Metabolism of the bioreductive cytotoxin SR 4233 by tumour cells: enzymatic studies.

abstract：:The pathophysiology of Raynaud's phenomenon after Cisplatin-Bleomycin-Vinblastine combination chemotherapy, its relationship to polyneuropathy, and response to transcutaneous nerve stimulation (TNS), was studied in eight patients previously treated for testicular cancer. Peripheral circulation in the index finger was ...

journal_title：British journal of cancer

authors： Heier MS,Nilsen T,Graver V,Aass N,Fosså SD

更新日期：1991-04-01 00:00:00

abstract：:This paper investigates the potential for long-term survivorship for young patients diagnosed with Ewing's sarcoma. Data are examined from two successive UKCCSG Ewing's Tumour studies (ET-1 and ET-2). Patients have been followed for up to 20 years. These studies had suggested that better 5-year survival with ET-2 over...

journal_title：British journal of cancer

authors： Weston CL,Douglas C,Craft AW,Lewis IJ,Machin D

更新日期：2004-07-19 00:00:00

abstract：:In the present multicentre randomized phase II trial, the activity and toxicity of three platinum-based combination regimens for the treatment of advanced non-small-cell lung cancer (NSCLC) were evaluated. The three regimens were: MVP (mitomycin-C 6 mg m(-2) on day 1, vindesine 3 mg m(-2) on days 1 and 15, and cisplat...

journal_title：British journal of cancer

authors： Baldini E,Tibaldi C,Ardizzoni A,Salvati F,Antilli A,Portalone L,Barbera S,Romano F,De Marinis F,Migliorino MR,Noseda MA,Borghini U,Crippa M,Ferrara G,Raimondi M,Fioretti M,Bandera M,Pennucci MC,Galeasso G,Cacciani G

更新日期：1998-06-01 00:00:00

abstract：:The survival of 64 consecutive patients with disseminated midgut carcinoid tumours was compared in a retrospective study with that of 25 consecutive patients with sporadic malignant endocrine pancreatic tumours treated according to similar surgical principles. The presence of hepatic metastases implied a worse prognos...

journal_title：British journal of cancer

authors： Johanson V,Tisell LE,Olbe L,Wängberg B,Nilsson O,Ahlman H

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:The diagnosis of neuroendocrine neoplasms (NENs) is often delayed. This first UK population-based epidemiological study of NENs compares outcomes with non-NENs to identify any inequalities. METHODS:Age-standardised incidence rate (ASR), 1-year overall survival, hazard ratios and standardised mortality rates...

journal_title：British journal of cancer

authors： Genus TSE,Bouvier C,Wong KF,Srirajaskanthan R,Rous BA,Talbot DC,Valle JW,Khan M,Pearce N,Elshafie M,Reed NS,Morgan E,Deas A,White C,Huws D,Ramage J

更新日期：2019-11-01 00:00:00

abstract：:Staging and surgical as well as post-operative treatment of primary Fallopian tube carcinoma (FTC) followed the lines established for primary ovarian cancer (OC). In a nationwide retrospective analysis we were able to find a distinct difference between these two tumours. A total of 262 patients, 68 with FTC and 194 wi...

journal_title：British journal of cancer

authors： Rosen AC,Sevelda P,Klein M,Graf AH,Lahousen M,Reiner A,Auerbach L,Vavra N,Rosen HR

更新日期：1994-03-01 00:00:00

abstract：:A screening programme designed to identify cases of Major Depressive Disorder (MDD) in patients attending a Regional Cancer Centre outpatient department was established. It comprised two stages: (1) The Hospital Anxiety and Depression Scale (HADS) self-rating questionnaire administered by a touch-screen computer; (2) ...

journal_title：British journal of cancer

authors： Sharpe M,Strong V,Allen K,Rush R,Postma K,Tulloh A,Maguire P,House A,Ramirez A,Cull A

更新日期：2004-01-26 00:00:00

abstract：BACKGROUND:Geriatric oncology guidelines state that fit older men with prostate cancer should receive curative treatment. In a population-based study, we investigated associations between age and non-receipt of curative treatment in men with localised prostate cancer, and the effect of clinical variables on this in dif...

journal_title：British journal of cancer

authors： de Camargo Cancela M,Comber H,Sharp L

更新日期：2013-07-09 00:00:00

abstract：:Ovulation is believed to contribute to the development of ovarian cancers that derive from the ovarian surface epithelium (OSE). The process of ovulation is synonymous with inflammation and inflammatory cytokines such as interleukin-1alpha (IL-1alpha) have recently been shown to induce both inflammatory and anti-infla...

journal_title：British journal of cancer

authors： Gubbay O,Guo W,Rae MT,Niven D,Langdon SP,Hillier SG

更新日期：2005-05-23 00:00:00

abstract：:People affected by cancer want information about their prognosis but clinicians have trouble estimating and talking about it. We sought to determine the nature and accuracy of medical oncologists' estimates of life expectancy in newly referred patients with incurable cancer. With reference to each patient, medical onc...

journal_title：British journal of cancer

authors： Stockler MR,Tattersall MH,Boyer MJ,Clarke SJ,Beale PJ,Simes RJ

更新日期：2006-01-30 00:00:00

abstract：:The normal-lymphocyte-transfer test has been advocated as a method of assessing the immuno-competence of lymphocytes from patients with breast and large-bowel cancer. Evidence is presented in this paper that the methodology is subject to many uncontrollable errors, that the reaction is the result of multiple factors, ...

journal_title：British journal of cancer

authors： Gaffney P

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:MSMB, a gene coding for beta-microseminoprotein, has been identified as a candidate susceptibility gene for prostate cancer (PrCa) in two genome-wide association studies (GWAS). SNP rs10993994 is 2 bp upstream of the transcription initiation site of MSMB and was identified as an associated PrCa risk variant....

journal_title：British journal of cancer

authors： Kote-Jarai Z,Leongamornlert D,Tymrakiewicz M,Field H,Guy M,Al Olama AA,Morrison J,O'Brien L,Wilkinson R,Hall A,Sawyer E,Muir K,Hamdy F,Donovan J,Neal D,Easton D,Eeles R

更新日期：2010-01-19 00:00:00

abstract：BACKGROUND:Patients whose colorectal cancer is treated after an emergency admission tend to have late-stage cancer and a poor prognosis. We identified risk factors for an emergency admission by linking data from the National Bowel Cancer Audit (NBCA) and the English Hospital Episode Statistics (HES), an administrative ...

journal_title：British journal of cancer

authors： Wallace D,Walker K,Kuryba A,Finan P,Scott N,van der Meulen J

更新日期：2014-07-29 00:00:00

abstract：:Based on the evaluation of 362 cases of squamous cell carcinoma of the uterine cervix, the distribution of the tumours in relation to their modified Broders' grade, histological cell type as proposed by Wentz and Reagan, and the clinical stage of disease was evaluated. The morphological characteristics of the 3 cell t...

journal_title：British journal of cancer

authors： Ng AB,Atkin NB

更新日期：1973-10-01 00:00:00

abstract：:The aim of this study was to ascertain whether assessing the growth fraction of cervical carcinoma of 28 patients, using antibody Ki-67, would be of value in clinical practice. The results showed no relationship between growth fraction and age, clinical stage, lymph node involvement or short term (3-5 years) survival....

journal_title：British journal of cancer

authors： Cole DJ,Brown DC,Crossley E,Alcock CJ,Gatter KC

更新日期：1992-05-01 00:00:00

abstract：:Caffeine has for many years been known to be involved in the sensitization of DNA to damage. One potential mechanism recently put forward is an override of the G2/M block induced by irradiation, which would leave the cells less time for DNA repair prior to mitosis. However, different cell types display a variety of re...

journal_title：British journal of cancer

authors： Deplanque G,Vincent F,Mah-Becherel MC,Cazenave JP,Bergerat JP,Klein-Soyer C

更新日期：2000-08-01 00:00:00

abstract：:Raised risks of several cancers have been found in patients with type II diabetes, but there are few data on cancer risk in type I diabetes. We conducted a cohort study of 28 900 UK patients with insulin-treated diabetes followed for 520 517 person-years, and compared their cancer incidence and mortality with national...

journal_title：British journal of cancer

authors： Swerdlow AJ,Laing SP,Qiao Z,Slater SD,Burden AC,Botha JL,Waugh NR,Morris AD,Gatling W,Gale EA,Patterson CC,Keen H

更新日期：2005-06-06 00:00:00

abstract：:At baseline, weight-losing pancreatic cancer patients (n=7) had lower leptin (P<0.05) but higher cortisol, interleukin-6, resting energy expenditure and fat oxidation than healthy subjects (n=6, P<0.05). Over a 4 h feeding period, the areas under the curve for glucose, cortisol and interleukin-6 were greater (P<0.05),...

journal_title：British journal of cancer

authors： Barber MD,McMillan DC,Wallace AM,Ross JA,Preston T,Fearon KC

更新日期：2004-03-22 00:00:00

abstract：BACKGROUND:Low-dose UCN-01 mediates G1 arrest in normal proliferating cell lines with an intact G1 to S transition but not tumour cells with a deregulated G1 to S checkpoint. Here we hypothesised that UCN-01 is effective in mediating a selective, reversible G1 arrest of normal proliferating cells, resulting in decrease...

journal_title：British journal of cancer

authors： Mull BB,Livingston JA,Patel N,Bui T,Hunt KK,Keyomarsi K

更新日期：2020-03-01 00:00:00

abstract：:Primary liver cancer, predominantly consisting of hepatocellular carcinoma (HCC), is one of the most common and aggressive human malignancies worldwide. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression post-transcriptionally. Emerging evidence indicates that miRNAs are often deregu...

journal_title：British journal of cancer

authors： Huang S,He X

更新日期：2011-01-18 00:00:00

abstract：:The purpose of this study was to determine the maximum-tolerated dose of gemcitabine plus mitoxantrone in women with metastatic breast cancer (MBC) and to evaluate activity and toxicity of this combination in a phase II trial. Sixty-three patients with MBC, previously treated with chemotherapy including anthracycline ...

journal_title：British journal of cancer

authors： Lorusso V,Crucitta E,Silvestris N,Catino A,Caporusso L,Mazzei A,Guida M,Latorre A,Sambiasi D,D'Amico C,Schittulli F,Calabrese P,De Lena M

更新日期：2003-02-24 00:00:00

abstract：:Three hundred and ninety women participated in the quality of life (QL) study of ACCOG1, a high-dose vs conventional adjuvant chemotherapy breast cancer trial, for patients with a high risk of relapse. Patients completed the European Organisation for Research and Treatment of Cancer QLQ-C30, questions on menopausal sy...

journal_title：British journal of cancer

authors： Malinovszky KM,Gould A,Foster E,Cameron D,Humphreys A,Crown J,Leonard RC,Anglo Celtic Co-operative Oncology Group.

更新日期：2006-12-18 00:00:00

abstract：:The efficacy of cisplatin [cis-diamminedichloroplatinum (II); DDP] is hampered by acquired or de novo resistance of malignant cells to its cytotoxic effects. We have previously reported that cisplatin resistance parallels glutathione S-transferase (GST) activity in several human small-cell lung cancer cell lines. In t...

journal_title：British journal of cancer

authors： Awasthi S,Sharma R,Singhal SS,Herzog NK,Chaubey M,Awasthi YC

更新日期：1994-08-01 00:00:00

abstract：:Tissue from 54 histologically-identified basal cell carcinomas of the skin was obtained at surgery and assayed using a combination of functional and immunochemical procedures for matrix metalloproteinases (MMPs) with collagenolytic activity and for MMPs with gelatinolytic activity. Collagenolytic enzymes included MMP-...

journal_title：British journal of cancer

authors： Varani J,Hattori Y,Chi Y,Schmidt T,Perone P,Zeigler ME,Fader DJ,Johnson TM

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Cisplatin-radiotherapy is a preferred standard for locally advanced, head and neck squamous cell carcinoma (HNSCC). However, the cisplatin-attributable survival benefit is small and toxicity substantial. A biomarker of cisplatin resistance could guide treatment selection and spare morbidity. The ERCC1-XPF nu...

journal_title：British journal of cancer

authors： Bauman JE,Austin MC,Schmidt R,Kurland BF,Vaezi A,Hayes DN,Mendez E,Parvathaneni U,Chai X,Sampath S,Martins RG

更新日期：2013-10-15 00:00:00

abstract：:The present study set out to evaluate perceptions of risk, psychological morbidity and health behaviours in women with a family history of breast cancer who have attended genetic counselling and determine how these differ from general population risk women. Data were collected from 62 genetic counselees (cases) attend...

journal_title：British journal of cancer

authors： Lloyd S,Watson M,Waites B,Meyer L,Eeles R,Ebbs S,Tylee A

更新日期：1996-08-01 00:00:00

abstract：:L-Glutamine is a requirement for many cells in tissue culture, an intermediate in many metabolic pathways, and an alternative substrate to glucose for energy metabolism. These properties suggest that glutamine concentration might be a determinant of cell viability in tumours, especially in regions that are deficient i...

journal_title：British journal of cancer

authors： Tannock IF,Steele D,Roberts J

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:The most significant problem of intra-arterial chemotherapy for advanced paranasal sinus carcinomas and residual cancers supplied by internal carotid artery (ICA) and involving the skull base is the lack of salvage therapies. OBJECTIVE:The objective of the study was to evaluate the usefulness of intra-arter...

journal_title：British journal of cancer

authors： Yokoyama J,Ohba S,Fujimaki M,Anzai T,Kojima M,Ikeda K,Suzuki M,Yoshimoto H,Inoue K

更新日期：2014-12-09 00:00:00

abstract：BACKGROUND:We evaluated the performance of primary high-risk human papillomavirus (hrHPV) testing by hybrid capture 2 (HC2) with different thresholds for positivity, in comparison with conventional cytology. METHODS:We used data of 25,871 women (aged 30-60 years) from the intervention group of the VUSA-Screen study (V...

journal_title：British journal of cancer

authors： Rijkaart DC,Coupe VM,van Kemenade FJ,Heideman DA,Hesselink AT,Verweij W,Rozendaal L,Verheijen RH,Snijders PJ,Berkhof J,Meijer CJ

更新日期：2010-09-28 00:00:00

abstract：:A phase I study of the bispecific antibody MDX-H210 in combination with granulocyte colony-stimulating factor (G-CSF) was performed in stage IV breast carcinoma patients, overexpressing HER-2/neu. MDX-H210, constructed by crosslinking antigen binding fragments (F(ab') fragments) of monoclonal antibody (mAb) H22 to Fc ...

journal_title：British journal of cancer

authors： Repp R,van Ojik HH,Valerius T,Groenewegen G,Wieland G,Oetzel C,Stockmeyer B,Becker W,Eisenhut M,Steininger H,Deo YM,Blijham GH,Kalden JR,van de Winkel JG,Gramatzki M

更新日期：2003-12-15 00:00:00