Abstract：
BACKGROUND:Current international guidelines recommend the use of platinum-based chemotherapy with thoracic radiotherapy (TRT) for patients with locally advanced non-small-cell lung cancer (NSCLC). METHODS:Patients with unresectable stage IIIA or IIIB NSCLC were treated with nedaplatin (NP) at 50 mg m(-2) and irinotecan (CPT) at 60 mg m(-2) on days 1 and 8 every 4 weeks for two to four cycles with concurrent TRT (2 Gy per day, total 60 Gy). RESULTS:All 35 patients were able to receive a total of 60 Gy. Adverse effects and events in chemotherapy with TRT were grade 3 or 4 anaemia, neutropenia and thrombocytopenia, which occurred in 3.0%, 32.8% and 6.0% of patients, respectively. There was no grade 3 pneumonitis or oesophagitis. Adverse effects and events in chemotherapy alone were mild. There was no treatment-related death. An overall response rate was 94.3%. The median progression-free and overall survivals were 13.0 and 36.0 months, respectively. The 5-year disease-free and overall survival rates were 25.7% and 40.0%, respectively. CONCLUSION:NP and CPT treatment with concurrent TRT is effective and safe for patients with unresectable, locally advanced NSCLC.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Oshita F,Ohe M,Honda T,Murakami S,Kondo T,Saito H,Noda K,Yamashita K,Nakayama Y,Yamada Kdoi
10.1038/sj.bjc.6605875subject
Has Abstractpub_date
2010-10-26 00:00:00pages
1325-30issue
9eissn
0007-0920issn
1532-1827pii
6605875journal_volume
103pub_type
杂志文章abstract：BACKGROUND:MiR-125b has critical role in non-small-cell lung cancer (NSCLC) cell migration, and its target genes have not been elucidated. Kinesin-1 light chain (KLC)-2 was predicted as one of miR-125b's targets by bioinformatics analysis. This study is to identify the function of KLC2 and its interaction with miR-125b...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.3
更新日期：2015-03-03 00:00:00
abstract：BACKGROUND:Treatment options for patients with metastatic gastroenteropancreatic neuroendocrine tumours (GEP NETs) are still limited. We investigated the antitumour activity and safety profile of pazopanib--a multitarget drug with anti-angiogenic activity in patients with metastatic GEP NETs. METHODS:This was a nonran...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.470
更新日期：2013-09-17 00:00:00
abstract：:The photodynamic effects of sulphonated aluminium phthalocyanine (SALPC) have been compared on cultured AR4-2J cells of a pancreatic carcinoma cell line and on exocrine cells of the normal phenotype freshly isolated from the rat pancreas; a multi-channel perifusion system was used for this kinetic study in vitro. Wher...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.157
更新日期：1990-05-01 00:00:00
abstract：BACKGROUND:Uncertainty remains about the associations of adiposity with intestinal cancer in China and by its anatomical subtype. METHODS:The prospective China Kadoorie Biobank recorded 3024 incident cases of colorectal (CRC) and 143 cases of small intestine (SIC) cancer during a 10-year follow-up among 509 568 partic...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0124-8
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Vegetable and/or fruit intakes in association with hepatocellular carcinoma (HCC) risk have been investigated in case-control studies conducted in specific European countries and cohort studies conducted in Asia, with inconclusive results. No multi-centre European cohort has investigated the indicated associ...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2014.654
更新日期：2015-03-31 00:00:00
abstract：:To distinguish risk factors for acquisition of cervical human papillomavirus (HPV) infection from the determinants of neoplasia among infected individuals we have conducted a three-arm case-control study nested within a large population-based cohort of women (the Manchester cohort) screened for HPV at entry using L1 c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1523
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:Combined-modality therapy is a promising approach to improve the therapeutic index of radiotherapy. However, these improvements could come at the cost of increased toxicities. Clinical trials evaluating anti-tumour efficacy of bevacizumab combined with radiotherapy have encountered unexpected side effects. T...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.236
更新日期：2012-07-10 00:00:00
abstract：:Increasingly, treatment choices leading to the same survival outcome can be offered to cancer patients (e.g. mastectomy or conservative surgery in early breast cancer). Two approaches available for post-orchidectomy, stage I patients with non-seminomatous germ cell tumours of the testis (NSGCTT), particularly those at...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.570
更新日期：1996-11-01 00:00:00
abstract：:Oesopharyngeal brush (OPB) sampling with cytological analysis can yield exfoliated cells from asymptomatic tumours of the upper aero-digestive tract and the oesophagus. In this study, we compared cytological evaluation and molecular analysis for the detection of exfoliated cancer cells sampled with an OPB. A total of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600953
更新日期：2003-06-02 00:00:00
abstract：BACKGROUND:The accuracy of prostate-specific antigen (PSA) testing in prostate cancer detection is constrained by low sensitivity and specificity. Dysregulated expression of minichromosome maintenance (Mcm) 2-7 proteins is an early event in epithelial multistep carcinogenesis and thus MCM proteins represent powerful ca...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605785
更新日期：2010-08-24 00:00:00
abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. We tested megestrol acetate (MA) against placebo in the treatment of advanced HCC. METHODS:From 2002 through 2007, this randomised double-blind trial enrolled 204 patients with treatment-naive advanced HCC (Eastern Coopera...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjc.2011.333
更新日期：2011-09-27 00:00:00
abstract：:Febrile neutropenia (FN) causes significant morbidity and mortality in patients receiving cytotoxic chemotherapy and can lead to reduced chemotherapy dose intensity and increased overall treatment costs. Antibiotic prophylaxis reduces the incidence of FN. Recent research and meta-analyses confirm that prophylactic flu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605270
更新日期：2009-09-01 00:00:00
abstract：:In premenopausal women with advanced breast cancer the luteinising hormone-releasing hormone agonist goserelin (Zoladex, ICI plc) will produce serum levels of oestradiol equivalent to those following surgical oophorectomy or the menopause. This paper reports our further experience of using this drug in 75 premenopausa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.397
更新日期：1990-11-01 00:00:00
abstract：:Anti-inflammatory corticosteroids administered to rats in high dosages before intravenous injection of allogeneic tumour cells caused 5-10 fold reductions in "take" and clonogenic growth of the cells in lung and kidney and decreased growth and spread of the cells transplanted to leg muscle. Steroid therapy also reduce...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.84
更新日期：1974-05-01 00:00:00
abstract：:The effect of selected marine compounds with anti-tumoral activity on the cell microtubule network was tested by immunofluorescence analyses, or by other in vitro analyses involving competition with colchicine or with GTP for tubulin binding and tubulin polymerisation, studies that were carried out in parallel with ot...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.176
更新日期：1996-04-01 00:00:00
abstract：:The last 15 years has seen an explosion of interest in the cancer stem cell (CSC). Although it was initially believed that only a rare population of stem cells are able to undergo self-renewing divisions and differentiate to form all populations within a malignancy, a recent work has shown that these cells may not be ...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6605821
更新日期：2010-08-10 00:00:00
abstract：:Malignant melanoma (MM) is thought to arise by sequential accumulation of genetic alterations in normal melanocytes. Previous cytogenetic and molecular studies indicated the 9p21 as the chromosomal region involved in MM pathogenesis. In addition to the CDKN genes (p16/CDKN2A, p15/CDKN2B and p19(ARF), frequently inacti...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1513
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:The aim of this work was to improve the knowledge of the role of histamine in breast cancer by assessing the therapeutic efficacy of histamine and histamine H4 receptor (H4R) ligands in a triple-negative breast cancer (TNBC) model developed in immunocompetent hosts. By using publicly available genomic data, ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0636-x
更新日期：2020-02-01 00:00:00
abstract：:The effects of polymorphisms in genes coding for key folate metabolism enzymes such as thymidylate synthetase (TS) on colorectal neoplasia risk are likely to be influenced by gene-gene and gene-nutrient interactions. We investigated the combined effects of three polymorphisms in the TS gene region, TSER, TS 3R G>C, an...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604056
更新日期：2007-11-19 00:00:00
abstract：:Renal tumours were induced in dietary-primed rats by injection of dimethylnitrosamine. Control and tumour tissue was excised at varying periods and maintained in short-term organ culture in the presence of 3H- or 14C-fucose. The plasma membranes were then isolated, and the isotopic profiles of normal kidney and renal ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.106
更新日期：1978-05-01 00:00:00
abstract：:In this paper, we develop a Markov chain model to estimate parameters pertaining to the natural history of nasopharyngeal carcinoma (NPC). The model is of progression from no disease to Epstein-Barr virus (EBV) infection, preclinical screen-detectable tumour and clinical tumour. We derive tentative estimates of the pa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690301
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:While current chemotherapy has increased cure rates for children with acute lymphoblastic leukaemia (ALL), the largest number of relapsing patients are still stratified as medium risk (MR) at diagnosis (50-60%). This highlights an opportunity to develop improved relapse-prediction models for MR patients. We ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0933-4
更新日期：2020-09-01 00:00:00
abstract：:There is increasing evidence that the presence of a systemic inflammatory response plays an important role in survival following curative resection for colorectal cancer. The present study evaluated the relationship between C-reactive protein concentrations and survival in a cohort of patients receiving adjuvant 5-flu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603185
更新日期：2006-06-19 00:00:00
abstract：:Wnt genes are transforming to mouse breast epithelium and are hormonally regulated in vivo. To assess their role in another endocrine-responsive human cancer, the expression of seven Wnt genes (Wnt 2, 3, 4, 5a, 7a, 7b and 10b) in normal human endometrium and endometrial cells, and endometrial carcinoma tissues and cel...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.195
更新日期：1997-01-01 00:00:00
abstract：:A death certificate-based case-control study was conducted on 207 women aged 25-44 who died of bladder cancer in England and Wales in the period 1971-89 and 411 controls matched on sex, year of death and age at death. An odds ratio of 12.0 (95% CI 1.5-99.7) was found for women with a history of paraplegia. Four of the...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.269
更新日期：1994-07-01 00:00:00
abstract：:Radiographically occult bronchogenic squamous cell carcinomas are early lung cancers that localize mainly in the bronchial wall, and are thought to be a good model for investigating genetic alterations through lung cancer progression. In order to elucidate sequential genetic changes in lung cancers, we analysed the in...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.549
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND:Panobinostat, a pan-deacetylase inhibitor, overcomes imatinib resistance in preclinical models of gastrointestinal stromal tumours (GIST). Here we determined the maximum tolerated dose (MTD) and dose-limiting toxicities (DLT) of panobinostat in combination with imatinib (IM) for treatment of patients with re...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.826
更新日期：2014-03-04 00:00:00
abstract：:In rapidly frozen livers from chickens affected with myeloblastosis and Marek's disease and from unaffected control birds there exists a strong correlation between catalase activity and catalase Electron Paramagnetic Resonance (EPR) signal intensities. The diseased chickens had activities and signals reduced to as lit...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1984.189
更新日期：1984-09-01 00:00:00
abstract：:In order to examine in detail the sensitivity to chemotherapy of tumour cells at various organ sites and at various stages of metastasis, we have used a series of cell lines, all selected from sister subpopulations derived from a single mouse mammary tumour, which can be distinguished and quantitated from normal cells...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.280
更新日期：1993-07-01 00:00:00
abstract：:Interferon-alpha (IFN-alpha) is a clinically useful cytokine for treatment of a variety of cancers, including chronic myelocytic leukaemia (CML). Most CML cells are sensitive to IFN-alpha; however, its biological effects on leukaemic cells are incompletely characterized. Here, we provide evidence that IFN-alpha induce...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690163
更新日期：1999-03-01 00:00:00
