DNA polymerase activity in plasma from leukaemic guinea-pigs.

abstract：:Adriamycin and cyclophosphamide are active agents in human and experimental tumours. Using the L1210 murine leukaemia, their effectiveness alone and in combination was studied. The combination is highly synergistic in this tumour, resulting in a greater than 50% survival rate when the agents used alone at optimal dose...

journal_title：British journal of cancer

authors： Tobias JS,Parker LM,Tattersall MH,Frei E 3rd

更新日期：1975-08-01 00:00:00

abstract：:Fifteen patients with acute myelogenous leukaemia were studied to determine if their remission blood leucocytes could be stimulated into taking up [3H] thymidine after in vitro culture with their own cryo-preserved irradiated AML leukaemia cells. In 6/15 patients it was possible to show autologous recognition and equa...

journal_title：British journal of cancer

authors： Cocks P,Powles RL,Chapuis B,Alexander P

更新日期：1977-03-01 00:00:00

abstract：:Cell fusion has been used to analyse the genetic determinants of metastasis at the cellular level. Highly metastatic mouse melanoma cells were fused with diploid mouse lymphocytes and a range of hybrid clones isolated and tested for tumorigenicity and metastatic potential by s.c. injection into newborn, histocompatibl...

journal_title：British journal of cancer

authors： Sidebottom E,Clark SR

更新日期：1983-03-01 00:00:00

abstract：:Cellular mechanisms that account for tumour osteolysis associated with Ewing's sarcoma are uncertain. Osteoclasts are marrow-derived multinucleated cells (MNCs) that effect tumour osteolysis. Osteoclasts are known to form from macrophages by both receptor activator for nuclear factor-kappaB (RANK) ligand (RANKL)-depen...

journal_title：British journal of cancer

authors： Lau YS,Adamopoulos IE,Sabokbar A,Giele H,Gibbons CL,Athanasou NA

更新日期：2007-06-04 00:00:00

abstract：:Members of the public are increasingly consulted over health care and research priorities. Patient involvement in determining cancer research priorities, however, has remained underdeveloped. This paper presents the findings of the first consultation to be conducted with UK cancer patients concerning research prioriti...

journal_title：British journal of cancer

authors： Corner J,Wright D,Hopkinson J,Gunaratnam Y,McDonald JW,Foster C

更新日期：2007-03-26 00:00:00

abstract：:Flow cytometric (FCM) estimation of DNA content has been performed on tumour tissue from 197 patients with high and intermediate grade non-Hodgkin's lymphoma (NHL) to investigate the clinicopathological correlations and prognostic significance of DNA ploidy and proliferative activity. Fifty-one per cent of tumours wer...

journal_title：British journal of cancer

authors： Cowan RA,Harris M,Jones M,Crowther D

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:MEK is activated in ∼40% colorectal cancer (CRC) and 20-30% non-small cell lung cancer (NSCLC). Selumetinib is a selective inhibitor of MEK1/2, which is currently in clinical development. METHODS:We evaluated the effects of selumetinib in vitro and in vivo in CRC and NSCLC cell lines to identify cancer cell...

journal_title：British journal of cancer

authors： Troiani T,Vecchione L,Martinelli E,Capasso A,Costantino S,Ciuffreda LP,Morgillo F,Vitagliano D,D'Aiuto E,De Palma R,Tejpar S,Van Cutsem E,De Lorenzi M,Caraglia M,Berrino L,Ciardiello F

更新日期：2012-05-08 00:00:00

abstract：:For the presentation of peptide antigens to cytotoxic CD8+ T lymphocytes of the immune system, the expression of human leukocyte antigen (HLA) class I molecules on the cell surface is necessary. There is increasing evidence that surface HLA class I antigen expression is altered in a variety of human tumours by either ...

journal_title：British journal of cancer

authors： Vora AR,Rodgers S,Parker AJ,Start R,Rees RC,Murray AK

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) has been proposed to guide breast cancer surgery by measuring residual tumour after neoadjuvant chemotherapy. This study-level meta-analysis examines MRI's agreement with pathology, compares MRI with alternative tests and investigates consistency between different measures of...

journal_title：British journal of cancer

authors： Marinovich ML,Macaskill P,Irwig L,Sardanelli F,von Minckwitz G,Mamounas E,Brennan M,Ciatto S,Houssami N

更新日期：2013-09-17 00:00:00

abstract：:In adults, the haemolytic-uraemic syndrome (HUS) is associated with probable causative factors in the minority of all cases. Cytotoxic drugs are one of these potential causative agents. Although metastatic cancer by itself is a recognized risk-factor for the development of HUS, therapy with mitomycin-C, with cis-plati...

journal_title：British journal of cancer

authors： Serke S,Riess H,Oettle H,Huhn D

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:We performed a cross-sectional study in Indonesia to evaluate the performance of a single-visit approach of cervical cancer screening, using visual inspection with acetic acid (VIA), histology and cryotherapy in low-resource settings. METHODS:Women having limited access to health-care facilities were screen...

journal_title：British journal of cancer

authors： Vet JN,Kooijman JL,Henderson FC,Aziz FM,Purwoto G,Susanto H,Surya IG,Budiningsih S,Cornain S,Fleuren GJ,Trimbos JB,Peters AA

更新日期：2012-08-21 00:00:00

abstract：BACKGROUND:This phase 1 study evaluated the maximum tolerated dose (MTD), safety, and efficacy of bosutinib (competitive Src/Abl tyrosine kinase inhibitor) plus capecitabine. METHODS:Patients with locally advanced/metastatic breast, pancreatic, or colorectal cancers; cholangiocarcinoma; or glioblastoma received bosuti...

journal_title：British journal of cancer

authors： Isakoff SJ,Wang D,Campone M,Calles A,Leip E,Turnbull K,Bardy-Bouxin N,Duvillié L,Calvo E

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:Non-epithelial gonadal tumours largely comprise sex cord-stromal tumours (SCSTs) and germ cell tumours (GCTs). Specific somatic mutations in DICER1, a microRNA maturation pathway gene, have been identified in these tumours. We conducted a study that aimed to confirm, refine and extend the previous observatio...

journal_title：British journal of cancer

authors： Witkowski L,Mattina J,Schönberger S,Murray MJ,Choong CS,Huntsman DG,Reis-Filho JS,McCluggage WG,Nicholson JC,Coleman N,Calaminus G,Schneider DT,Arseneau J,Stewart CJ,Foulkes WD

更新日期：2013-11-12 00:00:00

abstract：BACKGROUND:Bcl-xL has an important role in the control of cell death through its inhibition of apoptosis. The aim of this study was to investigate the clinicopathological significance of Bcl-xL in upper urinary tract urothelial carcinoma (UTUC) and the therapeutic effect of targeting Bcl-xL protein in urothelial carcin...

journal_title：British journal of cancer

authors： Yoshimine S,Kikuchi E,Kosaka T,Mikami S,Miyajima A,Okada Y,Oya M

更新日期：2013-06-11 00:00:00

abstract：:In the BUPA study, a prospective study of 22,000 men attending a screening centre in London, the mean serum cholesterol level of the 267 men who developed cancer was 6.66 mmol l-1, not significantly different from the mean level of 6.72 mmol l-1 among the 525 unaffected controls matched for age, smoking history and th...

journal_title：British journal of cancer

authors： Wald NJ,Thompson SG,Law MR,Densem JW,Bailey A

更新日期：1989-06-01 00:00:00

abstract：:A cytofluorometric assay allowing the measurement of thymidine phosphorylation in single cells had been established (Hengstschläger & Wawra, 1993). This assay enables us to correlate intracellular thymidine kinase (TK) activity with the DNA content of single cells. Enzyme activity levels from neuroblastoma cells and n...

journal_title：British journal of cancer

authors： Hengstschläger M,Wawra E

更新日期：1993-05-01 00:00:00

abstract：:The objective of the study was to investigate the predictive value of various clinical, biochemical, and histopathological parameters, with special emphasis on the expression of the retinoblastoma protein (pRB), on the radiation response in bladder cancer. In order to obtain a truly objective response measure, patient...

journal_title：British journal of cancer

authors： Agerbaek M,Alsner J,Marcussen N,Lundbeck F,von der Maase H

更新日期：2003-07-21 00:00:00

abstract：:The incidence of Kaposi's sarcoma (KS) in 1976-90 was assessed in Italy, taking advantage of a network of nine population-based cancer registries covering, at its maximum, approximately 5.6 million subjects. The first examined period (1976-84) substantially reflects the epidemiology of KS prior to the AIDS epidemic in...

journal_title：British journal of cancer

authors： Geddes M,Franceschi S,Barchielli A,Falcini F,Carli S,Cocconi G,Conti E,Crosignani P,Gafà L,Giarelli L

更新日期：1994-02-01 00:00:00

abstract：:In spite of the wide range of tumours successfully treated with 5-aminolevulinic acid mediated photodynamic therapy, the fact that 5-aminolevulinic acid has low lipid solubility, limits its clinical application. More lipophilic 5-aminolevulinic acid prodrugs and the use of liposomal carriers are two approaches aimed a...

journal_title：British journal of cancer

authors： Casas A,Perotti C,Saccoliti M,Sacca P,Fukuda H,Batlle AM

更新日期：2002-03-04 00:00:00

abstract：:The purpose of this study was to address the prognostic significance of circulating melanoma cells by reverse transcriptase-polymerase chain reaction in the peripheral blood of stage IIB and III melanoma patients on high-dose adjuvant interferon at multiple sequential time points from initiation of treatment. Tyrosina...

journal_title：British journal of cancer

authors： Gogas H,Kefala G,Bafaloukos D,Frangia K,Polyzos A,Pectasides D,Tsoutsos D,Panagiotou P,Ioannovich J,Loukopoulos D

更新日期：2002-07-15 00:00:00

abstract：:The influence of vascular endothelial growth factor (VEGF) expression and microvessel density (MVD) on prognosis and the relationship between VEGF expression and MVD in ovarian carcinoma are not well defined. We studied VEGF expression in parallel with MVD by immunohistochemistry in 94 ovarian tumours (64 malignant, 1...

journal_title：British journal of cancer

authors： Shen GH,Ghazizadeh M,Kawanami O,Shimizu H,Jin E,Araki T,Sugisaki Y

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:The role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to assess the prognostic significance of B and T lymphocytes and immune checkpoint proteins expression in DCIS. METHODS:A well characterised DCIS cohor...

journal_title：British journal of cancer

authors： Toss MS,Abidi A,Lesche D,Joseph C,Mahale S,Saunders H,Kader T,Miligy IM,Green AR,Gorringe KL,Rakha EA

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:The vascular disrupting agent ombrabulin shows synergy with docetaxel in vivo. Recommended phase II doses were determined in a dose escalation study in advanced solid tumours. METHODS:Ombrabulin (30-min infusion, day 1) followed by docetaxel (1-h infusion, day 2) every 3 weeks was explored. Ombrabulin was e...

journal_title：British journal of cancer

authors： Eskens FA,Tresca P,Tosi D,Van Doorn L,Fontaine H,Van der Gaast A,Veyrat-Follet C,Oprea C,Hospitel M,Dieras V

更新日期：2014-04-29 00:00:00

abstract：BACKGROUND:We conducted a multicentre feasibility study for single agent long-term S-1 chemotherapy following docetaxel plus cisplatin in patients with curatively resected stage II-IIIA non-small cell lung cancer. METHODS:Patients received three cycles of docetaxel (60 mg m(-2)) plus cisplatin (80 mg m(-2)) and then r...

journal_title：British journal of cancer

authors： Niho S,Ikeda N,Michimae H,Suzuki K,Sakai H,Kaburagi T,Minato K,Kato T,Okamoto H,Seto T,Hosomi Y,Shimizu K,Oshita F,Kunitoh H,Tsuboi M,Takeuchi M,Watanabe K

更新日期：2013-08-06 00:00:00

abstract：:Vascular endothelial growth factor-A (VEGF-A) has been demonstrated to play an important role in tumour angiogenesis and to influence prognosis in many cancers. However its prognostic value in head and neck squamous cell carcinomas (HNSCCs) remains controversial. Therefore, we investigated the clinical relevance of VE...

journal_title：British journal of cancer

authors： Onesto C,Hannoun-Lévi JM,Chamorey E,Formento JL,Ramaioli A,Pagès G

更新日期：2006-05-22 00:00:00

abstract：BACKGROUND:The urokinase plasminogen activator (uPA) system is one of the best-investigated protease systems, both under physiological and pathological conditions, including various types of cancer. However, effects of co-expression of members of the uPA system in soft-tissue sarcoma (STS) patients at the protein level...

journal_title：British journal of cancer

authors： Taubert H,Würl P,Greither T,Kappler M,Bache M,Lautenschläger C,Füssel S,Meye A,Eckert AW,Holzhausen HJ,Magdolen V,Kotzsch M

更新日期：2010-02-16 00:00:00

abstract：:In this study, we have investigated the expression of inhibin subunits and activin receptors (ActRs) in normal and malignant ovarian cells. Each product of the inhibin subunits (alpha, betaa, betab) and activin receptors (ActRs) amplified by reverse transcription polymerase chain reaction were detected as a single ban...

journal_title：British journal of cancer

authors： Ito I,Minegishi T,Fukuda J,Shinozaki H,Auersperg N,Leung PC

更新日期：2000-04-01 00:00:00

abstract：:The lymphocyte marker pattern of non-Hodgkin's lymphoma cells was related to current concepts of lymphoma classification. In a series of 28 lymphomas lymphocyte markers indicated that 2 were of histiocytic origin, 2 were unclassifiable, none were derived from T cells and the remainder were B-cell neoplasms. The immuno...

journal_title：British journal of cancer

authors： Payne SV,Smith JL,Jones DB,Wright DH

更新日期：1977-07-01 00:00:00

abstract：:In a previous study we found that aromatic amines, particularly 4-aminobiphenyl, formed haemoglobin adducts at higher concentrations in the blood of smokers compared to non-smokers. We re-analyse here data on haemoglobin adducts of 14 aromatic amines in order to ascertain if the inter-individual variability left unexp...

journal_title：British journal of cancer

authors： Ronco G,Vineis P,Bryant MS,Skipper PL,Tannenbaum SR

更新日期：1990-04-01 00:00:00

abstract：:We conducted a case-control study to investigate the role of early infections in the aetiology of childhood acute leukaemias. The study included 280 incident cases (240 acute lymphoblastic leukaemia and 40 acute non-lymphoblastic leukaemia) and 288 hospital controls, frequency matched by age, gender, hospital, catchme...

journal_title：British journal of cancer

authors： Perrillat F,Clavel J,Auclerc MF,Baruchel A,Leverger G,Nelken B,Philippe N,Schaison G,Sommelet D,Vilmer E,Hémon D

更新日期：2002-04-08 00:00:00