The clinical value of imaging with antibody to human chorionic gonadotrophin in the detection of residual choriocarcinoma.

abstract：BACKGROUND:It has been a challenge to determine breast cancer clonality accurately. The aim of the present study was to assess methods using formalin-fixed paraffin-embedded (FFPE) tissue to differentiate new primary tumours from true recurrences that are associated with poorer prognoses and often require more aggressi...

journal_title：British journal of cancer

authors： Masuda S,Kadowaki T,Kumaki N,Tang X,Tokuda Y,Yoshimura S,Takekoshi S,Osamura RY

更新日期：2012-12-04 00:00:00

abstract：:Chromosome 17 alterations are found in more cancers than those of any other chromosome, and frequently involve the p53 gene on 17p13. The aim of this study was to identify the correlations between the presence of loss of heterozygosity (LOH) and microsatellite instability (MI) on chromosome 17p13 in patients with cerv...

journal_title：British journal of cancer

authors： Harima Y,Shirahama S,Harima K,Aoki S,Ohnishi T,Tanaka Y

更新日期：1999-09-01 00:00:00

abstract：:Gain of 1q is one of the most common alterations in cancer and has been associated with adverse clinical behaviour in ependymoma. The aim of this study was to investigate this region to gain insight into the role of 1q genes in intracranial paediatric ependymoma. To address this issue we generated profiles of eleven e...

journal_title：British journal of cancer

authors： Rand V,Prebble E,Ridley L,Howard M,Wei W,Brundler MA,Fee BE,Riggins GJ,Coyle B,Grundy RG,Children's Cancer and Leukaemia Group Biological Studies Committee.

更新日期：2008-10-07 00:00:00

abstract：:The haemodynamics of the uterine arteries and myometrium were assessed using Doppler ultrasound in forty consecutive patients requiring treatment for invasive mole and choriocarcinoma. The investigations were performed prior to the commencement of chemotherapy and the subjects followed prospectively. The Doppler wavef...

journal_title：British journal of cancer

authors： Long MG,Boultbee JE,Langley R,Newlands ES,Begent RH,Bagshawe KD

更新日期：1992-11-01 00:00:00

abstract：:Two policies of palliative thoracic radiotherapy for non-small-cell lung cancer have been compared in a randomised multicentre controlled trial. A total of 369 patients with inoperable, histologically or cytologically confirmed disease, too advanced for radical 'curative' radiotherapy, and with their main symptoms rel...

journal_title：British journal of cancer

authors：

更新日期：1991-02-01 00:00:00

abstract：:Multiple primary tumours occurring in a three-year population-based series of patients with histopathologically peer-reviewed sarcomas from North West England were ascertained in order to look at the patterns of neoplasms seen. A total of 30 out of the 310 patients entered in the study had additional primary tumours. ...

journal_title：British journal of cancer

authors： Hartley AL,Blair V,Harris M,Birch JM,Banerjee SS,Freemont AJ,McClure J,McWilliam LJ

更新日期：1993-12-01 00:00:00

abstract：:It has been shown that some types of tumour cells produce activated transforming growth factor beta-1 (TGF-beta 1). However, the mechanism for the activation of TGF-beta 1 derived from tumour cells has not been fully elucidated. The present study was undertaken to characterise an activator of latent TGF-beta 1 secrete...

journal_title：British journal of cancer

authors： Horimoto M,Kato J,Takimoto R,Terui T,Mogi Y,Niitsu Y

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:The interaction between human prostate cancer (PCa) cells and bone marrow (BM) endothelium follows a rolling-and-adhesion cascade mediated by E-selectin ligand (ESL): E-selectin. This adhesion is enabled by elevated expression of α-1,3-fucosyltransferases (FTs), enzymes responsible for ESL-mediated bone meta...

journal_title：British journal of cancer

authors： Li J,Guillebon AD,Hsu JW,Barthel SR,Dimitroff CJ,Lee YF,King MR

更新日期：2013-12-10 00:00:00

abstract：:Both biodegradable emboli and pharmacological agents can enhance regional therapy for hepatic targeting. Using a rat model with similar haemodynamic characteristics to human colorectal liver tumour and a radio-labelled marker of similar molecular weight to Adriamycin, we have combined the two approaches to see if the ...

journal_title：British journal of cancer

authors： Carter R,Cooke TG,Hemingway D,McArdle CS,Angerson W

更新日期：1992-01-01 00:00:00

abstract：:For the first time in a clinical study oral Ifosfamide was used: 65 elderly or unfit patients with small cell lung cancer (SCLC) were treated as outpatients with fractionated oral Ifosfamide and Etoposide. Forty patients (62%) had extensive stage (ED) disease. The median age of the patients was 66 years. In the 60 pat...

journal_title：British journal of cancer

authors： Cerny T,Lind M,Thatcher N,Swindell R,Stout R

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Tumour hypoxia is associated with impaired apoptosis, resistance to therapy and poor prognosis. We previously reported that high stromal expression of the endogenous marker of hypoxia, carbonic anhydrase IX (CAIX), is associated with significantly reduced survival in oral squamous cell carcinoma (OSCC). In a...

journal_title：British journal of cancer

authors： Klimowicz AC,Bose P,Petrillo SK,Magliocco AM,Dort JC,Brockton NT

更新日期：2013-10-01 00:00:00

abstract：:To identify tumour and tumour-associated antigens in patients with hepatocellular carcinoma (HCC) one may find potential diagnostic markers and immunotherapeutic targets. In the current study, 30 distinct antigens reactive with serum IgG from HCC patients were identified by serological analysis of cDNA expression libr...

journal_title：British journal of cancer

authors： Shi YY,Wang HC,Yin YH,Sun WS,Li Y,Zhang CQ,Wang Y,Wang S,Chen WF

更新日期：2005-03-14 00:00:00

abstract：:The MIB-1 antibody has been raised against recombinant parts of the Ki-67 antigen and, unlike Ki-67, has wider application to routinely fixed specimens. The aim of this study was to compare the usefulness of MIB-1 with S-phase fraction (SPF) as a measure of proliferation. A total of 75 patients with operable breast ca...

journal_title：British journal of cancer

authors： Ellis PA,Makris A,Burton SA,Titley J,Ormerod MG,Salter J,Powles TJ,Smith IE,Dowsett M

更新日期：1996-03-01 00:00:00

abstract：:Expression of the calcium-dependent cell-cell adhesion molecule E-cadherin has been examined in 187 primary breast carcinomas using an immunohistochemical technique. The pattern and extent of reactivity has been correlated with clinicopathological data including tumour type, grade and lymph node status and with other ...

journal_title：British journal of cancer

authors： Jones JL,Royall JE,Walker RA

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:The precise timing of the angiogenic switch and the role of angiogenesis in the development of breast malignancy is currently unknown. METHODS:Therefore, the expression of CD31 (pan endothelial cells (ECs)), endoglin (actively proliferating ECs), hypoxia-inducible factor-1 (HIF-1alpha), vascular endothelial...

journal_title：British journal of cancer

authors： Bluff JE,Menakuru SR,Cross SS,Higham SE,Balasubramanian SP,Brown NJ,Reed MW,Staton CA

更新日期：2009-08-18 00:00:00

abstract：BACKGROUND:In the phase III AVAGAST trial, the addition of bevacizumab to chemotherapy improved progression-free survival (PFS) but not overall survival (OS) in patients with advanced gastric cancer. We studied the role of Angiopoietin-2 (Ang-2), a key driver of tumour angiogenesis, metastasis and resistance to antiang...

journal_title：British journal of cancer

authors： Hacker UT,Escalona-Espinosa L,Consalvo N,Goede V,Schiffmann L,Scherer SJ,Hedge P,Van Cutsem E,Coutelle O,Büning H

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:To date, no adjuvant treatment has been shown to have a clear benefit in patients with hepatocellular carcinoma (HCC). In this prospective phase I/IIa study, we evaluated the safety and efficacy of adjuvant dendritic cell (DC) therapy in HCC patients who received primary treatment for HCC. METHODS:Twelve HC...

journal_title：British journal of cancer

authors： Lee JH,Lee Y,Lee M,Heo MK,Song JS,Kim KH,Lee H,Yi NJ,Lee KW,Suh KS,Bae YS,Kim YJ

更新日期：2015-12-22 00:00:00

abstract：:The molecular events that drive the initiation and progression of ovarian adenocarcinoma are not well defined. We have investigated changes in gene expression in ovarian cancer cell lines compared to an immortalized human ovarian surface epithelial cell line (HOSE) using a cDNA array. We identified 17 genes that were ...

journal_title：British journal of cancer

authors： Arnold JM,Mok SC,Purdie D,Chenevix-Trench G

更新日期：2001-02-02 00:00:00

abstract：BACKGROUND:Non-invasive biomarkers of disease progression in mice with cancer are lacking making it challenging to implement appropriate humane end points. We investigated whether body temperature, food and water consumption could be used to predict tumour burden. METHODS:Thirty-six male, wild-type C57Bl/6 mice were i...

journal_title：British journal of cancer

authors： Hunter JE,Butterworth J,Perkins ND,Bateson M,Richardson CA

更新日期：2014-02-18 00:00:00

abstract：BACKGROUND:The small stress heat shock protein 27 (Hsp27) has recently turned as a promising target for cancer treatment. Hsp27 upregulation is associated with tumour growth and resistance to chemo- and radio-therapeutic treatments, and several ongoing drugs inhibiting Hsp27 expression are under clinical trial. Hsp27 i...

journal_title：British journal of cancer

authors： Gibert B,Eckel B,Gonin V,Goldschneider D,Fombonne J,Deux B,Mehlen P,Arrigo AP,Clézardin P,Diaz-Latoud C

更新日期：2012-06-26 00:00:00

abstract：:In a variety of adult and childhood leukaemia cell samples collected at different states of the disease, we analysed in a series of sequentially performed slot-blot or Northern-blot hybridisation experiments the expression of genes possibly involved in multiple drug resistance (MDR) (mdr1/P-glycoprotein, DNA topoisome...

journal_title：British journal of cancer

authors： Gekeler V,Frese G,Noller A,Handgretinger R,Wilisch A,Schmidt H,Muller CP,Dopfer R,Klingebiel T,Diddens H

更新日期：1992-09-01 00:00:00

abstract：:Metastasis of colorectal carcinomas rarely occurs in cirrhotic livers. Our study investigated the influence of activated Kupffer cells from cirrhotic rat livers on hepatic colonization and FasR-mediated apoptosis of colon cancer cells. A rat colon cancer cell line, RCN-9, was used to inoculate rat livers. Treatment wi...

journal_title：British journal of cancer

authors： Song E,Chen J,Ouyang N,Wang M,Exton MS,Heemann U

更新日期：2001-05-04 00:00:00

abstract：BACKGROUND:Gender-associated epigenetic alterations are poorly investigated in male and female familial breast cancer (fBC). MicroRNAs may contribute to the different biology in men and women particularly related to RASSF1A pathways. METHODS:Microarray technology was used to evaluate miRNA profile in 24 male and 43 fe...

journal_title：British journal of cancer

authors： Pinto R,De Summa S,Danza K,Popescu O,Paradiso A,Micale L,Merla G,Palumbo O,Carella M,Tommasi S

更新日期：2014-12-09 00:00:00

abstract：:Neurofilaments (NFs) are specific intermediate filaments to neural cells. Mammalian NFs are protein triplets composed of three major subunits with respective molecular weights of approximately 70, 150 and 200 kD. Using an immunohistochemical method, 13 carcinoid tumours from different sites were examined for the prese...

journal_title：British journal of cancer

authors： Astarloa R,Sánchez-Franco F,Cacicedo L,García-Villanueva M

更新日期：1991-05-01 00:00:00

abstract：:Manganese superoxide dismutase (SOD2) is an enzyme that catalyses the dismutation of superoxide in the mitochondria, leading to reduced levels of reactive oxygen species. Reduced expression levels of SOD2 have been shown to result in increased DNA damage and sod2 heterozygous mice have increased incidences of cancer. ...

journal_title：British journal of cancer

authors： Hurt EM,Thomas SB,Peng B,Farrar WL

更新日期：2007-10-22 00:00:00

abstract：:Four poly(ADP-ribose) polymerase (PADPRP) inhibitors [3-aminobenzamide, benzamide, 3,4-dihydro-5-methoxyisoquinolin-1(2H)-one (PD 128763) and 8-hydroxy-2-methylquinazolin-4(3H)-one (NU1025)] were compared with respect to their effects on a number of biological end points. The following parameters were assessed: their ...

journal_title：British journal of cancer

authors： Boulton S,Pemberton LC,Porteous JK,Curtin NJ,Griffin RJ,Golding BT,Durkacz BW

更新日期：1995-10-01 00:00:00

abstract：:Dendritic cells (DC) are professional antigen-presenting cells (APC) of the immune system, uniquely able to prime naive T-cell responses. They are the focus of a range of novel strategies for the immunotherapy of cancer, a proportion of which include treating DC with ionising radiation to high dose. The effects of rad...

journal_title：British journal of cancer

authors： Merrick A,Errington F,Milward K,O'Donnell D,Harrington K,Bateman A,Pandha H,Vile R,Morrison E,Selby P,Melcher A

更新日期：2005-04-25 00:00:00

abstract：:It is presently unclear whether carriers of BRCA1 mutations have an increased risk for colorectal cancer (CRC). To gain insight into this issue, 225 unselected Ashkenazi Jewish CRC patients were tested for the presence of the three common Jewish BRCA1/2 germline mutations: 185delAG and 5382insC (BRCA1) and 6174delT (B...

journal_title：British journal of cancer

authors： Chen-Shtoyerman R,Figer A,Fidder HH,Rath P,Yeremin L,Bar Meir S,Friedman E,Theodor L

更新日期：2001-02-01 00:00:00

abstract：:Sera from breast cancer patients and from female controls were tested for inhibition of lysis of antibody-coated target cells by human leukocytes (K cells). Sera from 39% of breast cancer patients, but from only 8% of controls, inhibited lysis by more than 30%. This inhibition was unrelated to the stage of the disease...

journal_title：British journal of cancer

authors： Matthews N,Whitehead RH

更新日期：1976-12-01 00:00:00

abstract：:Survivin is an apoptotic inhibitor that is expressed at high levels in a variety of malignancies. Survivin has four known alternative splice forms (Survivin, Survivin-2B, Survivin-deltaEx3, and Survivin-3B), and the recent literature suggests that these splice variants have unique functions and subcellular localisatio...

journal_title：British journal of cancer

authors： Fangusaro JR,Jiang Y,Holloway MP,Caldas H,Singh V,Boué DR,Hayes J,Altura RA

更新日期：2005-01-31 00:00:00