Association between smoking and deaths due to colorectal malignant carcinoma: a national population-based case-control study in China.

Abstract:

BACKGROUND:This study explored the association between smoking and colorectal malignant carcinoma (CRC) in the Chinese population at the national level for the first time. METHODS:In the China Nationwide Retrospective Mortality Survey conducted during 1989-1991, 12,942 CRC cases among 1,136,336 all-cause deaths aged ≥30 years were randomly assigned 25,884 control interviews from 325,255 surviving spouses of all-cause deaths across 103 urban and rural areas. RESULTS:Compared with non-smokers, smoking significantly increased the risk of CRC-specific mortality by 9.8% (odds ratio (OR)=1.098, 95% confidence interval (CI)=1.046-1.153) adjusted for sex, age, and residence. There were significant dose-response relationships between smoking and CRC, such as smoking years, cigarettes smoked daily, and age at onset of smoking. Long-term heavy smokers aged ≥50 years with ≥30 smoking years and ≥20 cigarettes daily had an excess risk of CRC deaths of 30.2% (OR=1.302, 95% CI=1.214-1.397). The strongest association between these smoking variables, such as long-term heavy smokers (OR=1.604, 95% CI=1.341-1.919), and CRC was observed among rural men. CONCLUSIONS:Quitting smoking at any time would likely be beneficial to CRC prevention. Long-term heavy smokers and rural men should be viewed as special targets for smoking prevention and cessation programs.

journal_name

Br J Cancer

authors

Hou L,Jiang J,Liu B,Nasca PC,Wu Y,Zou X,Han W,Chen Y,Zhang B,Xue F,Pang H,Li J

doi

10.1038/bjc.2014.9

subject

Has Abstract

pub_date

2014-03-04 00:00:00

pages

1351-8

issue

5

eissn

0007-0920

issn

1532-1827

pii

bjc20149

journal_volume

110

pub_type

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