Trends in mortality for cancers, comparing multiple- and underlying-cause rates, in an English population 1979-1999.

abstract：:The purpose of this study was to investigate the effect of breast density on breast cancer (BC) mortality in a mammography screening programme. The cohort included 48 052 women participating in mammography screening in Copenhagen, Denmark, where biennial screening is offered to women aged 50-69 years. We collected inf...

journal_title：British journal of cancer

authors： Olsen AH,Bihrmann K,Jensen MB,Vejborg I,Lynge E

更新日期：2009-04-07 00:00:00

abstract：:A clinical trial conducted according to a schedule of interim analyses written into the protocol, and stopped according to a predetermined rule, is known to statisticians as a sequential clinical trial. This methodology is becoming more widely used in trials concerning life-threatening diseases because of its ability ...

journal_title：British journal of cancer

authors： Whitehead J

更新日期：1993-12-01 00:00:00

abstract：:The relationship between melanoma incidence and latitude was investigated in North American and Europe, using the data collected by 43 population-based cancer registries. In North America melanoma incidence increased with decreasing latitude, supporting the role of UV light in the induction of melanoma. Within England...

journal_title：British journal of cancer

authors： Crombie IK

更新日期：1979-11-01 00:00:00

abstract：BACKGROUND:Oral squamous cell carcinoma (OSCC) has increased morbidity, and its high metastatic potential affects patient survival. Bromodomain containing 4 (BRD4) is a chromatin protein that associates with acetylated histone lysines and facilitates transcription. BRD4 has been implicated in cell proliferation, metast...

journal_title：British journal of cancer

authors： Yamamoto T,Hirosue A,Nakamoto M,Yoshida R,Sakata J,Matsuoka Y,Kawahara K,Nagao Y,Nagata M,Takahashi N,Hiraki A,Shinohara M,Nakao M,Saitoh N,Nakayama H

更新日期：2020-08-01 00:00:00

abstract：:Serum levels of pepsinogen and gastrin are parameters that can be used as biomarkers for gastric mucosa. The aim of this study was to validate these serum biomarkers, that is pepsinogen A (PGA), pepsinogen C (PGC), PGA/PGC ratio, and gastrin, as screening tests for precancerous lesions: atrophic chronic gastritis (ACG...

journal_title：British journal of cancer

authors： Broutet N,Plebani M,Sakarovitch C,Sipponen P,Mégraud F,Eurohepygast Study Group.

更新日期：2003-04-22 00:00:00

abstract：BACKGROUND:Eukaryotic translation elongation factor 1A2 (eEF1A2) is a known proto-oncogene. We proposed that stimulation of the eEF1A2 expression in cancer tissues is caused by the loss of miRNA-mediated control. METHODS:Impact of miRNAs on eEF1A2 at the mRNA and protein levels was examined by qPCR and western blot, r...

journal_title：British journal of cancer

authors： Vislovukh A,Kratassiouk G,Porto E,Gralievska N,Beldiman C,Pinna G,El'skaya A,Harel-Bellan A,Negrutskii B,Groisman I

更新日期：2013-06-11 00:00:00

abstract：:With few exceptions, the major limit to high-dose chemotherapeutic treatments is the severity and duration of drug-induced myelosuppression. We have recently developed a monoclonal antibody, MAD11, which reacts with the potent anti-tumour antibiotic doxorubicin and other anthracyclines. To protect directly pluripotent...

journal_title：British journal of cancer

authors： Morelli D,Ménard S,Cazzaniga S,Colnaghi MI,Balsari A

更新日期：1997-01-01 00:00:00

abstract：:In addition to hypoxia, acidic extracellular pH (pH(e)) is recognised as one of the microenvironmental characteristics of solid tumours. A number of studies have examined ways to increase tumour acidity in order to improve tumour-specific targeting of certain drugs and the effectiveness of hyperthermia. However, previ...

journal_title：British journal of cancer

authors： Kalliomäki T,Hill RP

更新日期：2004-05-04 00:00:00

abstract：:The aim of this study was to assess the prognostic value of pretreatment clinical and laboratory parameters in refractory or relapsed multiple myeloma (MM) patients who have a long-term response to thalidomide (THAL), lasting at least 18 months. The study was carried out on 234 patients who received THAL for relapsed/...

journal_title：British journal of cancer

authors： Hus I,Dmoszynska A,Manko J,Hus M,Jawniak D,Soroka-Wojtaszko M,Hellmann A,Ciepluch H,Skotnicki A,Wolska-Smolen T,Sulek K,Robak T,Konopka L,Kloczko J

更新日期：2004-11-29 00:00:00

abstract：BACKGROUND:Current international guidelines recommend the use of platinum-based chemotherapy with thoracic radiotherapy (TRT) for patients with locally advanced non-small-cell lung cancer (NSCLC). METHODS:Patients with unresectable stage IIIA or IIIB NSCLC were treated with nedaplatin (NP) at 50 mg m(-2) and irinoteca...

journal_title：British journal of cancer

authors： Oshita F,Ohe M,Honda T,Murakami S,Kondo T,Saito H,Noda K,Yamashita K,Nakayama Y,Yamada K

更新日期：2010-10-26 00:00:00

abstract：:The patterns of early and late relapses (those occurring later than 3 years after diagnosis) in 432 patients achieving complete remission after treatment for stage I and II Hodgkin's disease at the Royal Marsden Hospital between 1964 and 1983 were studied to identify factors predicting for late relapse. The incidence ...

journal_title：British journal of cancer

authors： Duchesne G,Crow J,Ashley S,Brada M,Horwich A

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Breast cancer, a heterogeneous disease has been broadly classified into oestrogen receptor positive (ER+) or oestrogen receptor negative (ER-) tumour types. Each of these tumours is dependent on specific signalling pathways for their progression. While high levels of survivin, an anti-apoptotic protein, incr...

journal_title：British journal of cancer

authors： Pervin S,Tran L,Urman R,Braga M,Parveen M,Li SA,Chaudhuri G,Singh R

更新日期：2013-03-05 00:00:00

abstract：:Chromosomal translocation t(11;22)(q24:q12) is detected in approximately 90% of tumours of the Ewing family (ET). This translocation results in EWS-Fli1 gene fusion which produces a EWS-Fli1 fusion protein acting as an aberrant transcriptional activator. We previously reported that the inhibition of EWS-Fli1 expressio...

journal_title：British journal of cancer

authors： Matsumoto Y,Tanaka K,Nakatani F,Matsunobu T,Matsuda S,Iwamoto Y

更新日期：2001-03-23 00:00:00

abstract：:A new cancer-associated antigen CA130, recognised by two monoclonal antibodies (moABs) 130-22 and 145-9, was often found to be present at high levels in the sera of patients with ovarian cancer. There was a strong correlation between CA130 and CA125 values. The epitopes recognised by moABs 130-22 and 145-9 were proved...

journal_title：British journal of cancer

authors： Kobayashi H,Ohi H,Fujii T,Terao T

更新日期：1993-02-01 00:00:00

abstract：:During the development of indazolylpyrimidines as novel and potent inhibitors of vascular endothelial growth factor (VEGF) receptor-2 (VEGFR2) tyrosine kinase, we observed that some human tumour xenografts are more sensitive to VEGFR2 kinase inhibitors than others. A better understanding of the basis for this differen...

journal_title：British journal of cancer

authors： Dev IK,Dornsife RE,Hopper TM,Onori JA,Miller CG,Harrington LE,Dold KM,Mullin RJ,Johnson JH,Crosby RM,Truesdale AT,Epperly AH,Hinkle KW,Cheung M,Stafford JA,Luttrell DK,Kumar R

更新日期：2004-10-04 00:00:00

abstract：:Promoter region hypermethylation and transcriptional silencing is a frequent cause of tumour suppressor gene (TSG) inactivation in many human cancers. Previously, to identify candidate epigenetically inactivated TSGs in renal cell carcinoma (RCC), we monitored changes in gene expression in four RCC cell lines after tr...

journal_title：British journal of cancer

authors： Morris MR,Gentle D,Abdulrahman M,Clarke N,Brown M,Kishida T,Yao M,Teh BT,Latif F,Maher ER

更新日期：2008-01-29 00:00:00

abstract：BACKGROUND:The aim was to evaluate whether this gastric cancer-screening programme was effective in reducing oesophageal cancer mortality. METHODS:A population-based retrospective cohort study was conducted using the Korean National Cancer Screening Programme (NCSP) database. The study cohort comprised 16,969 oesophag...

journal_title：British journal of cancer

authors： Kim JH,Han KD,Lee JK,Kim HS,Cha JM,Park S,Kim JS,Kim WH,Big Data Research Group (BDRG) of the Korean Society of Gastroenterology (KSG).

更新日期：2020-08-01 00:00:00

abstract：:Trends in long-term relative survival from breast cancer are examined for women diagnosed in England and Wales up to 2001, using both period and hybrid approaches. Large improvements in long-term survival are predicted. Women with breast cancer still experience persistent excess mortality up to at least 20 years after...

journal_title：British journal of cancer

authors： Woods LM,Rachet B,Cooper N,Coleman MP

更新日期：2007-04-10 00:00:00

abstract：:Plasma concentrations of certain hormones linked to breast cancer risk were measured in age-pooled samples from 3,250 rural Chinese women in 65 counties, and 300 British women, all aged 35-64. In age-groups 35-44, 45-54 and 55-64 respectively, mean oestradiol concentrations were 36% (P = 0.043), 90% (P less than 0.001...

journal_title：British journal of cancer

authors： Key TJ,Chen J,Wang DY,Pike MC,Boreham J

更新日期：1990-10-01 00:00:00

abstract：:Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation of premalignant cells. However, several lines of evidence show that senescent cells, which often persist in vivo, can also promote tumour progression in addition to other age-related pathologies via the senescence-associ...

journal_title：British journal of cancer

authors： Lecot P,Alimirah F,Desprez PY,Campisi J,Wiley C

更新日期：2016-05-24 00:00:00

abstract：:Lung cancer is the primary cause of cancer mortality in developed countries. First diagnosis only when disease has already reached the metastatic phase is the main reason for failure in treatment. To this regard, although low-dose spiral computed tomography (CT) has proven to be effective in the early detection of lun...

journal_title：British journal of cancer

authors： Pastorino U

更新日期：2010-06-08 00:00:00

abstract：BACKGROUND:Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. METHODS:We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease. RESULTS:A high protein e...

journal_title：British journal of cancer

authors： Langers AM,Verspaget HW,Hawinkels LJ,Kubben FJ,van Duijn W,van der Reijden JJ,Hardwick JC,Hommes DW,Sier CF

更新日期：2012-04-24 00:00:00

abstract：BACKGROUND:The recognition that cancer is not a single entity, rather that different cancers have different causes and trajectories, has been a key development in the scientific understanding of cancer. However, little is known about the British public's awareness of differences between cancers. This study examined dif...

journal_title：British journal of cancer

authors： Whitaker KL,Simon AE,Beeken RJ,Wardle J

更新日期：2012-06-05 00:00:00

abstract：:Our objective was to determine whether oral etoposide and cisplatin combination (EoP) is superior to paclitaxel in the treatment of advanced breast cancer (ABC) patients pretreated with anthracyclines. From December 1997 to August 2003, 201 patients were randomised, 100 to EoP and 101 to paclitaxel arms. Four patients...

journal_title：British journal of cancer

authors： Icli F,Akbulut H,Uner A,Yalcin B,Baltali E,Altinbas M,Coşkun S,Komurcu S,Erkisi M,Demirkazik A,Senler FC,Sencan O,Büyükcelik A,Boruban C,Onur H,Zengin N,Sak SD

更新日期：2005-02-28 00:00:00

abstract：:We have previously reported that supplementation with folic acid (1.2 mg day(-1) for 12 week) elicited a significant improvement in the folate status of 61 healthy volunteers. We have examined effects of this supplement on markers of genomic stability. Little is known about the effect of folate supplementation on DNA ...

journal_title：British journal of cancer

authors： Basten GP,Duthie SJ,Pirie L,Vaughan N,Hill MH,Powers HJ

更新日期：2006-06-19 00:00:00

abstract：BACKGROUND:Ovarian cancer is frequently advanced at presentation when treatment is rarely curative. Response to first-line platinum-based chemotherapy significantly influences survival, but clinical response is unpredictable and is frequently limited by the development of drug-resistant disease. METHODS:We used qRT-PC...

journal_title：British journal of cancer

authors： Smith G,Ng MT,Shepherd L,Herrington CS,Gourley C,Ferguson MJ,Wolf CR

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:Clinical heterogeneity reflects the complexity of genetic events associated with neuroblastoma (NB). To identify the status of all described genetic loci with possible prognostic interest, high-throughput approaches have been used, but only with tumour cell content >60%. In some tumours, necrotic, haemorrhag...

journal_title：British journal of cancer

authors： Piqueras M,Navarro S,Cañete A,Castel V,Noguera R

更新日期：2011-06-28 00:00:00

abstract：:Exploring the fundamental mechanisms behind the low tumour uptake of labelled monoclonal antibodies (MoAbs) during in vivo immunotargeting, experiments were performed to estimate the in vivo value of the association constant (Ka) in an experimental targeting reaction. An artificial tumour model was utilised, based on ...

journal_title：British journal of cancer

authors： Fjeld JG,Benestad HB,Stigbrand T,Nustad K

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:The eicosanoid signalling pathway promotes the progression of malignancies through the production of proliferative prostaglandins (PGs). Cytosolic phospholipase A(2)α (cPLA(2)α) activity provides the substrate for cyclooxygenase-dependent PG release, and we have previously found that cPLA(2)α expression corr...

journal_title：British journal of cancer

authors： Caiazza F,McCarthy NS,Young L,Hill AD,Harvey BJ,Thomas W

更新日期：2011-01-18 00:00:00

abstract：:A bispecific monoclonal antibody recognising both carcinoembryonic antigen (CEA) and ricin toxin A chain (RTA) was tested for its ability to target recombinant RTA (r-RTA) to CEA-expressing tumour cells, alone and in combination with ricin B chain (RTB). The antibody, 636 (Robins et al., 1990), induced significant RTA...

journal_title：British journal of cancer

authors： Embleton MJ,Charleston A,Robins RA,Pimm MV,Baldwin RW

更新日期：1991-05-01 00:00:00