Abstract：
BACKGROUND:Although mortality rates are elevated in psychiatric patients relative to their healthy counterparts, little is known about the impact of mental health on survival in people with cancer. METHODS AND RESULTS:Among 16 498 Swedish men with cancer, survival was worse in those with a history of psychiatric hospital admissions: multiply-adjusted hazard ratio (95% confidence interval) comparing cancer mortality in men with and without psychiatric admissions: 1.59 (1.39, 1.83). CONCLUSION:Survival in cancer patients is worse among those with a history of psychiatric disease. The mechanisms underlying this association should be further explored.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Batty GD,Whitley E,Gale CR,Osborn D,Tynelius P,Rasmussen Fdoi
10.1038/bjc.2012.150subject
Has Abstractpub_date
2012-05-22 00:00:00pages
1842-5issue
11eissn
0007-0920issn
1532-1827pii
bjc2012150journal_volume
106pub_type
杂志文章abstract：:Thymidine incorporation in vitro by remission lymphocytes from a total of 6 patients with acute myeloid leukaemia (AML) was measured following stimulation by autochthonous and allogeneic AML blasts and cell lines. The early peak response to autochthonous blasts in 2 of these patients (48-72 h) is consistent with the c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.81
更新日期：1976-05-01 00:00:00
abstract：:Extramammary Paget's disease is a particular form of skin cancer of unknown histogenesis. To look for the genetic defects underlying the pathogenesis of this tumour, we have examined loss of heterozygosity (LOH), p53 and human papillomavirus (HPV) status, and the expression of c-erbB-2 and bcl-2 proteins in 14 cases. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.482
更新日期：1997-01-01 00:00:00
abstract：:Cytotoxic antibodies to antigens specific for leukaemic myeloblasts have been sought in the serum of patients with acute myeloblastic leukaemia treated by immunotherapy with irradiated allogeneic myeloblasts and BCG. Assays of complement- and K-cell-mediated activity were used. Cytotoxicity to allogeneic myeloblasts w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.40
更新日期：1977-03-01 00:00:00
abstract：:Serum concentrations of oestradiol-17β were measured by radio-immunoassay during 40 menstrual cycles from 38 normal premenopausal women. Repeated samples were studied from 25 normal postmenopausal women. The method was highly specific and extremely sensitive. In premenopausal women the pattern of serum oestradiol-17β ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.98
更新日期：1974-06-01 00:00:00
abstract：:Trastuzumab has significantly improved the overall survival of patients with HER2+ metastatic breast cancer (MBC). However, outcomes can vary, with patients progressing within 1 year of treatment or exceptional cases of complete response to trastuzumab for ≥10 years. Identification of the underlying genomic aberration...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0999-z
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Renal cell carcinoma (RCC) is highly resistant to chemotherapy because of a high apoptotic threshold. Recent evidences suggest that GSK-3beta positively regulates human pancreatic cancer and leukaemia cell survival in part through regulation of nuclear factor (NF-kappaB)-mediated expression of anti-apoptotic...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605437
更新日期：2009-12-15 00:00:00
abstract：BACKGROUND:The vascular disrupting agent ombrabulin shows synergy with docetaxel in vivo. Recommended phase II doses were determined in a dose escalation study in advanced solid tumours. METHODS:Ombrabulin (30-min infusion, day 1) followed by docetaxel (1-h infusion, day 2) every 3 weeks was explored. Ombrabulin was e...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.137
更新日期：2014-04-29 00:00:00
abstract：BACKGROUND:The urokinase plasminogen activator (uPA) system is one of the best-investigated protease systems, both under physiological and pathological conditions, including various types of cancer. However, effects of co-expression of members of the uPA system in soft-tissue sarcoma (STS) patients at the protein level...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605520
更新日期：2010-02-16 00:00:00
abstract：:Mechanisms of resistance to Tomudex include increased thymidylate synthase activity, as well as reduced intracellular drug uptake and polyglutamation. However, little is known about other mechanisms of resistance, such as a possible protection against Tomudex-induced apoptosis mediated by bcl-2. We transfected the MDA...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690685
更新日期：1999-09-01 00:00:00
abstract：:Teratomas have been induced in Japanese quail (Coturnix coturnix Japonica) by intra-testicular injections of 3% zinc chloride solution during a period of testicular growth artificially stimulated by increased photoperiod. These tumours resemble those previously induced by similar methods in domestic fow1 and have hist...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1971.40
更新日期：1971-06-01 00:00:00
abstract：:Tumour angiogenesis is essential for progression of solid tumours and constitutes an interesting target for therapy. However, impaired tumour blood supply may also be an important obstacle for treatment by radiotherapy and chemotherapy. Estramustine has been shown to increase tumour blood flow and potentiate the effec...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690333
更新日期：1999-04-01 00:00:00
abstract：:Van Trommel et al have previously shown that serum human chorionic gonadotropin (hCG) cutoff levels can provide early prediction of resistance to first-line methotrexate (MTX) in patients with persistent trophoblastic disease (PTD). In this study, we validate this approach of prediction of resistance to single-agent c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604849
更新日期：2009-03-24 00:00:00
abstract：:The molecular events that drive the initiation and progression of ovarian adenocarcinoma are not well defined. We have investigated changes in gene expression in ovarian cancer cell lines compared to an immortalized human ovarian surface epithelial cell line (HOSE) using a cDNA array. We identified 17 genes that were ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1620
更新日期：2001-02-02 00:00:00
abstract：:A late-gestation neonatal antigen (gamma foetal antigen; gamma-FA) immunologically and biochemically unrelated to murine alpha-foetoprotein, was identified in several spontaneous and carcinogen-induced sarcomas and hepatic carcinomas of the mouse and rat. An approximate mol. wt of 35,000 for gamma-FA from both foetus ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.173
更新日期：1979-08-01 00:00:00
abstract：:Dendritic cells (DC) are professional antigen-presenting cells (APC) of the immune system, uniquely able to prime naive T-cell responses. They are the focus of a range of novel strategies for the immunotherapy of cancer, a proportion of which include treating DC with ionising radiation to high dose. The effects of rad...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602518
更新日期：2005-04-25 00:00:00
abstract：:Oestrogen (RE) and progesterone (RP) cytosolic receptors have been studied in 59 clinically inflammatory tumours of the human breast. The results were compared to those obtained in a series of 496 operable tumours. A single saturating dose of oestradiol for RE and R 5020 for RP was used and the cut-off between negativ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.291
更新日期：1981-12-01 00:00:00
abstract：:Cyclooxygenase-2 (COX-2) is overexpressed in several epithelial tumours, including breast cancer. Cyclooxygenase-2-positive tumours tend to be larger, higher grade, node-positive and HER-2/neu-positive. High COX-2 expression is associated with poor prognosis. Cyclooxygenase-2 inhibition reduces the incidence of tumour...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6602690
更新日期：2005-08-01 00:00:00
abstract：:The 5T4 oncofetal antigen is a 72 kDa glycoprotein defined by a monoclonal antibody raised against human placental trophoblast and is expressed in many different carcinomas but detected only at low levels in some normal epithelia. Immunohistochemical analysis of the patterns of expression in colorectal carcinomas has ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.173
更新日期：1994-05-01 00:00:00
abstract：:Vascular endothelial growth factor is an important angiogenic factor for tumour progression because it increases endothelial-cell proliferation and remodels extracellular matrix in blood vessels. We demonstrated that hyperthermia at 42 degrees C, termed heat shock, suppressed the gene expression and production of vasc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600268
更新日期：2002-05-20 00:00:00
abstract：BACKGROUND:Evidence suggests that dysregulation of energy-sensing pathways closely associates with renal cell carcinoma (RCC) development. The metabolic regulation is largely controlled by 5'-AMP activated protein kinase (AMPK) which is activated through phosphorylation by LKB1. METHODS:The expression of LKB1 was dete...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.574
更新日期：2013-02-05 00:00:00
abstract：BACKGROUND:Robot-assisted radical prostatectomy (RARP) has been rapidly adopted without robust evidence comparing its functional outcomes against laparoscopic radical prostatectomy (LRP) or open retropubic radical prostatectomy (ORP) approaches. This study compared patient-reported functional outcomes following RARP, L...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.454
更新日期：2018-02-20 00:00:00
abstract：BACKGROUND:Childhood cancer survivors can experience learning problems resulting in lower-than-expected attained education as adults. It is unclear whether learning problems manifest already during adolescence. METHODS:We analysed nationwide Danish registries on school grades for Danish children during 2001-2014. Appl...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.438
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:The co-chaperone protein Bcl-2-associated athanogene-1 (BAG-1) is overexpressed in breast cancer and has been incorporated in the oncotype DX and PAM50 breast cancer prognostic assays. Bcl-2-associated athanogene-1 exists as multiple protein isoforms that interact with diverse partners, including chaperones ...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析,评审
doi：10.1038/bjc.2017.130
更新日期：2017-06-06 00:00:00
abstract：BACKGROUND:A decade ago it was reported that childhood cancer incidence was higher in boys than girls in many countries, particularly those with low gross domestic product (GDP) and high infant mortality rate. Research suggests that socio-economic and cultural factors are likely to be responsible. This study aimed to i...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.191
更新日期：2012-06-26 00:00:00
abstract：:Records of approximately 310,000 patients admitted to the 10 hospitals in Botswana between 1960 and 1972 have been studied and details of 1445 patients with malignant tumours abstracted. For the 894 tumours for which there was some supporting evidence--at best histological proof and minimally a clinical description of...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1975.138
更新日期：1975-07-01 00:00:00
abstract：:Studies in animal models of mouse mammary carcinoma have shown that ovine submaxillary mucin, which carries multiple sialyl-Tn (STn) epitopes, is effective in stimulating an immune response and inhibiting tumour growth. In similar studies using carbohydrate antigens, pretreatment with low-dose cyclophosphamide has bee...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1996.532
更新日期：1996-10-01 00:00:00
abstract：:Melanoma is one of the most aggressive types of cancer and resection of the tumour prior to dissemination of tumour cells is still the most effective treatment. Therefore, early diagnosis of melanocytic lesions is important and identification of novel (molecular) markers would be helpful to improve diagnosis. Moreover...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602612
更新日期：2005-06-20 00:00:00
abstract：BACKGROUND:There are phase 3 clinical trials underway evaluating anti-PD-L1 antibodies as adjuvant (postoperative) monotherapies for resectable renal cell carcinoma (RCC) and triple-negative breast cancer (TNBC); in combination with antiangiogenic VEGF/VEGFR2 inhibitors (e.g., bevacizumab and sunitinib) for metastatic ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0297-1
更新日期：2019-01-01 00:00:00
abstract：:Incidence and mortality data, stage of disease and treatment information for female breast cancer were obtained for the years 1975-1999 for the former Yorkshire Regional Health Authority area, from the Northern and Yorkshire Cancer Registry and Information Service. Deaths by age group and 3-year calendar period were s...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601614
更新日期：2004-02-09 00:00:00
abstract：:We evaluated the therapeutic usefulness of adjuvant chemotherapy in patients with completely resected non-small cell lung cancer (NSCLC). We also examined the relation between DNA ploidy pattern and the response to chemotherapy. A total of 267 patients with NSCLC (pathologically documented stage I, II, or IIIA) underw...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.bjc.6603336
更新日期：2006-10-09 00:00:00
