Abstract：
:This study aimed to evaluate the clinical and economic implications of integrating human papilloma virus (HPV) load testing into the follow-up and management protocol of women postconisation for high-grade cervical intraepithelial neoplasia (CIN2-3). We evaluated 130 suitable women: 63 were screened biannually by Pap smears ('conventional approach') and 67 also had HPV-load testing ('HPV approach'). More stringent criteria for undergoing colposcopy or reconisation were observed by the former group compared to the latter. Both approaches were analysed for cost effectiveness. There were 33 out of 67 (49.2%) colposcopic referrals and 24 out of 67 (35.8%) reconisation/hysterectomies with the 'conventional approach' compared to 9 out of 63 (14.2%) and 7 out of 63 (11.1%) with the 'HPV approach'. Cervical intraepithelial neoplasia 2-3 residual disease was detected in 7 out of 67 (10.5%) and 7 out of 63 (11.1%) women. The 'conventional approach' had more negative colposcopic biopsies and more negative reconisation/hysterectomy histologies than the 'HPV approach'. The respective cost per detection of one case of residual disease was US$3573 and US$3485. The 'HPV approach' required fewer colposcopic and reconisation procedures to detect one case of residual CIN2-3. Its higher positive predictive value than that of cytology provided a significant decrease in false positive rates and a reduction of US$88 per detected case.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Almog B,Gamzu R,Bornstein J,Levin I,Fainaru O,Niv J,Lessing JB,Bar-Am Adoi
10.1038/sj.bjc.6601032subject
Has Abstractpub_date
2003-07-07 00:00:00pages
109-12issue
1eissn
0007-0920issn
1532-1827pii
6601032journal_volume
89pub_type
杂志文章abstract：:The inhibitor of apoptosis protein, XIAP, is frequently overexpressed in chemoresistant human tumours. An antisense oligonucleotide (AEG 35156/GEM 640) that targets XIAP has recently entered phase I trials in the UK. Method validation data are presented on three pharmacodynamic assays that will be utilised during this...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602363
更新日期：2005-02-14 00:00:00
abstract：BACKGROUND:CA-125 as a tumour progression criterion in relapsing ovarian cancer (ROC) trials remains controversial. CALYPSO is a large randomised trial incorporating CA-125 (GCIG criteria) and symptomatic deterioration in addition to Response Evaluation Criteria in Solid Tumours (RECIST) criteria (radiological) to dete...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjc.2011.593
更新日期：2012-02-14 00:00:00
abstract：:Alcohol consumption has been inconsistently associated with breast cancer risk. Recent studies suggest that genetic polymorphisms of glutathione S-transferases (GSTs) may modify this relation. To determine if breast cancer risk is associated with GSTM1 and GSTT1 genetic polymorphisms, and to evaluate the effect modifi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600708
更新日期：2003-01-13 00:00:00
abstract：:In addition to hypoxia, acidic extracellular pH (pH(e)) is recognised as one of the microenvironmental characteristics of solid tumours. A number of studies have examined ways to increase tumour acidity in order to improve tumour-specific targeting of certain drugs and the effectiveness of hyperthermia. However, previ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601766
更新日期：2004-05-04 00:00:00
abstract：:The influence on heat sensitivity of interactions between HT29 human colon adenocarcinoma cells grown in two- or three-dimensional contact was investigated. No evidence for intercellular cooperation affecting cellular sensitivity to hyperthermia was found. Cells grown in monolayer were found to be more heat sensitive ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.268
更新日期：1985-12-01 00:00:00
abstract：:We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, named PTC, is a novel rearranged version of the ret proto-oncogene. In fact PTC is the product of the fusion of the tyrosine kinase domain of the ret proto-oncogene with the 5'-terminal region of another ge...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.416
更新日期：1992-12-01 00:00:00
abstract：BACKGROUND:Immunohistological assessment of Ki 67 expression is less expensive than Oncotype Dx, which is currently used to identify patients with lymph node-negative breast cancer, who will benefit from adjuvant chemotherapy. METHODS:The relationship of immunohistologically measured Ki 67 to Oncotype DX recurrence sc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.402
更新日期：2011-10-25 00:00:00
abstract：:Anti-Her-2/neu antibody is known to induce apoptosis in HER-2/neu overexpressing breast cancer cells. However, exact regulatory mechanisms mediating and controlling this phenomenon are still unknown. In the present study, we have investigated the effect of anti-Her-2/neu antibody on apoptosis of HER-2/neu overexpressi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.2197
更新日期：2001-11-30 00:00:00
abstract：BACKGROUND:Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are commonly used antihypertensives. Recently, these drugs have been associated with a protective effect against pancreatic cancer, but data on this putative association remain limited. Thus, the objective of this study...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.375
更新日期：2017-01-03 00:00:00
abstract：:High-dose busulphan-containing chemotherapy regimens have shown high response rates in children with relapsed or refractory neuroblastoma, Ewing's sarcoma and medulloblastoma. However, the anti-tumour activity of busulfan as a single agent remains to be defined, and this was evaluated in athymic mice bearing advanced ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690126
更新日期：1999-02-01 00:00:00
abstract：BACKGROUND:Non-persistence and non-compliance are common in women prescribed hormonal therapy for breast cancer, but little is known about their influence on recurrence. METHODS:A nested case-control study of associations between hormonal therapy non-persistence and non-compliance and the risk of early recurrence in w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.518
更新日期：2013-09-17 00:00:00
abstract：:Little is known about chemoradiotherapy (CRT) in elderly patients with a locally advanced oesophageal cancer (OC). The aim of our study was to evaluate the tolerance and the outcome of elderly patients older than 70 years treated with CRT for a non-metastatic OC. Chemoradiotherapy was based on radiotherapy combined wi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604749
更新日期：2008-11-18 00:00:00
abstract：:It is suggested that the proximate carcinogenic forms of dialkylnitrosamines are their oxidation products, which retain the alkylnitrosamino moiety, but have acquired a carbonyl function as a result of omega or beta oxidation of an alkyl group. Such metabolites resemble the locally acting carcinogenic "nitrosamides" a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.169
更新日期：1973-11-01 00:00:00
abstract：:We compared the long-term impact of 1- and 2-year screening mammography intervals using prognostic, screening, and outcome information for women aged 50-74 years obtained from the Screening Mammography Program of British Columbia in two time periods, prior to 1997 (policy of annual mammography) and after 1997 (biennia...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602393
更新日期：2005-03-14 00:00:00
abstract：BACKGROUND:Tumour hypoxia is associated with impaired apoptosis, resistance to therapy and poor prognosis. We previously reported that high stromal expression of the endogenous marker of hypoxia, carbonic anhydrase IX (CAIX), is associated with significantly reduced survival in oral squamous cell carcinoma (OSCC). In a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.533
更新日期：2013-10-01 00:00:00
abstract：:We have analysed DNA extracted from the serum and peritoneal fluid of 20 ovarian cancer patients for the presence of tumour-specific genetic alterations. The 20 patients included six with stage Ia disease. Using six polymorphic microsatellite loci we were able to detect novel alleles or loss of heterozygosity in 17/20...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690601
更新日期：1999-08-01 00:00:00
abstract：:Using bivariate flow cytofluorometry, we have determined the nuclear DNA distribution and the expression of the p21 protein (coded by the Ha-ras oncogene) in the bone marrow (BM) cells of five solid tumour patients having histologically normal BM and in those of 57 patients with plasma cell dyscrasia (28 with monoclon...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.379
更新日期：1990-11-01 00:00:00
abstract：:Fine-needle aspiration cytology, which is well established to be accurate for the diagnosis of thyroid cancer, may be inconclusive for the follicular thyroid neoplasms. As galectin-3 was suggested to be a marker of malignant thyrocytes, we investigated whether this protein might be helpful in the diagnosis of aspirate...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6602822
更新日期：2005-11-14 00:00:00
abstract：:Monoclonal antibody MUC 2-63 recognises neurogenic tumours and has been used successfully for radioimaging human malignant gliomas. We now show that the MUC 2-63 antigen has the same tissue distribution and molecular weight range as the CD44 antigen and confirm the identity of these two molecules in blocking studies u...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.402
更新日期：1994-11-01 00:00:00
abstract：:Because the focus of nasopharyngeal carcinoma (NPC) is very close to intracranial organs, it often makes incursions into cranial cavity. Identification of intracranial invasion-associated indicators will provide potential therapeutic targets for NPC patients with intracranial invasion. In this regard, Human Xpro HC-pl...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604167
更新日期：2008-01-29 00:00:00
abstract：:The treatment of breast cancer patients has changed rapidly in the past decade, but empirical data at local and national level are scarce. Predicting the consequences of screening for primary treatment is consequently difficult. The aim of this analysis of records on admissions to hospital of women with breast cancer ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.466
更新日期：1994-12-01 00:00:00
abstract：BACKGROUND:Complete tumour response (pCR) to neo-adjuvant chemo-radiotherapy for rectal cancer is associated with a reduction in local recurrence and improved disease-free and overall survival, but is achieved in only 20-30% of patients. Drug repurposing for anti-cancer treatments is gaining momentum, but the potential...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/bjc.2017.175
更新日期：2017-07-11 00:00:00
abstract：:No published data are available concerning the activity and tolerability of intramuscularly administered granulocyte colony-stimulating factor (G-CSF) in humans. To fill this gap, 19 patients with advanced ovarian cancer previously treated with at least one first-line chemotherapy cycle received the following myelosup...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1994.186
更新日期：1994-05-01 00:00:00
abstract：:The purpose of the study is to test the hypothesis that expression of cell cycle regulatory proteins p16(INK4a) and pRb is significantly associated with prognosis in ovarian carcinomas. We performed immunohistochemical analysis of p16(INK4a) and pRb expression and correlated with survival in a series of 300 patients w...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.bjc.6603531
更新日期：2007-01-29 00:00:00
abstract：:An apparently unique circulating common oncofoetal protein has been identified in rat small-bowel, colonic and pancreatic adenocarcinomas. The tumours were induced by ionizing radiation (small bowel), an alkyl hydrocarbon, 1,2-dimethylhydrazine (colon) and a polyaromatic hydrocarbon, 7,12-dimethylbenz[a]anthracene (pa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.120
更新日期：1981-06-01 00:00:00
abstract：BACKGROUND:Body mass index (BMI) has been associated with the risk of oesophageal cancer. But the influence of BMI on postoperative complication and prognosis has always been controversial. METHODS:In total, 2031 consecutive patients who underwent oesophagectomy between 1998 and 2008 were classified according to Asian...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/bjc.2013.666
更新日期：2013-11-26 00:00:00
abstract：BACKGROUND:The clinical course of World Health Organisation grade II gliomas remains variable and their time point of transformation into a more malignant phenotype is unpredictable. Identification of biological markers that can predict prognosis in individual patients is of great clinical value. PROX1 is a transcripti...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.162
更新日期：2011-05-24 00:00:00
abstract：:Capecitabine is an oral prodrug of 5-fluorouracil (FU). Since FU concentrations achieved in malignant lesions are an important determinant of efficacy, we investigated the intratumoral transcapillary transfer of capecitabine and its metabolites in vivo. A total of 10 patients with skin metastases from breast cancer re...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600809
更新日期：2003-03-10 00:00:00
abstract：BACKGROUND:For patients with locally advanced rectal cancer (LARC), it is unclear whether neoadjuvant chemoradiotherapy-induced pathologic complete response (pCR) individuals would further benefit from adjuvant chemotherapy (ACT). METHODS:The pCR individuals who received different ACT cycles were paired by propensity ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0989-1
更新日期：2020-10-01 00:00:00
abstract：:Deletion of chromosome arm 1p and amplification of the MYCN oncogene are well-recognized genetic alterations in neuroblastoma cells. Recently, another alteration has been reported; gain of the distal part of chromosome arm 17q. In this study 48 neuroblastoma tumours were successfully analysed for 17q status in relatio...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6692231
更新日期：1999-12-01 00:00:00
