Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat.

abstract：:In 101 breast cancer patients, measurement of oestrogen receptor status in multiple biopsies across a tumour reveals a highly significant difference in the proportion of patients remaining either disease-free (P less than 0.04) or alive (P less than 0.005), when those with uniformly receptor positive (++) primary tumo...

journal_title：British journal of cancer

authors： Castagnetta L,Traina A,Di Carlo A,Carruba G,Lo Casto M,Mesiti M,Leake R

更新日期：1989-04-01 00:00:00

abstract：:An increase in the number of identified therapeutic cancer targets achieved through recent biomedical research has resulted in the generation of a large number of molecules that need to be tested further. Current development of (anticancer) drugs is a rather inefficient process that for an average new molecule takes a...

journal_title：British journal of cancer

authors： Marchetti S,Schellens JH

更新日期：2007-09-03 00:00:00

abstract：:The aim of the study was to investigate whether 99Tc(m)-MIBI (Cardiolite), recently shown to be a substrate for P-glycoprotein, has the potential to be used as a marker for mdr1 gene expression and whether cyclosporin A (CyA) can modify its accumulation in vivo. Leukaemic cells from ten patients with acute myelocytic ...

journal_title：British journal of cancer

authors： Gruber A,Areström I,Xu D,Liliemark J,Larsson SA,Jacobsson H

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Preoperative radiotherapy (RT) is commonly used to treat localised soft-tissue sarcomas (STS). Hypoxia is an important determinant of radioresistance. Whether antiangiogenic therapy can 'normalise' tumour vasculature, thereby improving oxygenation, remains unknown. METHODS:Two cohorts were prospectively enr...

journal_title：British journal of cancer

authors： Lewin J,Khamly KK,Young RJ,Mitchell C,Hicks RJ,Toner GC,Ngan SY,Chander S,Powell GJ,Herschtal A,Te Marvelde L,Desai J,Choong PF,Stacker SA,Achen MG,Ferris N,Fox S,Slavin J,Thomas DM

更新日期：2014-12-09 00:00:00

abstract：:The function of the reticulo-endothelial system in mice bearing Lewis lung carcinomas has been measured by(1) the rate of clearance of carbon particles from the circulation in vivo and calculation of the phagocytic index K; (2) chemotactic locomotion of macrophages in vitro in the presence or absence of serum or tumou...

journal_title：British journal of cancer

authors： Otu AA,Russell RJ,Wilkinson PC,White RG

更新日期：1977-09-01 00:00:00

abstract：:Adenosine deaminase (EC 3.5.4.4, ADA) has been assayed in lymphocytes, granulocytes and erythrocytes from 45 patients with haematological malignancies. Activities were uniformly low in lymphocytes from patients with chronic lymphocytic leukaemia. Variable, but abnormal activities were frequently found in multiple myel...

journal_title：British journal of cancer

authors： Meier J,Coleman MS,Hutton JJ

更新日期：1976-03-01 00:00:00

abstract：:Hypomethylation has been reported to be responsible for the activation of several oncogenes. The possibility that hypomethylation is involved in the regulation of MET transcription was investigated through the analysis of the methylation status of one CpG island containing 43 CpGs in six cases of papillary carcinoma, ...

journal_title：British journal of cancer

authors： Scarpino S,Di Napoli A,Rapazzotti-Onelli M,Pilozzi E,Ruco L

更新日期：2004-08-16 00:00:00

abstract：BACKGROUND:In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of health-related quality of life (HRQOL) from coBRIM is reported. METHODS:Patients completing the Eur...

journal_title：British journal of cancer

authors： Dréno B,Ascierto PA,Atkinson V,Liszkay G,Maio M,Mandalà M,Demidov L,Stroyakovskiy D,Thomas L,de la Cruz-Merino L,Dutriaux C,Garbe C,Bartley K,Karagiannis T,Chang I,Rooney I,Koralek DO,Larkin J,McArthur GA,Ribas A

更新日期：2018-03-20 00:00:00

abstract：:In premenopausal women with advanced breast cancer the luteinising hormone-releasing hormone agonist goserelin (Zoladex, ICI plc) will produce serum levels of oestradiol equivalent to those following surgical oophorectomy or the menopause. This paper reports our further experience of using this drug in 75 premenopausa...

journal_title：British journal of cancer

authors： Dixon AR,Robertson JF,Jackson L,Nicholson RI,Walker KJ,Blamey RW

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Around 60% of women ≥ 80 years old, in the UK do not have surgery for their breast cancer (vs<10% of younger age groups). The extent to which this difference can be accounted for by co-morbidity has not been established. METHODS:A Cancer Registry/Hospital Episode Statistics-linked data set identified women ...

journal_title：British journal of cancer

authors： Lavelle K,Downing A,Thomas J,Lawrence G,Forman D,Oliver SE

更新日期：2012-09-25 00:00:00

abstract：:To study the effect of oral supplemental calcium on colonic epithelial proliferation, 17 adenomatous polyp patients received 1.5 g Ca2+ as calcium carbonate daily during 12 weeks, while on a calcium constant diet, based on the patients' habitual diet. Seven subsequently continued calcium supplementation for 9 months w...

journal_title：British journal of cancer

authors： Kleibeuker JH,Welberg JW,Mulder NH,van der Meer R,Cats A,Limburg AJ,Kreumer WM,Hardonk MJ,de Vries EG

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Low cancer awareness contributes to delay in presentation for cancer symptoms and may lead to delay in cancer diagnosis. The aim of this study was to review the evidence for the effectiveness of interventions to raise cancer awareness and promote early presentation in cancer to inform policy and future resea...

journal_title：British journal of cancer

authors： Austoker J,Bankhead C,Forbes LJ,Atkins L,Martin F,Robb K,Wardle J,Ramirez AJ

更新日期：2009-12-03 00:00:00

abstract：BACKGROUND:A remarkably better prognosis is associated with oropharyngeal squamous cell carcinomas (OPSCC) driven by human papillomaviruses (HPV) compared with HPV-negative OPSCC. Consequently, de-escalation of standard treatment has been suggested. Due to modest specificity rates, debates are ongoing, whether p16INK4a...

journal_title：British journal of cancer

authors： Wagner S,Prigge ES,Wuerdemann N,Reder H,Bushnak A,Sharma SJ,Obermueller T,von Knebel Doeberitz M,Dreyer T,Gattenlöhner S,Wolf G,Pons-Kühnemann J,Wittekindt C,Klussmann JP

更新日期：2020-09-01 00:00:00

abstract：:A method for testing organic chemicals for their carcinogenic potential is described. Baby hamster kidney cells (BHK-21/C1 13) were exposed to different doses of test compound in liquid tissue culture medium containing rat liver post-mitochondrial supernatant and cofactors (S-9 mix) to aid metabolism, but without seru...

journal_title：British journal of cancer

authors： Styles JA

更新日期：1977-11-01 00:00:00

abstract：:Over a wide range of pH, the semiquinone free radicals formed by reduction of adriamycin exist as a form which is strongly stabilised by internal hydrogen bonding and resonance. They protonate with pKa = 2.9. Below this pH they exhibit absorption maxima at 430 nm (Emax = 13,200 dm3 mol-1 cm-1) and approximately 720 nm...

journal_title：British journal of cancer

authors： Land EJ,Mukherjee T,Swallow AJ,Bruce JM

更新日期：1985-04-01 00:00:00

abstract：:The reverse transcription polymerase chain reaction (RT-PCR) amplification of cytokeratin 20 (CK20) mRNA is considered a promising candidate method for the detection of circulating tumour cells in bone marrow and peripheral blood of cancer patients. In this study we have investigated the diagnostic specificity of the ...

journal_title：British journal of cancer

authors： Jung R,Petersen K,Krüger W,Wolf M,Wagener C,Zander A,Neumaier M

更新日期：1999-11-01 00:00:00

abstract：:The identification of peptide vaccine candidates to date has been focused on human leukocyte antigen (HLA)-A2 and -A24 alleles. In this study, we attempted to identify cytotoxic T lymphocyte (CTL)-directed Lck-derived peptides applicable to HLA-A11(+), -A31(+), or -A33(+) cancer patients, because these HLA-A alleles s...

journal_title：British journal of cancer

authors： Naito M,Komohara Y,Ishihara Y,Noguchi M,Yamashita Y,Shirakusa T,Yamada A,Itoh K,Harada M

更新日期：2007-12-17 00:00:00

abstract：BACKGROUND:To date, there are few reports on gene products contributing to colon cancer progression. METHODS:We used a gene trap comprised of an enhanced retroviral mutagen (ERM) cassette that includes a tetracycline-responsive promoter upstream of a haemagglutinin (HA) tag and a splice donor site. Integration of the ...

journal_title：British journal of cancer

authors： Ishiguro T,Avila H,Lin SY,Nakamura T,Yamamoto M,Boyd DD

更新日期：2010-02-16 00:00:00

abstract：:New therapeutic strategies are now being developed against adenocarcinoma associated with erbB-2 amplification, particularly by inhibiting p185erbB-2 expression. Antisense oligodeoxynucleotides seem promising for this purpose as long as they are efficiently protected against degradation and targeted into the cells. We...

journal_title：British journal of cancer

authors： Allal C,Sixou S,Kravtzoff R,Soulet N,Soula G,Favre G

更新日期：1998-05-01 00:00:00

abstract：:Until recently, endocrine therapy for breast cancer was relatively simple. If the tumour expressed hormone receptors, regardless of stage and age, tamoxifen was indicated. While this largely remains the case for premenopausal women, clinical trials in postmenopausal women have broadened our choice to include one of th...

journal_title：British journal of cancer

authors： Wong ZW,Ellis MJ

更新日期：2004-01-12 00:00:00

abstract：:Magnetic resonance spectroscopy was used to study intracellular pH and compounds which contain phosphorus in normal human brain and primary brain tumours non-invasively. In normal subjects (n = 7) intracellular pH (pHi) of the brain was 7.03 +/- 0.02 (mean +/- s.e.m.). The pHi did not vary between superficial (2 cm, m...

journal_title：British journal of cancer

authors： Cadoux-Hudson TA,Blackledge MJ,Rajagopalan B,Taylor DJ,Radda GK

更新日期：1989-09-01 00:00:00

abstract：:Tumour angiogenesis is essential for progression of solid tumours and constitutes an interesting target for therapy. However, impaired tumour blood supply may also be an important obstacle for treatment by radiotherapy and chemotherapy. Estramustine has been shown to increase tumour blood flow and potentiate the effec...

journal_title：British journal of cancer

authors： Johansson M,Bergenheim AT,Widmark A,Henriksson R

更新日期：1999-04-01 00:00:00

abstract：:In a meta-analysis of testicular cancer in twins, twins had a 30% increased risk (estimate 1.31, 95% CI 1.1-1.6), providing indirect support for the hypothesis that in utero hormone variations influence risk of testicular cancer. The summary-estimate for dizygotic twins was 1.3 (1.0-1.7) and for monozygotic or same se...

journal_title：British journal of cancer

authors： Neale RE,Carrière P,Murphy MF,Baade PD

更新日期：2008-01-15 00:00:00

abstract：BACKGROUND:Oestrogen (E2) induces apoptosis in long-term E2-deprived MCF7 cells (MCF7:5C). Taxanes have been used extensively in the treatment of early and advanced breast cancer. We have interrogated the sequence of events that involve the apoptotic signalling pathway induced by E2 in comparison with paclitaxel. METH...

journal_title：British journal of cancer

authors： Obiorah I,Sengupta S,Fan P,Jordan VC

更新日期：2014-03-18 00:00:00

abstract：:A urinary gonadotrophin peptide (UGP) was isolated and purified from semi-purified human chorionic gonadotrophin (hCG), prepared from pregnancy urine. The peptide showed hCG-B subunit activity and no hCG-alpha subunit activity as demonstrated by binding studies with the relevant antibodies. It had a molecular weight s...

journal_title：British journal of cancer

authors： Kardana A,Taylor ME,Southall PJ,Boxer GM,Rowan AJ,Bagshawe KD

更新日期：1988-09-01 00:00:00

abstract：:The blood-brain barrier is a major obstacle for the chemotherapeutic drugs to effectively reach primary or secondary brain tumours. Stealth liposomal drugs are highly accumulated in tumoural tissues. In the present study we investigated the relative accumulation of(99m)Tc-DTPA radiolabelled stealth liposomal doxorubic...

journal_title：British journal of cancer

authors： Koukourakis MI,Koukouraki S,Fezoulidis I,Kelekis N,Kyrias G,Archimandritis S,Karkavitsas N

更新日期：2000-11-01 00:00:00

abstract：:The aim of this study is to evaluate different options for introducing liquid-based cytology (LBC) and human papillomavirus (HPV) testing into the UK cervical cancer screening programme. These include options that incorporate HPV testing either as a triage for mild and borderline smear abnormalities or as a primary sc...

journal_title：British journal of cancer

authors： Sherlaw-Johnson C,Philips Z

更新日期：2004-07-05 00:00:00

abstract：:The use of oncolytic viruses has received considerable attention in recent years and many viruses have proved to be effective against a variety of cancer models and a few are currently being used in clinical trials. However, the possible emergence and outcome of virus-resistant tumour cells has not been addressed. We ...

journal_title：British journal of cancer

authors： Alain T,Kim M,Johnston RN,Urbanski S,Kossakowska AE,Forsyth PA,Lee PW

更新日期：2006-10-23 00:00:00

abstract：BACKGROUND:Activating mutations of Fms-like tyrosine kinase 3 (FLT3) constitute a major driver in the pathogenesis of acute myeloid leukaemia (AML). Hence, pharmacological inhibitors of FLT3 are of therapeutic interest for AML. METHODS:The effects of inhibition of FLT3 activity by a novel potent FLT3 inhibitor, BPR1J-...

journal_title：British journal of cancer

authors： Lin WH,Jiaang WT,Chen CW,Yen KJ,Hsieh SY,Yen SC,Chen CP,Chang KY,Chang CY,Chang TY,Huang YL,Yeh TK,Chao YS,Chen CT,Hsu JT

更新日期：2012-01-31 00:00:00

abstract：:The in vitro deamination, cytotoxicity, cellular drug uptake, distribution and cellular pharmacology in HL-60 cells of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine (NHAC), a lipophilic derivative of arabinofuranosylcytosine (ara-C), were studied. Compared with ara-C, NHAC in liposomal formulations was highly resista...

journal_title：British journal of cancer

authors： Horber DH,Schott H,Schwendener RA

更新日期：1995-05-01 00:00:00