当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Mutation analysis of the MSMB gene in familial prostate cancer.

Mutation analysis of the MSMB gene in familial prostate cancer.

Abstract：

BACKGROUND:MSMB, a gene coding for beta-microseminoprotein, has been identified as a candidate susceptibility gene for prostate cancer (PrCa) in two genome-wide association studies (GWAS). SNP rs10993994 is 2 bp upstream of the transcription initiation site of MSMB and was identified as an associated PrCa risk variant. The MSMB protein is underexpressed in PrCa and it was previously proposed to be an independent marker for the recurrence of cancer after radical prostatectomy. METHODS:In this study, the coding region of this gene and 1500 bp upstream of the 5'UTR has been sequenced in germline DNA in 192 PrCa patients with family history. To evaluate the possible effects of these variants we used in silico analysis. RESULTS:No deleterious mutations were identified, however, nine new sequence variants were found, most of these in the promoter and 5'UTR region. In silico analysis suggests that four of these SNPs are likely to have some effect on gene expression either by affecting ubiquitous or prostate-specific transcription factor (TF)-binding sites or modifying splicing efficiency. INTERPRETATION:We conclude that MSMB is unlikely to be a familial PrCa gene and propose that the high-risk alleles of the SNPs in the 5'UTR effect PrCa risk by modifying MSMB gene expression in response to hormones in a tissue-specific manner.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Kote-Jarai Z,Leongamornlert D,Tymrakiewicz M,Field H,Guy M,Al Olama AA,Morrison J,O'Brien L,Wilkinson R,Hall A,Sawyer E,Muir K,Hamdy F,Donovan J,Neal D,Easton D,Eeles R

doi

10.1038/sj.bjc.6605485

subject

Has Abstract

pub_date

2010-01-19 00:00:00

pages

414-8

issue

2

eissn

0007-0920

issn

1532-1827

pii

6605485

journal_volume

102

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Effect of glucose transport inhibitors on vincristine efflux in multidrug-resistant murine erythroleukaemia cells overexpressing the multidrug resistance-associated protein (MRP) and two glucose transport proteins, GLUT1 and GLUT3.

    abstract：:The relationship between mammalian facilitative glucose transport proteins (GLUT) and multidrug resistance was examined in two vincristine (VCR)-selected murine erythroleukaemia (MEL) PC4 cell lines. GLUT proteins, GLUT1 and GLUT3, were constitutively coexpressed in the parental cell line and also in the VCR-selected ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.27

    authors： Martell RL,Slapak CA,Levy SB

    更新日期：1997-01-01 00:00:00

  • The intramuscular administration of granulocyte colony-stimulating factor as an adjunct to chemotherapy in pretreated ovarian cancer patients: an Italian Trials in Medical Oncology (ITMO) Group pilot study.

    abstract：:No published data are available concerning the activity and tolerability of intramuscularly administered granulocyte colony-stimulating factor (G-CSF) in humans. To fill this gap, 19 patients with advanced ovarian cancer previously treated with at least one first-line chemotherapy cycle received the following myelosup...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/bjc.1994.186

    authors： Di Leo A,Bajetta E,Nolè F,Biganzoli L,Ferrari L,Oriana S,Riboldi G,Bohm S,Spatti G,Raspagliesi F

    更新日期：1994-05-01 00:00:00

  • p53 immunohistochemistry as an independent prognostic factor for superficial transitional cell carcinoma of the bladder.

    abstract：:Although patients with superficial bladder cancer (Ta, T1) have a generally good prognosis, those patients who develop muscle-invasive tumours or metastatic disease at recurrence do poorly clinically. In the current study 69 patients undergoing complete transurethral resection for superficial transitional cell cancer ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.41

    authors： Serth J,Kuczyk MA,Bokemeyer C,Hervatin C,Nafe R,Tan HK,Jonas U

    更新日期：1995-01-01 00:00:00

  • Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer.

    abstract：:Microsatellite instability is present in over 80% of the hereditary non-polyposis colorectal carcinoma and about 15-20% of the sporadic cancer. Microsatellite instability is caused by the inactivation of the mismatch repair genes, such as primarily hMLH1, hMSH2. To study the mechanisms of the inactivation of mismatch ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600148

    authors： Deng G,Peng E,Gum J,Terdiman J,Sleisenger M,Kim YS

    更新日期：2002-02-12 00:00:00

  • Breast cancer risk among first-generation migrants in the Netherlands.

    abstract：:We investigated breast cancer incidence in migrants in the Netherlands in 1988-1998. The standardised incidence ratio for breast cancer in Northwest-Netherlands was statistically significantly reduced for women born in Surinam (0.56), Turkey (0.29) and Morocco (0.22). The proportion of women with advanced stages (III ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601821

    authors： Visser O,van der Kooy K,van Peppen AM,Ory FG,van Leeuwen FE

    更新日期：2004-06-01 00:00:00

  • Intake of wholegrain products and risk of colorectal cancers in the Diet, Cancer and Health cohort study.

    abstract：BACKGROUND:Consumption of wholegrain (WG) products may protect against colon and rectal cancer. METHODS:The associations between total and individual WG product consumption and colon and rectal cancer risk were prospectively examined using data on 461 incident cases of colon cancer and 283 incident cases of rectal can...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605806

    authors： Egeberg R,Olsen A,Loft S,Christensen J,Johnsen NF,Overvad K,Tjønneland A

    更新日期：2010-08-24 00:00:00

  • Prognostic significance of Bcl-xL expression and efficacy of Bcl-xL targeting therapy in urothelial carcinoma.

    abstract：BACKGROUND:Bcl-xL has an important role in the control of cell death through its inhibition of apoptosis. The aim of this study was to investigate the clinicopathological significance of Bcl-xL in upper urinary tract urothelial carcinoma (UTUC) and the therapeutic effect of targeting Bcl-xL protein in urothelial carcin...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.216

    authors： Yoshimine S,Kikuchi E,Kosaka T,Mikami S,Miyajima A,Okada Y,Oya M

    更新日期：2013-06-11 00:00:00

  • Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer.

    abstract：BACKGROUND:Several recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in the plasma/serum. We hypothesised that miR-18a in the plasma is a potential biomarker in patients with pancreatic cancer. METHODS:miR-18a is located in the miR-17-92 cluster and reported to be highly expressed in pancr...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.453

    authors： Morimura R,Komatsu S,Ichikawa D,Takeshita H,Tsujiura M,Nagata H,Konishi H,Shiozaki A,Ikoma H,Okamoto K,Ochiai T,Taniguchi H,Otsuji E

    更新日期：2011-11-22 00:00:00

  • Case-control study: soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols.

    abstract：:In 1977 a number of patients with soft-tissue sarcomas and previous exposure to phenoxyacetic acids were described. Following from these observations a matched case-control study was made. Exposure to chlorophenols was also included in this study. The results showed that exposure to phenoxyacetic acids or chlorophenol...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1979.125

    authors： Hardell L,Sandström A

    更新日期：1979-06-01 00:00:00

  • Mortality and incidence of second cancers following treatment for testicular cancer.

    abstract：:We studied 5555 seminoma patients and 3733 patients with nonseminomatous testicular cancers diagnosed in Southeast England between 1960 and 2004. For both groups survival improved over time: 10-year relative survival increased from 78% in 1960-1969 to 99% in 1990-2004 for seminomas, and from 55 to 95% for nonseminomas...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603589

    authors： Robinson D,Møller H,Horwich A

    更新日期：2007-02-12 00:00:00

  • Multicentre phase II trial of trastuzumab and capecitabine in patients with HER2 overexpressing metastatic pancreatic cancer.

    abstract：BACKGROUND:New therapeutic options for metastatic pancreatic cancer are urgently needed. In pancreatic cancer, overexpression of the epidermal growth factor receptor 2 (HER2) has been reported in up to 45%. This multicentre phase II study investigated the efficacy and toxicity of the HER2 antibody trastuzumab combined ...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1038/bjc.2012.18

    authors： Harder J,Ihorst G,Heinemann V,Hofheinz R,Moehler M,Buechler P,Kloeppel G,Röcken C,Bitzer M,Boeck S,Endlicher E,Reinacher-Schick A,Schmoor C,Geissler M

    更新日期：2012-03-13 00:00:00

  • Allostimulation of patients' lymphocytes generates both T and NK-like cells cytotoxic for autologous melanoma.

    abstract：:Killing of autologous melanoma (auto-Me) was obtained with pooled allostimulated peripheral blood lymphocytes (PBL) in 34/42 cases and found not to be due to a cross-reactivity between melanoma and allogeneic normal antigens. To see whether generation of tumour cytotoxic PBL by allostimulation was due to release of IL...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1985.151

    authors： Balsari A,Fossati G,Taramelli D,Tona G,Delia D,Giardini R,Parmiani G

    更新日期：1985-07-01 00:00:00

  • Antitumour activity of adenovirus-12 structural proteins against Moloney sarcoma tumours in mice.

    abstract：:When purified fibre and hexon proteins of adenovirus 12 were given intramuscularly to 4-week-old BALB/c mice (250-300 mug/mouse) 2 h prior to inoculation with mouse sarcoma virus (0.05 ml of 10(4) FFU/ml) at the same site, significant suppression of tumour growth (P less than 0.001), and rapid regression in tumour siz...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1976.63

    authors： Abid SH,Khoobyarian N

    更新日期：1976-04-01 00:00:00

  • Comparison of the RNA-amplification based methods RT-PCR and NASBA for the detection of circulating tumour cells.

    abstract：:Increasingly, reverse transcriptase polymerase chain reaction (RT-PCR) is used to detect clinically significant tumour cells in blood or bone marrow. This may result in a redefinition of disease-free and clinical relapse. However, its clinical utility may be limited by lack of automation or reproducibility. Recent stu...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600014

    authors： Burchill SA,Perebolte L,Johnston C,Top B,Selby P

    更新日期：2002-01-07 00:00:00

  • Cetuximab and platinum-based chemoradio- or chemotherapy of patients with epidermal growth factor receptor expressing adenoid cystic carcinoma: a phase II trial.

    abstract：BACKGROUND:Epidermal growth factor receptor (EGFR) is highly expressed in adenoid cystic carcinoma (ACC). The efficacy and toxicity of cetuximab with concomitant platinum-based chemoradio- or chemotherapy in patients with locally advanced or metastatic ACC, respectively, was evaluated. METHODS:Eligible patients (9 wit...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.468

    authors： Hitre E,Budai B,Takácsi-Nagy Z,Rubovszky G,Tóth E,Remenár É,Polgár C,Láng I

    更新日期：2013-09-03 00:00:00

  • Phase II study of rhizoxin in squamous cell head and neck cancer. The EORTC Early Clinical Trials Group.

    abstract：:To test the anti-tumour activity of rhizoxin in recurrent and/or metastatic squamous cell head and neck cancer, we performed a phase II study. Eligibility required histologically proven squamous cell head and neck cancer. Patients could only have received one prior chemotherapy. Patients were entered if WHO PS was < o...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1038/bjc.1996.69

    authors： Verweij J,Wanders J,Gil T,Schöffski P,Catimel G,te Velde A,de Mulder PH

    更新日期：1996-02-01 00:00:00

  • Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10.

    abstract：BACKGROUND:The human epidermal growth factor receptor (EGFR) is an important therapeutic target in oncology, and three different types of EGFR inhibitors have been approved for the treatment of cancer patients. However, there has been no clear association between the expression levels of EGFR protein in the tumours det...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.27

    authors： Modjtahedi H,Khelwatty SA,Kirk RS,Seddon AM,Essapen S,Del Vecchio CA,Wong AJ,Eccles S

    更新日期：2012-02-28 00:00:00

  • Natural history of smouldering leukaemia.

    abstract：:The natural history of 45 cases of smouldering leukaemia has been studied. Males and females were equally represented, with a median age of 60.5. The median survival of the whole group was only 20 months, but rare cases lived 10 years or longer. 38% developed acute leukaemia; the remainder usually died of the results ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1982.179

    authors： Joseph AS,Cinkotai KI,Hunt L,Geary CG

    更新日期：1982-08-01 00:00:00

  • Potentiation of anchorage-independent colony formation by sodium polyanethol sulphonate.

    abstract：:Sodium polyanethol sulphonate (SPS) when incorporated into rat erythrocyte lysate (REL) containing semi-solid agar medium at 1 mg ml-1. markedly enhanced colony formation by a number of anchorage-independent cell lines. REL usually needed to be included for the expression of SPS induced potentiation as in its absence ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1984.230

    authors： Sheridan JW,Bishop CJ,Simmons RJ,Ward CJ,Baumann KC

    更新日期：1984-11-01 00:00:00

  • The impact of regulatory T cells on carcinogen-induced sarcogenesis.

    abstract：:Burnet proposed in the 1950's that the immune system is engaged in identifying and destroying abnormal cancerous cells. This process, termed immune surveillance, has been at the centre of intense debate for decades. Results using immunodeficient mice lend support to the immune surveillance hypothesis. We surmised that...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603824

    authors： Betts G,Twohig J,Van den Broek M,Sierro S,Godkin A,Gallimore A

    更新日期：2007-06-18 00:00:00

  • Effect of megestrol acetate on weight loss induced by tumour necrosis factor alpha and a cachexia-inducing tumour (MAC16) in NMRI mice.

    abstract：:The effect of the synthetic progesterone, megestrol acetate, on weight loss induced by both tumour necrosis factor alpha (TNF) as a model for the cachexia accompanying the acquired immunodeficiency syndrome and by a cachexia-inducing tumour (MAC16) has been studied in NMRI mice. Megestrol acetate was effective in prev...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1990.310

    authors： Beck SA,Tisdale MJ

    更新日期：1990-09-01 00:00:00

  • High density of FOXP3-positive T cells infiltrating colorectal cancers with microsatellite instability.

    abstract：:High-level microsatellite instability (MSI-H) in colorectal cancer accounts for about 12% of colorectal cancers and is typically associated with a dense infiltration with cytotoxic CD8-positive lymphocytes. The role of regulatory T cells that may interfere with the host's antitumoural immune response in MSI-H colorect...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604756

    authors： Michel S,Benner A,Tariverdian M,Wentzensen N,Hoefler P,Pommerencke T,Grabe N,von Knebel Doeberitz M,Kloor M

    更新日期：2008-12-02 00:00:00

  • Haemoccult test properties according to type and number of positive slides in mass screening for colorectal cancer.

    abstract：:Despite encouraging results from recent studies, there is still no consensus to undertake mass screening using the Haemoccult test in the general population. The success of mass screening for colorectal cancer depends among other things on Haemoccult test properties. In on-going screening programmes, the Haemoccult te...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.459

    authors： Launoy G,Herbert C,Reaud JM,Thezee Y,Tichet J,Maurel J,Ollivier V,Pegulu L,Caces E,Valla A

    更新日期：1995-10-01 00:00:00

  • Prognostic significance of circumferential resection margin involvement following oesophagectomy for cancer.

    abstract：:The factors affecting long-term survival following oesophagectomy for oesophageal cancer are poorly understood. We examined the significance of microscopic tumour involvement at the circumferential resection margin (CRM) on postoperative survival following oesophagectomy. The case notes of 329 patients who underwent a...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600931

    authors： Khan OA,Fitzgerald JJ,Soomro I,Beggs FD,Morgan WE,Duffy JP

    更新日期：2003-05-19 00:00:00

  • Years of life lost as a measure of cancer burden on a national level.

    abstract：BACKGROUND:The severity of cancers is often measured in number of deaths. However, number of years of life lost (YLL) may be a more appropriate indicator of impact on society. Here we have calculated the YLL of adult cancers in Norway for the year 2012, as well as for the previous 15-year period. METHODS:Data on age c...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.364

    authors： Brustugun OT,Møller B,Helland A

    更新日期：2014-08-26 00:00:00

  • Similarities of the anti-tumour actions of endotoxin, lipid A and double-stranded RNA.

    abstract：:Double stranded RNA (dsRNA) whether isolated from a fungal virus or prepared synthetically (i.e., Poly I Poly C) and endotoxin were found to exert very similar effects on syngeneic murine lymphomata and fibrosarcomata. They cause complete regressions of some established subcutaneous (s.c.) or intradermal (i.d.) tumour...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1973.45

    authors： Parr I,Wheeler E,Alexander P

    更新日期：1973-05-01 00:00:00

  • Prevalence and determinants of human papillomavirus genital infection in men.

    abstract：:Four-hundred-forty-five husbands of women with invasive cervical carcinoma, 165 of women with in situ cervical cancer, and 717 of control women (age range 19-82 years) were interviewed and a sample of exfoliated cells from the penis obtained in seven case-control studies conducted by the International Agency for Resea...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600194

    authors： Franceschi S,Castellsagué X,Dal Maso L,Smith JS,Plummer M,Ngelangel C,Chichareon S,Eluf-Neto J,Shah KV,Snijders PJ,Meijer CJ,Bosch FX,Muñoz N

    更新日期：2002-03-04 00:00:00

  • Investigating prostate cancer tumour-stroma interactions: clinical and biological insights from an evolutionary game.

    abstract：BACKGROUND:Tumours are made up of a mixed population of different types of cells that include normal structures as well as ones associated with the malignancy, and there are multiple interactions between the malignant cells and the local microenvironment. These intercellular interactions, modulated by the microenvironm...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.517

    authors： Basanta D,Scott JG,Fishman MN,Ayala G,Hayward SW,Anderson AR

    更新日期：2012-01-03 00:00:00

  • Indomethacin induces apoptosis via a MRP1-dependent mechanism in doxorubicin-resistant small-cell lung cancer cells overexpressing MRP1.

    abstract：:Small-cell lung cancers (SCLCs) initially respond to chemotherapy, but are often resistant at recurrence. The non-steroidal anti-inflammatory drug indomethacin is an inhibitor of multidrug resistance protein 1 (MRP1) function. The doxorubicin-resistant MRP1-overexpressing human SCLC cell line GLC(4)-Adr was highly sen...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604010

    authors： de Groot DJ,van der Deen M,Le TK,Regeling A,de Jong S,de Vries EG

    更新日期：2007-10-22 00:00:00

  • The frequency of M-components in sera of patients with solid malignant neoplasms.

    abstract：:The frequency of M-components was studied by agar gel electrophoresis in sera from 807 patients, 467 (57%) females and 340 (43%) males with histologically proven solid malignant neoplasms.M-components were found in the sera of 40 male and 20 female patients. Apart from two known cases of multiple myeloma and one case ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1973.34

    authors： Talerman A,Haije WG

    更新日期：1973-04-01 00:00:00