Role of carbohydrate response element-binding protein (ChREBP) in generating an aerobic metabolic phenotype and in breast cancer progression.

abstract：:We have established a novel ascites tumour model (MDA435/LCC6) from the oestrogen receptor-negative, invasive and metastatic MDA-MB-435 human breast cancer cell line. MDA435/LCC6 cells grow as both malignant ascites and solid tumours in vivo in nude mice and nude rats, with a tumour incidence of approximately 100%. Un...

journal_title：British journal of cancer

authors： Leonessa F,Green D,Licht T,Wright A,Wingate-Legette K,Lippman J,Gottesman MM,Clarke R

更新日期：1996-01-01 00:00:00

abstract：:Counter-irritation (CI) triggered by different non-specific irritant stimuli delayed the growth of a murine tumour of non-detected immunogenicity. The syngeneic LB tumour transplant by itself also induced CI and decreased the number of leukocytes migrating to a secondary s.c. irritant stimulus, e.g. sponge or carragee...

journal_title：British journal of cancer

authors： Sordelli DO,Fontán PA,Meiss RP,Ruggiero RA,Bustuoabad OD

更新日期：1989-11-01 00:00:00

abstract：:Bispecific antibodies (bsAb) are considered as promising tools for the elimination of disseminated tumour cells in a minimal residual disease situation. The bsAb-mediated recruitment of an immune effector cell in close vicinity of a tumour cell is thought to induce an antitumoural immune response. However, classical b...

journal_title：British journal of cancer

authors： Zeidler R,Mysliwietz J,Csánady M,Walz A,Ziegler I,Schmitt B,Wollenberg B,Lindhofer H

更新日期：2000-07-01 00:00:00

abstract：:Double stranded RNA (dsRNA) whether isolated from a fungal virus or prepared synthetically (i.e., Poly I Poly C) and endotoxin were found to exert very similar effects on syngeneic murine lymphomata and fibrosarcomata. They cause complete regressions of some established subcutaneous (s.c.) or intradermal (i.d.) tumour...

journal_title：British journal of cancer

authors： Parr I,Wheeler E,Alexander P

更新日期：1973-05-01 00:00:00

abstract：BACKGROUND:Several tyrosine kinase inhibitors (TKIs) can decrease docetaxel clearance in patients by an unknown mechanism. We hypothesised that these interactions are mediated by the hepatic uptake transporter OATP1B1. METHODS:The influence of 16 approved TKIs on transport was studied in vitro using HEK293 cells expre...

journal_title：British journal of cancer

authors： Hu S,Mathijssen RH,de Bruijn P,Baker SD,Sparreboom A

更新日期：2014-02-18 00:00:00

abstract：:Increases of individual beta tubulin isotypes in antimicrotubule drug resistant cell lines have been reported by several laboratories. We have previously described elevations in beta(III)and beta(IVa)isotypes in estramustine and paclitaxel resistant human prostate carcinoma cells. To investigate further the function o...

journal_title：British journal of cancer

authors： Ranganathan S,McCauley RA,Dexter DW,Hudes GR

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:This phase 1 study evaluated the maximum tolerated dose (MTD), safety, and efficacy of bosutinib (competitive Src/Abl tyrosine kinase inhibitor) plus capecitabine. METHODS:Patients with locally advanced/metastatic breast, pancreatic, or colorectal cancers; cholangiocarcinoma; or glioblastoma received bosuti...

journal_title：British journal of cancer

authors： Isakoff SJ,Wang D,Campone M,Calles A,Leip E,Turnbull K,Bardy-Bouxin N,Duvillié L,Calvo E

更新日期：2014-11-25 00:00:00

abstract：:The objective of this study was to document the occurrence and to correlate the prevalence of different human papillomavirus (HPV) types with the cytological results on simultaneously performed thin-layer preparations in a large population of Flemish women. During 1 year, 69 290 thin-layer preparations were interprete...

journal_title：British journal of cancer

authors： Depuydt CE,Vereecken AJ,Salembier GM,Vanbrabant AS,Boels LA,van Herck E,Arbyn M,Segers K,Bogers JJ

更新日期：2003-02-24 00:00:00

abstract：:2-Amino-3,4-dihydro-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride (nolatrexed dihydrochloride, Thymitaq, AG337), a specific inhibitor of thymidylate synthase, was developed using protein structure-based drug design. Intravenously administered nolatrexed is active clinically. As oral bioavailability is h...

journal_title：British journal of cancer

authors： Jodrell DI,Bowman A,Rye R,Byrne B,Boddy A,Rafi I,Taylor GA,Johnston A,Clendeninn NJ

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of B100 common, low-penetrance PrCa susceptibility variants identified so far by genome-wid...

journal_title：British journal of cancer

authors： Saunders EJ,Dadaev T,Leongamornlert DA,Al Olama AA,Benlloch S,Giles GG,Wiklund F,Gronberg H,Haiman CA,Schleutker J,Nordestgaard BG,Travis RC,Neal D,Pasayan N,Khaw KT,Stanford JL,Blot WJ,Thibodeau SN,Maier C,Kibel AS

更新日期：2016-04-12 00:00:00

abstract：:Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology, accurate detection of hypoxia is important, as it impacts on prognosis and could influence treatment planning. A variet...

journal_title：British journal of cancer

authors： Fleming IN,Manavaki R,Blower PJ,West C,Williams KJ,Harris AL,Domarkas J,Lord S,Baldry C,Gilbert FJ

更新日期：2015-01-20 00:00:00

abstract：:The efficacy of cisplatin [cis-diamminedichloroplatinum (II); DDP] is hampered by acquired or de novo resistance of malignant cells to its cytotoxic effects. We have previously reported that cisplatin resistance parallels glutathione S-transferase (GST) activity in several human small-cell lung cancer cell lines. In t...

journal_title：British journal of cancer

authors： Awasthi S,Sharma R,Singhal SS,Herzog NK,Chaubey M,Awasthi YC

更新日期：1994-08-01 00:00:00

abstract：:The GER human pancreatic carcinoma cell line possesses receptors for 1,25-dihydroxyvitamin D3. We report that the vitamin D analogue EB 1089 inhibits the growth of these cells in vitro and when grown as tumour xenografts in immunodeficient mice. Tumour-bearing mice were given EB 1089 at a dose of 5 microg kg(-1) body ...

journal_title：British journal of cancer

authors： Colston KW,James SY,Ofori-Kuragu EA,Binderup L,Grant AG

更新日期：1997-01-01 00:00:00

abstract：:We reviewed 134 patients with breast cancer (screen detected = 85, interval = 49) who had been reported as negative at previous mammographic screening in the Florence District Programme. At prior mammograms review, 12% of the cases were classified as 'screening error' (suspicious signs missed owing to misperception or...

journal_title：British journal of cancer

authors： Ciatto S,Rosselli Del Turco M,Zappa M

更新日期：1995-02-01 00:00:00

abstract：:Cell line studies demonstrate that the PI3K/Akt pathway is upregulated in hormone-refractory prostate cancer (HRPC) and can result in phosphorylation of the androgen receptor (AR). The current study therefore aims to establish if this has relevance to the development of clinical HRPC. Immunohistochemistry was employed...

journal_title：British journal of cancer

authors： McCall P,Gemmell LK,Mukherjee R,Bartlett JM,Edwards J

更新日期：2008-03-25 00:00:00

abstract：BACKGROUND:Placental-site trophoblastic (PSTT) and epithelioid trophoblastic tumours (ETT) are the rarest malignant forms of gestational trophoblastic disease (GTD). Our prior work demonstrated that an interval of ≥48 months from the antecedent pregnancy was associated with 100% death rate, independent of the stage. He...

journal_title：British journal of cancer

authors： Froeling FEM,Ramaswami R,Papanastasopoulos P,Kaur B,Sebire NJ,Short D,Fisher RA,Sarwar N,Wells M,Singh K,Ellis L,Horsman JM,Winter MC,Tidy J,Hancock BW,Seckl MJ

更新日期：2019-03-01 00:00:00

abstract：:We analysed 29 consecutive cases of primary gastric lymphoma (20 men and 9 women) treated in our unit between January 1977 and May 1983. Median age was 55 years. Abdominal pain and weight loss were the main presenting symptoms while there was no palpable disease in the majority of cases. Upper gastrointestinal radiolo...

journal_title：British journal of cancer

authors： Economopoulos T,Alexopoulos C,Stathakis N,Styloyannis S,Dervenoulas J,Tsousis S,Raptis S

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:A remarkably better prognosis is associated with oropharyngeal squamous cell carcinomas (OPSCC) driven by human papillomaviruses (HPV) compared with HPV-negative OPSCC. Consequently, de-escalation of standard treatment has been suggested. Due to modest specificity rates, debates are ongoing, whether p16INK4a...

journal_title：British journal of cancer

authors： Wagner S,Prigge ES,Wuerdemann N,Reder H,Bushnak A,Sharma SJ,Obermueller T,von Knebel Doeberitz M,Dreyer T,Gattenlöhner S,Wolf G,Pons-Kühnemann J,Wittekindt C,Klussmann JP

更新日期：2020-09-01 00:00:00

abstract：:Hepatic infiltration by lymphoma can be difficult to detect by conventional methods. We have studied 22 patients in vivo 31P magnetic resonance spectroscopy of the liver and compared the results with the clinical staging and assessment of liver involvement by computed tomography (CT), ultrasound (US), and liver functi...

journal_title：British journal of cancer

authors： Dixon RM,Angus PW,Rajagopalan B,Radda GK

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Recent studies have indicated the prognostic value of tumour subtype and pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). However these results were reported after a short follow-up and using a standard Cox model which could be unsatisfactory for time-dependent factors. In the prese...

journal_title：British journal of cancer

authors： Baulies S,Belin L,Mallon P,Senechal C,Pierga JY,Cottu P,Sablin MP,Sastre X,Asselain B,Rouzier R,Reyal F

更新日期：2015-06-30 00:00:00

abstract：:The evidence base for head and neck cancers is low with relatively few randomized controlled trials of the two main treatments, surgery and radiotherapy. The aim of the study was to investigate the patterns of surgery and radiotherapy treatment for head and neck cancers in three large areas of England and to investiga...

journal_title：British journal of cancer

authors： Edwards DM,Johnson NW

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Although mortality rates are elevated in psychiatric patients relative to their healthy counterparts, little is known about the impact of mental health on survival in people with cancer. METHODS AND RESULTS:Among 16 498 Swedish men with cancer, survival was worse in those with a history of psychiatric hospi...

journal_title：British journal of cancer

authors： Batty GD,Whitley E,Gale CR,Osborn D,Tynelius P,Rasmussen F

更新日期：2012-05-22 00:00:00

abstract：BACKGROUND:We conducted a multicentre feasibility study for single agent long-term S-1 chemotherapy following docetaxel plus cisplatin in patients with curatively resected stage II-IIIA non-small cell lung cancer. METHODS:Patients received three cycles of docetaxel (60 mg m(-2)) plus cisplatin (80 mg m(-2)) and then r...

journal_title：British journal of cancer

authors： Niho S,Ikeda N,Michimae H,Suzuki K,Sakai H,Kaburagi T,Minato K,Kato T,Okamoto H,Seto T,Hosomi Y,Shimizu K,Oshita F,Kunitoh H,Tsuboi M,Takeuchi M,Watanabe K

更新日期：2013-08-06 00:00:00

abstract：BACKGROUND:Low cancer awareness contributes to delay in presentation for cancer symptoms and may lead to delay in cancer diagnosis. The aim of this study was to review the evidence for the effectiveness of interventions to raise cancer awareness and promote early presentation in cancer to inform policy and future resea...

journal_title：British journal of cancer

authors： Austoker J,Bankhead C,Forbes LJ,Atkins L,Martin F,Robb K,Wardle J,Ramirez AJ

更新日期：2009-12-03 00:00:00

abstract：:The relationship between fetal growth as indicated by weight and length at birth, and cancer risk in 1080 adult Swedish women was examined. Birth factors were retrieved from original midwife records for the years 1914, 1918, 1922 and 1930, and primary cancer cases were identified by matching with national and regional...

journal_title：British journal of cancer

authors： Andersson SW,Bengtsson C,Hallberg L,Lapidus L,Niklasson A,Wallgren A,Hulthén L

更新日期：2001-05-04 00:00:00

abstract：:The secosteroid hormones, all-trans- and 9-cis-retinoic acid and vitamin D3, have demonstrated significant capacity to control proliferation in vitro of many solid tumour cell lines. Cooperative synergistic effects by these two ligands have been reported, and it is, therefore, possible that greater therapeutic effects...

journal_title：British journal of cancer

authors： Campbell MJ,Park S,Uskokovic MR,Dawson MI,Jong L,Koeffler HP

更新日期：1999-01-01 00:00:00

abstract：:The relationship of cytogenetic changes with the acquisition of an indefinite life span in vitro, the ability of cells to grow in soft agar and their tumourigenicity in syngeneic animals has been studied in control, trans-7,8-dihydrodiolbenzo(a)pyrene and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrah...

journal_title：British journal of cancer

authors： Connell JR

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:In neuroblastoma (NB), the most powerful prognostic marker, the MYCN amplification (MNA), occasionally shows intratumoural heterogeneity (ITH), i.e. coexistence of MYCN-amplified and non-MYCN-amplified tumour cell clones, called heterogeneous MNA (hetMNA). Prognostication and therapy allocation are still uns...

journal_title：British journal of cancer

authors： Berbegall AP,Bogen D,Pötschger U,Beiske K,Bown N,Combaret V,Defferrari R,Jeison M,Mazzocco K,Varesio L,Vicha A,Ash S,Castel V,Coze C,Ladenstein R,Owens C,Papadakis V,Ruud E,Amann G,Sementa AR,Navarro S,Ambros PF

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Evasion of apoptosis contributes to the pathogenesis of solid tumours including non-small cell lung cancer (NSCLC). Malignant cells resist apoptosis through over-expression of inhibitor of apoptosis proteins (IAPs), such as X-linked IAP (XIAP). METHODS:A phenylurea-based small molecule inhibitor of XIAP, XI...

journal_title：British journal of cancer

authors： Dean EJ,Ward T,Pinilla C,Houghten R,Welsh K,Makin G,Ranson M,Dive C

更新日期：2010-01-05 00:00:00

abstract：:Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation of premalignant cells. However, several lines of evidence show that senescent cells, which often persist in vivo, can also promote tumour progression in addition to other age-related pathologies via the senescence-associ...

journal_title：British journal of cancer

authors： Lecot P,Alimirah F,Desprez PY,Campisi J,Wiley C

更新日期：2016-05-24 00:00:00