Abstract:
BACKGROUND:Combined oral contraceptive (COC) use reduces epithelial ovarian cancer (EOC) risk. However, little is known about risk with COC use before the first full-term pregnancy (FFTP). METHODS:This Canadian population-based case-control study (2001-2012) included 854 invasive cases/2139 controls aged ⩾40 years who were parous and had information on COC use. We estimated odds ratios (aORs) and 95% confidence intervals (CI) adjusted for study site, age, parity, breastfeeding, age at FFTP, familial breast/ovarian cancer, tubal ligation, and body mass. RESULTS:Among parous women, per year of COC use exclusively before the FFTP was associated with a 9% risk reduction (95% CI=0.86-0.96). Results were similar for high-grade serous and endometrioid/clear cell EOC. In contrast, per year of use exclusively after the FFTP was not associated with risk (aOR=0.98, 95% CI=0.95-1.02). CONCLUSIONS:Combined oral contraceptive use before the FFTP may provide a risk reduction that remains for many years, informing possible prevention strategies.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Cook LS,Pestak CR,Leung AC,Steed H,Nation J,Swenerton K,Gallagher R,Magliocco A,Köbel M,Brooks-Wilson A,Le Ndoi
10.1038/bjc.2016.400subject
Has Abstractpub_date
2017-01-17 00:00:00pages
265-269issue
2eissn
0007-0920issn
1532-1827pii
bjc2016400journal_volume
116pub_type
杂志文章abstract:BACKGROUND:Immunohistological assessment of Ki 67 expression is less expensive than Oncotype Dx, which is currently used to identify patients with lymph node-negative breast cancer, who will benefit from adjuvant chemotherapy. METHODS:The relationship of immunohistologically measured Ki 67 to Oncotype DX recurrence sc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.402
更新日期:2011-10-25 00:00:00
abstract:BACKGROUND:Robot-assisted radical prostatectomy (RARP) has been rapidly adopted without robust evidence comparing its functional outcomes against laparoscopic radical prostatectomy (LRP) or open retropubic radical prostatectomy (ORP) approaches. This study compared patient-reported functional outcomes following RARP, L...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2017.454
更新日期:2018-02-20 00:00:00
abstract::Erbicin is a human anti-ErbB2 single-chain antibody fragment with high affinity and selectivity for ErbB2-positive cancer cells. Two anti-ErbB2 immunoconjugates, called Erb-hRNase and Erb-hcAb, have been prepared and found to be selectively cytotoxic on ErbB2-positive cancer cells in vitro and vivo. In Erb-hRNase, Erb...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604022
更新日期:2007-11-19 00:00:00
abstract::A population-based, case-control study was conducted in Los Angeles County, California, to investigate the inter-relationships of obesity, hypertension and medications in relation to renal cell carcinoma (RCC) risk. A total of 1204 RCC patients and an equal number of neighbourhood controls were included. Obesity was a...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.248
更新日期:1998-05-01 00:00:00
abstract::Summary Antibodies against Candida albicans antigenic determinants have been reported to cross-react with human tumour cells. We have found that two monoclonal antibodies, C6 and PA1OF, developed at our laboratory against C. albicans antigenic determinants, cross-react with human ovarian cancer on Western blots and im...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.167
更新日期:1998-03-01 00:00:00
abstract::Our purpose was to determine the response rate and median and overall survival of gemcitabine as monotherapy versus gemcitabine plus irinotecan in advanced or metastatic pancreatic cancer. Patients with histologically or cytologically confirmed adenocarcinoma who were chemotherapy and radiotherapy naive were enrolled....
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/sj.bjc.6603301
更新日期:2006-09-04 00:00:00
abstract:BACKGROUND:Regulator of cullins-1 (ROC1) is a key subunit in the cullin-RING ligase (CRL) protein complex. Our previous study indicated that ROC1 was essential for bladder cancer cell survival and that ROC1 knockdown inhibited CRL activity, triggering G2 phase arrest and senescence. However, the role of ROC1 in the mal...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.444
更新日期:2016-02-02 00:00:00
abstract::Multiple primary tumours occurring in a three-year population-based series of patients with histopathologically peer-reviewed sarcomas from North West England were ascertained in order to look at the patterns of neoplasms seen. A total of 30 out of the 310 patients entered in the study had additional primary tumours. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.512
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:We evaluated the associations of anthropometric indicators of general obesity (body mass index, BMI), an established risk factor of various cancer, and body fat distribution (waist circumference, WC; hip circumference, HC; and waist-to-hip ratio, WHR), which may better reflect metabolic complications of obes...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1038/bjc.2017.106
更新日期:2017-05-23 00:00:00
abstract::Ovarian cancer is the fifth leading cause of female cancer deaths in the Western world. Significant progress has been made in the treatment of patients with ovarian cancer, however, the majority of patients experience disease recurrence and new therapies are being sought for such patients. Clinical investigation of po...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.2015.395
更新日期:2015-12-15 00:00:00
abstract::Aminoglutethimide has been used in combination with hydrocortisone in patients with advanced prostatic cancer with the rationale that it causes a 'medical adrenalectomy'. Both objective and subjective responses have been recorded. We have examined the effect of AG and HC alone and in combination on plasma androgen lev...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.40
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:The mitogen-activated protein kinase (MAPK) pathway has been implicated in the molecular pathogenesis of human cancers, including metastatic colorectal cancer (mCRC). This provides a rationale for the development of MAPK-targeted agents such as pimasertib. METHODS:Patients with KRAS mutant mCRC were treated...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/bjc.2015.144
更新日期:2015-06-09 00:00:00
abstract:BACKGROUND:We aimed to analyse clinical and gene expression profiles to predict pathologic complete response and disease-free survival using two consecutive, prospective, preoperative chemotherapy trial cohorts. METHODS:Clinicopathological and gene expression data were evaluated in a cohort from two consecutive phase ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.184
更新日期:2016-08-09 00:00:00
abstract:BACKGROUND:Gene mutations in the RAS family rule out metastatic colorectal carcinomas (mCRCs) from anti-EGFR therapies. METHODS:We report a retrospective analysis by Sequenom Massarray and fast COLD-PCR followed by Sanger sequencing on 240 mCRCs. RESULTS:By Sequenom, KRAS and NRAS exons 2-3-4 were mutated in 52.9% (1...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2017.170
更新日期:2017-07-25 00:00:00
abstract::The association between soya foods and breast cancer risk was investigated in a prospective study of 34759 women in Hiroshima and Nagasaki, Japan. Women completed dietary questionnaires in 1969-1970 and/or in 1979-1981 and were followed for incident breast cancer until 1993. The analysis involved 427 cases of primary ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690837
更新日期:1999-12-01 00:00:00
abstract::Increasingly, treatment choices leading to the same survival outcome can be offered to cancer patients (e.g. mastectomy or conservative surgery in early breast cancer). Two approaches available for post-orchidectomy, stage I patients with non-seminomatous germ cell tumours of the testis (NSGCTT), particularly those at...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.570
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Limited evidence exists regarding associations between obesity and kidney cancer among Asians. We examined the associations between obesity measures and risk of kidney cancer. METHODS:We included 23,313,046 adults who underwent health examinations provided by the Korean National Health Insurance Service 200...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0500-z
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:To prospectively examine the association between diabetes and risk of prostate cancer defined by clinical and molecular features. METHODS:A total of 49,392 men from the Health Professionals Follow-up Study (HPFS) were followed from 1986 to 2014. Data on self-reported diabetes were collected at baseline and ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0910-y
更新日期:2020-08-01 00:00:00
abstract::To investigate the efficacy and safety of combining weekly oxaliplatin with weekly 24-h infusion of high-dose 5-fluorouracil (5-FU) and folinic acid (FA) in treatment of patients with advanced gastric cancer. Patients with histologically confirmed, locally advanced or recurrent/metastatic gastric cancer were studied. ...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/sj.bjc.6601985
更新日期:2004-08-02 00:00:00
abstract:BACKGROUND:Accumulating evidence demonstrates high levels of aldehyde dehydrogense (ALDH) activity in human cancer types, in part, because of its association with cancer stem cells. Whereas ALDH1A1 and ALDH7A1 isoforms were reported to associate with prostate tumorigenesis, whether other ALDH isoforms are associated wi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.201
更新日期:2014-05-13 00:00:00
abstract::New therapeutic strategies are now being developed against adenocarcinoma associated with erbB-2 amplification, particularly by inhibiting p185erbB-2 expression. Antisense oligodeoxynucleotides seem promising for this purpose as long as they are efficiently protected against degradation and targeted into the cells. We...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.238
更新日期:1998-05-01 00:00:00
abstract::A human prostate tumour cell line, LNCaP C4-2, when injected into athymic male nude mice, produced tumours containing: (1) only human cancer cells similar to those injected; (2) only murine stromal cells containing abnormal chromosome constitutions; or (3) both human prostate cancer cells similar to those injected and...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.524
更新日期:1997-01-01 00:00:00
abstract::Temozolomide is an oral alkylating agent that readily crosses the blood-brain barrier and has activity in patients with advanced melanoma. Carboplatin is a convenient outpatient treatment that also has activity in patients with melanoma. The purpose of this study was to assess the safety of a combination of temozolomi...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6601414
更新日期:2003-11-17 00:00:00
abstract::Helicobacter has been suggested to play a possible role in hepatitis, gallstones, and hepatobiliary tumours. We assessed whether seropositivity to 15 H. pylori proteins was associated with subsequent incidence of 74 biliary tract and 105 liver cancer cases vs. 357 matched controls in the Prostate, Lung, Colorectal, an...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0961-0
更新日期:2020-09-01 00:00:00
abstract::The appearance of a liver DNA synthesis promoter (HP) in rat plasma after dimethylnitrosamine (DMNA) or thioacetamide injection was investigated. After 48 h, DMNA (30 mg kg-1 body weight) produced liver (centrilobular) necrosis and intense hepatic regeneration, as assessed by microscopic observations of liver slices, ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.122
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:Ovarian and endometrial high-grade serous carcinomas (HGSCs) have similar clinical and pathological characteristics; however, exhaustive protein expression profiling of these cancers has yet to be reported. METHODS:We performed protein expression profiling on 14 cases of HGSCs (7 ovarian and 7 endometrial) ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.27
更新日期:2016-03-01 00:00:00
abstract::The human gene sequences encoding the translation-associated functions of alpha-subunit of elongation factor 1 (EF-1 alpha) and the ubiquitin carboxyl extension protein (HUBCEP80) have been isolated by differential cDNA screening, and found to have significantly higher levels of expression in fibroadenomas (benign) co...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.12
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:We assessed the sensitivity to adjuvant chemotherapy in cell cycle checkpoint kinase 2 (CHEK2) vs non-CHEK2 breast cancer patients by comparing the contralateral breast cancer incidence and distant disease-free and breast cancer-specific survival between both groups, stratified for adjuvant chemotherapy. ME...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.306
更新日期:2014-08-26 00:00:00
abstract::Mechanisms of resistance to Tomudex include increased thymidylate synthase activity, as well as reduced intracellular drug uptake and polyglutamation. However, little is known about other mechanisms of resistance, such as a possible protection against Tomudex-induced apoptosis mediated by bcl-2. We transfected the MDA...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690685
更新日期:1999-09-01 00:00:00
abstract::Expression of the 37-kDa laminin binding protein (37LBP/p40), a precursor of the 67-kDa laminin receptor, is well-correlated with the biological aggressiveness of cancer cells. To elucidate the direct role played by 37LBP/p40 in cancer cells, a murine lung cancer cell line T11, the 37LBP/p40 expression of which was re...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690474
更新日期:1999-06-01 00:00:00