Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53.

abstract：:Angiotensin II, a main effector peptide in the renin-angiotensin system, acts as a growth-promoting and angiogenic factor via type 1 angiotensin II receptors (AT(1)R). We have recently demonstrated that angiotensin II enhanced tumour cell invasion and vascular endothelial growth factor (VEGF) secretion via AT1R in ova...

journal_title：British journal of cancer

authors： Ino K,Shibata K,Kajiyama H,Yamamoto E,Nagasaka T,Nawa A,Nomura S,Kikkawa F

更新日期：2006-02-27 00:00:00

abstract：BACKGROUND:Erythropoietin-stimulating agents (ESAs) effectively decrease the transfusion requirements of patients with chemotherapy-induced anaemia (CIA). Recent studies indicate that ESAs increase mortality and accelerate tumour progression. The studies also identify a 1.6-fold increased risk of venous thromboembolism...

journal_title：British journal of cancer

authors： Fujisaka Y,Sugiyama T,Saito H,Nagase S,Kudoh S,Endo M,Sakai H,Ohashi Y,Saijo N

更新日期：2011-10-25 00:00:00

abstract：:Recent studies indicate that cancer antigen 125 (CA125) response criteria tend to overestimate a tumour reduction measured by standard WHO response criteria in recurrent epithelial ovarian carcinoma. The aim of the study was to validate the recently introduced GCIG (The Gynaecological Cancer Intergroup) CA125 response...

journal_title：British journal of cancer

authors： Gronlund B,Hansen HH,Høgdall C,Høgdall EV,Engelholm SA

更新日期：2004-01-26 00:00:00

abstract：:The geographical distribution of mortality from mesothelioma of the pleura during the years 1968-78 in England and Wales has been studied using extracts from the death records held by the Office of Population Censuses and Surveys. Using the national death rate as standard, Local Authority areas with raised mortality a...

journal_title：British journal of cancer

authors： Gardner MJ,Acheson ED,Winter PD

更新日期：1982-07-01 00:00:00

abstract：:The cytocidal properties of metronidazole against hypoxic mammalian cells are described. This chemotherapeutic action has been shown to be dependent on drug concentration and duration of exposure. The x-ray TCD50 for a murine anaplastic carcinoma was reduced from 6081 rad to 4643 rad when animals were given metronidaz...

journal_title：British journal of cancer

authors： Foster JL,Conroy PJ,Searle AJ,Willson RL

更新日期：1976-05-01 00:00:00

abstract：:PS2, an oestrogen-inducible protein, was measured in the cytosol of 230 primary tumours from patients who were subjected to first-line tamoxifen therapy for advanced disease without prior adjuvant therapy with tamoxifen. PS2 correlated positively with oestrogen receptor (ER, P < 0.01) and progesterone receptor content...

journal_title：British journal of cancer

authors： Foekens JA,Portengen H,Look MP,van Putten WL,Thirion B,Bontenbal M,Klijn JG

更新日期：1994-12-01 00:00:00

abstract：:We evaluated whether social deprivation affected decision-making for breast cancer surgery. Of 3419 patients, 53.6% had mastectomy and this was predicted by deprivation, age, tumour size and hospital, all of which retained significance on multivariate analysis, except deprivation. Pathological characteristics and surg...

journal_title：British journal of cancer

authors： Henley NC,Hole DJ,Kesson E,Burns HJ,George WD,Cooke TG

更新日期：2005-02-28 00:00:00

abstract：:We report here a case of a patient affected by endometrial cancer and treated primarily with leuprolide, the surgical approach being unfeasible due to her compromised conditions. The therapy was continued for more than 6 years, and no progression of the disease was observed. During this period, some histological and i...

journal_title：British journal of cancer

authors： Noci I,Borri P,Bonfirraro G,Chieffi O,Arcangeli A,Cherubini A,Dabizzi S,Buccoliero AM,Paglierani M,Taddei GL

更新日期：2001-08-03 00:00:00

abstract：:The effect on cell-cycle progression in various phases of the cell cycle caused by an acute exposure to hypoxia in absence and presence of misonidazole (MISO) was investigated. Exponentially growing and synchronized cells of the human line NHIK 3025 were exposed to different degrees of hypoxia for a short period (1.5 ...

journal_title：British journal of cancer

authors： Pettersen EO,Lindmo T

更新日期：1983-12-01 00:00:00

abstract：:E-cadherin function is thought to be impaired in epithelial cancer. To investigate the alterations in E-cadherin associated with cytoplasmic molecules including alpha-catenin, beta-catenin, gamma-catenin, p120CAS, and IQGAP1 in various endometrial cancers with different degree of differentiation, we examined the local...

journal_title：British journal of cancer

authors： Miyamoto S,Baba H,Kuroda S,Kaibuchi K,Fukuda T,Maehara Y,Saito T

更新日期：2000-11-01 00:00:00

abstract：:The malignant epithelial cells of nasopharyngeal carcinoma (NPC) and cells of lines derived form the lymphoid cells which infiltrate this tumour have been investigated cytogenetically. Chromosome spreads of lymphoblastoid cells of lines established from 7 different NPC biopsy specimens were examined after banding stai...

journal_title：British journal of cancer

authors： Finerty S,Jarvis JE,Epstein MA,Trumper PA,Ball G,Giovanella BC

更新日期：1978-02-01 00:00:00

abstract：:In a blind study, 518 serum samples were assayed for serum levels of mammary serum antigen (MSA) by an enzyme immunoassay (EIA) using the 3E1.2 monoclonal antibody. Using 300 IU as the arbitrary cut off to distinguish normal from abnormal individuals, 75% of patients with primary Stage I carcinoma of the breast (n = 1...

journal_title：British journal of cancer

authors： Stacker SA,Sacks NP,Golder J,Tjandra JJ,Thompson CH,Smithyman A,McKenzie IF

更新日期：1988-03-01 00:00:00

abstract：:The use of oncolytic viruses has received considerable attention in recent years and many viruses have proved to be effective against a variety of cancer models and a few are currently being used in clinical trials. However, the possible emergence and outcome of virus-resistant tumour cells has not been addressed. We ...

journal_title：British journal of cancer

authors： Alain T,Kim M,Johnston RN,Urbanski S,Kossakowska AE,Forsyth PA,Lee PW

更新日期：2006-10-23 00:00:00

abstract：:Squamous cell carcinoma and adenocarcinoma of the oesophagus are cancers that develop from distinct epithelial sub-types; however, they are both related to chronic inflammation of differing aetiologies. Inflammation leads to somatically inherited genetic mutations altering control of the cell cycle, DNA replication an...

journal_title：British journal of cancer

authors： Bird-Lieberman EL,Fitzgerald RC

更新日期：2009-07-07 00:00:00

abstract：:We have studied whether N-methylformamide can affect the expression pattern of adhesion molecules and the attachment behaviour of M14 human melanoma cells. The role of N-methylformamide on experimental and spontaneous pulmonary metastases from M14 cells in nude mice was also investigated. We demonstrate that N-methylf...

journal_title：British journal of cancer

authors： Del Bufalo D,Leonetti C,Bucci B,Amedeo C,Falcioni R,Biroccio A,Zupi G

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Tumoural interstitial hypertension, possibly modulated by platelet-derived and vascular endothelial growth factor receptors (PDGFR and VEGFR), may mediate resistance to chemotherapy. METHODS:Forty-eight patients with advanced solid tumours received oral PDGFR inhibitor CP-868,596 (60-100 mg twice daily (BID...

journal_title：British journal of cancer

authors： Michael M,Vlahovic G,Khamly K,Pierce KJ,Guo F,Olszanski AJ

更新日期：2010-11-09 00:00:00

abstract：:In the BUPA Study, a prospective study of 22,000 men attending a screening centre in London, serum samples were collected and stored. The concentration of beta-carotene was measured in the stored serum samples from 271 men who were subsequently notified as having cancer and from 533 unaffected controls, matched for ag...

journal_title：British journal of cancer

authors： Wald NJ,Thompson SG,Densem JW,Boreham J,Bailey A

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Lapatinib, a dual EGFR and HER2 inhibitor has shown disappointing results in clinical trials of metastatic oesophago-gastric adenocarcinomas (OGAs), and in vitro studies suggest that MET, IGFR, and HER3 confer resistance. This trial applied Lapatinib in the curative neoadjuvant setting and investigated the f...

journal_title：British journal of cancer

authors： De Silva N,Schulz L,Paterson A,Qain W,Secrier M,Godfrey E,Cheow H,O'Donovan M,Lao-Sirieix P,Jobanputra M,Hochhauser D,Fitzgerald R,Ford H

更新日期：2015-11-03 00:00:00

abstract：:Question prompt lists (QPLs) have been shown to be an inexpensive and effective communication tool for patients in oncology consultations. We aimed to develop and pilot a QPL for palliative care (PC) patients. In order to identify suitable questions for inclusion in the QPL, we conducted focus groups and individual in...

journal_title：British journal of cancer

authors： Clayton J,Butow P,Tattersall M,Chye R,Noel M,Davis JM,Glare P

更新日期：2003-12-01 00:00:00

abstract：:The development of resistance to vincristine, actinomycin D and cisplatin has been examined in a human epidermoid lung carcinoma xenograft line (HXL 55) growing in nude mice. Treatment of HXL 55 with 1 mg kg-1 vincristine or 0.5 mg kg-1 actinomycin D once in each in vivo passage resulted in a rapid reduction in tumour...

journal_title：British journal of cancer

authors： Mattern J,Bak M Jr,Hoever KH,Volm M

更新日期：1988-07-01 00:00:00

abstract：:The aim of this study was to investigate whether immunohistochemical staining patterns of tissue inhibitor of metalloproteinases TIMP-2 and matrix metalloproteinases MMP-2 and MMP-9 can be predictors of tumour stage and survival time in colorectal cancer. Frozen tumour sections from 212 patients operated on between Ja...

journal_title：British journal of cancer

authors： Ring P,Johansson K,Höyhtyä M,Rubin K,Lindmark G

更新日期：1997-01-01 00:00:00

abstract：:Cell fusion has been used to analyse the genetic determinants of metastasis at the cellular level. Highly metastatic mouse melanoma cells were fused with diploid mouse lymphocytes and a range of hybrid clones isolated and tested for tumorigenicity and metastatic potential by s.c. injection into newborn, histocompatibl...

journal_title：British journal of cancer

authors： Sidebottom E,Clark SR

更新日期：1983-03-01 00:00:00

abstract：:A case-control study of lung cancer involving interviews with 965 female patients and 959 controls in Shenyang and Harbin, two industrial cities which have among the highest rates of lung cancer in China, revealed that cigarette smoking is the main causal factor and accounted for about 35% of the tumours among women. ...

journal_title：British journal of cancer

authors： Wu-Williams AH,Dai XD,Blot W,Xu ZY,Sun XW,Xiao HP,Stone BJ,Yu SF,Feng YP,Ershow AG

更新日期：1990-12-01 00:00:00

abstract：:A cytogenetic study was performed in 27 patients suspected of t-MDS or t-ANLL. In 12 patients the diagnosis of t-MDS or t-ANLL was confirmed by morphological, cytochemical and immunophenotypical analysis. The cases were classified as RA (one), RAEB (four), CMML (two), ANLL (five). They had received chemotherapy and/or...

journal_title：British journal of cancer

authors： Sozzi G,Miozzo M,Orazi A,Calderone C,Castellano M,Viviani S,Santoro A,Pierotti MA,Della Porta G

更新日期：1990-03-01 00:00:00

abstract：:New therapeutic strategies are now being developed against adenocarcinoma associated with erbB-2 amplification, particularly by inhibiting p185erbB-2 expression. Antisense oligodeoxynucleotides seem promising for this purpose as long as they are efficiently protected against degradation and targeted into the cells. We...

journal_title：British journal of cancer

authors： Allal C,Sixou S,Kravtzoff R,Soulet N,Soula G,Favre G

更新日期：1998-05-01 00:00:00

abstract：:From 1984 to 1989, 63 patients with diffuse, malignant mesothelioma of the pleura were treated with 4-8 courses of high-dose methotrexate (HDMTX, 3 g total dose) and citrovorum factor rescue. There were 61 male and two female patients of median age 60 years. CT scan was performed before and after treatment and used fo...

journal_title：British journal of cancer

authors： Solheim OP,Saeter G,Finnanger AM,Stenwig AE

更新日期：1992-06-01 00:00:00

abstract：:The aim of the study is to assess the value of carbonic anhydrase isozyme IX (CA IX) expression as a predictor of disease-free survival (DFS) and disease-specific survival (DSS) in rectal cancer treated by preoperative radio- or chemoradiotherapy or surgery only. Archival tumour samples from 166 patients were analysed...

journal_title：British journal of cancer

authors： Korkeila E,Talvinen K,Jaakkola PM,Minn H,Syrjänen K,Sundström J,Pyrhönen S

更新日期：2009-03-24 00:00:00

abstract：BACKGROUND:This study explored the association between smoking and colorectal malignant carcinoma (CRC) in the Chinese population at the national level for the first time. METHODS:In the China Nationwide Retrospective Mortality Survey conducted during 1989-1991, 12,942 CRC cases among 1,136,336 all-cause deaths aged ≥...

journal_title：British journal of cancer

authors： Hou L,Jiang J,Liu B,Nasca PC,Wu Y,Zou X,Han W,Chen Y,Zhang B,Xue F,Pang H,Li J

更新日期：2014-03-04 00:00:00

abstract：:Women with gross cystic breast disease may have an increased risk of breast cancer. In this study the ability of breast cyst fluid (BCF), obtained from British or Hungarian women, to modulate oestrone sulphate (E1S) formation or hydrolysis, has been examined. For this, oestrogen receptor-positive (ER+) MCF-7 or MDA-MB...

journal_title：British journal of cancer

authors： Purohit A,Budai B,Wang DY,Willemsen EL,de Winkel A,Parish D,Ghilchik MW,Szamel I,Reed MJ

更新日期：2000-01-01 00:00:00

abstract：:Choriocarcinoma can be imaged by external scintigraphy after intravenous administration of radiolabelled antibody directed against human chorionic gonadotrophin (HCG). The purpose of this study was to investigate whether antibody imaging was sufficiently sensitive and specific to improve the selection of patients for ...

journal_title：British journal of cancer

authors： Begent RH,Bagshawe KD,Green AJ,Searle F

更新日期：1987-06-01 00:00:00