Abstract:
:The extent to which plasma levels of angiogenic factors in healthy individuals and tumour volume-related variations in colorectal cancer affect the accuracy of circulating angiogenic factors as predictors of colorectal cancer vascularity is unknown. We used enzyme-linked immunosorbant assay to measure plasma vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) levels in colorectal liver metastasis (CLM) patients, and 'no cancer' controls. CLM volume was determined from computerized tomography scans, and tumour vessel count and vessel volume from anti-endothelial antibody-stained biopsies. There was a significant (P= 0.03) increase in plasma VEGF level in 29 CLM patients (median 180.3 pg/ml(-1), iqr 132.5-284.8 pg/ml(-1) compared with 19 controls (median 125.8 pg/ml(-1), iqr 58.2-235.9 pg/ml(-1). There were significant correlations between plasma VEGF and tumour vessel count (r = 0.66, P = 0.03), tumour vessel volume (r= 0.59, P = 0.03), and CLM volume (r= 0.53, P = 0.03). A VEGF level in the upper quartile of the plasma VEGF distribution had a 70% sensitivity and 75% specificity in predicting an upper quartile liver metastasis tumour vessel count. No relation was identified between CLM and plasma bFGF levels. Plasma VEGF level predicted CLM vascularity, despite an overlap with normal levels and tumour volume-related variations.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Davies MM,Jonas SK,Kaur S,Allen-Mersh TGdoi
10.1054/bjoc.1999.1033subject
Has Abstractpub_date
2000-03-01 00:00:00pages
1004-8issue
5eissn
0007-0920issn
1532-1827pii
S0007092099910339journal_volume
82pub_type
杂志文章abstract::A Phase I study of oral daily misonidazole (MISO) with conventional pelvic irradiation, has been conducted in patients with carcinoma of the cervix Stages IB, IIB, IIIB and IVA. MISO was administered in daily dosages to sequential groups of patients at doses of 0.15 g/m2, 0.30 g/m2 or 0.45 g/m2 for 22 days over 5 week...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/bjc.1982.138
更新日期:1982-06-01 00:00:00
abstract::We studied 5555 seminoma patients and 3733 patients with nonseminomatous testicular cancers diagnosed in Southeast England between 1960 and 2004. For both groups survival improved over time: 10-year relative survival increased from 78% in 1960-1969 to 99% in 1990-2004 for seminomas, and from 55 to 95% for nonseminomas...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603589
更新日期:2007-02-12 00:00:00
abstract::Increased fibre intake has been shown to reduce serum oestrogen concentrations. We hypothesized that fibre exerts this effect by decreasing the time available for reabsorption of oestrogens in the colon. We tested this in volunteers by measuring changes in serum oestrogen levels in response to manipulation of intestin...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/bjc.1997.397
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Patients with borderline resectable pancreatic cancer (BRPC) have poor prognosis with upfront surgery. METHODS:This was a single-arm Phase 2 trial for clinical and biomarker analysis. The primary endpoint is 1-year progression-free survival (PFS) rate. Patients received 8 cycles of neoadjuvant modified (m) ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0867-x
更新日期:2020-08-01 00:00:00
abstract::A multicentric, prospective phase III study was carried out with the aim of testing the so-called 'worst drug rule' hypothesis, which suggests the use of an effective but 'less active' regimen that first eradicates tumoral cells resistant to a second effective and 'more active' regimen. With respect to this hypothesis...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1038/bjc.1997.586
更新日期:1997-01-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:British journal of cancer
pub_type: 已发布勘误
doi:10.1038/s41416-020-0830-x
更新日期:2020-05-01 00:00:00
abstract::The natural history of 45 cases of smouldering leukaemia has been studied. Males and females were equally represented, with a median age of 60.5. The median survival of the whole group was only 20 months, but rare cases lived 10 years or longer. 38% developed acute leukaemia; the remainder usually died of the results ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1982.179
更新日期:1982-08-01 00:00:00
abstract:BACKGROUND:The eicosanoid signalling pathway promotes the progression of malignancies through the production of proliferative prostaglandins (PGs). Cytosolic phospholipase A(2)α (cPLA(2)α) activity provides the substrate for cyclooxygenase-dependent PG release, and we have previously found that cPLA(2)α expression corr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6606025
更新日期:2011-01-18 00:00:00
abstract::The role of two common polymorphisms of enzymes involved in the metabolism of drugs and carcinogens was studied in relation to prostate cancer. The gene encoding one of these enzymes (NAT2) is located in an area where frequent allelic loss occurs in prostate cancer. Mutations at the genes CYP2D6 and NAT2 were analysed...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.685
更新日期:1998-11-01 00:00:00
abstract::The function of the reticulo-endothelial system in mice bearing Lewis lung carcinomas has been measured by(1) the rate of clearance of carbon particles from the circulation in vivo and calculation of the phagocytic index K; (2) chemotactic locomotion of macrophages in vitro in the presence or absence of serum or tumou...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1977.197
更新日期:1977-09-01 00:00:00
abstract::The cytocidal properties of metronidazole against hypoxic mammalian cells are described. This chemotherapeutic action has been shown to be dependent on drug concentration and duration of exposure. The x-ray TCD50 for a murine anaplastic carcinoma was reduced from 6081 rad to 4643 rad when animals were given metronidaz...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1976.78
更新日期:1976-05-01 00:00:00
abstract::A case-control study was conducted in Italy and Switzerland between 1992 and 2000 on 527 cases of laryngeal cancer and 1,297 hospital controls. The risk of laryngeal cancer steadily decreased from 3 years after stopping smoking. Some decline in risk was observed only 20 years or more after stopping drinking. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600638
更新日期:2002-11-18 00:00:00
abstract:BACKGROUND:Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are commonly used antihypertensives. Recently, these drugs have been associated with a protective effect against pancreatic cancer, but data on this putative association remain limited. Thus, the objective of this study...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.375
更新日期:2017-01-03 00:00:00
abstract:BACKGROUND:Tissue micro-arrays (TMAs) are increasingly used to generate data of the molecular phenotype of tumours in clinical epidemiology studies, such as studies of disease prognosis. However, TMA data are particularly prone to missingness. A variety of methods to deal with missing data are available. However, the v...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1038/sj.bjc.6606078
更新日期:2011-02-15 00:00:00
abstract::The prevalence (lifetime occurrence) rate of cancers of the reproductive system (uterus, ovary, cervix and vagina) and breast cancer was determined for 5,398 living alumnae, 2,622 of whom were former college athletes and 2,776 non-athletes, from data on medical and reproductive history, athletic training and diet. The...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1985.273
更新日期:1985-12-01 00:00:00
abstract::Pamidronate belongs to the class of nitrogen-containing bisphosphonates that are potent inhibitors of bone resorption frequently used for the treatment of osteoporosis and cancer-induced osteolysis. The inhibition of osteoclasts' growth has been suggested as the main mechanism of the inhibitory effect of pamidronate o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600476
更新日期:2002-07-29 00:00:00
abstract::In the UK there are standardized surveillance procedures for gestational trophoblastic disease. However, there are differences in practice between the two treatment centres in terms of definition of persistent gestational trophoblastic disease, prognostic risk assessment and chemotherapeutic regimens. The role of prop...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690203
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:The incidence of oesophageal adenocarcinoma is increasing globally. Barrett's oesophagus (BO) is a pre-malignant condition with no biomarker to risk stratify those at highest risk of dysplasia and malignant transformation. METHODS:Subcellular epithelial protein (HMGB1, p53, RUNX3) expression, alongside expr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0685-1
更新日期:2020-02-01 00:00:00
abstract::Cell line studies demonstrate that the PI3K/Akt pathway is upregulated in hormone-refractory prostate cancer (HRPC) and can result in phosphorylation of the androgen receptor (AR). The current study therefore aims to establish if this has relevance to the development of clinical HRPC. Immunohistochemistry was employed...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604152
更新日期:2008-03-25 00:00:00
abstract:BACKGROUND:The detection of V600E BRAF mutation in melanoma is fundamental since here BRAF inhibitors represent an effective treatment. Non-V600E BRAF mutations that may also respond are not detected by certain screening methods. Thus, knowledge about detection of these mutations is needed. METHODS:A total of 276 tumo...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.143
更新日期:2013-05-28 00:00:00
abstract::The growth of s.c. Walker 256 carcinoma was found to be independent of secondary growths induced by i.v. injection. Tumour cells injected i.v. lodged mainly in the lungs, with small clusters of cells in the lymph nodes. The rate of cellular proliferation of these secondary growths of Walker carcinoma was significantly...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.12
更新日期:1978-01-01 00:00:00
abstract::In a variety of adult and childhood leukaemia cell samples collected at different states of the disease, we analysed in a series of sequentially performed slot-blot or Northern-blot hybridisation experiments the expression of genes possibly involved in multiple drug resistance (MDR) (mdr1/P-glycoprotein, DNA topoisome...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.304
更新日期:1992-09-01 00:00:00
abstract::In this study, we have investigated the expression of inhibin subunits and activin receptors (ActRs) in normal and malignant ovarian cells. Each product of the inhibin subunits (alpha, betaa, betab) and activin receptors (ActRs) amplified by reverse transcription polymerase chain reaction were detected as a single ban...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.1127
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:To report the long-term outcomes of a phase III trial designed to test two hypotheses: (1) elective nodal irradiation (ENI) is superior to conventional field irradiation (CFI), and (2) chemoradiotherapy plus erlotinib is superior to chemoradiotherapy in locally advanced oesophageal squamous cell cancer (ESCC...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01054-6
更新日期:2020-11-01 00:00:00
abstract::The treatment of breast cancer patients has changed rapidly in the past decade, but empirical data at local and national level are scarce. Predicting the consequences of screening for primary treatment is consequently difficult. The aim of this analysis of records on admissions to hospital of women with breast cancer ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.466
更新日期:1994-12-01 00:00:00
abstract::Several techniques are under development to diagnose oesophageal adenocarcinoma at an earlier stage. We have demonstrated the potential of Raman spectroscopy, an optical diagnostic technique, for the identification and classification of malignant changes. However, there is no clear recognition of the biochemical chang...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603102
更新日期:2006-05-22 00:00:00
abstract::A number of polyunsaturated fatty acids have been shown to inhibit the growth of malignant cells in vitro. To investigate whether fatty acids modify the growth of human pancreatic cancer, lauric, stearic, palmitic, oleic, linoleic, alpha-linolenic, gamma-linolenic, arachidonic, docosahexaenoic and eicosapentaenoic (EP...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.161
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:The precise timing of the angiogenic switch and the role of angiogenesis in the development of breast malignancy is currently unknown. METHODS:Therefore, the expression of CD31 (pan endothelial cells (ECs)), endoglin (actively proliferating ECs), hypoxia-inducible factor-1 (HIF-1alpha), vascular endothelial...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605196
更新日期:2009-08-18 00:00:00
abstract::Pancreatic cancers occurring in carriers of a pathogenic germline alteration in BRCA1/2 (gBRCA1/2) are assumed to demonstrate homologous recombination repair deficiency (HRD), associated with sensitivity to platinum-based chemotherapy and synthetic lethality with PARP inhibitors (PARPi). However, primary and secondary...
journal_title:British journal of cancer
pub_type: 评论,社论
doi:10.1038/s41416-019-0645-9
更新日期:2020-02-01 00:00:00
abstract::A crude membrane fraction isolated from mouse tumour cells was treated with various chemicals. The effects on the immunogenicity of the membrane sample were tested in syngeneic mice for tumour protection, using a challenge dose of 10(5) viable tumour cells. Best protection was obtained after immunization of mice with ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.236
更新日期:1978-10-01 00:00:00