Abstract：
:Two subtypes of thrombospondin (TSP-1 and TSP-2) have inhibitory roles in angiogenesis in vitro, although the biological significance of these TSP isoforms has not been determined in vivo. We examined TSP-1 and TSP-2 gene expression by reverse transcription polymerase chain reaction (RT-PCR) analysis in 61 colon cancers. Thirty-eight of these 61 colon cancers were positive for TSP-2 expression and showed hepatic metastasis at a significantly lower incidence than those without TSP-2 expression (P = 0.02). TSP-2 expression was significantly associated with M0 stage in these colon cancers (P = 0.03), whereas TSP-1 expression showed no apparent correlation with these factors. The colon cancer patients with TSP-2 expression showed a significantly low frequency of liver metastasis correlated with the cell-associated isoform of vascular endothelial growth factor (VEGF-189) (P = 0.0006). Vascularity was estimated by CD34 staining, and TSP-2(-)/VEGF-189(+) colon cancers showed significantly increased vessel counts and density in the stroma (P < 0.0001). TSP-2(-)/VEGF-189(+) colon cancer patients also showed significantly poorer prognosis compared with those with TSP-2(+)/VEGF-189(-) (P = 0.0014). These results suggest that colon cancer metastasis is critically determined by angiogenesis resulting from the balance between the angioinhibitory factor TSP-2 and angiogenic factor VEGF-189.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Tokunaga T,Nakamura M,Oshika Y,Abe Y,Ozeki Y,Fukushima Y,Hatanaka H,Sadahiro S,Kijima H,Tsuchida T,Yamazaki H,Tamaoki N,Ueyama Ydoi
10.1038/sj.bjc.6690056subject
Has Abstractpub_date
1999-01-01 00:00:00pages
354-9issue
2eissn
0007-0920issn
1532-1827journal_volume
79pub_type
杂志文章abstract：BACKGROUND:Circulating tumour cells (CTCs) can be assessed through a minimally invasive blood sample with potential utility as a predictive, prognostic and pharmacodynamic biomarker. The large heterogeneity of melanoma CTCs has hindered their detection and clinical application. METHODS:Here we compared two microfluidi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0750-9
更新日期：2020-03-01 00:00:00
abstract：:In resection tissue samples of colorectal carcinomas, the concentration of urokinase-type plasminogen activator (u-Pa) was found to be significantly higher than in the normal parent mucosal tissue, while there was less tissue-type plasminogen activator (t-PA). u-PA and t-PA were also determined in endoscopic biopsies ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.293
更新日期：1989-09-01 00:00:00
abstract：:The aim of this study was to evaluate the expression of CC chemokine receptor 7 (CCR7) in squamous cell cancer of the tonsil with respect to patterns of spread, relapse-free, overall and disease-specific survival. Eighty-four patients with squamous cell cancer of the tonsil were identified. There was a male predominan...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603907
更新日期：2007-09-03 00:00:00
abstract：:Hepatic infiltration by lymphoma can be difficult to detect by conventional methods. We have studied 22 patients in vivo 31P magnetic resonance spectroscopy of the liver and compared the results with the clinical staging and assessment of liver involvement by computed tomography (CT), ultrasound (US), and liver functi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.208
更新日期：1991-06-01 00:00:00
abstract：:Use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the risk of gastric or oesophageal adenocarcinomas. We examined the association between self-reported use of aspirin or non-aspirin NSAIDs in the earlier 12 months and gastric non-cardia (N=182), gastric cardia (N=178), and oesophageal a...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/sj.bjc.6604880
更新日期：2009-02-10 00:00:00
abstract：:The purpose of this study was to compare the growth-inhibitory effect of cisplatin-paclitaxel with that obtained with a cisplatin-docetaxel combination and to assess the type of interaction. Concomitant use of taxanes and cisplatin was studied in seven human ovarian carcinoma cell lines, using the 96-well plate clonog...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690046
更新日期：1999-01-01 00:00:00
abstract：:When L2C leukaemic B lymphocytes from guinea-pigs were incubated in vitro with antibody directed to their surface immunoglobulin (Ig), a rapid rise in intracellular adenosine 3':5'-phosphate (cyclic adenosine monophosphate, cAMP) was observed. Estimation of cAMP was by a protein-binding assay using bovine adrenal prot...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.77
更新日期：1979-04-01 00:00:00
abstract：BACKGROUND:Tumours are responsive to temozolomide (TMZ) if they are deficient in O(6)-methylguanine-DNA methyltransferase (MGMT), and mismatch repair (MMR) proficient. METHODS:The effect of TMZ on medulloblastoma (MB) cell killing was analysed with clonogenic survival assays. Expression of DNA repair genes and enzymes...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.403
更新日期：2012-10-09 00:00:00
abstract：:We carried out a comparison of three commonly used mucin markers, CA549, CA15.3 and MCA. Serum samples from 184 healthy women and 237 patients with primary breast cancer were evaluated. The markers were measured using commercially available immunometric assays. Like CA15.3 and MCA, CA549 was significantly associated w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.136
更新日期：1994-04-01 00:00:00
abstract：:Increases of individual beta tubulin isotypes in antimicrotubule drug resistant cell lines have been reported by several laboratories. We have previously described elevations in beta(III)and beta(IVa)isotypes in estramustine and paclitaxel resistant human prostate carcinoma cells. To investigate further the function o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1956
更新日期：2001-09-01 00:00:00
abstract：:In the early period following radical hepatectomy for hepatoma, recurrences in the remaining liver are frequently found. In regenerating liver, implantation and growth of tumour cells released into the portal system during surgical treatment might be promoted. We examined the relationship between liver regeneration an...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.170
更新日期：1992-06-01 00:00:00
abstract：:One hundred and one histologically confirmed gastric cancer patients in Gwynedd, North Wales, were matched by sex, age and social class to two hospital inpatients without cancer. Seventy-seven of the gastric cancer cases were also matched, using the same criteria, to a patient with a confirmed cancer of a different si...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.165
更新日期：1990-05-01 00:00:00
abstract：:This study addresses the hypothesis that altered expression of oestrogen receptor-beta and/or altered relative expression of coactivators and corepressors of oestrogen receptors are associated with and may be mechanisms of de novo tamoxifen resistance in oestrogen receptor positive breast cancer. All cases were oestro...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600654
更新日期：2002-12-02 00:00:00
abstract：:The incidence of B cell leukaemia in 186 consecutive untreated patients with histologically defined B cell neoplasms is described. The lymphomas were classified by the Kiel convention. B cell leukaemia in the context of this paper refers to the situation where a neoplastic clone of B cells in the blood greatly outnumb...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1983.174
更新日期：1983-08-01 00:00:00
abstract：:We investigated trends in first-time hospital admissions and deaths attributable to hepatocellular carcinoma (HCC) in a large population-based cohort of 22 073 individuals diagnosed with hepatitis C viral (HCV) infection through laboratory testing in Scotland in 1991-2006. We identified new cases of HCC through record...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604563
更新日期：2008-09-02 00:00:00
abstract：:Since 1975, 191 patients with Hodgkin's disease have been treated with a combination of chlorambucil, vinblastine, procarbazine and prednisolone (ChlVPP). Complete remission rates were 73% for previously untreated patients, 91% for patients previously treated with radiotherapy and 55% for patients previously treated w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.137
更新日期：1982-06-01 00:00:00
abstract：:ERBB2 is frequently amplified in breast tumours as part of a wide region of amplification on chromosome 17q21. This amplicon contains many candidate genes for breast cancer susceptibility. We used a genetic association study design to determine if common genetic variation (frequency>or=5%) in a 400-kb region surroundi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603473
更新日期：2006-12-18 00:00:00
abstract：BACKGROUND:Gold(III) porphyrin 1a is a new class of anticancer drug, which inhibits cell proliferation of wide range of human cancer cell lines and induces apoptosis in human nasopharyngeal carcinoma cells. However, the underlying signalling mechanism by which gold(III) porphyrin 1a modifies the intracellular apoptosis...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605147
更新日期：2009-07-21 00:00:00
abstract：BACKGROUND:Myelosuppression has been observed with several multikinase angiogenesis inhibitors in clinical studies, although the frequency and severity varies among the different agents. Inhibitors targeting vascular endothelial growth factor receptor (VEGFR) often inhibit other kinases, which may contribute to their a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605366
更新日期：2009-11-17 00:00:00
abstract：:Adenosine deaminase (EC 3.5.4.4, ADA) has been assayed in lymphocytes, granulocytes and erythrocytes from 45 patients with haematological malignancies. Activities were uniformly low in lymphocytes from patients with chronic lymphocytic leukaemia. Variable, but abnormal activities were frequently found in multiple myel...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.45
更新日期：1976-03-01 00:00:00
abstract：BACKGROUND:Favourable outcomes of breast cancer screening trials in the 1970s and 1980s resulted in the launch of population-based service screening programmes in many Western countries. We investigated whether improvements in mammography and treatment modalities have had an influence on the effectiveness of breast can...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.44
更新日期：2011-03-15 00:00:00
abstract：BACKGROUND:There is emerging evidence to suggest that the association between socioeconomic circumstances and colorectal cancer incidence has changed over recent decades. METHODS:We conducted a descriptive population-based study to describe the relationship between socioeconomic circumstances and the incidence of colo...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.149
更新日期：2011-05-24 00:00:00
abstract：:Apoptosis plays an important role in tumorigenesis. Tumour growth is determined by the rate of cell proliferation and cell death. We counted the number of apoptotic cells in haematoxylin and eosin (H&E)-stained tumour sections in series of 172 grade I and II invasive breast cancers with long-term follow-up. The number...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.0928
更新日期：2000-01-01 00:00:00
abstract：:The identification of peptide vaccine candidates to date has been focused on human leukocyte antigen (HLA)-A2 and -A24 alleles. In this study, we attempted to identify cytotoxic T lymphocyte (CTL)-directed Lck-derived peptides applicable to HLA-A11(+), -A31(+), or -A33(+) cancer patients, because these HLA-A alleles s...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604071
更新日期：2007-12-17 00:00:00
abstract：:Alveolar macrophage (AM) phagocytic activity and glucose metabolism were evaluated during lung tumour growth in adult rats challenged i.v. with 10(5) viable Walker 256 tumour cells. Phagocytosis was estimated by the in vitro uptake of (14)C-labelled Pseudomonas aeruginosa and glucose oxidation was evaluated by (14)CO(...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.249
更新日期：1977-12-01 00:00:00
abstract：:Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical efficacy of novel ex...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6604213
更新日期：2008-03-11 00:00:00
abstract：:The cardiotoxicity of 5-fluorouracil (FU) was attributed to impurities present in the injected vials. One of these impurities was identified as fluoroacetaldehyde which is metabolised by isolated perfused rabbit hearts into fluoroacetate (FAC), a highly cardiotoxic compound. FAC was also detected in the urine of patie...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.227
更新日期：1992-07-01 00:00:00
abstract：BACKGROUND:To date, there are few reports on gene products contributing to colon cancer progression. METHODS:We used a gene trap comprised of an enhanced retroviral mutagen (ERM) cassette that includes a tetracycline-responsive promoter upstream of a haemagglutinin (HA) tag and a splice donor site. Integration of the ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605536
更新日期：2010-02-16 00:00:00
abstract：:We examined a panel of 25 small cell lung cancer (SCLC) cell lines and nude mouse xenografts for expression of the proto-oncogenes c-met and c-kit, and for expression of the corresponding ligands, hepatocyte growth factor (HGF) (also known as scatter factor (SF)), and stem cell factor (SCF), respectively. Expression o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.7
更新日期：1993-01-01 00:00:00
abstract：:Cardiotoxicity is the main dose-limiting side effect of doxorubicin in the clinic. Being a free radical producer, doxorubicin affects the heart specifically because of its low antioxidant capacity. Among those antioxidants, catalase is present in very low levels in the heart compared to other organs. Since catalase is...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601430
更新日期：2003-12-01 00:00:00
