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Determination of cell-free interleukin 2 receptor level in the serum of normal animals and of animals bearing IL-2 receptor positive tumours with high or low metastatic capacity.

Abstract：

:Serum levels of cell-free interleukin-2 receptors were elevated above normal in mice bearing the IL-2R positive T-cell lymphoma Eb or its highly metastatic variant ESb. Although ESb cells expressed less IL-2R molecules than Eb cells on their cell surface, serum receptor levels were raised more quickly in ESb than in Eb tumour bearing animals. Elevated IL-2R serum levels were a sensitive tumour marker in animals bearing the aggressive variant ESb but not in animals bearing the low metastatic line Eb. Peritoneal ascites tumour-bearing animals had higher serum IL-2R levels than corresponding animals with subcutaneously growing tumours. Thus, serum IL-2R levels in tumour-bearing animals were dependent on the tumour line and influenced by the site and mode of tumour growth.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Schirrmacher V,Josimovic-Alasevic O,Osawa H,Diamantstein T

doi

10.1038/bjc.1987.119

subject

Has Abstract

pub_date

1987-06-01 00:00:00

pages

583-7

issue

6

eissn

0007-0920

issn

1532-1827

journal_volume

55

pub_type

杂志文章

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