Abstract：
:Epstein-Barr virus (EBV) expression was investigated by immunohistochemistry (latent membrane protein 1 [LMP-1]) and in situ hybridization (EBV encoded RNA [EBER]) in biopsies from 95 patients with untreated Hodgkin's disease (HD). Tumour EBV status was related to EBV antibody titres, spontaneous and concanavalin A induced blood lymphocyte DNA synthesis, serum levels of soluble (s) CD4, sCD8, sCD25, sCD30, sCD54, beta2-microglobulin, thymidine-kinase, routine chemistry, patient characteristics, complete remission and survival. The median follow-up time was 145 months (range 60-257). Tumour EBV-positive (n = 30; 33%) and negative (n = 62; 67%) patients did not differ with regard to sex, age, stage, presence of bulky disease or B-symptoms, remission rate or survival. The proportion of EBV+ cases was significantly higher among patients with mixed cellularity histopathology (58%) as compared to the nodular sclerosis subtype (18%; P < 0.001). The total white blood cell (WBC) counts were significantly lower in EBV+ patients (P < 0.01), who also had significantly higher levels of sCD54 (P < 0.02) and a tendency towards lower levels of sCD30 (P = 0.056). Patients in the tumour EBV+ group had significantly higher IgG antibody titres to restricted early antigen (EA-R) (P < 0.02). Hence, clinical features and outcome were not related to tumour EBV status. However, HD patients with EBV+ tumours had elevated sCD54 levels, higher antibody titres to EA-R and decreased total WBC counts. A potential causal relationship between EBV tumour status and these findings needs to be further explored.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Axdorph U,Porwit-MacDonald A,Sjöberg J,Grimfors G,Ekman M,Wang W,Biberfeld P,Björkholm Mdoi
10.1038/sj.bjc.6690827subject
Has Abstractpub_date
1999-12-01 00:00:00pages
1182-7issue
7eissn
0007-0920issn
1532-1827journal_volume
81pub_type
杂志文章abstract：:The purpose of this study was to determine the maximum-tolerated dose of gemcitabine plus mitoxantrone in women with metastatic breast cancer (MBC) and to evaluate activity and toxicity of this combination in a phase II trial. Sixty-three patients with MBC, previously treated with chemotherapy including anthracycline ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6600780
更新日期：2003-02-24 00:00:00
abstract：:We have evaluated the relation between cancer of the lower urinary tract ("bladder cancer") and the use of artificial sweeteners, by means of case-control studies in Manchester, U.K., and Nagoya, Japan, areas where extensive use occurred 30-40 years ago. In each area, a broadly based series of cases (555 in Manchester...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.59
更新日期：1982-03-01 00:00:00
abstract：:The death certificate only (DCO) index, which quantifies the proportion of patients for whom the death certificate provides the only notification to the registry, is a widely used measure of incompleteness of population-based cancer registration. This paper provides an algebraic assessment and a quantitative illustrat...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.363
更新日期：1995-08-01 00:00:00
abstract：BACKGROUND:Tumours consist of heterogeneous cancer cells and are likely to contain drug-tolerant cell subpopulations, causing early relapse. However, treatment strategies to eliminate these cells have not been established. METHODS:We established gastric cancer patient-derived cells (PDCs) to examine the contribution o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0600-9
更新日期：2019-11-01 00:00:00
abstract：:E-cadherin function is thought to be impaired in epithelial cancer. To investigate the alterations in E-cadherin associated with cytoplasmic molecules including alpha-catenin, beta-catenin, gamma-catenin, p120CAS, and IQGAP1 in various endometrial cancers with different degree of differentiation, we examined the local...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1386
更新日期：2000-11-01 00:00:00
abstract：:Some 1220 male and 2102 female cases of malignant neoplasms diagnosed histologically at the Department of Pathology of the Gadjah Mada University in Yogyakarta during the period 1970-73 were analysed. The most frequent tumour sites were among men: nasopharyngeal cancer, 21-8% and skin cancer, 17-6%. Among women the ge...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.164
更新日期：1977-07-01 00:00:00
abstract：BACKGROUND:Ovarian cancer is frequently advanced at presentation when treatment is rarely curative. Response to first-line platinum-based chemotherapy significantly influences survival, but clinical response is unpredictable and is frequently limited by the development of drug-resistant disease. METHODS:We used qRT-PC...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.410
更新日期：2012-10-09 00:00:00
abstract：BACKGROUND:We analysed critically the potential usefulness of RNA- and DNA-based biomarkers in supporting conventional histological diagnostic tests for prostate carcinoma (PCa) detection. METHODS:Microarray profiling of gene expression and DNA methylation was performed on 16 benign prostatic hyperplasia (BPH) and 32 ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.337
更新日期：2014-08-12 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.379
更新日期：1992-11-01 00:00:00
abstract：:Leucocytes are a major component of the tumour microenvironment. Recent studies have indicated that the infiltration and activity of these host cells are regulated by the tumour to promote its survival and progression. Through the production of an array of growth factors, proteases and angiogenic mediators, leucocytes...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6601705
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Antihypertensives may inhibit pancreatic carcinogenesis. We examined the association between use of these drugs and pancreatic cancer in patients with chronic pancreatitis. METHODS:We conducted a nationwide population-based cohort study of all chronic pancreatitis patients diagnosed in Denmark during 1996-2...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0562-y
更新日期：2019-10-01 00:00:00
abstract：:HuR, a ubiquitously expressed member of the Hu protein family that binds and stabilizes an AU-rich element (ARE)-containing mRNAs, is known to shuttle between the nucleus and the cytoplasm via several export pathways. When normal cells were treated with heat shock, HuR was exported to the cytoplasm in a chromosome mai...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605084
更新日期：2009-06-16 00:00:00
abstract：:The origin of metastatic adenocarcinoma lesions can sometimes be difficult to diagnose. The objectives of our study were to establish the cytokeratin staining pattern of primary and metastatic lung and colorectal adenocarcinomas, and to determine if this helps to identify the site of origin of metastatic lesions. We r...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600326
更新日期：2002-06-17 00:00:00
abstract：BACKGROUND:Multiple myeloma is a plasma cell disorder that is characterised by clonal proliferation of malignant plasma cells in the bone marrow, monoclonal paraprotein in the blood or urine and associated organ dysfunction. It accounts for approximately 1% of cancers and 13% of haematological cancers. Myeloma arises f...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.525
更新日期：2012-12-04 00:00:00
abstract：BACKGROUND:The Nottinghamshire Lymphoma Registry contains the details of all the patients diagnosed with lymphoma (since 1 January 1973) within a defined geographical area with a population of 1.1 million. It was therefore possible to study the outcome of treatment for Hodgkin's disease for three 10-year cohorts (1973-...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.228
更新日期：2012-07-24 00:00:00
abstract：:Spontaneous and radiation-induced genetic instability of peripheral blood mononuclear cells derived from unselected breast cancer (BC) patients (n=50) was examined using the single-cell gel electrophoresis (Comet) assay and a modified G2 micronucleus (MN) test. Cells from apparently healthy donors (n=16) and from canc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603005
更新日期：2006-04-24 00:00:00
abstract：:Eighteen patients with inoperable hepatocellular carcinoma (HCC) were treated with intrahepatic arterial yttrium-90 microspheres. All these patients showed a lung shunting below 15% and a tumour-to-normal ratio higher than 2 as determined by diagnostic technetium-99m macroaggregated albumin (Tc-MAA) gamma scintigraphy...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1994.436
更新日期：1994-11-01 00:00:00
abstract：:Arginase activity was found to be increased in precancerous nodules and mammary tumour when compared with the mammary gland. Proline inhibited the mammary tumour arginase and up to 30 mmo1 concentration the inhibition follows first order kinetics. Hill analysis of the inhibition of arginase by proline showed that prol...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.123
更新日期：1974-08-01 00:00:00
abstract：:The prognostic value of flow cytometric parameters and tumour growth rate of melanoma metastases under the mouse renal capsule was investigated for tumours from 117 consecutive patients referred to the Helsinki University Central Hospital Melanoma Team. DNA flow cytometry (FCM) was interpretable for the tumours of 114...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.307
更新日期：1992-09-01 00:00:00
abstract：BACKGROUND:Epithelial ovarian cancer (EOC) cells are prone to metastasise throughout the peritoneal cavity. The epithelial-to-mesenchymal transition (EMT) is a necessary step towards metastatic tumour progression. CA125/MUC16 mucin is a high-molecular-weight glycoprotein overexpressed in the majority of serous carcinom...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.34
更新日期：2011-03-15 00:00:00
abstract：:A total of 152 non-small cell lung cancers (NSCLC) were studied retrospectively to determine the relationship between epidermal growth factor receptor (EGF-R) status and the histological type, tumour size, nodal status and prognosis. EGF-R status was assessed on routinely embedded paraffin sections with an antibody to...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.156
更新日期：1989-05-01 00:00:00
abstract：BACKGROUND:Circulating tumour cells (CTCs) can provide information on patient prognosis and treatment efficacy. However, there is no universal method to detect CTC currently available. Here, we compared the performance of two CTC detection systems based on the expression of the EpCAM antigen (CellSearch assay) or on ce...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.294
更新日期：2011-09-06 00:00:00
abstract：:The aims of this study were to identify prognostic variables for toxicity and survival in patients with cancer participating in phase I clinical trials and compare characteristics of those treated with cytotoxic chemotherapy (CT) and non-cytotoxic drugs (non-CT). Data were collected from 420 (114 CT, 306 non-CT) patie...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601218
更新日期：2003-10-06 00:00:00
abstract：BACKGROUND:In neuroblastoma (NB), the most powerful prognostic marker, the MYCN amplification (MNA), occasionally shows intratumoural heterogeneity (ITH), i.e. coexistence of MYCN-amplified and non-MYCN-amplified tumour cell clones, called heterogeneous MNA (hetMNA). Prognostication and therapy allocation are still uns...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/s41416-018-0098-6
更新日期：2018-05-01 00:00:00
abstract：:This study was undertaken to investigate the intracellular induction of reactive oxygen species (ROS) by cis-dichlorodiammineplatinum (CDDP) and the augmentation of their cytotoxicity in bladder cancer cells (KU7) by enhancement of ROS generation by the glutathione (GSH) depletors buthionine sulphoximine (BSO) and die...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.363
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:While current chemotherapy has increased cure rates for children with acute lymphoblastic leukaemia (ALL), the largest number of relapsing patients are still stratified as medium risk (MR) at diagnosis (50-60%). This highlights an opportunity to develop improved relapse-prediction models for MR patients. We ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0933-4
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:There are limited data comparing the prognosis and fertility outcomes of the patients with early cervical cancer treated by trans-vaginal radical trachelectomy (VRT) or abdominal radical trachelectomy (ART).The objective of this study was to compare the surgical and pathologic characteristics, the prognosis ...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2013.656
更新日期：2013-11-26 00:00:00
abstract：:By using a quantitative RNA-RNA solution hybridisation method, the average number of mdr1 RNA transcripts per cell was measured in total nucleic acid extracts of leukaemic cells from patients with acute leukaemia. The results in different types of leukaemia were (number of patients with detectable mdr1 RNA/total numbe...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.255
更新日期：1992-08-01 00:00:00
abstract：BACKGROUND:Record-based studies have generally reported association of higher childhood leukaemia incidence with higher socioeconomic status (SES), but recent findings are less consistent. METHODS:We examined records from the National Registry of Childhood Tumours for evidence of this association in England and Wales ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.415
更新日期：2011-11-22 00:00:00
abstract：:Urokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA acts in vivo by binding to a membrane receptor known as uPAR. In this study, uPA and uPAR levels were semiquantitated by immunocytochemistry in 36 primary breast carcinomas. Using monoclonal antibody HD-UK 1, uPA...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.268
更新日期：1998-05-01 00:00:00
