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Combination chemotherapy in advanced gastrointestinal cancers: ex vivo sensitivity to gemcitabine and mitomycin C.

Abstract：

:Advanced or metastatic disease is common in both oesophagogastric and colorectal cancers, with poor 5-year survival despite palliative chemotherapy. We have investigated the sensitivity of gastrointestinal tumours to gemcitabine in combination with mitomycin C (GeM), using a modified ex vivo ATP-based tumour chemosensitivity assay (ATP-TCA). Tumour material from 41 colorectal and 22 oesophagogastric cancers were assessed. The GeM combination showed variable but definite activity in most of the samples tested. The results show that GeM achieves >95% inhibition at concentrations within the range achievable clinically in 60% of colorectal tumours (21 out of 35) and 38% of oesophagogastric tumours (five out of 13) tested. We did not identify any significant difference in sensitivity using concurrent or sequential exposure of tumour-derived cells to these two drugs. The results from this study suggest that GeM may be a useful combination in the treatment of advanced gastrointestinal malignancy.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Whitehouse PA,Mercer SJ,Knight LA,Di Nicolantonio F,O'Callaghan A,Cree IA,Portsmouth Upper GI and Colorectal Cancer Multidisciplinary Teams.

doi

10.1038/sj.bjc.6601403

subject

Has Abstract

pub_date

2003-12-15 00:00:00

pages

2299-304

issue

12

eissn

0007-0920

issn

1532-1827

pii

6601403

journal_volume

89

pub_type

杂志文章

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