Abstract:
:The vascular architecture of four different tumour cell lines (CaX, CaNT, SaS, HEC-1B) transplanted subcutaneously in mice was examined by means of microvascular corrosion casting in order to determine whether there is a characteristic vascular pattern for different tumour types and whether it differs significantly from two normal tissues, muscle and gut. Three-dimensional reconstructed scanning electron microscope images were used for quantitative measurements. Vessel diameters, intervessel and interbranch distances showed large differences between tumour types, whereas the branching angles were similar. In all tumours, the variability of the vessel diameters was significantly higher than in normal tissue. The quantitative data provide strong evidence for a characteristic vascular network determined by the tumour cells themselves.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Konerding MA,Malkusch W,Klapthor B,van Ackern C,Fait E,Hill SA,Parkins C,Chaplin DJ,Presta M,Denekamp Jdoi
10.1038/sj.bjc.6690416subject
Has Abstractpub_date
1999-05-01 00:00:00pages
724-32issue
5-6eissn
0007-0920issn
1532-1827journal_volume
80pub_type
杂志文章abstract::We examined polymorphisms in exons 3 and 4 of microsomal epoxide hydrolase in 101 patients with colon cancer and compared the results with 203 control samples. The frequency of the exon 3 T to C mutation was higher in cancer patients than in controls (odds ratio 3.8; 95% confidence intervals 1.8-8.0). This sequence al...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690028
更新日期:1999-01-01 00:00:00
abstract::Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical efficacy of novel ex...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
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更新日期:2008-03-11 00:00:00
abstract::Carboxypeptidase G2, a zinc metalloenzyme isolated from Pseudomonas sp. strain RS-16, which catalyses the hydrolytic cleavage of reduced and non-reduced folates to pteroates and L-glutamate, has been linked to a monoclonal antibody (W14A) raised to human chorionic gonadotrophin. The coupling efficiency and retention o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1986.62
更新日期:1986-03-01 00:00:00
abstract::A study is presented of all cases of primary sarcoma of bone registered during the period 1946 to 1974 for a specified population resident in south-western England. Ninety-six per cent of the 365 cases were histologically and radiologically verified and are separated into 8 categories of sarcoma. The number of tumours...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1977.221
更新日期:1977-10-01 00:00:00
abstract::We investigated breast cancer incidence in migrants in the Netherlands in 1988-1998. The standardised incidence ratio for breast cancer in Northwest-Netherlands was statistically significantly reduced for women born in Surinam (0.56), Turkey (0.29) and Morocco (0.22). The proportion of women with advanced stages (III ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601821
更新日期:2004-06-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.196
更新日期:1994-06-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/bjc.2017.25
更新日期:2017-03-14 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2013-06-11 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.325
更新日期:2014-08-12 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602248
更新日期:2004-12-13 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6601611
更新日期:2004-02-23 00:00:00
abstract::A cohort study was conducted to investigate the mortality of individuals employed by biological research institutes in the UK. The inclusion criteria were met by 12,703 individuals, of whom 95% were traced (11,502 alive, 395 deaths, 246 embarkations). All-cause mortality was significantly reduced in men (standardised)...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.221
更新日期:1996-05-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.11
更新日期:1997-01-01 00:00:00
abstract::Deletion of chromosome arm 1p and amplification of the MYCN oncogene are well-recognized genetic alterations in neuroblastoma cells. Recently, another alteration has been reported; gain of the distal part of chromosome arm 17q. In this study 48 neuroblastoma tumours were successfully analysed for 17q status in relatio...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6692231
更新日期:1999-12-01 00:00:00
abstract::Activation of Met by its ligand HGF has been shown to elicit both mitogenic and motogenic responses in thyrocytes in vitro. In the present study we have investigated the expression of Met in human anaplastic thyroid carcinoma cells in culture. There was a variation in expression level and size of Met in the different ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690406
更新日期:1999-05-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.8
更新日期:1994-01-01 00:00:00
abstract::Tumour-associated angiogenesis is partly regulated by the hypoxia-inducible factor (HIF) pathway. Endocrine tumours are highly vascularised and the molecular mechanisms of their angiogenesis are not fully delineated. The aim of this study is to evaluate angiogenesis and expression of HIF-related molecules in a series ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602245
更新日期:2005-01-17 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604258
更新日期:2008-04-22 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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doi:10.1038/sj.bjc.6605129
更新日期:2009-07-21 00:00:00
abstract::Forty-three children with malignant soft tissue sarcomas (IRS Groups II-IV) were treated with rapid dose delivery chemotherapy protocol comprising six courses of vincristine, adriamycin and cyclophosphamide, given in most cases within 8 weeks (Rapid VAC). This was followed in 36 patients by high dose melphalan with au...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1991-08-01 00:00:00
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更新日期:2013-02-19 00:00:00
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doi:10.1038/bjc.1992.291
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journal_title:British journal of cancer
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更新日期:2015-12-22 00:00:00
abstract::The addition of lapatinib (Tykerb/Tyverb) to capecitabine (Xeloda) delays disease progression more effectively than capecitabine monotherapy in women with previously treated HER2+ metastatic breast cancer (MBC). The quality-adjusted time without symptoms of disease or toxicity of treatment (Q-TWiST) method was used to...
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abstract::Piwi proteins and their interaction with piRNAs have rapidly emerged as important contributors to gene regulation, indicating their crucial function in germline and stem cell development. However, data on the Hiwi 1 (Hiwi) gene, one of the four human Piwi homologues, are still scarce. Therefore, we investigated the Hi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604653
更新日期:2008-10-07 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2005-01-17 00:00:00
abstract::Plasma concentrations of certain hormones linked to breast cancer risk were measured in age-pooled samples from 3,250 rural Chinese women in 65 counties, and 300 British women, all aged 35-64. In age-groups 35-44, 45-54 and 55-64 respectively, mean oestradiol concentrations were 36% (P = 0.043), 90% (P less than 0.001...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1990.344
更新日期:1990-10-01 00:00:00
abstract::A case-control study from Uganda found that the risk of Kaposi's sarcoma increased with increasing titre of antibodies against Kaposi's sarcoma-associated herpesvirus (KSHV) latent nuclear antigens, independently of HIV infection. Clinically, widespread Kaposi's sarcoma was more frequent among patients with HIV infect...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601113
更新日期:2003-08-04 00:00:00