Abstract：
:Based on the evaluation of 362 cases of squamous cell carcinoma of the uterine cervix, the distribution of the tumours in relation to their modified Broders' grade, histological cell type as proposed by Wentz and Reagan, and the clinical stage of disease was evaluated. The morphological characteristics of the 3 cell types-large cell non-keratinizing, keratinizing, and small cell cancers-were described. The 5 year survival in relation to Broders' grade, cell type, extent and DNA values of the malignant cells were evaluated and compared. Broders' grading system was not useful in predicting the biological behaviour of cervical squamous cancer. The histological cell type and extent of the tumour were important factors in prognosis. The 5 year survival for large cell cancer was 51·8%, keratinizing cancer 34·7% and small cell cancer 10·0%. The 5 year survival was 63·3% for stage I neoplasms, 52·9% for stage II neoplasms, 30·7% for stage III neoplasms and 15·0% for stage IV neoplasms. When the DNA values of neoplastic cells were considered in relation to cell type and extent of disease, the biological behaviour of cervical squamous cell cancers was determined more accurately. The 5 year survival of women with cervical cancer in which the DNA values of the neoplastic cells exceeded 155 was more favourable than those with DNA values of less than 155. This difference in 5 year survival was evident for comparable cell type and clinical stage of disease.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Ng AB,Atkin NBdoi
10.1038/bjc.1973.155subject
Has Abstractpub_date
1973-10-01 00:00:00pages
322-31issue
4eissn
0007-0920issn
1532-1827journal_volume
28pub_type
杂志文章abstract：BACKGROUND:Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. METHODS:We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease. RESULTS:A high protein e...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.80
更新日期：2012-04-24 00:00:00
abstract：BACKGROUND:In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of health-related quality of life (HRQOL) from coBRIM is reported. METHODS:Patients completing the Eur...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.2017.488
更新日期：2018-03-20 00:00:00
abstract：:The largest single underlying cause of hepatocellular carcinoma (HCC) worldwide is hepatitis B virus (HBV) infection. Hepatitis B virus increases cellular oxidative stress and the development of HCC occurs after a long latency period. The study was carried out to determine whether mitochondrial DNA abnormalities were ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602496
更新日期：2005-04-11 00:00:00
abstract：BACKGROUND:Health-related quality of life (HRQoL) comprises different domains of physical, mental, and social well-being. In this analysis, we focus on sexual quality of life in Hodgkin Lymphoma (HL) patients. METHODS:Four-thousand one-hundred and sixty patients enroled in the HD10-HD12 trials underwent HRQoL assessme...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.550
更新日期：2013-01-15 00:00:00
abstract：:SR 4233 (3-amino-1,2,4-benzotriazine 1,4-dioxide) is an anti-tumour agent that has a highly selective toxicity to hypoxic cells. In this study we delineate the role of several different bioreductive enzymes in the metabolism of SR 4233 by two tumour cell lines HT 1080 (human fibrosarcoma) and SCCVII (mouse carcinoma)....
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.59
更新日期：1993-02-01 00:00:00
abstract：:An antigen common to human sarcomas, S3, has been further characterized. It is antigenically distinct from human blood-group substances A and B and from heterophile antigens such as Forssman, infectious mononucleosis and serum sickness antigens. Whilst S3 antigen preparations may contain small amounts of CEA and AFP t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.43
更新日期：1981-03-01 00:00:00
abstract：BACKGROUND:The interaction between human prostate cancer (PCa) cells and bone marrow (BM) endothelium follows a rolling-and-adhesion cascade mediated by E-selectin ligand (ESL): E-selectin. This adhesion is enabled by elevated expression of α-1,3-fucosyltransferases (FTs), enzymes responsible for ESL-mediated bone meta...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.690
更新日期：2013-12-10 00:00:00
abstract：:The survival and clonogenic growth (measured in terms of colony forming efficiency (CFE) of intravenously injected (i.v.) Walker (W256) tumour cells in the lungs of rats was greatly enhanced by states of topical and systemic stress induced by the intraperitoneal (i.p.) injection of rats with a single dose of 10(-5)-10...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.7
更新日期：1976-01-01 00:00:00
abstract：:To investigate the efficacy and safety of combining weekly oxaliplatin with weekly 24-h infusion of high-dose 5-fluorouracil (5-FU) and folinic acid (FA) in treatment of patients with advanced gastric cancer. Patients with histologically confirmed, locally advanced or recurrent/metastatic gastric cancer were studied. ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/sj.bjc.6601985
更新日期：2004-08-02 00:00:00
abstract：BACKGROUND:The lipogenic transcription factor carbohydrate response element-binding protein (ChREBP) may play a key role in malignant progression of breast cancer by allowing metabolic adaptations to take place in response to changes in oxygenation. METHODS:Immunohistochemical analysis of ChREBP was carried out in hum...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.765
更新日期：2014-02-04 00:00:00
abstract：:The NCA (nonspecific cross-reacting antigen) was assayed in sera of patients with chronic myeloid leukaemia (CML). It was elevated to a mean value of 145·6 ng/ml (± 104·4 ng/ml) compared to 37·8 ng/ml (± 14·6 ng/ml) the sera of normal subjects. Patients with active disease generally had higher serum NCA levels than th...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.269
更新日期：1982-11-01 00:00:00
abstract：:The aim of this study was to assess the prognostic value of pretreatment clinical and laboratory parameters in refractory or relapsed multiple myeloma (MM) patients who have a long-term response to thalidomide (THAL), lasting at least 18 months. The study was carried out on 234 patients who received THAL for relapsed/...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602225
更新日期：2004-11-29 00:00:00
abstract：:While statins have been highly effective for lowering serum cholesterol and reducing the incidence of coronary events, they have multiple other effects. Certain statins block the interaction of adhesion molecules that are important for cell-cell interactions including those between EBV-transformed B cells. These same ...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6602561
更新日期：2005-05-09 00:00:00
abstract：:Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned. Improved survival has previously been found in patients with expression of HLA-DR antige...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600507
更新日期：2002-09-23 00:00:00
abstract：:Oestrogen receptor protein (ER) was detected in 9 of 11 samples of malignant breast tissue and 8 of 9 samples of normal breast tissue. Levels of cytosolic ER (ERc) in malignant breast were 21-1102 fmol mg-1 soluble protein (Kd 1.8 X 10(-9)-3.1 X 10(-8) mol l-1) and those of nucleosolic ER (ERn), 13-526 fmol mg-1 solub...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.196
更新日期：1986-09-01 00:00:00
abstract：BACKGROUND:The role of telomerase reverse transcriptase (TERT) in gliomagenesis has been recently further strengthened by the frequent occurrence of TERT promoter mutations (TERTp-mut) in gliomas and evidence that the TERT SNP genetic rs2736100 influences glioma risk. TERTp-mut creates a binding site for Ets/TCF transc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.538
更新日期：2014-11-11 00:00:00
abstract：:For the presentation of peptide antigens to cytotoxic CD8+ T lymphocytes of the immune system, the expression of human leukocyte antigen (HLA) class I molecules on the cell surface is necessary. There is increasing evidence that surface HLA class I antigen expression is altered in a variety of human tumours by either ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.472
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:The role of processed meat in the aetiology of several cancers was explored in detail. METHODS:In the time period 1996-2004, a multisite case-control study was conducted in Montevideo, Uruguay. The study included 6 060 participants (3 528 cases and 2 532 controls) corresponding to cancers of the oral cavity...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2012.433
更新日期：2012-10-23 00:00:00
abstract：:Protein kinases play a key role in intracellular signalling, participating at multiple levels along the transduction cascades that trigger mitogenic response. Because protein kinases are involved in mitogenic pathways, they are likely to play a role in the abnormal proliferation of malignant cells. In this study we co...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.675
更新日期：1998-11-01 00:00:00
abstract：:Elderly patients are recommended to have a reduced starting dose (300 mg m(-2) once every 3 weeks) of irinotecan monotherapy. The aims of this analysis are to compare toxicity and survival according to age, performance status (PS), gender and prior radical pelvic radiotherapy (RT). The primary end points were overall ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.bjc.6602169
更新日期：2004-10-18 00:00:00
abstract：:The integrin alpha(v)beta6 is not detectable on normal keratinocytes in vivo but expression is increased significantly in oral squamous cell carcinoma where this heterodimer has been shown to play a role in cell migration, invasion and protease expression. Although regarded initially as a fibronectin receptor, alpha(v...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600545
更新日期：2002-10-07 00:00:00
abstract：:The effect of selected marine compounds with anti-tumoral activity on the cell microtubule network was tested by immunofluorescence analyses, or by other in vitro analyses involving competition with colchicine or with GTP for tubulin binding and tubulin polymerisation, studies that were carried out in parallel with ot...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.176
更新日期：1996-04-01 00:00:00
abstract：:In a study involving 50 breast cancer tumours, we compared two oestrogen receptor (ER) detection methods developed by us--a microplate immunoenzymometric assay (EIA96) and an immunohistochemistry kit (HistoCIS-ER)--with the radioligand assay (RLA), the Abbott immunoenzymometric assay ER-EIA and the reverse transcripta...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.418
更新日期：1997-01-01 00:00:00
abstract：:The establishment and characterisation (morphology, ultrastructure, tumourigenicity) of six cell lines from primary human colorectal adenocarcinomas is described. These lines were established from surgical specimens, from 49 unselected patients, without the use of 'feeder' cells, 'conditioned' medium or passage of cel...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.132
更新日期：1986-06-01 00:00:00
abstract：:The matrix metalloprotease MMP-9 localizes to tumour-associated macrophages in human ovarian cancer but little is known of its regulation. Co-culture of human ovarian cancer cells (PEO-1) and a monocytic cell line (THP-1) led to production of 92-kDa proMMP-9. PEO-1-conditioned medium (CM) also stimulated THP-1 cells o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.568
更新日期：1998-09-01 00:00:00
abstract：:Photodynamic therapy (PDT) is a form of cancer treatment based on the destruction of cells by the interaction of light, oxygen and a photosensitizer. Aminolaevulinic acid (ALA) is the prodrug of the photosensitizer protoporphyrin IX (PpIX). ALA-induced PDT depends on the rate of cellular synthesis of PpIX, which may v...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.441
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:Therapies targeting ERBB2 have shown success in the clinic. However, response is not determined solely by expression of ERBB2. Levels of ERBB3, its preferred heterodimerisation partner and ERBB ligands may also have a role. METHODS:We measured NRG1 expression by real-time quantitative RT-PCR and ERBB recept...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.39
更新日期：2011-03-29 00:00:00
abstract：:Selection of patients for randomised clinical trials may have a large impact on the applicability of the study results to the general population presenting the same disorder. However, clinical characteristics and outcome data on non-entered patients are usually not available. The effects of patient selection for the E...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.bjc.6600514
更新日期：2002-09-09 00:00:00
abstract：:This corrects the article DOI: 10.1038/bjc.2017.327. ...
journal_title：British journal of cancer
pub_type： 杂志文章,已发布勘误
doi：10.1038/bjc.2017.438
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:We conducted a multicentre feasibility study for single agent long-term S-1 chemotherapy following docetaxel plus cisplatin in patients with curatively resected stage II-IIIA non-small cell lung cancer. METHODS:Patients received three cycles of docetaxel (60 mg m(-2)) plus cisplatin (80 mg m(-2)) and then r...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/bjc.2013.378
更新日期：2013-08-06 00:00:00
