Abstract:
:Intrapleurally injected cells of an ascitic rat tumour produced intrapleural effusions and solid pleural deposits. BCG, or its methanol extraction residue (MER) injected into the pleural space, suppressed tumour development and prolonged survival. Treatment was effective if given a few days before or after tumour injection. In contrast, active specific immunotherapy by repeated s.c. injection of viable or radiation-attenuated tumour cells in admixture with BCG was unsuccessful, and did not improve the response to intrapleural BCG treatment.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Pimm MV,Hopper DG,Baldwin RWdoi
10.1038/bjc.1976.179subject
Has Abstractpub_date
1976-10-01 00:00:00pages
368-73issue
4eissn
0007-0920issn
1532-1827journal_volume
34pub_type
杂志文章abstract:BACKGROUND:The addition of breast magnetic resonance imaging (MRI) to screening mammography for women with BRCA mutations significantly increases sensitivity, but there is little data on clinical outcomes. We report screening performance, cancer stage, distant recurrence rate, and breast cancer-specific mortality in ou...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.204
更新日期:2012-06-26 00:00:00
abstract:BACKGROUND:We conducted a multicentre feasibility study for single agent long-term S-1 chemotherapy following docetaxel plus cisplatin in patients with curatively resected stage II-IIIA non-small cell lung cancer. METHODS:Patients received three cycles of docetaxel (60 mg m(-2)) plus cisplatin (80 mg m(-2)) and then r...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/bjc.2013.378
更新日期:2013-08-06 00:00:00
abstract::One hundred and seventy-eight patients with non metastatic inflammatory breast cancer (IBC) have been treated at the Centre H. Becquerel. Median follow up is 67 months (6-178). Every patient received neoadjuvant chemotherapy (mean number of cycles = 4; range: 2-8), followed by a loco regional treatment (radiotherapy =...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.109
更新日期:1993-03-01 00:00:00
abstract::Lysophosphatidic acid (LPA) is a potent lipid mediator that acts on a series of specific G protein-coupled receptors, leading to diverse biological actions. Lysophosphatidic acid induces cell proliferation, survival and migration, which are critically required for tumour formation and metastasis. This bioactive lipid ...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/sj.bjc.6605588
更新日期:2010-03-16 00:00:00
abstract::Gap junctions provide a route for small molecules to pass directly between cells. Toxic species may spread through junctions into 'bystander' cells, which may be exploited in chemotherapy and radiotherapy. However, this may be prevented by junction closure, and therefore an understanding of the dose-dependency of inhi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601686
更新日期:2004-04-05 00:00:00
abstract::Angiogenesis is an essential requirement for tumour growth and metastasis and is regulated by a complex network of factors produced by both stromal cells and neoplastic cells within solid tumours. The cytokine tumour necrosis factor alpha (TNF-alpha) and the enzyme thymidine phosphorylase (TP) are two factors known to...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.373
更新日期:1998-06-01 00:00:00
abstract::When assessing the value of a particular treatment, it is important to consider the impact it may have on the quality of life of those being treated. This is particularly so for cancer patients, whose life expectancy may be short. Patients with advanced colorectal cancer who participated in two international comparati...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1038/bjc.1998.420
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of B100 common, low-penetrance PrCa susceptibility variants identified so far by genome-wid...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.50
更新日期:2016-04-12 00:00:00
abstract:BACKGROUND:We evaluated systemic immune-inflammation index (SII) and its association with patient outcome in germ-cell tumours (GCTs). METHODS:Two independent cohorts of patients were analysed; the discovery set (n=171) from a single institution and the validation set (n=181) previously included in a study evaluating ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2017.460
更新日期:2018-03-20 00:00:00
abstract::Previous studies have shown that multidrug resistance (MDR) in the doxorubicin-selected lung tumour cell lines COR-L23/R, GLC4/ADR and MOR/R is associated with overexpression of the MRP gene. In this study we report that resistance to daunorubicin, vincristine and rhodamine 123 can be partially reversed in these cell ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.281
更新日期:1995-07-01 00:00:00
abstract::In the present study the putative chemopreventive effect of dietary fish oil (MaxEPA) on azaserine-induced pancreatic carcinogenesis in rats was investigated. Groups of rats were maintained on a semipurified low-fat (LF; 5 wt%) diet or on semipurified high-fat (HF; 25 wt%) diets containing 5 wt% linoleic acid (LA) and...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.7
更新日期:1996-01-01 00:00:00
abstract::The objective of this study was to prospectively measure peri-diagnostic and surgical time intervals for patients with suspected colorectal, lung, or prostate cancer. Prospective eligible patients were referred to a regional hospital in Ottawa, Canada between February 2004 and February 2005 for diagnostic assessment o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604819
更新日期:2009-01-13 00:00:00
abstract::The sera of 80 newly diagnosed lung-cancer patients have been examined for immune complexes and autoantibodies. Control subjects consisted of 20 bronchitic patients and 150 normal blood donors. Immune-complex measurements used 4 established and sensitive techniques (Raji cell assay, fluid and solid-phase C1q assays an...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.45
更新日期:1981-03-01 00:00:00
abstract::The management of older patients with aggressive non-Hodgkin's lymphoma presents a challenge to the physician. Age is a poor prognostic indicator, due to reduced ability to tolerate and maintain dose-intensive chemotherapy. Generally, older patients demonstrate a lower response rate, reduced survival and increased tox...
journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.bjc.6602975
更新日期:2006-03-27 00:00:00
abstract::In this study, we aimed to analyse human cancer cell-platelet interactions in functional cell analyses and explore the molecular mechanisms behind tumour progression. Various functional analyses of gastric cancer (GC) cells were performed after direct/indirect co-incubation with platelets derived from GC patients. Fur...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01134-7
更新日期:2020-10-28 00:00:00
abstract::Serum protein induced by vitamin K absence or antagonist II (PIVKAII), hepatoma-specific band of serum gamma-glutamyl transferase (GGTII), and alpha-fetoprotein (AFP) levels were determined in 120 patients with hepatocellular carcinoma (HCC) and 90 patients with cirrhosis. The mean serum concentration of PIVKAII in HC...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601018
更新日期:2003-06-16 00:00:00
abstract::Since hyperinsulinaemia may promote obesity-linked cancers, we compared type 2 diabetes prevalence among oesophageal adenocarcinoma (OAC) patients and population controls. Diabetes increased the risk of OAC (adjusted odds ratio 1.59, 95% confidence interval (CI) 1.04-2.43), although the risk was attenuated after furth...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604908
更新日期:2009-03-10 00:00:00
abstract::There is evidence that patients living in outlying areas have poorer survival from cancer. This study set out to investigate whether they have more advanced disease at diagnosis. Case notes of 1323 patients in north and northeast Scotland who were diagnosed with lung or colorectal cancer in 1995 or 1996 were reviewed....
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1708
更新日期:2001-04-06 00:00:00
abstract:BACKGROUND:The role of melanoma inhibitory activity 2 (MIA2) was examined in human oral squamous cell carcinoma (OSCC). METHODS:MIA2 role was examined by immunohistochemistry of human OSCCs and knockdown studies using human 3 OSCC cell lines with MIA2 expression. RESULTS:MIA2 expression was observed in 62 (66.7%) of ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.27
更新日期:2013-04-16 00:00:00
abstract:BACKGROUND:We evaluated the efficacy of aprepitant plus granisetron and an increased dose of dexamethasone in selected patients undergoing moderately emetogenic chemotherapy (MEC). METHODS:Nondrinking women <70 years undergoing MEC were randomly assigned to aprepitant (day 1, 125 mg; days 2 and 3, 80 mg) or placebo. D...
journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/bjc.2013.400
更新日期:2013-08-20 00:00:00
abstract::Two subtypes of thrombospondin (TSP-1 and TSP-2) have inhibitory roles in angiogenesis in vitro, although the biological significance of these TSP isoforms has not been determined in vivo. We examined TSP-1 and TSP-2 gene expression by reverse transcription polymerase chain reaction (RT-PCR) analysis in 61 colon cance...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690056
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:RSPO ligands, activators of the Wnt/β-catenin pathway, are overexpressed in different cancers. The objective of this study was to investigate the role of RSPOs in breast cancer (BC). METHODS:Expression of RSPO and markers of various cancer pathways were measured in breast tumours and cell lines by qRT-PCR. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2017.131
更新日期:2017-06-06 00:00:00
abstract::Carcinomas of unknown primary (CUP) represent between 3 and 10% of malignancies. Treatment with nonspecific chemotherapy is commonly unhelpful and the median survival is between 3 and 6 months. Gene expression microarray (GEM) analysis has demonstrated that molecular signatures can aid in tumour classification and pro...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604315
更新日期:2008-04-22 00:00:00
abstract::Phorbol-12-myristate-13-acetate (PMA) induces p21WAF-1 expression in human myeloid leukaemic HL-60 cells. We show that this induction is specifically mediated by protein kinase C (PKC). In addition, the PKC inhibitor Ro 31-8220 with predominant PKC-alpha isoform specificity almost completely inhibited PMA-induced up-r...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.595
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:In neuroblastoma (NB), the most powerful prognostic marker, the MYCN amplification (MNA), occasionally shows intratumoural heterogeneity (ITH), i.e. coexistence of MYCN-amplified and non-MYCN-amplified tumour cell clones, called heterogeneous MNA (hetMNA). Prognostication and therapy allocation are still uns...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/s41416-018-0098-6
更新日期:2018-05-01 00:00:00
abstract::BALB/c mice born to and nursed by females immunized against MSV-M showed a reduced tumour incidence and a high tumour regression rate following MSV-M injection at 7-14 days of age. Females immunized long before mating could also confer protection to their offspring whereas females immunized after parturition could not...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1973.143
更新日期:1973-09-01 00:00:00
abstract:BACKGROUND:PI3K/Akt (PKB) pathway has been shown in several cell types to be activated by ligands to cell surface integrins, leading to the metastasis of tumour cells. The signalling pathways involved in the metastatic spread of human scirrhous gastric carcinoma cells have not been defined. METHODS:The role of the PI3...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.107
更新日期:2012-04-24 00:00:00
abstract::Alcohol consumption has been inconsistently associated with breast cancer risk. Recent studies suggest that genetic polymorphisms of glutathione S-transferases (GSTs) may modify this relation. To determine if breast cancer risk is associated with GSTM1 and GSTT1 genetic polymorphisms, and to evaluate the effect modifi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600708
更新日期:2003-01-13 00:00:00
abstract::The incidence of gastro-oesophageal junction (GEJ) adenocarcinoma is increasing in Western countries and prognosis is poor since metastasis is most often present at diagnosis. We examined samples from 87 resected type II GEJ adenocarcinomas, 30 of these with endoscopic diagnostic biopsy material, to evaluate transform...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.1013
更新日期:2000-02-01 00:00:00
abstract::This corrects the article DOI: 10.1038/bjc.2017.327. ...
journal_title:British journal of cancer
pub_type: 杂志文章,已发布勘误
doi:10.1038/bjc.2017.438
更新日期:2018-01-01 00:00:00