Expression of topoisomerase II alpha and beta in an adenocarcinoma cell line carrying amplified topoisomerase II alpha and retinoic acid receptor alpha genes.

abstract：:MBD3: is a member of the methyl-CpG-binding domain family and is located on chromosome 19p13.3, a region of loss of heterozygosity in colon and lung cancers. We therefore screened samples for abnormalities in MBD3. Our results indicate that MBD3 is not a major target of genetic and epigenetic alteration in these cance...

journal_title：British journal of cancer

authors： Zhu Y,Harrison DJ,Bader SA

更新日期：2004-05-17 00:00:00

abstract：:Urokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA acts in vivo by binding to a membrane receptor known as uPAR. In this study, uPA and uPAR levels were semiquantitated by immunocytochemistry in 36 primary breast carcinomas. Using monoclonal antibody HD-UK 1, uPA...

journal_title：British journal of cancer

authors： Kennedy S,Duffy MJ,Duggan C,Barnes C,Rafferty R,Kramer MD

更新日期：1998-05-01 00:00:00

abstract：:In the past decade, an increasing number of frequently positive randomised clinical trials have been completed, allowing new consideration of the present therapeutic armamentarium for advanced renal cell carcinoma. These studies were predominantly designed to compare the experimental drugs with 1 of 2 active control a...

journal_title：British journal of cancer

authors： Bracarda S,Porta C,Sisani M,Marrocolo F,Paglino C,Hamzaj A,D Buono S,Sternberg CN

更新日期：2015-01-06 00:00:00

abstract：:Human papillomavirus (HPV) is thought to cause some vulval squamous cell carcinomas (VSCC) by degrading p53 product. Evidence on whether HPV-negative VSCC results from p53 mutation is conflicting. We performed immunohistochemistry for p53 product on 52 cases of lone vulval intraepithelial neoplasia (VIN), 21 cases of ...

journal_title：British journal of cancer

authors： Rosenthal AN,Hopster D,Ryan A,Jacobs IJ

更新日期：2003-01-27 00:00:00

abstract：:Delta-aminolevulinic acid (ALA) is the precursor in the biosynthesis of porphyrins. The knowledge of both the regulation of ALA entrance and efflux from the cells and the control of porphyrin biosynthesis is essential to improve ALA-mediated photodynamic therapy. In this work, we studied the regulation of ALA uptake a...

journal_title：British journal of cancer

authors： Correa García S,Casas A,Perotti C,Batlle A,Bermúdez Moretti M

更新日期：2003-07-07 00:00:00

abstract：:The effects of cis-dichlorodiammine platinum II (DDP) on the intestinal mucosa and the kidney were studied after single and multiple treatments with intervals of 7-45 days. After a single treatment, the jejunal epithelium underwent a transient interruption of cell proliferation followed by a hyperplastic recovery and ...

journal_title：British journal of cancer

authors： Kovacs CJ,Braunschweiger PG,Schenken LL,Burholt DR

更新日期：1982-02-01 00:00:00

abstract：:NK911 is a novel supramolecular nanocarrier designed for the enhanced delivery of doxorubicin (DXR) and is one of the successful polymer micelle systems to exhibit an efficient accumulation in solid tumours in mice. The purpose of this study was to define the maximum-tolerated dose (MTD) and dose-limiting toxicities (...

journal_title：British journal of cancer

authors： Matsumura Y,Hamaguchi T,Ura T,Muro K,Yamada Y,Shimada Y,Shirao K,Okusaka T,Ueno H,Ikeda M,Watanabe N

更新日期：2004-11-15 00:00:00

abstract：:We conducted a national, retrospective population-based cohort study of 705 patients hospitalized with a first diagnosis of dermatomyositis (DM) or polymyositis (PM) during 1982-1996 based on linkage of hospital discharge, cancer registration, and death records in Scotland. Risks of cancer were assessed by calculating...

journal_title：British journal of cancer

authors： Stockton D,Doherty VR,Brewster DH

更新日期：2001-07-06 00:00:00

abstract：:A serological assay for the quantitative determination of the novel tumour-associated epitope CA242 was developed and used for determination of sensitivity and specificity of CA242 in gastrointestinal cancer. The CA242 assay showed a better tumour specificity than CA50 (and CA 19-9). This was most noticeable in benign...

journal_title：British journal of cancer

authors： Nilsson O,Johansson C,Glimelius B,Persson B,Nørgaard-Pedersen B,Andrén-Sandberg A,Lindholm L

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cancer worldwide. Accurately identifying stage II CRC patients at risk for recurrence is an unmet clinical need. KCNQ1 was previously identified as a tumour suppressor gene and loss of expression was associated with poor survival in patients with CRC liver met...

journal_title：British journal of cancer

authors： den Uil SH,Coupé VM,Linnekamp JF,van den Broek E,Goos JA,Delis-van Diemen PM,Belt EJ,van Grieken NC,Scott PM,Vermeulen L,Medema JP,Bril H,Stockmann HB,Cormier RT,Meijer GA,Fijneman RJ

更新日期：2016-12-06 00:00:00

abstract：:We investigated whether lower birth weight was associated with lower risk of melanoma later in life. This population-based case-control study included all incident cases of histologically verified invasive melanoma diagnosed until 31 December 2003 in the Norwegian population born between 1967 and 1986 (n=709). The con...

journal_title：British journal of cancer

authors： Franco-Lie I,Iversen T,Robsahm TE,Abdelnoor M

更新日期：2008-01-15 00:00:00

abstract：:Basal cell carcinomas (BCCs) are very frequent cutaneous cancers, often located on the face. Cure rates with surgery and radiotherapy are high, but these treatments have never been compared prospectively. A randomized trial was initiated in 1982 to compare surgery and radiotherapy in the treatment of primary BCC of th...

journal_title：British journal of cancer

authors： Avril MF,Auperin A,Margulis A,Gerbaulet A,Duvillard P,Benhamou E,Guillaume JC,Chalon R,Petit JY,Sancho-Garnier H,Prade M,Bouzy J,Chassagne D

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Tissue micro-arrays (TMAs) are increasingly used to generate data of the molecular phenotype of tumours in clinical epidemiology studies, such as studies of disease prognosis. However, TMA data are particularly prone to missingness. A variety of methods to deal with missing data are available. However, the v...

journal_title：British journal of cancer

authors： Ali AM,Dawson SJ,Blows FM,Provenzano E,Ellis IO,Baglietto L,Huntsman D,Caldas C,Pharoah PD

更新日期：2011-02-15 00:00:00

abstract：BACKGROUND:Based on the microRNA (miRNA) signature of bladder cancer (BC) by deep sequencing, we recently found that several double-stranded mature miRNAs derived from the same pre-miRNAs were sufficiently expressed and acted as tumour suppressors by regulating common target genes in BC. Our deep-sequencing signature o...

journal_title：British journal of cancer

authors： Sakaguchi T,Yoshino H,Yonemori M,Miyamoto K,Sugita S,Matsushita R,Itesako T,Tatarano S,Nakagawa M,Enokida H

更新日期：2017-04-11 00:00:00

abstract：:The incidence of colorectal carcinoma is rising at an alarming pace in Asian urban societies such as Hong Kong. Detailed examination of the epidemiological pattern and genetic mutation of colorectal cancer in the Hong Kong Chinese population is overdue. We compared the reported age incidence of colorectal carcinoma in...

journal_title：British journal of cancer

authors： Yuen ST,Chung LP,Leung SY,Luk IS,Chan SY,Ho JC,Ho JW,Wyllie AH

更新日期：1997-01-01 00:00:00

abstract：:The traditional cancer drug development pathway is increasingly being superseded by trials that address multiple clinical questions. These are collectively termed Complex Innovative Design (CID) trials. CID trials not only assess the safety and toxicity of novel anticancer medicines but also their efficacy in biomarke...

journal_title：British journal of cancer

authors： Blagden SP,Billingham L,Brown LC,Buckland SW,Cooper AM,Ellis S,Fisher W,Hughes H,Keatley DA,Maignen FM,Morozov A,Navaie W,Pearson S,Shaaban A,Wydenbach K,Kearns PR,Experimental Cancer Medicine Centres (ECMC) CID trials wo

更新日期：2020-02-01 00:00:00

abstract：:Colorectal tumours from MYH polyposis patients display an excess of somatic G : C --> T : A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous morphology (P=0.0...

journal_title：British journal of cancer

authors： Jones S,Lambert S,Williams GT,Best JM,Sampson JR,Cheadle JP

更新日期：2004-04-19 00:00:00

abstract：BACKGROUND:Understanding the molecular biology of colorectal cancer (CRC) provides opportunities for effective personalised patient management. We evaluated whether chromosomal aberrations, mutations in the PI(3)K signalling pathway and the CpG-island methylator phenotype (CIMP) in primary colorectal tumours can predic...

journal_title：British journal of cancer

authors： Bruin SC,He Y,Mikolajewska-Hanclich I,Liefers GJ,Klijn C,Vincent A,Verwaal VJ,de Groot KA,Morreau H,van Velthuysen ML,Tollenaar RA,van 't Veer LJ

更新日期：2011-07-12 00:00:00

abstract：:Sera from 182 newly diagnosed breast cancer patients were assayed for antibodies to p53 using an enzyme-linked immunosorbent assay (ELISA) method, and antibodies were detected in 48 (26%) compared with 1 out of 76 (1.3%) normal control volunteers (P = 0.0001). In breast cancer patients, autoantibodies were found in al...

journal_title：British journal of cancer

authors： Mudenda B,Green JA,Green B,Jenkins JR,Robertson L,Tarunina M,Leinster SJ

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Bevacizumab has broad anti-tumour activity, but substantial risk of hypertension. No reliable markers are available for predicting bevacizumab-induced hypertension. METHODS:A genome-wide association study (GWAS) was performed in the phase III bevacizumab-based adjuvant breast cancer trial, ECOG-5103, to eva...

journal_title：British journal of cancer

authors： Schneider BP,Li L,Shen F,Miller KD,Radovich M,O'Neill A,Gray RJ,Lane D,Flockhart DA,Jiang G,Wang Z,Lai D,Koller D,Pratt JH,Dang CT,Northfelt D,Perez EA,Shenkier T,Cobleigh M,Smith ML,Railey E,Partridge A,Gralo

更新日期：2014-09-09 00:00:00

abstract：:The MBD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides. In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than origi...

journal_title：British journal of cancer

authors： Bader S,Walker M,Harrison D

更新日期：2000-12-01 00:00:00

abstract：:Several studies have shown that dietary lipid exerts an effect on carcinogenesis. We report here that progression to malignancy in vitro is associated with changes in the response to fatty acids (FAs). Tumorigenic (THKE) cells were more sensitive to the n-3 FAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA...

journal_title：British journal of cancer

authors： Maehle L,Eilertsen E,Mollerup S,Schønberg S,Krokan HE,Haugen A

更新日期：1995-04-01 00:00:00

abstract：:A urinary gonadotrophin peptide (UGP) was isolated and purified from semi-purified human chorionic gonadotrophin (hCG), prepared from pregnancy urine. The peptide showed hCG-B subunit activity and no hCG-alpha subunit activity as demonstrated by binding studies with the relevant antibodies. It had a molecular weight s...

journal_title：British journal of cancer

authors： Kardana A,Taylor ME,Southall PJ,Boxer GM,Rowan AJ,Bagshawe KD

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Inter-individual differences in dihydropyrimidine dehydrogenase (DPYD encoding DPD) and thiopurine S-methyltransferase (TPMT) activity are important predictors for fluoropyrimidine and thiopurine toxicity. While several variants in these genes are known to decrease enzyme activities, many additional genetic ...

journal_title：British journal of cancer

authors： Zhou Y,Dagli Hernandez C,Lauschke VM

更新日期：2020-12-01 00:00:00

abstract：:We assessed the association of postmenopausal serum levels of oestrogens and sex hormone-binding globulin (SHBG) with endometrial cancer risk in a case-control study nested within the NYU Women's Health Study cohort. Among 7054 women postmenopausal at enrolment, 57 cases of endometrial cancer were diagnosed a median o...

journal_title：British journal of cancer

authors： Zeleniuch-Jacquotte A,Akhmedkhanov A,Kato I,Koenig KL,Shore RE,Kim MY,Levitz M,Mittal KR,Raju U,Banerjee S,Toniolo P

更新日期：2001-04-06 00:00:00

abstract：BACKGROUND:MiR-125b has critical role in non-small-cell lung cancer (NSCLC) cell migration, and its target genes have not been elucidated. Kinesin-1 light chain (KLC)-2 was predicted as one of miR-125b's targets by bioinformatics analysis. This study is to identify the function of KLC2 and its interaction with miR-125b...

journal_title：British journal of cancer

authors： Wang M,Zhu X,Sha Z,Li N,Li D,Chen L

更新日期：2015-03-03 00:00:00

abstract：:Tumour-associated prostaglandin-like material, assessed by bioassay, has been examined in 37 patients with primary and metastatic squamous carcinomas of the head and neck, previously treated by radiotherapy and chemotherapy followed by radical surgery. High amounts of prostaglandin-like material were extracted from tu...

journal_title：British journal of cancer

authors： Bennett A,Carter RL,Stamford IF,Tanner NS

更新日期：1980-02-01 00:00:00

abstract：:Limb-sparing surgeries have been performed more frequently than amputation based on the belief that limb-sparing surgeries provide improved function and quality-of-life (QOL). However, this has not been extensively studied in the paediatric population, which has unique characteristics that have implications for functi...

journal_title：British journal of cancer

authors： Nagarajan R,Clohisy DR,Neglia JP,Yasui Y,Mitby PA,Sklar C,Finklestein JZ,Greenberg M,Reaman GH,Zeltzer L,Robison LL

更新日期：2004-11-29 00:00:00

abstract：BACKGROUND:Here, we explore the therapeutic potential of dasatinib, a small-molecule inhibitor that targets multiple cytosolic and membrane-bound tyrosine kinases, including members of the Src kinase family, EphA2, and focal adhesion kinase for the treatment of ovarian cancer. METHODS:We examined the effects of dasati...

journal_title：British journal of cancer

authors： Konecny GE,Glas R,Dering J,Manivong K,Qi J,Finn RS,Yang GR,Hong KL,Ginther C,Winterhoff B,Gao G,Brugge J,Slamon DJ

更新日期：2009-11-17 00:00:00

abstract：BACKGROUND:The need to unfold the underlying mechanisms of lung cancer aggressiveness, the deadliest cancer in the world, is of prime importance. Because Fas-associated death domain protein (FADD) is the key adaptor molecule transmitting the apoptotic signal delivered by death receptors, we studied the presence and cor...

journal_title：British journal of cancer

authors： Cimino Y,Costes A,Damotte D,Validire P,Mistou S,Cagnard N,Alifano M,Régnard JF,Chiocchia G,Sautès-Fridman C,Tourneur L

更新日期：2012-06-05 00:00:00