Increasingly strong reduction in breast cancer mortality due to screening.


BACKGROUND:Favourable outcomes of breast cancer screening trials in the 1970s and 1980s resulted in the launch of population-based service screening programmes in many Western countries. We investigated whether improvements in mammography and treatment modalities have had an influence on the effectiveness of breast cancer screening from 1975 to 2008. METHODS:In Nijmegen, the Netherlands, 55,529 women received an invitation for screening between 1975 and 2008. We designed a case-referent study to evaluate the impact of mammographic screening on breast cancer mortality over time from 1975 to 2008. A total number of 282 breast cancer deaths were identified, and 1410 referents aged 50-69 were sampled from the population invited for screening. We estimated the effectiveness by calculating the odds ratio (OR) indicating the breast cancer death rate for screened vs unscreened women. RESULTS:The breast cancer death rate in the screened group over the complete period was 35% lower than in the unscreened group (OR=0.65; 95% CI=0.49-0.87). Analysis by calendar year showed an increasing effectiveness from a 28% reduction in breast cancer mortality in the period 1975-1991 (OR=0.72; 95% CI=0.47-1.09) to 65% in the period 1992-2008 (OR=0.35; 95% CI=0.19-0.64). CONCLUSION:Our results show an increasingly strong reduction in breast cancer mortality over time because of mammographic screening.


Br J Cancer


van Schoor G,Moss SM,Otten JD,Donders R,Paap E,den Heeten GJ,Holland R,Broeders MJ,Verbeek AL




Has Abstract


2011-03-15 00:00:00














  • The impact of FDA and EMEA guidelines on drug development in relation to Phase 0 trials.

    abstract::An increase in the number of identified therapeutic cancer targets achieved through recent biomedical research has resulted in the generation of a large number of molecules that need to be tested further. Current development of (anticancer) drugs is a rather inefficient process that for an average new molecule takes a...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审


    authors: Marchetti S,Schellens JH

    更新日期:2007-09-03 00:00:00

  • Foscan (mTHPC) photosensitized macrophage activation: enhancement of phagocytosis, nitric oxide release and tumour necrosis factor-alpha-mediated cytolytic activity.

    abstract::Photodynamic activation of macrophage-like cells contributes to an effective outcome of photodynamic therapy (PDT) treatment. The possibility for an enhancement of macrophage activity by photosensitization with meta-tetra(hydroxyphenyl)chlorin (mTHPC) (1 microg ml(-1)) was studied in U937, monocyte cell line different...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Coutier S,Bezdetnaya L,Marchal S,Melnikova V,Belitchenko I,Merlin JL,Guillemin F

    更新日期:1999-09-01 00:00:00

  • Cigarette smoking and thyroid cancer risk: a cohort study.

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    pub_type: 杂志文章


    authors: Cho A,Chang Y,Ahn J,Shin H,Ryu S

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    abstract::Photodynamic therapy is a potential treatment for superficial bladder cancer that utilizes photosensitizer drugs, which are activated by light to cause tissue destruction. However, first-generation photosensitizers cause prolonged phototoxicity, have poor tumour specificity and can accumulate within detrusor muscle, r...

    journal_title:British journal of cancer

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    authors: Datta SN,Loh CS,MacRobert AJ,Whatley SD,Matthews PN

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  • Zinc induction of testicular teratomas in Japanese quail (Coturnix coturnix Japonica) after photoperiodic stimulation of testis.

    abstract::Teratomas have been induced in Japanese quail (Coturnix coturnix Japonica) by intra-testicular injections of 3% zinc chloride solution during a period of testicular growth artificially stimulated by increased photoperiod. These tumours resemble those previously induced by similar methods in domestic fow1 and have hist...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Guthrie J

    更新日期:1971-06-01 00:00:00

  • Syndecan-1 expression has prognostic significance in head and neck carcinoma.

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Anttonen A,Kajanti M,Heikkilä P,Jalkanen M,Joensuu H

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Kriege M,Hollestelle A,Jager A,Huijts PE,Berns EM,Sieuwerts AM,Meijer-van Gelder ME,Collée JM,Devilee P,Hooning MJ,Martens JW,Seynaeve C

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    pub_type: 杂志文章


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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Van Den Brenk HA,Stone MG,Kelly H,Sharpington C

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    journal_title:British journal of cancer

    pub_type: 杂志文章


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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Shetty G,Kendall C,Shepherd N,Stone N,Barr H

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    pub_type: 杂志文章


    authors: Hamuro J,Kikuchi T,Takatsuki F,Suzuki M

    更新日期:1996-02-01 00:00:00

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    abstract::The sequential histological changes and neoplastic response occurring in the subcutaneous tissue of rats after injection of surfactants or carcinogens were compared. Twice weekly subcutaneous injections of the surfactants Blue VRS and Light Green SF elicited a deranged connective tissue repair with continued prolifera...

    journal_title:British journal of cancer

    pub_type: 杂志文章


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    pub_type: 杂志文章,meta分析


    authors: Dixon SC,Nagle CM,Wentzensen N,Trabert B,Beeghly-Fadiel A,Schildkraut JM,Moysich KB,deFazio A,Australian Ovarian Cancer Study Group.,Risch HA,Rossing MA,Doherty JA,Wicklund KG,Goodman MT,Modugno F,Ness RB,Edwards RP,Jen

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Zhu YM,Bradbury D,Russell N

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  • Increasing incidence of childhood tumours of the central nervous system in Denmark, 1980-1996.

    abstract::The registered incidence rate of childhood central nervous system (CNS) tumours has increased in several countries. It is uncertain whether these increases are biologically real or owing to improved diagnostic methods. We explored the medical records of 626 CNS tumours diagnosed in Danish children between 1980 and 199...

    journal_title:British journal of cancer

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    authors: Raaschou-Nielsen O,Sørensen M,Carstensen H,Jensen T,Bernhardtsen T,Gjerris F,Schmiegelow K

    更新日期:2006-08-07 00:00:00

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    abstract::In small-cell lung cancer cell lines resistance to growth inhibition by transforming growth factor (TGF)-beta 1, was previously shown to correlate with lack of TGF-beta receptor I (RI) and II (RII) proteins. To further investigate the role of these receptors, the expression of mRNA for RI, RII and beta-glycan (RIII) w...

    journal_title:British journal of cancer

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  • Augmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children's Oncology Group study.

    abstract:BACKGROUND:MYCN amplification with subsequent MYCN protein overexpression is a powerful indicator of poor prognosis of neuroblastoma patients. Little is known regarding the prognostic significance of the homologous MYC protein expression in neuroblastoma. METHODS:Immunostaining for MYCN and MYC protein was performed o...

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    authors: Wang LL,Teshiba R,Ikegaki N,Tang XX,Naranjo A,London WB,Hogarty MD,Gastier-Foster JM,Look AT,Park JR,Maris JM,Cohn SL,Seeger RC,Asgharzadeh S,Shimada H

    更新日期:2015-06-30 00:00:00

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Gelardi T,Damiano V,Rosa R,Bianco R,Cozzolino R,Tortora G,Laccetti P,D'Alessio G,De Lorenzo C

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    abstract:BACKGROUND:Tumours are made up of a mixed population of different types of cells that include normal structures as well as ones associated with the malignancy, and there are multiple interactions between the malignant cells and the local microenvironment. These intercellular interactions, modulated by the microenvironm...

    journal_title:British journal of cancer

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Weinzierl SM,Webb M

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  • The impact of antigen density and antibody affinity on antibody-dependent cellular cytotoxicity: relevance for immunotherapy of carcinomas.

    abstract::Antibody-dependent cellular cytotoxicity (ADCC) is considered to be the major mechanism through which tumour cells, upon treatment with anti-tumour MAbs, are eliminated in vivo. However, the relative importance of various parameters that influence the efficacy of ADCC is unclear. Here we present in vitro data on the i...

    journal_title:British journal of cancer

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    更新日期:1998-08-01 00:00:00

  • The in vitro genetic effects of fibrous erionite and crocidolite asbestos.

    abstract::Epidemiologic evidence has recently identified an association between an endemic outbreak of pleural and peritoneal mesothelioma in the Urgup region of Turkey and exposure to zeolite fibres. This malignancy is usually associated with exposure to asbestos dusts whose mineralogical characteristics differ from those of z...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Kelsey KT,Yano E,Liber HL,Little JB

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    authors: Ota E,Abe Y,Oshika Y,Ozeki Y,Iwasaki M,Inoue H,Yamazaki H,Ueyama Y,Takagi K,Ogata T

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  • Butyrate augments interferon-alpha-induced S phase accumulation and persistent tyrosine phosphorylation of cdc2 in K562 cells.

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    journal_title:British journal of cancer

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    authors: Miyachi T,Adachi M,Hinoda Y,Imai K

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    authors: Kummar S,Fogarasi M,Canova A,Mota A,Ciesielski T

    更新日期:2002-06-17 00:00:00

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    journal_title:British journal of cancer

    pub_type: 杂志文章


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    journal_title:British journal of cancer

    pub_type: 杂志文章


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    journal_title:British journal of cancer

    pub_type: 杂志文章,评审


    authors: Riley RD,Sauerbrei W,Altman DG

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    pub_type: 杂志文章


    authors: Di Lauro L,Nunziata C,Arena MG,Foggi P,Sperduti I,Lopez M

    更新日期:2007-09-03 00:00:00