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Adiposity and risks of colorectal and small intestine cancer in Chinese adults: a prospective study of 0.5 million people.

Abstract：

BACKGROUND:Uncertainty remains about the associations of adiposity with intestinal cancer in China and by its anatomical subtype. METHODS:The prospective China Kadoorie Biobank recorded 3024 incident cases of colorectal (CRC) and 143 cases of small intestine (SIC) cancer during a 10-year follow-up among 509 568 participants without prior cancer at baseline. Cox regression was used to estimate adjusted hazard ratios (HRs) for specific cancers associated with adiposity. RESULTS:Overall mean body mass index (BMI) was 23.7  kg/m2. BMI was positively associated with CRC (HR per SD 1.10 [95% CI 1.06-1.14]), colon (1.13 [1.07-1.18]), and rectal (1.07 [1.02-1.13]) cancer. For waist circumference, the corresponding HRs per SD were 1.14 (1.10-1.18), 1.18 (1.13-1.24), and 1.11 (1.05-1.16), respectively. The adjusted HRs were somewhat greater in men than women. Adiposity was positively, but non-significantly, associated with SIC risk. CONCLUSIONS:Among relatively lean Chinese adults, adiposity was associated with risks of colon and rectal cancer, with the associations somewhat stronger in men than women.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Pang Y,Kartsonaki C,Guo Y,Chen Y,Yang L,Bian Z,Bragg F,Millwood IY,Mao E,Li Y,Shi L,Chen J,Li L,Holmes MV,Chen Z

doi

10.1038/s41416-018-0124-8

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

248-250

issue

2

eissn

0007-0920

issn

1532-1827

pii

10.1038/s41416-018-0124-8

journal_volume

119

pub_type

杂志文章

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