Correction: Chromatin structure, transcriptional activity and DNA repair efficiency affect the outcome of chemotherapy in multiple myeloma.

abstract：:Several radiotherapeutic schedules compatible with continued structural-functional integrity of the gastrointestinal (GI) mucosa were compared utilizing the P815X2 murine mastocytoma grown as a solid subcutaneous tumour. Both the tumour and underlying normal tissues were irradiated during the treatments. The tumour ex...

journal_title：British journal of cancer

authors： Schenken LL,Poulakos L,Hagemann RF

更新日期：1975-02-01 00:00:00

abstract：:Serum levels of cell-free interleukin-2 receptors were elevated above normal in mice bearing the IL-2R positive T-cell lymphoma Eb or its highly metastatic variant ESb. Although ESb cells expressed less IL-2R molecules than Eb cells on their cell surface, serum receptor levels were raised more quickly in ESb than in E...

journal_title：British journal of cancer

authors： Schirrmacher V,Josimovic-Alasevic O,Osawa H,Diamantstein T

更新日期：1987-06-01 00:00:00

abstract：:Many kallikrein genes were found to be differentially expressed in various malignancies, and prostate specific antigen (encoded by the KLK3 gene) is the best tumour marker for prostate cancer. Prostate specific antigen has recently been shown to be an independent favourable prognostic marker for breast cancer. KLK15 i...

journal_title：British journal of cancer

authors： Yousef GM,Scorilas A,Magklara A,Memari N,Ponzone R,Sismondi P,Biglia N,Abd Ellatif M,Diamandis EP

更新日期：2002-11-18 00:00:00

abstract：:We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA ...

journal_title：British journal of cancer

authors： Szybka M,Zawlik I,Kulczycka D,Golanska E,Jesien E,Kupnicka D,Stawski R,Piaskowski S,Bieniek E,Zakrzewska M,Kordek R,Liberski PP,Rieske P

更新日期：2008-04-22 00:00:00

abstract：:Measurement of DNA polymerase in leukaemic guinea-pig plasms reveals the presence of low levels of sedimentable and non-sedimentable enzymic activities. Since the sedimentable DNA polymerase is ribonuclease sensitive, uses poly(C).oligo(dG) as template, and bands in a sucrose density gradient at 1-17 g/ml it is though...

journal_title：British journal of cancer

authors： Hallinan FM,Maclean N

更新日期：1976-04-01 00:00:00

abstract：:Large-scale genomic analyses of cutaneous melanoma have revealed insights into the aetiology and heterogeneity of this disease, as well as opportunities to further personalise treatment for patients with targeted and immune therapies. Herein, we review the proposed genomic classification of cutaneous melanoma from lar...

journal_title：British journal of cancer

authors： Rajkumar S,Watson IR

更新日期：2016-07-12 00:00:00

abstract：:The degree of lymphocyte infiltration is a prognostic factor in liver cancer, but to date the mechanisms by which lymphocytes infiltrate into and are retained in hepatic tumours are poorly understood. We hypothesised that the extracellular matrix glycoprotein vitronectin, a major component of the stroma of hepatic tum...

journal_title：British journal of cancer

authors： Edwards S,Lalor PF,Tuncer C,Adams DH

更新日期：2006-12-04 00:00:00

abstract：:We have previously reported that supplementation with folic acid (1.2 mg day(-1) for 12 week) elicited a significant improvement in the folate status of 61 healthy volunteers. We have examined effects of this supplement on markers of genomic stability. Little is known about the effect of folate supplementation on DNA ...

journal_title：British journal of cancer

authors： Basten GP,Duthie SJ,Pirie L,Vaughan N,Hill MH,Powers HJ

更新日期：2006-06-19 00:00:00

abstract：:We conducted a national, retrospective population-based cohort study of 705 patients hospitalized with a first diagnosis of dermatomyositis (DM) or polymyositis (PM) during 1982-1996 based on linkage of hospital discharge, cancer registration, and death records in Scotland. Risks of cancer were assessed by calculating...

journal_title：British journal of cancer

authors： Stockton D,Doherty VR,Brewster DH

更新日期：2001-07-06 00:00:00

abstract：:The murine dose of i.v. C. parvum (466 microgram) was compared with a single, low, human-equivalent dose of 70 microgram and with repeated weekly low doses. All treatments increased the antibody titre against C. parvum (CP). However, repeated doses stimulated a much higher titre than single doses. In all treated anima...

journal_title：British journal of cancer

authors： Mitcheson HD,Sadler TE,Castro JE

更新日期：1980-03-01 00:00:00

abstract：:Androgen receptor (AR) signalling drives neoplastic growth and therapy resistance in prostate cancer. Recent clinical data show that docetaxel combined with androgen deprivation therapy improves outcome in hormone-sensitive disease. We studied whether testosterone and AR signalling interferes with docetaxel treatment ...

journal_title：British journal of cancer

authors： Mout L,Moll JM,Chen M,de Morrée ES,de Ridder CMA,Gibson A,Stuurman D,Aghai A,Erkens-Schulze S,Mathijssen RHJ,Sparreboom A,de Wit R,Lolkema MP,van Weerden WM

更新日期：2020-12-01 00:00:00

abstract：:The association between breast and endometrial cancer was investigated in a cohort consisting of 60,065 subjects (99% of all women in whom a first breast cancer was diagnosed in Sweden in 1960-63 and 1968-81). Complete follow-up until 1981 revealed a total of 260 endometrial cancers, as against an expected number of 1...

journal_title：British journal of cancer

authors： Adami HO,Krusemo UB,Bergkvist L,Persson I,Pettersson B

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:BRCAness is defined as shared tumour characteristics between sporadic and BRCA-mutated cancers. However, how to exactly measure BRCAness and its frequency in breast cancer is not known. Assays to establish BRCAness would be extremely valuable for the clinical management of these tumours. We assessed BRCAness...

journal_title：British journal of cancer

authors： Lips EH,Mulder L,Oonk A,van der Kolk LE,Hogervorst FB,Imholz AL,Wesseling J,Rodenhuis S,Nederlof PM

更新日期：2013-05-28 00:00:00

abstract：BACKGROUND:Lymphovascular invasion (LVI) is associated with the development of metastasis in invasive breast cancer (BC). However, the complex molecular mechanisms of LVI, which overlap with other oncogenic pathways, remain unclear. This study, using available large transcriptomic datasets, aims to identify genes assoc...

journal_title：British journal of cancer

authors： Kurozumi S,Joseph C,Sonbul S,Alsaeed S,Kariri Y,Aljohani A,Raafat S,Alsaleem M,Ogden A,Johnston SJ,Aleskandarany MA,Fujii T,Shirabe K,Caldas C,Ashankyty I,Dalton L,Ellis IO,Desmedt C,Green AR,Mongan NP,Rakha EA

更新日期：2019-06-01 00:00:00

abstract：:Endocrine therapy is a recognised option in the treatment of chemo-resistant ovarian cancer. We conducted a nonrandomised phase II evaluation of combination endocrine therapy with tamoxifen and goserelin in patients with advanced ovarian cancer that had recurred following chemotherapy. In total, 26 patients entered th...

journal_title：British journal of cancer

authors： Hasan J,Ton N,Mullamitha S,Clamp A,McNeilly A,Marshall E,Jayson GC

更新日期：2005-09-19 00:00:00

abstract：:Until recently, endocrine therapy for breast cancer was relatively simple. If the tumour expressed hormone receptors, regardless of stage and age, tamoxifen was indicated. While this largely remains the case for premenopausal women, clinical trials in postmenopausal women have broadened our choice to include one of th...

journal_title：British journal of cancer

authors： Wong ZW,Ellis MJ

更新日期：2004-01-12 00:00:00

abstract：BACKGROUND:Mesothelin is expressed in various types of malignant tumour, and we recently reported that expression of mesothelin was related to an unfavourable patient outcome in pancreatic ductal adenocarcinoma. In this study, we examined the clinicopathological significance of the mesothelin expression in gastric canc...

journal_title：British journal of cancer

authors： Einama T,Homma S,Kamachi H,Kawamata F,Takahashi K,Takahashi N,Taniguchi M,Kamiyama T,Furukawa H,Matsuno Y,Tanaka S,Nishihara H,Taketomi A,Todo S

更新日期：2012-06-26 00:00:00

abstract：:Twenty patients with non-Hodgkin's lymphoma were treated with a combination of cyclophosphamide (750 mg m(-2), day 1), epidoxorubicin (60 mg m(-2), day 1), vincristine (1.4 mg m(-2), day 1) and prednisone (100 mg m(-2), days 1-5) every 14 days. Shortening of intervals was associated with the prophylactic employment of...

journal_title：British journal of cancer

authors： Pronzato P,Lionetto R,Botto F,Pensa F,Tognoni A

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Circulating tumour cells (CTCs) can provide information on patient prognosis and treatment efficacy. However, there is no universal method to detect CTC currently available. Here, we compared the performance of two CTC detection systems based on the expression of the EpCAM antigen (CellSearch assay) or on ce...

journal_title：British journal of cancer

authors： Farace F,Massard C,Vimond N,Drusch F,Jacques N,Billiot F,Laplanche A,Chauchereau A,Lacroix L,Planchard D,Le Moulec S,André F,Fizazi K,Soria JC,Vielh P

更新日期：2011-09-06 00:00:00

abstract：:Photodynamic therapy (PDT) for cancer in the oesophagus and bronchi with red (630 nm) light may occasionally lead to wall perforation and fistula. Therefore, we investigated the clinical use of a less penetrating wavelength (514 nm) for the curative treatment of nine superficial carcinomas in the oesophagus and bronch...

journal_title：British journal of cancer

authors： Grosjean P,Wagnieres G,Fontolliet C,van den Bergh H,Monnier P

更新日期：1998-06-01 00:00:00

abstract：METHODS:Maternally reported congenital abnormalities (CAs) were examined in a case-control study of 278 cases of paediatric germ cell tumours (GCTs) and 423 controls. RESULTS AND CONCLUSIONS:Germ cell tumours were significantly associated with cryptorchidism in males (OR=10.8, 95% CI: 2.1-55.1), but not with any other...

journal_title：British journal of cancer

authors： Johnson KJ,Ross JA,Poynter JN,Linabery AM,Robison LL,Shu XO

更新日期：2009-08-04 00:00:00

abstract：:The characteristics of 7 human melanoma cell lines were compared with those of the xenografts from which they were established. The ultrastructure, melanin content, isozyme pattern and chromosome numbers of the cell lines were closely similar to those of the corresponding xenografts. The different cell lines gave rise...

journal_title：British journal of cancer

authors： Tveit KM,Pihl A

更新日期：1981-12-01 00:00:00

abstract：:The effects of cis-dichlorodiammine platinum II (DDP) on the intestinal mucosa and the kidney were studied after single and multiple treatments with intervals of 7-45 days. After a single treatment, the jejunal epithelium underwent a transient interruption of cell proliferation followed by a hyperplastic recovery and ...

journal_title：British journal of cancer

authors： Kovacs CJ,Braunschweiger PG,Schenken LL,Burholt DR

更新日期：1982-02-01 00:00:00

abstract：:Although epithelial cell adhesion/activating molecule (EpCAM/CD326) is one of the first tumour-associated antigens identified, it has never received the same level of attention as other target proteins for therapy of cancer. It is also striking that ever since its discovery in the late 1970s the actual contribution of...

journal_title：British journal of cancer

authors： Baeuerle PA,Gires O

更新日期：2007-02-12 00:00:00

abstract：:Tumour necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL/APO2L) is a recently identified member of the TNF family, which induces programmed cell death in a variety of neoplastic cell types, but not in most nonneoplastic cells. In this study, we report on the identification of two novel alternative splice ...

journal_title：British journal of cancer

authors： Krieg A,Krieg T,Wenzel M,Schmitt M,Ramp U,Fang B,Gabbert HE,Gerharz CD,Mahotka C

更新日期：2003-03-24 00:00:00

abstract：BACKGROUND:This study is to investigate the effects of geserelin+tamoxifen (TAM) on estradiol level, breast density (BD), endometrial thickness (ET), and blood lipids in premenopausal and perimenopausal women with hormone receptor-positive early-stage breast cancer. METHODS:This study recruited 110 premenopausal and p...

journal_title：British journal of cancer

authors： Yang H,Zong X,Yu Y,Shao G,Zhang L,Qian C,Bian Y,Xu X,Sun W,Meng X,Ding X,Chen D,Zou D,Xie S,Zheng Y,Zhang J,He X,Sun C,Yu X,Ni J

更新日期：2013-08-06 00:00:00

abstract：BACKGROUND:CYFRA 21-1 serves as biomarker in several epithelial malignancies. However, its role in pancreatic cancer (PC) has not yet been investigated. METHODS:Within a prospective single-centre study serial blood samples were collected from patients with confirmed advanced PC. Pre-treatment values and weekly measure...

journal_title：British journal of cancer

authors： Boeck S,Wittwer C,Heinemann V,Haas M,Kern C,Stieber P,Nagel D,Holdenrieder S

更新日期：2013-04-30 00:00:00

abstract：:MDM2 is an oncoprotein that inhibits p53 tumour-suppressor protein. Amplification of the MDM2 gene and overexpression of its protein have been observed in some human malignancies, and these abnormalities have a role in tumorigenesis through inactivation of p53 function. To determine the clinicopathological and prognos...

journal_title：British journal of cancer

authors： Higashiyama M,Doi O,Kodama K,Yokouchi H,Kasugai T,Ishiguro S,Takami K,Nakayama T,Nishisho I

更新日期：1997-01-01 00:00:00

abstract：:The oestrogen receptor (RE) status of the primary tumour has been assessed in 466 of a consecutive series of 550 patients with primary operable breast cancer. All patients were followed up (without treatment) until the development of recurrence or metastases. Distant metastases have so far occurred in 124 patients and...

journal_title：British journal of cancer

authors： Campbell FC,Blamey RW,Elston CW,Nicholson RI,Griffiths K,Haybittle JL

更新日期：1981-09-01 00:00:00

abstract：:This study sought to use a microdialysis technique to relate clinical and biochemical responses to the time course of melphalan concentrations in the subcutaneous interstitial space and in tumour tissue (melanoma, malignant fibrous histiocytoma, Merkel cell tumour and osteosarcoma) in patients undergoing regional chem...

journal_title：British journal of cancer

authors： Thompson JF,Siebert GA,Anissimov YG,Smithers BM,Doubrovsky A,Anderson CD,Roberts MS

更新日期：2001-07-20 00:00:00