Abstract：
:The development of resistance to vincristine, actinomycin D and cisplatin has been examined in a human epidermoid lung carcinoma xenograft line (HXL 55) growing in nude mice. Treatment of HXL 55 with 1 mg kg-1 vincristine or 0.5 mg kg-1 actinomycin D once in each in vivo passage resulted in a rapid reduction in tumour responsiveness to these drugs. A partial resistance was already acquired at the 2nd transplant generation. In contrast, a gradual decrease in therapeutic response was observed with 10 mg kg-1 cisplatin. Irradiation with a local dose of 10 Gy induced no resistance. The three induced drug-resistant sublines were characterized in terms of the time course of development of resistance, the degree of induced resistance, cross-resistance, growth rate and stability of the phenotype.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Mattern J,Bak M Jr,Hoever KH,Volm Mdoi
10.1038/bjc.1988.155subject
Has Abstractpub_date
1988-07-01 00:00:00pages
30-3issue
1eissn
0007-0920issn
1532-1827journal_volume
58pub_type
杂志文章abstract：:A total of 164 consecutive adults with newly confirmed stage IIIB, IVA or IVB Hodgkin's disease (HD) commenced cyclical combination chemotherapy comprising mustine, vinblastine, prednisolone and procarbazine (MVPP) every 6 weeks (145 patients) or minor variants (19) at St Bartholomew's Hospital between 1968 and 1984. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.88
更新日期：1992-03-01 00:00:00
abstract：:Multicellular tumour spheroids are cellular aggregates that can be prepared from many types of tumour cells. These three-dimensional structures provide a model for analysing the effects of cell-cell contact and intercellular microenvironments on phenomena such as autocrine regulation of growth factor synthesis. Autore...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.34
更新日期：1992-02-01 00:00:00
abstract：:For stage III non-small cell lung cancer (NSCLC), approximately a third of patients survive up to 5 years, with decreasing 5-year survival rates for stage IIIB and stage IIIC disease. Although curable, stage III NSCLC encompasses a diverse range of disease presentation, with an equally complex range of multi-modal tre...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/s41416-020-01069-z
更新日期：2020-12-01 00:00:00
abstract：:The sera of 80 newly diagnosed lung-cancer patients have been examined for immune complexes and autoantibodies. Control subjects consisted of 20 bronchitic patients and 150 normal blood donors. Immune-complex measurements used 4 established and sensitive techniques (Raji cell assay, fluid and solid-phase C1q assays an...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.45
更新日期：1981-03-01 00:00:00
abstract：:A number of growth factors have been implicated in the control of the proliferation of breast cancer cells and some have been reported to mediate the proliferative effects of oestradiol. MCF-7 cells were treated with growth factors in the presence and absence of oestradiol. Oestradiol increased the response of cells t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.330
更新日期：1992-10-01 00:00:00
abstract：:Serine proteases, such as alpha-chymotrypsin or elastase, caused an aggregation of rat ascites tumour cell lines, AH-130, AH-109A and YS, in a protein free medium which preserved the cell viability. This aggregation, which was monitored spectrophotometrically, was dependent upon the protease activities and was resista...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.339
更新日期：1990-10-01 00:00:00
abstract：:To test the hypothesis that steroid hormone receptor expression is particularly pronounced in breast tumours when compared with non-neoplastic tissue, mastectomy samples were divided into 16 sectors. Multifocal tumours, of varying receptor phenotype were found in 4 patients and in addition different regions of large t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.90
更新日期：1987-04-01 00:00:00
abstract：:Cell viability following short (1 h) contact with paclitaxel or docetaxel was assayed using synchronised HeLa cells. Docetaxel proved almost totally lethal against S-phase cells. Its toxicity was only partial against cells in mitosis, and declined to a minimum with progression to G1. For paclitaxel, cytotoxicity incre...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.232
更新日期：1995-06-01 00:00:00
abstract：:The acute toxicity, pharmacokinetics and hypoxic cytotoxicity of RSU-1069 were investigated using the subcutaneous (sc) rat 9L tumour model. The pharmacokinetics were studied after i.p. injection of RSU-1069 (20 mg kg-1 or 100 mg kg-1). For both doses, the elimination of RSU-1069 followed first-order kinetics in both ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.116
更新日期：1991-04-01 00:00:00
abstract：BACKGROUND:Folate receptor 1 (FOLR1) is expressed in the majority of ovarian carcinomas (OvCa), making it an attractive target for therapy. However, clinical trials testing anti-FOLR1 therapies in OvCa show mixed results and require better understanding of the prognostic relevance of FOLR1 expression. We conducted a la...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.567
更新日期：2014-12-09 00:00:00
abstract：:We have studied loss of heterozygosity at the BRCA1 and BRCA2 loci in 992 normal cell clones derived from topographically defined areas of normal tissue in four samples from BRCA1/BRCA2 mutation carriers. The frequency of loss of heterozygosity in the clones was low (1.01%), but it was found in all four samples, wheth...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603298
更新日期：2006-08-21 00:00:00
abstract：:A cytogenetic study was performed in 27 patients suspected of t-MDS or t-ANLL. In 12 patients the diagnosis of t-MDS or t-ANLL was confirmed by morphological, cytochemical and immunophenotypical analysis. The cases were classified as RA (one), RAEB (four), CMML (two), ANLL (five). They had received chemotherapy and/or...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.93
更新日期：1990-03-01 00:00:00
abstract：:Individuals with a deficiency in the enzyme dihydropyrimidine dehydrogenase (DPD) may experience severe life-threatening toxicity when treated with 5-fluorouracil (5-FU). As routine measurement of enzyme activity is not practical in many clinical centres, we have investigated the use of DNA mutation analysis to identi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.79
更新日期：1998-01-01 00:00:00
abstract：:We have treated 40 patients was relapsed or resistant lymphoma with the combination of Etoposide, Prednisolone, Ifosfamide and Cisplatin (EPIC). Complete response was obtained in 11 patients (28%) with an overall response of 58%. The presence of bulky disease (P < 0.005), elevated LDH serum levels (P < 0.005), respons...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1993.393
更新日期：1993-09-01 00:00:00
abstract：BACKGROUND:Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated in patients with recurrent or refractory acute myeloid leukaemia (AML) or advanced solid tumours. ME...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/s41416-018-0082-1
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Cediranib is a highly potent inhibitor of vascular endothelial growth factor (VEGF) signalling with activity against all three VEGF receptors. Bevacizumab is an anti-VEGF-A monoclonal antibody with clinical benefit in previously treated metastatic colorectal cancer (mCRC). METHODS:Patients with mCRC who had...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.2012.545
更新日期：2013-02-19 00:00:00
abstract：:We investigated whether cholecystectomy is associated with subsequent cancer and, if so, whether the association is likely to be causal, by undertaking a retrospective cohort study using linked medical statistics, comprising a cholecystectomy group (n=39 254) and a reference cohort admitted for a range of other medica...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602392
更新日期：2005-04-11 00:00:00
abstract：BACKGROUND:Previous epidemiologic studies have shown inconsistent results for the association between alcohol intake and endometrial cancer risk. Most of the studies, however, assessed alcohol intake after cancer diagnosis, or measured alcohol intake at baseline only. METHODS:We prospectively examined the association ...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2014.257
更新日期：2014-07-08 00:00:00
abstract：:Response to endocrine therapy in 51 patients with advanced breast cancer was compared with the amount of elastosis in histological sections from their primary tumours. There appeared to be an association between elastosis and response: tumours with no elastosis showed a lower rate of response than those with gross ela...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.98
更新日期：1979-05-01 00:00:00
abstract：:Platinum diamine dichloride and tetrachloride inhibit the formation of antibody-forming cells in the mouse spleen after injection of sheep red cells. The dichloride is the more effective agent. It acts best when given 2 days after the antigen, which suggests that cells are more sensitive to its action when they are ra...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1971.27
更新日期：1971-03-01 00:00:00
abstract：BACKGROUND:This open-label, phase 1 trial (NCT02316197) aimed to determine the maximum-tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) of peposertib (formerly M3814), a DNA-dependent protein kinase (DNA-PK) inhibitor in patients with advanced solid tumours. Secondary/exploratory objectives included safety/t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-01151-6
更新日期：2020-11-24 00:00:00
abstract：:To examine the hypothesis that colorectal carcinomas with and without TP53 mutations may be characterised by aetiological heterogeneity, we analysed a group of 107 patients with primary Dukes' C colorectal cancer seen at the Memorial Sloan-Kettering Cancer Center (MSKCC) from 1986 to 1990. We assessed p53 overexpressi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.171
更新日期：1995-04-01 00:00:00
abstract：:The activity of ZD 1839 on brain metastases (BM) from Non-Small-Cell Lung Cancer (NSCLC) is unknown. We report four cases of BM responding to ZD 1839 theraphy. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601116
更新日期：2003-07-21 00:00:00
abstract：:Transforming growth factor alpha (TGF alpha) and Transforming growth factor beta-1 (TGF-beta 1) are growth regulatory for breast cancer cell lines in vitro and several studies have suggested that levels of the receptor for TGF alpha, the epidermal growth factor (EGFR) in tumour biopsies predict relapse and survival. W...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.261
更新日期：1993-06-01 00:00:00
abstract：:The carcinoembryonic antigen (CEA) was produced and released by human colorectal carcinomata and also the normal attached mucosa when maintained in both monolayer and organ culture. Immunoperoxidase cytochemical methods were employed for the cellular localization of CEA which was demonstrable only on the neoplastic ce...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1975.97
更新日期：1975-05-01 00:00:00
abstract：:Protein kinases play a key role in intracellular signalling, participating at multiple levels along the transduction cascades that trigger mitogenic response. Because protein kinases are involved in mitogenic pathways, they are likely to play a role in the abnormal proliferation of malignant cells. In this study we co...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.675
更新日期：1998-11-01 00:00:00
abstract：:In an Italian case-control study of oral cancer, number of missing teeth and other aspects of dental care were similar, but the general condition of the mouth, as indicated by gum bleeding, tartar deposits and mucosal irritation, was worse among oral cancer cases than controls. No differences were detected in sexual p...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1398
更新日期：2000-11-01 00:00:00
abstract：:One hundred and eighteen doctors who treat pulmonary neoplasms in Ontario were asked how they would wish to be treated if they had non-small cell lung cancer. Four different scenarios were given. The physicians were then asked if they would consent to take part as subjects in one or more clinical trials for which they...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.224
更新日期：1986-10-01 00:00:00
abstract：BACKGROUND:We assessed the sensitivity to adjuvant chemotherapy in cell cycle checkpoint kinase 2 (CHEK2) vs non-CHEK2 breast cancer patients by comparing the contralateral breast cancer incidence and distant disease-free and breast cancer-specific survival between both groups, stratified for adjuvant chemotherapy. ME...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.306
更新日期：2014-08-26 00:00:00
abstract：:The objective of this study was to document the occurrence and to correlate the prevalence of different human papillomavirus (HPV) types with the cytological results on simultaneously performed thin-layer preparations in a large population of Flemish women. During 1 year, 69 290 thin-layer preparations were interprete...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600756
更新日期：2003-02-24 00:00:00
