphamide.

    abstract：:We have shown that large numbers of haemopoietic progenitor cells are mobilised into the blood after filgrastim [granulocyte colony-stimulating factor (G-CSF)] alone and filgrastim following cyclophosphamide chemotherapy in previously untreated patients with ovarian cancer. These cells may be used to provide safe and ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.637

    authors： Weaver A,Wrigley E,Watson A,Chang J,Collins CD,Jenkins B,Gill C,Pettengell R,Dexter TM,Testa NG,Crowther D

    更新日期：1996-12-01 00:00:00