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Cancer incidence and mortality in patients with insulin-treated diabetes: a UK cohort study.

Abstract：

:Raised risks of several cancers have been found in patients with type II diabetes, but there are few data on cancer risk in type I diabetes. We conducted a cohort study of 28 900 UK patients with insulin-treated diabetes followed for 520 517 person-years, and compared their cancer incidence and mortality with national expectations. To analyse by diabetes type, we examined risks separately in 23 834 patients diagnosed with diabetes under the age of 30 years, who will almost all have had type I diabetes, and 5066 patients diagnosed at ages 30-49 years, who probably mainly had type II. Relative risks of cancer overall were close to unity, but ovarian cancer risk was highly significantly raised in patients with diabetes diagnosed under age 30 years (standardised incidence ratio (SIR)=2.14; 95% confidence interval (CI) 1.22-3.48; standardised mortality ratio (SMR)=2.90; 95% CI 1.45-5.19), with greatest risks for those with diabetes diagnosed at ages 10-19 years. Risks of cancer at other major sites were not substantially raised for type I patients. The excesses of obesity- and alcohol-related cancers in type II diabetes may be due to confounding rather than diabetes per se.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Swerdlow AJ,Laing SP,Qiao Z,Slater SD,Burden AC,Botha JL,Waugh NR,Morris AD,Gatling W,Gale EA,Patterson CC,Keen H

doi

10.1038/sj.bjc.6602611

subject

Has Abstract

pub_date

2005-06-06 00:00:00

pages

2070-5

issue

11

eissn

0007-0920

issn

1532-1827

pii

6602611

journal_volume

92

pub_type

杂志文章

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