Abstract：
BACKGROUND:Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. METHODS:We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease. RESULTS:A high protein expression of MMP-2 as well as MMP-9 in normal mucosa was found to be correlated with worse 5-year survival. The combination of both parameters was an even stronger prognostic factor. These protein levels were found not to be related to the corresponding single nucleotide polymorphisms of MMP-2 (-1306C>T) and MMP-9 (-1562C>T). Multivariate analyses indicated that the MMP-2 and MMP-9 levels in normal mucosa are prognostic for survival, independent of TNM classification. CONCLUSION:MMP-2 and MMP-9 levels in normal mucosa are indicative of the course of disease in colorectal cancer patients.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Langers AM,Verspaget HW,Hawinkels LJ,Kubben FJ,van Duijn W,van der Reijden JJ,Hardwick JC,Hommes DW,Sier CFdoi
10.1038/bjc.2012.80subject
Has Abstractpub_date
2012-04-24 00:00:00pages
1495-8issue
9eissn
0007-0920issn
1532-1827pii
bjc201280journal_volume
106pub_type
杂志文章abstract：:In 1985 a second randomisation was initiated for women in the treatment arm of the Scottish Tamoxifen Trial either to stop tamoxifen at 5 years or to continue indefinitely. A preliminary analysis of outcome in 342 patients at a median follow-up of 6 years suggests that a worthwhile gain in disease control from continu...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.1996.356
更新日期：1996-07-01 00:00:00
abstract：:In this population-based Norwegian cohort study (2.1 million children), the impact of birth and parental characteristics on the risk of neuroblastoma (178 cases) was evaluated. In children below the age of 18 months, there was an increased neuroblastoma risk among those with congenital malformations and suggestion of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604646
更新日期：2008-10-07 00:00:00
abstract：:In the district of Srikakulam in Andhra Pradesh in South India the habit of reverse smoking is widespread. In a house to house survey of oral cancer and precancerous conditions, comprising 10,169 villagers, 43·8% were reverse smokers; the female: male ratio being 1·7: 1. Ten previously undiagnosed cases of oral cancer...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1971.2
更新日期：1971-03-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.267
更新日期：1990-08-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.100
更新日期：1974-06-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605097
更新日期：2009-06-16 00:00:00
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journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1995.299
更新日期：1995-07-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600224
更新日期：2002-04-22 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.119
更新日期：1987-06-01 00:00:00
abstract：BACKGROUND:Breast cancer, a heterogeneous disease has been broadly classified into oestrogen receptor positive (ER+) or oestrogen receptor negative (ER-) tumour types. Each of these tumours is dependent on specific signalling pathways for their progression. While high levels of survivin, an anti-apoptotic protein, incr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.40
更新日期：2013-03-05 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.14
更新日期：1973-02-01 00:00:00
abstract：BACKGROUND:The role of melanoma inhibitory activity 2 (MIA2) was examined in human oral squamous cell carcinoma (OSCC). METHODS:MIA2 role was examined by immunohistochemistry of human OSCCs and knockdown studies using human 3 OSCC cell lines with MIA2 expression. RESULTS:MIA2 expression was observed in 62 (66.7%) of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.27
更新日期：2013-04-16 00:00:00
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journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6602204
更新日期：2004-11-15 00:00:00
abstract：:Local infiltrates of eosinophilic leucocytes and macrophages and the deposition of acid mucopolysaccharides (AMPS) in 72 operable primary lung cancers and 17 isolated pulmonary metastases of known origin were correlated to tumour stage (radically or non-radically operable) and clinical course, by following the patient...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.196
更新日期：1979-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/s41416-020-0824-8
更新日期：2020-06-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.123
更新日期：1974-08-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605359
更新日期：2009-11-17 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.309
更新日期：1989-10-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.332
更新日期：1980-12-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2015-12-15 00:00:00
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journal_title：British journal of cancer
pub_type： 评论,社论
doi：10.1038/s41416-019-0645-9
更新日期：2020-02-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0779-9
更新日期：2020-05-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.244
更新日期：2012-06-26 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.818
更新日期：2014-02-18 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.261
更新日期：1993-06-01 00:00:00
abstract：:The oncogenicity of Duck hepatitis B virus (DHBV) is unclear since hepatocellular carcinomas (HCCs) have been reported only in domestic ducks in Qidong, an area of China where hepatitis B virus (HBV) and aflatoxin B1 (AFB1) are risk factors for liver cancer in man. In order to better define the association between DHB...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.16
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND:Renal cell carcinoma (RCC) is highly resistant to chemotherapy because of a high apoptotic threshold. Recent evidences suggest that GSK-3beta positively regulates human pancreatic cancer and leukaemia cell survival in part through regulation of nuclear factor (NF-kappaB)-mediated expression of anti-apoptotic...
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6605437
更新日期：2009-12-15 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.153
更新日期：1991-05-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.56
更新日期：2013-03-19 00:00:00
abstract：BACKGROUND:Focal adhesion kinase (FAK) is overexpressed in a variety of cancers, such as breast, colon, prostate, ovary, and lung cancers. However, the mechanism by which extracellular matrix fibronectin stimulates lung cancer cell migration and invasion through FAK remains to be investigated. METHODS:The signalling p...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605154
更新日期：2009-07-21 00:00:00
