Doppler assessment of the uterine circulation and the clinical behaviour of gestational trophoblastic tumours requiring chemotherapy.

Abstract:

:The haemodynamics of the uterine arteries and myometrium were assessed using Doppler ultrasound in forty consecutive patients requiring treatment for invasive mole and choriocarcinoma. The investigations were performed prior to the commencement of chemotherapy and the subjects followed prospectively. The Doppler waveforms from the uterine arteries were analysed using the pulsatility index. It was found that patients with a pulsatility index of 1.1 or less were significantly more likely to develop drug resistance than those with a higher value (P < 0.04). There was no significant association between the pulsatility index and metastatic disease or uterine bleeding. Five out of eight patients who developed drug resistance could have avoided initial inadequate treatment if the Doppler findings were included in the scoring system for selecting chemotherapy for these tumours. It can be concluded that assessment of the uterine arteries using the pulsatility index prior to the treatment of patients with invasive mole and choriocarcinoma is of help in predicting those who will develop drug resistance.

journal_name

Br J Cancer

authors

Long MG,Boultbee JE,Langley R,Newlands ES,Begent RH,Bagshawe KD

doi

10.1038/bjc.1992.379

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

883-7

issue

5

eissn

0007-0920

issn

1532-1827

journal_volume

66

pub_type

杂志文章
  • Evaluation of dimethylhydrazine induced tumours in mice as a model system for colorectal cancer.

    abstract::The evolution and structure of adenomatous polyps and adenocarcinomata of the colon in NMRI mice induced by dimethylhydrazine are described. Severe toxic reactions in the liver and other organs are produced by dimethylhydrazine (DMH), but tumours are induced only in the colon and around the anus. The 100% incidence an...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1973.183

    authors: Haase P,Cowen DM,Knowles JC,Cooper EH

    更新日期:1973-12-01 00:00:00

  • Prostate cancer in BRCA2 germline mutation carriers is associated with poorer prognosis.

    abstract:BACKGROUND:The germline BRCA2 mutation is associated with increased prostate cancer (PrCa) risk. We have assessed survival in young PrCa cases with a germline mutation in BRCA2 and investigated loss of heterozygosity at BRCA2 in their tumours. METHODS:Two cohorts were compared: one was a group with young-onset PrCa, t...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6605822

    authors: Edwards SM,Evans DG,Hope Q,Norman AR,Barbachano Y,Bullock S,Kote-Jarai Z,Meitz J,Falconer A,Osin P,Fisher C,Guy M,Jhavar SG,Hall AL,O'Brien LT,Gehr-Swain BN,Wilkinson RA,Forrest MS,Dearnaley DP,Ardern-Jones AT,Pag

    更新日期:2010-09-07 00:00:00

  • Tumour necrosis factor gene polymorphism: a predictive factor for the development of post-transplant lymphoproliferative disease.

    abstract:BACKGROUND:Epstein-Barr virus-positive post-transplant lymphoproliferative disease (PTLD) is a potentially lethal complication of iatrogenic immunosupression after transplantation. Predicting the development of PTLD allowing early and effective intervention is therefore of importance. Polymorphisms within cytokine gene...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6605278

    authors: McAulay KA,Haque T,Crawford DH

    更新日期:2009-09-15 00:00:00

  • Number of apoptotic cells as a prognostic marker in invasive breast cancer.

    abstract::Apoptosis plays an important role in tumorigenesis. Tumour growth is determined by the rate of cell proliferation and cell death. We counted the number of apoptotic cells in haematoxylin and eosin (H&E)-stained tumour sections in series of 172 grade I and II invasive breast cancers with long-term follow-up. The number...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1054/bjoc.1999.0928

    authors: de Jong JS,van Diest PJ,Baak JP

    更新日期:2000-01-01 00:00:00

  • Detection and prognostic role of heterogeneous populations of melanoma circulating tumour cells.

    abstract:BACKGROUND:Circulating tumour cells (CTCs) can be assessed through a minimally invasive blood sample with potential utility as a predictive, prognostic and pharmacodynamic biomarker. The large heterogeneity of melanoma CTCs has hindered their detection and clinical application. METHODS:Here we compared two microfluidi...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0750-9

    authors: Aya-Bonilla CA,Morici M,Hong X,McEvoy AC,Sullivan RJ,Freeman J,Calapre L,Khattak MA,Meniawy T,Millward M,Ziman M,Gray ES

    更新日期:2020-03-01 00:00:00

  • Treatment of childhood lymphocytic leukaemia with high white-cell counts.

    abstract::Combination chemotherapy with cytosine arabinoside, cyclophosphamide and L-asparaginase (Asnase) was given to 22 children with acute lymphocytic leukaemia (ALL) with a white-cell count greater than 30 X 10(9)/1, and other features suggestive of poor prognosis. Complete remission was induced in all patients--in 19 afte...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1978.258

    authors: Ekert H,Waters KD,Smith PJ,Matthews RN,Ellis WM

    更新日期:1978-11-01 00:00:00

  • Benzo[b]thiophenesulphonamide 1,1-dioxide derivatives inhibit tNOX activity in a redox state-dependent manner.

    abstract::Benzo[b]thiophenesulphonamide 1,1-dioxide (BTS) derivatives are strong cytotoxic agents that induce reactive oxygen species (ROS) overproduction and apoptosis in tumour cells. Although the precise origin of BTS-induced ROS is not known, a clear correlation between their cytotoxic effect and ability to inhibit a tumour...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6602383

    authors: Encío I,Morré DJ,Villar R,Gil MJ,Martínez-Merino V

    更新日期:2005-02-28 00:00:00

  • Influence of misonidazole on the incidence of radiation-induced intestinal tumours in mice.

    abstract::C57BL mice were given local irradiation to 2 cm2 of the lower abdomen in the dose range 16--24 Gy. There were some early deaths, but mice dying between 50--240 days predominantly developed invasive adenocarcinomas of the intestine. When the radiosensitizer misonidazole was given in a single dose shortly before irradia...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1978.240

    authors: Rostom AY,Kauffman SL,Steel GG

    更新日期:1978-10-01 00:00:00

  • Syngeneic immune response to rat tracheal epithelial cells transformed in vitro by N-methyl-N-nitro-N-nitrosoguanidine.

    abstract::Two cell lines (2-10-1 and 8-10-2) derived by exposure to primary tracheal explants to MNNG in vitro were not tumorigenic in syngeneic F-344 rats or athymic BALB/c (nu/nu) mice at early passage, but became tumorigenic at late passage. These cell lines are therefore suited to study the expression of neoantigens during ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1981.176

    authors: Braslawsky GR,Steele V,Kennel SJ,Nettesheim P

    更新日期:1981-08-01 00:00:00

  • Obesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East Asians.

    abstract:BACKGROUND:Limited evidence exists regarding associations between obesity and kidney cancer among Asians. We examined the associations between obesity measures and risk of kidney cancer. METHODS:We included 23,313,046 adults who underwent health examinations provided by the Korean National Health Insurance Service 200...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-019-0500-z

    authors: Nam GE,Cho KH,Han K,Kim CM,Han B,Cho SJ,Jung SJ,Kwon Y,Kim YH,Kim DH,Kim SM,Choi YS,Roh YK,Park YG

    更新日期:2019-07-01 00:00:00

  • Costs and consequences of different chemotherapy regimens in metastatic colorectal cancer.

    abstract::An economic sub-study was run alongside a large multi-centre randomised trial (MRC-CR06) comparing three chemotherapy regimens; de Gramont, Lokich and raltitrexed in patients with metastatic colorectal cancer. Patients in six of 45 centres in the main trial were approached to take part in the sub-study. Chemotherapy d...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1038/sj.bjc.6600273

    authors: Hale JP,Cohen DR,Maughan TS,Stephens RJ

    更新日期:2002-06-05 00:00:00

  • Nutrient intakes in relation to cancer incidence in Hawaii.

    abstract::A representative sample of 4657 adults greater than or equal to 45 years of age from the 5 main ethnic groups in Hawaii (Caucasians, Japanese, Chinese, Filipinos and Hawaiians) were interviewed during 1977-1979 regarding their diets. Quantitative food-consumption histories were obtained, from which average daily intak...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1981.189

    authors: Kolonel LN,Hankin JH,Lee J,Chu SY,Nomura AM,Hinds MW

    更新日期:1981-09-01 00:00:00

  • Photodynamic therapy using intravenous delta-aminolaevulinic acid-induced protoporphyrin IX sensitisation in experimental hepatic tumours in rats.

    abstract::The efficacy of photodynamic therapy (PDT) using delta-aminolaevulinic acid (ALA)-induced protoporphyrin IX (PpIX) sensitisation and laser light at 635 nm was investigated in the treatment of experimental hepatic tumours. The model of liver tumours was induced either by local inoculation or by administration of tumour...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1996.584

    authors: Svanberg K,Liu DL,Wang I,Andersson-Engels S,Stenram U,Svanberg S

    更新日期:1996-11-01 00:00:00

  • Lysophosphatidic acid production and action: critical new players in breast cancer initiation and progression.

    abstract::Lysophosphatidic acid (LPA) is a potent lipid mediator that acts on a series of specific G protein-coupled receptors, leading to diverse biological actions. Lysophosphatidic acid induces cell proliferation, survival and migration, which are critically required for tumour formation and metastasis. This bioactive lipid ...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1038/sj.bjc.6605588

    authors: Panupinthu N,Lee HY,Mills GB

    更新日期:2010-03-16 00:00:00

  • Bcl-2 protein expression: association with p53 and prognosis in colorectal cancer.

    abstract::Bcl-2 expression in colorectal carcinomas was studied in a series of 224 patients and the relation to p53 expression, stage and survival assessed. Bcl-2 expression was down-regulated compared with normal mucosa in 67% (151) of the cases. In 144 cases staining was positive for p53 (MAB DO7), and 41 of these 144 p53-pos...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1998.310

    authors: Kaklamanis L,Savage A,Whitehouse R,Doussis-Anagnostopoulou I,Biddolph S,Tsiotos P,Mortensen N,Gatter KC,Harris AL

    更新日期:1998-06-01 00:00:00

  • Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer: results of secondary end points analyses.

    abstract::In advanced pancreatic cancer, level one evidence has established a significant survival advantage with chemotherapy, compared to best supportive care. The treatment-associated toxicity needs to be evaluated. This study examines the secondary outcome measures for chemotherapy in advanced pancreatic cancer using meta-a...

    journal_title:British journal of cancer

    pub_type: 杂志文章,meta分析

    doi:10.1038/sj.bjc.6604436

    authors: Sultana A,Tudur Smith C,Cunningham D,Starling N,Neoptolemos JP,Ghaneh P

    更新日期:2008-07-08 00:00:00

  • Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway.

    abstract::Chordomas are radio- and chemo-resistant tumours and metastasise in as many as 40% of patients. The aim of this study was to identify potential molecular targets for the treatment of chordoma. In view of the reported association of chordoma and tuberous sclerosis complex syndrome, and the available therapeutic agents ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6605019

    authors: Presneau N,Shalaby A,Idowu B,Gikas P,Cannon SR,Gout I,Diss T,Tirabosco R,Flanagan AM

    更新日期:2009-05-05 00:00:00

  • Prospective surveillance of women with a family history of breast cancer: auditing the risk threshold.

    abstract::To evaluate current guidelines criteria for inclusion of women in special 'breast cancer family history' surveillance programmes, records were reviewed of women referred to Scottish breast cancer family clinics between January 1994 and December 2003 but discharged as at 'less than 'moderate' familial risk'. The Scotti...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1038/sj.bjc.6604155

    authors: Anderson E,Berg J,Black R,Bradshaw N,Campbell J,Carnaghan H,Cetnarkyj R,Drummond S,Davidson R,Dunlop J,Fordyce A,Gibbons B,Goudie D,Gregory H,Holloway S,Longmuir M,McLeish L,Murday V,Miedzybrodska Z,Nicholson D,Pe

    更新日期:2008-02-26 00:00:00

  • Correction: AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL.

    abstract::A correction to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:British journal of cancer

    pub_type: 已发布勘误

    doi:10.1038/s41416-019-0505-7

    authors: Weisberg E,Manley P,Mestan J,Cowan-Jacob S,Ray A,Griffin JD

    更新日期:2019-07-01 00:00:00

  • Underexpression of tumour suppressor LKB1 in clear cell renal cell carcinoma is common and confers growth advantage in vitro and in vivo.

    abstract:BACKGROUND:Evidence suggests that dysregulation of energy-sensing pathways closely associates with renal cell carcinoma (RCC) development. The metabolic regulation is largely controlled by 5'-AMP activated protein kinase (AMPK) which is activated through phosphorylation by LKB1. METHODS:The expression of LKB1 was dete...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.2012.574

    authors: Duivenvoorden WC,Beatty LK,Lhotak S,Hill B,Mak I,Paulin G,Gallino D,Popovic S,Austin RC,Pinthus JH

    更新日期:2013-02-05 00:00:00

  • Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2-· production in cancer cells.

    abstract:BACKGROUND:The TP53 tumor suppressor gene is the most frequently altered gene in tumors and mutant p53 gain-of-function isoforms actively promote cancer malignancy. METHODS:A panel of wild-type and mutant p53 cancer cell lines of different tissues, including pancreas, breast, skin, and lung were used, as well as chron...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-018-0288-2

    authors: Cordani M,Butera G,Dando I,Torrens-Mas M,Butturini E,Pacchiana R,Oppici E,Cavallini C,Gasperini S,Tamassia N,Nadal-Serrano M,Coan M,Rossi D,Gaidano G,Caraglia M,Mariotto S,Spizzo R,Roca P,Oliver J,Scupoli MT,Donad

    更新日期:2018-10-01 00:00:00

  • Serine protease-induced enhancement of blood-borne metastasis of rat ascites tumour cells and its prevention with deoxyribonuclease.

    abstract::Serine proteases, such as alpha-chymotrypsin or elastase, caused an aggregation of rat ascites tumour cell lines, AH-130, AH-109A and YS, in a protein free medium which preserved the cell viability. This aggregation, which was monitored spectrophotometrically, was dependent upon the protease activities and was resista...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1990.339

    authors: Sugihara S,Yamamoto T,Tsuruta J,Tanaka J,Kambara T,Hiraoka T,Miyauchi Y

    更新日期:1990-10-01 00:00:00

  • What are the information priorities for cancer patients involved in treatment decisions? An experienced surrogate study in Hodgkin's disease.

    abstract::A total of 165 adult patients with Hodgkin's disease (HD) were questioned following treatment to examine their perceptions of actual and desired involvement and provision of information in the treatment decision-making process. Irrespective of the degree to which patients felt they had been involved in the decision-ma...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1996.39

    authors: Turner S,Maher EJ,Young T,Young J,Vaughan Hudson G

    更新日期:1996-01-01 00:00:00

  • International consensus guidelines for scoring the histopathological growth patterns of liver metastasis.

    abstract:BACKGROUND:Liver metastases present with distinct histopathological growth patterns (HGPs), including the desmoplastic, pushing and replacement HGPs and two rarer HGPs. The HGPs are defined owing to the distinct interface between the cancer cells and the adjacent normal liver parenchyma that is present in each pattern ...

    journal_title:British journal of cancer

    pub_type: 杂志文章,实务指引

    doi:10.1038/bjc.2017.334

    authors: van Dam PJ,van der Stok EP,Teuwen LA,Van den Eynden GG,Illemann M,Frentzas S,Majeed AW,Eefsen RL,Coebergh van den Braak RRJ,Lazaris A,Fernandez MC,Galjart B,Laerum OD,Rayes R,Grünhagen DJ,Van de Paer M,Sucaet Y,Mudhar H

    更新日期:2017-11-07 00:00:00

  • Determination of cell-free interleukin 2 receptor level in the serum of normal animals and of animals bearing IL-2 receptor positive tumours with high or low metastatic capacity.

    abstract::Serum levels of cell-free interleukin-2 receptors were elevated above normal in mice bearing the IL-2R positive T-cell lymphoma Eb or its highly metastatic variant ESb. Although ESb cells expressed less IL-2R molecules than Eb cells on their cell surface, serum receptor levels were raised more quickly in ESb than in E...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1987.119

    authors: Schirrmacher V,Josimovic-Alasevic O,Osawa H,Diamantstein T

    更新日期:1987-06-01 00:00:00

  • Mediterranean diet and risk of endometrial cancer: a pooled analysis of three Italian case-control studies.

    abstract:BACKGROUND:Some components of the Mediterranean diet have favourable effects on endometrial cancer, and the Mediterranean diet as a whole has been shown to have a beneficial role on various neoplasms. METHODS:We analysed this issue pooling data from three case-control studies carried out between 1983 and 2006 in vario...

    journal_title:British journal of cancer

    pub_type: 杂志文章,meta分析

    doi:10.1038/bjc.2015.153

    authors: Filomeno M,Bosetti C,Bidoli E,Levi F,Serraino D,Montella M,La Vecchia C,Tavani A

    更新日期:2015-05-26 00:00:00

  • The effects of transdermal and oral oestrogen replacement therapy on colorectal cancer risk in postmenopausal women.

    abstract::The aim of this study was to examine the effects of oral and transdermal oestrogen replacement therapy on the risk of colorectal cancer. Data from a nested case-control study, designed to investigate the effect of hormone replacement therapy (HRT) on colorectal cancer were analysed. New cases of colorectal cancer, dia...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6601438

    authors: Csizmadi I,Collet JP,Benedetti A,Boivin JF,Hanley JA

    更新日期:2004-01-12 00:00:00

  • Expression of the multidrug resistance-associated protein (MRP) gene in non-small-cell lung cancer.

    abstract::We examined the levels of expression of the multidrug resistance-associated protein (MRP) gene quantified by Northern blot analysis in comparison with those of the MDR1 gene determined by reverse transcription-polymerase chain reaction (RT-PCR) in 104 non-small-cell lung cancer (NSCLC) specimens [59 adenocarcinoma (Ad...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1995.372

    authors: Ota E,Abe Y,Oshika Y,Ozeki Y,Iwasaki M,Inoue H,Yamazaki H,Ueyama Y,Takagi K,Ogata T

    更新日期:1995-09-01 00:00:00

  • Cessation of smoking and drinking and the risk of laryngeal cancer.

    abstract::A case-control study was conducted in Italy and Switzerland between 1992 and 2000 on 527 cases of laryngeal cancer and 1,297 hospital controls. The risk of laryngeal cancer steadily decreased from 3 years after stopping smoking. Some decline in risk was observed only 20 years or more after stopping drinking. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6600638

    authors: Altieri A,Bosetti C,Talamini R,Gallus S,Franceschi S,Levi F,Dal Maso L,Negri E,La Vecchia C

    更新日期:2002-11-18 00:00:00

  • Outcome of patients with HIV-related germ cell tumours: a case-control study.

    abstract::Testicular germ cell tumour (GCT) is not an AIDS-defining illness despite an increased incidence in men with HIV infection. We performed a matched case-control study comparing outcomes in HIV-positive men and the general population with GCT, using three age and stage matched controls for each case. There was no differ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6601762

    authors: Powles T,Bower M,Shamash J,Stebbing J,Ong J,Daugaard G,De Ruiter A,Johnson M,Fisher M,Anderson J,Nelson M,Gazzard B,Oliver T

    更新日期:2004-04-19 00:00:00