Abstract：
:Leucocytes are a major component of the tumour microenvironment. Recent studies have indicated that the infiltration and activity of these host cells are regulated by the tumour to promote its survival and progression. Through the production of an array of growth factors, proteases and angiogenic mediators, leucocytes in the tumour microenvironment promote tumour growth, angiogenesis and metastasis.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Lin EY,Pollard JWdoi
10.1038/sj.bjc.6601705subject
Has Abstractpub_date
2004-06-01 00:00:00pages
2053-8issue
11eissn
0007-0920issn
1532-1827pii
6601705journal_volume
90pub_type
杂志文章,评审abstract：:The mechanism of down-regulation of c-myc RNA associated with androgen-induced suppression of the transformed phenotype in the human prostate carcinoma cell line LNCaP was investigated. The synthetic androgen mibolerone (7 alpha-17 alpha-Dimethyl-19-nortestosterone) reversibly inhibits the proliferation of LNCaP cells...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.76
更新日期：1992-03-01 00:00:00
abstract：:The objective of the study was to evaluate the effect of neoadjuvant chemotherapy on the survival of patients with oropharyngeal cancer. Patients with a squamous cell carcinoma of the oropharynx for whom curative radiotherapy or surgery was considered feasible were entered in a multicentric randomized trial comparing ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1054/bjoc.2000.1512
更新日期：2000-12-01 00:00:00
abstract：:A recent study showed an association between a single base substitution, T-->C, in the promotor region of the CYP17 gene, the risk of breast cancer and age at menarche in Asian, African-American and Latino women from California and Hawaii. The C allele was associated with increased risk of breast cancer, significantly...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.340
更新日期：1998-06-01 00:00:00
abstract：:A representative sample of 4657 adults greater than or equal to 45 years of age from the 5 main ethnic groups in Hawaii (Caucasians, Japanese, Chinese, Filipinos and Hawaiians) were interviewed during 1977-1979 regarding their diets. Quantitative food-consumption histories were obtained, from which average daily intak...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.189
更新日期：1981-09-01 00:00:00
abstract：:Steroid receptor was assessed immunohistochemically in 158 samples of normal breast for variation through the menstrual cycle. Patterns and intensity of reaction were used in a semi-quantitative scoring system to examine the influence of cycle phase, cycle type, parity and age. The changes in oestrogen receptor for na...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.122
更新日期：1992-04-01 00:00:00
abstract：:Cisplatin is one of the most active cytotoxic agents in the treatment of testicular cancer, but its clinical use is associated with side-effects such as ototoxicity, neurotoxicity and nephrotoxicity. Long-term kidney damage from cisplatin particularly affects the proximal tubular apparatus and can be detected by incre...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.673
更新日期：1996-12-01 00:00:00
abstract：BACKGROUND:Most lung cancer patients are diagnosed at an advanced disease stage and predominantly receive palliative treatment, which increasingly consists of several chemotherapy lines. We report on patients' quality of life (QOL) to gain knowledge on QOL during and across multiple lines of chemotherapy. This includes...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.585
更新日期：2013-10-29 00:00:00
abstract：:The last 15 years has seen an explosion of interest in the cancer stem cell (CSC). Although it was initially believed that only a rare population of stem cells are able to undergo self-renewing divisions and differentiate to form all populations within a malignancy, a recent work has shown that these cells may not be ...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6605821
更新日期：2010-08-10 00:00:00
abstract：:Fifty patients affected by histologically confirmed gastrointestinal tract cancer (GTC) were treated with oral tegafur (TG) 1,000 mg m-2 p.o. on days 1-14 repeated after a 14 day interval. Out of 42 evaluable patients seven patients had a partial response (PR. 17%) with a median duration of 20.5 weeks, three had a min...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.105
更新日期：1990-03-01 00:00:00
abstract：BACKGROUND:The vascular disrupting agent combretastatin A4 phosphate (CA4P) causes major regression of animal tumours when given as combination therapy. METHODS:Patients with advanced cancer refractory to standard therapy were treated with CA4P as a 10-min infusion, 20 h before carboplatin, paclitaxel, or paclitaxel, ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605650
更新日期：2010-04-27 00:00:00
abstract：:The traditional cancer drug development pathway is increasingly being superseded by trials that address multiple clinical questions. These are collectively termed Complex Innovative Design (CID) trials. CID trials not only assess the safety and toxicity of novel anticancer medicines but also their efficacy in biomarke...
journal_title：British journal of cancer
pub_type： 共识发展会议,杂志文章,评审
doi：10.1038/s41416-019-0653-9
更新日期：2020-02-01 00:00:00
abstract：:The association between breast and endometrial cancer was investigated in a cohort consisting of 60,065 subjects (99% of all women in whom a first breast cancer was diagnosed in Sweden in 1960-63 and 1968-81). Complete follow-up until 1981 revealed a total of 260 endometrial cancers, as against an expected number of 1...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.16
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND:Among patients with cancer, prior research suggests that patients with mental illness may have reduced survival. The objective was to assess the impact of psychiatric utilisation (PU) prior to cancer diagnosis on survival outcomes. METHODS:All residents of Ontario diagnosed with one of the top 10 malignanci...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0390-0
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:To document the effect of bivalent HPV immunisation on cervical cytology as a screening test and assess the implications of any change, using a retrospective analysis of routinely collected data from the Scottish Cervical Screening Programme (SCSP). METHODS:Data were extracted from the Scottish Cervical Cal...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.474
更新日期：2016-03-01 00:00:00
abstract：:The incidence of Kaposi's sarcoma (KS) in 1976-90 was assessed in Italy, taking advantage of a network of nine population-based cancer registries covering, at its maximum, approximately 5.6 million subjects. The first examined period (1976-84) substantially reflects the epidemiology of KS prior to the AIDS epidemic in...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.60
更新日期：1994-02-01 00:00:00
abstract：:People affected by cancer want information about their prognosis but clinicians have trouble estimating and talking about it. We sought to determine the nature and accuracy of medical oncologists' estimates of life expectancy in newly referred patients with incurable cancer. With reference to each patient, medical onc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602908
更新日期：2006-01-30 00:00:00
abstract：:Epidemiology has shown an association between exposure to extremely low frequency (ELF) electromagnetic fields (EMF) and childhood leukaemia. The causal nature and biological basis of this association are however questionable. Studies with aneuploid cell lines raised the hypothesis that ELF EMF may act as a coleukaemo...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601010
更新日期：2003-06-16 00:00:00
abstract：:Nasopharyngeal carcinoma (NPC) is a distinct type of head and neck cancer. Approximately 70% of patients with newly diagnosed NPC present with locally advanced disease. Phase III clinical trials support the addition of chemotherapy to radiotherapy for the initial treatment of these patients. Once metastatic disease de...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6602449
更新日期：2005-03-14 00:00:00
abstract：:We identified 2384 patients in the Danish Cancer Register in whom cancer had been diagnosed in 1960-1996 before they reached the age of 20 and compared them with 53 143 sex- and age-matched controls identified from the Register of Population Statistics. Complete education records and demographic and socioeconomic info...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602085
更新日期：2004-08-31 00:00:00
abstract：:A clinical trial conducted according to a schedule of interim analyses written into the protocol, and stopped according to a predetermined rule, is known to statisticians as a sequential clinical trial. This methodology is becoming more widely used in trials concerning life-threatening diseases because of its ability ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.500
更新日期：1993-12-01 00:00:00
abstract：:Two hundred and thirteen lung tumours of primary site and 42 metastases were heterotransplanted into nude mice with an overall success rate of 44%. There were differences in success between the histological types. Squamous cell and adenocarcinoma had the highest success rate (51% and 43%, respectively) whereas large c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.29
更新日期：1985-02-01 00:00:00
abstract：:The oestrogen receptor (RE) status of the primary tumour has been assessed in 466 of a consecutive series of 550 patients with primary operable breast cancer. All patients were followed up (without treatment) until the development of recurrence or metastases. Distant metastases have so far occurred in 124 patients and...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.205
更新日期：1981-09-01 00:00:00
abstract：:Chemotherapy has been regarded as standard therapy for the majority of women with advanced epithelial ovarian cancer for several decades, with this role filled largely by the alkylating agents - used as monotherapy - until the mid-1980s. The activity of cisplatin in this disorder was established during the 1970s, and ...
journal_title：British journal of cancer
pub_type： 历史文章,杂志文章,评审
doi：10.1038/sj.bjc.6601494
更新日期：2003-12-01 00:00:00
abstract：:Estimation of FGF-3 oncogene amplification in DNA samples extracted from paraffin embedded sections of 136 ovarian cancer samples was carried out by a quantitative PCR method. The aim of this study was to elucidate a possible association of FGF-3 copy numbers with established prognostic factors such as age, histology,...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.206
更新日期：1993-05-01 00:00:00
abstract：:The humanised form of an antagonistic anti-IGF-1R mAb (AVE1642) selectively inhibits the growth of CD45(neg) myeloma cells. AVE1642 strongly increased bortezomib-induced apoptosis, correlated with an increase of Noxa expression. These results support the therapeutic use of anti-IGF-1R/bortezomib in CD45(neg) Myeloma p...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604839
更新日期：2009-01-27 00:00:00
abstract：:Human papillomavirus (HPV) is thought to cause some vulval squamous cell carcinomas (VSCC) by degrading p53 product. Evidence on whether HPV-negative VSCC results from p53 mutation is conflicting. We performed immunohistochemistry for p53 product on 52 cases of lone vulval intraepithelial neoplasia (VIN), 21 cases of ...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析,多中心研究
doi：10.1038/sj.bjc.6600677
更新日期：2003-01-27 00:00:00
abstract：BACKGROUND:Low-dose UCN-01 mediates G1 arrest in normal proliferating cell lines with an intact G1 to S transition but not tumour cells with a deregulated G1 to S checkpoint. Here we hypothesised that UCN-01 is effective in mediating a selective, reversible G1 arrest of normal proliferating cells, resulting in decrease...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0707-z
更新日期：2020-03-01 00:00:00
abstract：:The oncogenicity of Duck hepatitis B virus (DHBV) is unclear since hepatocellular carcinomas (HCCs) have been reported only in domestic ducks in Qidong, an area of China where hepatitis B virus (HBV) and aflatoxin B1 (AFB1) are risk factors for liver cancer in man. In order to better define the association between DHB...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.16
更新日期：1994-01-01 00:00:00
abstract：:In this paper, we develop a Markov chain model to estimate parameters pertaining to the natural history of nasopharyngeal carcinoma (NPC). The model is of progression from no disease to Epstein-Barr virus (EBV) infection, preclinical screen-detectable tumour and clinical tumour. We derive tentative estimates of the pa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690301
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:Radio- and chemotherapy (RT/CT) resistance hampers success in combating small and non-small cell lung cancers (SCLC/NSCLC). The underlying molecular mechanisms of RT/CT resistance of LCs are multifactorial and have been understood in part hitherto. miRNAs, key regulators of mRNAs, are well-recognised oncomir...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.382
更新日期：2012-10-09 00:00:00
