Abstract：
:When assessing the value of a particular treatment, it is important to consider the impact it may have on the quality of life of those being treated. This is particularly so for cancer patients, whose life expectancy may be short. Patients with advanced colorectal cancer who participated in two international comparative studies of raltitrexed ('Tomudex') vs standard 5-fluorouracil (5-FU) plus leucovorin (LV) completed previously validated quality-of-life questionnaires (EORTC questionnaire, EuroQol and Rotterdam Symptom Check List) at various times during the studies. Early statistically significant advantages of raltitrexed vs 5-FU plus LV on quality of life were observed at week 2 in five of eight of the EuroQol and three of four of the Rotterdam Symptom Check List dimensions. Such advantages were not observed using the EORTC questionnaire, which was not completed until week 12. The necessary dose delays and different dose schedules made it difficult in these studies to compare the impact on quality of life of the two treatments. It may be that performance status, effect on disease-related symptoms and the incidence of toxicity are the most important indications of a patient's quality of life.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Anderson H,Palmer MKdoi
10.1038/bjc.1998.420subject
Has Abstractpub_date
1998-01-01 00:00:00pages
9-14eissn
0007-0920issn
1532-1827journal_volume
77 Suppl 2pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract：:Two aspects of the aerobic metabolism of nitroimidazole markers for hypoxia were investigated. Several normal murine tissues which are likely to be well oxygenated bind misonidazole at rates comparable to those of hypoxic regions in tumours. The possibility that this aerobic activation occurs via an oxygen independent...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.418
更新日期：1992-12-01 00:00:00
abstract：:To study the effect of oral supplemental calcium on colonic epithelial proliferation, 17 adenomatous polyp patients received 1.5 g Ca2+ as calcium carbonate daily during 12 weeks, while on a calcium constant diet, based on the patients' habitual diet. Seven subsequently continued calcium supplementation for 9 months w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.93
更新日期：1993-03-01 00:00:00
abstract：:The relationship of cytogenetic changes with the acquisition of an indefinite life span in vitro, the ability of cells to grow in soft agar and their tumourigenicity in syngeneic animals has been studied in control, trans-7,8-dihydrodiolbenzo(a)pyrene and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrah...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1984.159
更新日期：1984-08-01 00:00:00
abstract：:To assess the precise role of IGF1 in benign and malignant breast diseases, we analysed the tissular localisation, characterised, and quantified specific insulin-like growth factor 1 (IGF1) binding sites in these heterogenous tissues, using histo-autoradiographic analysis (HAA). The 125I-IGF1 binding was performed on ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.252
更新日期：1992-08-01 00:00:00
abstract：:We examined the expression of the midkine (MK) and alpha-fetoprotein (AFP) genes in 15 paired human specimens obtained from hepatocellular carcinoma (HCC) and the corresponding noncancerous regions of the same patients. A total of 14 HCC but none of the noncancerous specimens were positive for the MK mRNA. In contrast...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601246
更新日期：2003-09-15 00:00:00
abstract：BACKGROUND:This phase I, dose-finding study determined the safety, maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D), pharmacokinetics, and antitumour activity of PX-866, a phosphatidylinositol 3-kinase inhibitor, combined with docetaxel in patients with incurable solid tumours. METHODS:PX-866 was administe...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2013.474
更新日期：2013-09-03 00:00:00
abstract：:We assessed incidence and mortality of colorectal cancer (CRC) at various ages among women and men in 38 European countries. The ages at which defined levels of incidence and mortality were reached varied between 9 and 17 years between countries. This variation requires consideration in the definition of screening gui...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604488
更新日期：2008-08-05 00:00:00
abstract：:Tumour necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL/APO2L) is a recently identified member of the TNF family, which induces programmed cell death in a variety of neoplastic cell types, but not in most nonneoplastic cells. In this study, we report on the identification of two novel alternative splice ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600772
更新日期：2003-03-24 00:00:00
abstract：BACKGROUND:A remarkably better prognosis is associated with oropharyngeal squamous cell carcinomas (OPSCC) driven by human papillomaviruses (HPV) compared with HPV-negative OPSCC. Consequently, de-escalation of standard treatment has been suggested. Due to modest specificity rates, debates are ongoing, whether p16INK4a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0964-x
更新日期：2020-09-01 00:00:00
abstract：:Cell fusion has been used to analyse the genetic determinants of metastasis at the cellular level. Highly metastatic mouse melanoma cells were fused with diploid mouse lymphocytes and a range of hybrid clones isolated and tested for tumorigenicity and metastatic potential by s.c. injection into newborn, histocompatibl...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1983.60
更新日期：1983-03-01 00:00:00
abstract：:We have recently established a cancer-reactive human monoclonal antibody, GAH, with a positive ratio of over 90% against stomach cancer. GAH was formulated as polyethyleneglycol (PEG)-modified immunoliposomal doxorubicin (DXR) (ILD) and its efficacy was examined against gastrointestinal human cancers. In in vitro stud...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601341
更新日期：2003-10-20 00:00:00
abstract：:Multiple primary tumours occurring in a three-year population-based series of patients with histopathologically peer-reviewed sarcomas from North West England were ascertained in order to look at the patterns of neoplasms seen. A total of 30 out of the 310 patients entered in the study had additional primary tumours. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.512
更新日期：1993-12-01 00:00:00
abstract：:Postoperative hyperplasia enhances experimental intestinal carcinogenesis, but the effects of nonsurgical adaptation are uncertain. The tropic and tumour-promoting potentials of moderate hypothermia were tested in two groups of male Sprague-Dawley rats housed at 10 degrees C for 30 weeks. One group (n = 10) received a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.51
更新日期：1987-03-01 00:00:00
abstract：BACKGROUND:Cancer stem cells (CSCs) are responsible for tumour initiation, metastasis and recurrence. However, the mechanism of CSC formation, maintenance and expansion in colorectal cancer (CRC) remains poorly characterised. METHODS:The role of COP9 signalosome subunit 6 (CSN6) in regulating cancer stemness was evalu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0779-9
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:Epidemiological studies evaluating the association of vitamin B6, vitamin B12 and methionine with breast cancer risk have produced inconsistent results. METHODS:Pertinent studies were identified by a search in PubMed and Web of Knowledge. Random-effect model was used. Dose-response relationship was assessed...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/bjc.2013.438
更新日期：2013-10-01 00:00:00
abstract：:Although osteosclerotic bone metastases are characteristic of prostate cancer, mixed metastases with a lytic component are not uncommon. Type I collagen is synthesised by osteoblasts and accounts for about 90% of the organic matrix of bone. We have used new specific immunoassays for PICP (carboxy-terminal propeptide o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.204
更新日期：1995-05-01 00:00:00
abstract：BACKGROUND:The amplification of epidermal growth factor receptor (EGFR) in triple negative breast carcinomas (TNBC) suggests its potential therapeutic application, as for HER-2, using standardised methods of measurement. In this regard, we aimed to compare several methods for evaluating EGFR amplification along with po...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.794
更新日期：2014-02-18 00:00:00
abstract：BACKGROUND:The poor prognosis of patients with colorectal-cancer liver metastases (CRLM) and the insufficiency of available treatments have raised the need for alternative curative strategies. We aimed to assess the therapeutic potential of TL-118, a new anti-angiogenic drug combination, for CRLM treatment, in a mouse ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.322
更新日期：2012-08-07 00:00:00
abstract：:The management of older patients with aggressive non-Hodgkin's lymphoma presents a challenge to the physician. Age is a poor prognostic indicator, due to reduced ability to tolerate and maintain dose-intensive chemotherapy. Generally, older patients demonstrate a lower response rate, reduced survival and increased tox...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.bjc.6602975
更新日期：2006-03-27 00:00:00
abstract：:Treatment of ex-breeder male NMRI mice with lipid mobilising factor isolated from the urine of cachectic cancer patients, caused a significant increase in glucose oxidation to CO2 compared with control mice receiving phosphate buffered saline. Glucose utilisation by various tissues was determined by the 2-deoxyglucose...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600493
更新日期：2002-08-27 00:00:00
abstract：:The multivariate lognormal survival model can be used to determine the relationship of prognostic covariates to two important parameters of malignancy. Cured fraction and median survival time among uncured patients. Analysis with this model revealed that cured fraction is primarily a function of histologic type and no...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.196
更新日期：1993-05-01 00:00:00
abstract：BACKGROUND:A Population-Based Cancer Registry (PBCR) was set up in Sikkim (a state in the North Eastern India) in 2003. We examined incidence rates by ethnic groups from 2003-2008. METHODS:Age-adjusted incidence rates (AARs) per 100,000 person-years were calculated by direct method using the world standard population,...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.598
更新日期：2012-02-28 00:00:00
abstract：:Fifty-one patients with advanced non-small cell lung carcinoma were treated with a combination of mitomycin C, vinblastine and cis-platin (MVP). Most cycles were given on an out-patient basis. Major side effects were leukopenia and peripheral neurotoxicity; one patient died of sepsis while leukopenic. In 44 evaluable ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.227
更新日期：1987-10-01 00:00:00
abstract：:We investigated the risk of gastric cancer by subsite in relation to cigarette smoking and alcohol in a large population-based cohort of 669 570 Korean men in an insurance plan followed for an average 6.5 years, yielding 3452 new cases of gastric cancer, of which 127 were cardia and upper-third gastric cancer, 2409 we...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603893
更新日期：2007-09-03 00:00:00
abstract：:In resection tissue samples of colorectal carcinomas, the concentration of urokinase-type plasminogen activator (u-Pa) was found to be significantly higher than in the normal parent mucosal tissue, while there was less tissue-type plasminogen activator (t-PA). u-PA and t-PA were also determined in endoscopic biopsies ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.293
更新日期：1989-09-01 00:00:00
abstract：BACKGROUND:Non-epithelial gonadal tumours largely comprise sex cord-stromal tumours (SCSTs) and germ cell tumours (GCTs). Specific somatic mutations in DICER1, a microRNA maturation pathway gene, have been identified in these tumours. We conducted a study that aimed to confirm, refine and extend the previous observatio...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.637
更新日期：2013-11-12 00:00:00
abstract：BACKGROUND:PI3K/Akt (PKB) pathway has been shown in several cell types to be activated by ligands to cell surface integrins, leading to the metastasis of tumour cells. The signalling pathways involved in the metastatic spread of human scirrhous gastric carcinoma cells have not been defined. METHODS:The role of the PI3...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.107
更新日期：2012-04-24 00:00:00
abstract：:The extent to which plasma levels of angiogenic factors in healthy individuals and tumour volume-related variations in colorectal cancer affect the accuracy of circulating angiogenic factors as predictors of colorectal cancer vascularity is unknown. We used enzyme-linked immunosorbant assay to measure plasma vascular ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.1033
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumour and has poor prognosis. Currently, systematic chemotherapy is the only approach to prolong survival. Thus the development of new treatment regimens is urgently needed to improve the therapeutic efficacy. Our study intended to ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.55
更新日期：2017-04-11 00:00:00
abstract：:Supplementary Table 1 and the Supplementary Figure legends were not included when this manuscript was first published. The files are now available here. ...
journal_title：British journal of cancer
pub_type： 已发布勘误
doi：10.1038/s41416-018-0130-x
更新日期：2018-08-01 00:00:00
