Abstract:
:No published data are available concerning the activity and tolerability of intramuscularly administered granulocyte colony-stimulating factor (G-CSF) in humans. To fill this gap, 19 patients with advanced ovarian cancer previously treated with at least one first-line chemotherapy cycle received the following myelosuppressive regimen: mitoxantrone (DHAD) 12 mg m-2 i.v. on day 1; ifosfamide (IFO) 4 g m-2 i.v. on days 1 and 2; mesna 800 mg m-2 i.v. t.i.d. on days 1 and 2. G-CSF (Filgrastim) was given at a dose of 5 micrograms/kg/day i.m. from day 6 to day 19, its pharmacokinetics being assessed in five patients. The neutrophil nadir was observed after a mean period of 8 days, and the neutrophil count was < 1.0 x 10(3) mm-3 for a mean of 6 days during the cycle of chemotherapy. The neutrophil count fell after the withdrawal of G-CSF on the 19th day of treatment. The difference in absolute neutrophil count between day 19 and day 21 was statistically significant (P = 0.0001); nevertheless, at day 21 no WHO grade 3-4 neutropenia was reported. DHAD and IFO were respectively given at 95% and 93% of the planned dose. The pharmacokinetics of G-CSF i.m. seems to be similar to that of the drug given subcutaneously. No evidence of cumulative myelosuppression was observed. G-CSF was well tolerated and no complications were observed at the injection sites. In conclusion, if the results obtained in this pilot study regarding the activity of i.m. G-CSF are confirmed by a randomised trial, the intramuscular administration of G-CSF could become a valid alternative for patients who dislike the subcutaneous route and who are being treated with chemotherapy that does not induce profound thrombocytopenia.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Di Leo A,Bajetta E,Nolè F,Biganzoli L,Ferrari L,Oriana S,Riboldi G,Bohm S,Spatti G,Raspagliesi Fdoi
10.1038/bjc.1994.186subject
Has Abstract,Author List Incompletepub_date
1994-05-01 00:00:00pages
961-6issue
5eissn
0007-0920issn
1532-1827journal_volume
69pub_type
临床试验,杂志文章abstract:BACKGROUND:Earlier studies have shown raised risks of leukaemia and non-Hodgkin lymphoma in children, teenagers and young adults resident either at birth or diagnosis in Seascale. Some increases in cancer risk in these age groups have also been noted among those living around Dounreay. We aimed to update previous analy...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.357
更新日期:2014-10-28 00:00:00
abstract::In addition to hypoxia, acidic extracellular pH (pH(e)) is recognised as one of the microenvironmental characteristics of solid tumours. A number of studies have examined ways to increase tumour acidity in order to improve tumour-specific targeting of certain drugs and the effectiveness of hyperthermia. However, previ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601766
更新日期:2004-05-04 00:00:00
abstract::Mismatch repair (MMR) deficiency in tumours from patients with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome is mainly caused by mutations in the MLH1, MSH2, and MSH6 genes. A major challenge in the clinical management of patients with suspected HNPCC is the frequent occurrence of missense mutations i...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602129
更新日期:2004-10-04 00:00:00
abstract:BACKGROUND:Recently, many studies have suggested a possible adjuvant role of aspirin in colorectal cancer, reporting a positive prognostic effect with its use in patients with established disease. The aim of this study was to investigate the anticancer effect of aspirin use during preoperative chemoradiation for rectal...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.336
更新日期:2015-10-20 00:00:00
abstract::Survival data on female invasive breast cancer with 9-year follow-up from five French cancer registries were analysed by logistic regression for prognostic factors of cancer stage. The Kaplan-Meier method and log-rank test were used to estimate and compare the overall survival probability at 5 and 7 years, and at the ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604163
更新日期:2008-01-15 00:00:00
abstract::Mutations of the p53 tumour suppressor gene are infrequent at presentation of both acute myeloblastic leukaemia (AML) and acute lymphoblastic leukaemia (ALL), being found in between 5-10% of AML and 2-3% of ALL. Here we have studied the frequency of detection of p53 mutations at relapse of both AML and B-precursor ALL...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690183
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:Despite the widespread use of neoadjuvant chemotherapy in breast cancer patients, prediction of individual response to treatment remains an unsolved clinical problem. Particularly, administration of an inefficient chemotherapeutic regimen should be avoided. Therefore, a better understanding of the molecular ...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6605909
更新日期:2010-10-12 00:00:00
abstract::In a longitudinal study of the evolution of serum beta 2-microglobulin (beta 2-m) levels in 37 patients with myelomatosis, those patients with a level of < 4 mg/l at first presentation had a median survival of 46 months, whereas those with an initial level of > mg/l had a median survival of 15 months. THe beta 2-m app...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1980.273
更新日期:1980-10-01 00:00:00
abstract::Pulmonary metastasectomy is widely and increasingly practiced in the belief that this intervention can cure patients with colorectal cancer, and that without it few survive 5 years. No good evidence exists supporting such convictions, indeed recent trial results challenge them. What evidence underpins this acceptance ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0927-2
更新日期:2020-08-01 00:00:00
abstract::Advanced or metastatic disease is common in both oesophagogastric and colorectal cancers, with poor 5-year survival despite palliative chemotherapy. We have investigated the sensitivity of gastrointestinal tumours to gemcitabine in combination with mitomycin C (GeM), using a modified ex vivo ATP-based tumour chemosens...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601403
更新日期:2003-12-15 00:00:00
abstract::Extracellular proteases of the matrix metalloproteinase (MMP) and serine protease families participate in many aspects of tumour growth and metastasis. Using quantitative real-time RT-PCR analysis, we have undertaken a comprehensive survey of the expression of these enzymes and of their natural inhibitors in 44 cases ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602630
更新日期:2005-06-20 00:00:00
abstract::Exposure to the fibrous mineral erionite is known to induce mesothelioma in man and laboratory animals. Previous studies demonstrated the presence of a trypsin-like protease associated with tumour cells. This protease could be demonstrated by the use of fluorescent probes which located cells possessing this enzyme. We...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.269
更新日期:1988-11-01 00:00:00
abstract::For stage III non-small cell lung cancer (NSCLC), approximately a third of patients survive up to 5 years, with decreasing 5-year survival rates for stage IIIB and stage IIIC disease. Although curable, stage III NSCLC encompasses a diverse range of disease presentation, with an equally complex range of multi-modal tre...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/s41416-020-01069-z
更新日期:2020-12-01 00:00:00
abstract::With the recent approval of the combinations of axitinib with the immune checkpoint inhibitor (ICI) pembrolizumab or avelumab for first-line treatment of advanced renal cell carcinoma, guidance on how to distinguish between immune-related adverse events (AEs) caused by ICI versus axitinib-related AEs is necessary to o...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/s41416-020-0949-9
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:The United Kingdom performs poorly in international comparisons of colorectal cancer survival with much of the deficit owing to high numbers of deaths close to the time of diagnosis. This retrospective cohort study investigates the patient, tumour and treatment characteristics of those who die in the first y...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.585
更新日期:2013-02-19 00:00:00
abstract:BACKGROUND:The recognition that cancer is not a single entity, rather that different cancers have different causes and trajectories, has been a key development in the scientific understanding of cancer. However, little is known about the British public's awareness of differences between cancers. This study examined dif...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.185
更新日期:2012-06-05 00:00:00
abstract:BACKGROUND:Accumulating evidence demonstrates high levels of aldehyde dehydrogense (ALDH) activity in human cancer types, in part, because of its association with cancer stem cells. Whereas ALDH1A1 and ALDH7A1 isoforms were reported to associate with prostate tumorigenesis, whether other ALDH isoforms are associated wi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.201
更新日期:2014-05-13 00:00:00
abstract:BACKGROUND:Lymph node metastasis is one of the most important adverse prognostic factors for pancreatic cancer. The aim of this study was to identify novel lymphatic metastasis-associated markers and therapeutic targets for pancreatic cancer. METHODS:DNA microarray study was carried out to identify genes differentiall...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.37
更新日期:2011-03-15 00:00:00
abstract:BACKGROUND:Operable non-small cell lung cancer (NSCLC) patients whose tumours have spread to regional or central lymph nodes at the time of diagnosis have dismal prognoses compared with those who have limited disease. The current TNM staging system for NSCLC poorly distinguishes patients with lymph-node metastases who ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.92
更新日期:2016-05-10 00:00:00
abstract::Measurements of methotrexate have been made in the liver and plasma of 4 patients and in the bile and plasma of 1 patient receiving [(3)H]methotrexate. Projections from a theoretical model of concentration of methotrexate in liver are confirmed but projections of biliary excretion are not. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1973.190
更新日期:1973-12-01 00:00:00
abstract::We investigated expression of a human p53-inducible gene, P2XM, a member of the P2X-receptor family of ATP-gated ion channels, in 56 human primary soft-tissue tumours including 47 sarcomas and nine benign tumors. Among the 47 sarcomas examined by reverse transcription polymerase chain reaction, 12 had lost expression ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690484
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:A decade ago it was reported that childhood cancer incidence was higher in boys than girls in many countries, particularly those with low gross domestic product (GDP) and high infant mortality rate. Research suggests that socio-economic and cultural factors are likely to be responsible. This study aimed to i...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.191
更新日期:2012-06-26 00:00:00
abstract::In the past decade, an increasing number of frequently positive randomised clinical trials have been completed, allowing new consideration of the present therapeutic armamentarium for advanced renal cell carcinoma. These studies were predominantly designed to compare the experimental drugs with 1 of 2 active control a...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.2014.240
更新日期:2015-01-06 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the number of ovarian cancer and primary peritoneal cancer (PPC) progressive disease cases identified via routine follow-up procedures and the corresponding cost throughout a 16-year period at a single medical institution. METHODS:Previously undiagnosed epithelial o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605963
更新日期:2010-11-23 00:00:00
abstract::The testis is the third common site of relapse after primary treatment of childhood acute lymphoblastic leukaemia, but in adults relatively few testicular relapses of acute lymphoblastic leukaemia have been reported. In the present investigation the differences in the behaviour of leukaemia in immature and mature rat ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.166
更新日期:1993-05-01 00:00:00
abstract::Although most colorectal cancer develops based on the adenoma-adenocarcinoma sequence, morphologically, colorectal cancer is not a homogeneous disease entity. Generally, there are two distinct morphological types: polypoid and ulcerative colorectal tumours. Previous studies have demonstrated that K-ras codon 12 mutati...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600214
更新日期:2002-04-08 00:00:00
abstract::The expression of urokinase-type plasminogen activator (uPA) was investigated in squamous cell carcinoma of the human larynx. For this purpose, tissue extracts from 25 matched samples of normal mucosa and neoplastic larynx were compared for the levels of uPA activity as evaluated by a chromogenic PA assay and sodium d...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.512
更新日期:1996-10-01 00:00:00
abstract::In the first part of this study the availability of folinic acid (FA) and its main active circulating metabolite, 5-methyltetrahydrofolate (5-MTHF), were studied in plasma and cerebrospinal fluid (CSF) from normal subjects after i.v. administration of 100 and 250 mg of FA. 5-MTHF rapidly appeared in plasma, the maximu...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.127
更新日期:1989-04-01 00:00:00
abstract::NK911 is a novel supramolecular nanocarrier designed for the enhanced delivery of doxorubicin (DXR) and is one of the successful polymer micelle systems to exhibit an efficient accumulation in solid tumours in mice. The purpose of this study was to define the maximum-tolerated dose (MTD) and dose-limiting toxicities (...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6602204
更新日期:2004-11-15 00:00:00
abstract:BACKGROUND:The Mediterranean diet has been shown to have a beneficial role on various neoplasms, but data are scanty on pancreatic cancer. METHODS:We analysed data from two case-control studies conducted in Italy between 1983 and 2008, including 362 and 326 pancreatic cancer cases and 1552 and 652 hospital-controls, r...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.345
更新日期:2013-09-03 00:00:00