Abstract：
:Magnetic resonance spectroscopy was used to study intracellular pH and compounds which contain phosphorus in normal human brain and primary brain tumours non-invasively. In normal subjects (n = 7) intracellular pH (pHi) of the brain was 7.03 +/- 0.02 (mean +/- s.e.m.). The pHi did not vary between superficial (2 cm, majority grey matter) and deep brain (5 cm, majority white matter). The relative concentrations of phosphocreatine (PCr) and phosphomonoesters (PME) to ATP were also constant with depth. The relative concentration of phosphodiesters (PDE) increased from superficial to deep in normal brain. The astrocytomas (n = 7, grade II-IV) were significantly more alkaline (pHi = 7.08 +/- 0.03), and contained more PCr and PME, with respect to ATP, than normal brain at similar depth. The meningiomas (n = 4) were also more alkaline (pHi = 7.19 +/- 0.02) with a raised PME level but reduced PCr. The reduction in meningioma PCr may be due to the significant necrosis (greater than 20%) seen in the surgical biopsies. No significant necrosis was seen in the gliomas. Previous in vitro studies suggest that increased PME may be due to accumulation of phosphoethanolamine (PE), a phospholipid precursor. These results suggest that human primary brain tumours characteristically are more alkaline with increased PME than normal brain.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Cadoux-Hudson TA,Blackledge MJ,Rajagopalan B,Taylor DJ,Radda GKdoi
10.1038/bjc.1989.300subject
Has Abstractpub_date
1989-09-01 00:00:00pages
430-6issue
3eissn
0007-0920issn
1532-1827journal_volume
60pub_type
杂志文章abstract：:The purpose of this study was to address the prognostic significance of circulating melanoma cells by reverse transcriptase-polymerase chain reaction in the peripheral blood of stage IIB and III melanoma patients on high-dose adjuvant interferon at multiple sequential time points from initiation of treatment. Tyrosina...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600419
更新日期：2002-07-15 00:00:00
abstract：:The combination of heat and chemotherapy was studied in an intraperitoneal tumour model. Rats bearing peritoneal CC531 tumours (2-6 mm) were treated i.p. with cDDP or CBDCA [maximal tolerated dose (MTD)] in combination with regional hyperthermia (41.5 degrees C, 1 h) of the peritoneal cavity. The addition of hyperther...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.45
更新日期：1994-02-01 00:00:00
abstract：BACKGROUND:Multiple early gastric cancers (EGCs) may develop in 6-14% of patients even after achieving curative endoscopic submucosal dissection (ESD); however, a useful biomarker for predicting recurrence is not available. The present study investigated whether the expression of CD44 variant 9 (CD44v9), a functional c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.314
更新日期：2013-07-23 00:00:00
abstract：:Breast cancer is the second most common cancer among women in Madras and southern India after cervix cancer. The Madras Metropolitan Tumour Registry (MMTR), a population-based cancer registry, collects data on the outcome of cancer diagnosis by both active and passive methods. A total of 2080 cases of invasive female ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.137
更新日期：1997-01-01 00:00:00
abstract：:Chemotherapy or radiotherapy often cause mucosal damage in the gut (gut mucositis) in cancer patients. As a step to investigate mechanisms underlying subsequent intestinal repair, we have examined the expression profiles of hepatocyte growth factor (HGF) and its receptor c-met, two molecules previously implicated in t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.1023
更新日期：2000-02-01 00:00:00
abstract：:The relation between pretreatment night-time urinary catecholamine excretion and chemotherapy-induced nausea and vomiting was studied. The first cohort included 17 women and three men with various cancer forms receiving low or moderately emetogenic chemotherapy. The second cohort included 42 women receiving cisplatinu...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1994.364
更新日期：1994-10-01 00:00:00
abstract：:Eighteen patients with inoperable hepatocellular carcinoma (HCC) were treated with intrahepatic arterial yttrium-90 microspheres. All these patients showed a lung shunting below 15% and a tumour-to-normal ratio higher than 2 as determined by diagnostic technetium-99m macroaggregated albumin (Tc-MAA) gamma scintigraphy...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1994.436
更新日期：1994-11-01 00:00:00
abstract：:P450 reductase (NADPH:cytochrome P450 reductase, EC 1.6.2.4) is known to be important in the reductive activation of the benzotriazene-di-N-oxide tirapazamine (SR 4233). Using a panel of six human breast adenocarcinoma cell lines we have examined the relationship between P450 reductase activity and sensitivity to tira...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.478
更新日期：1995-11-01 00:00:00
abstract：:Endosialin is a transmembrane glycoprotein selectively expressed in blood vessels and stromal fibroblasts of various human tumours. It has been functionally implicated in angiogenesis, but the factors that control its expression have remained unclear. As insufficient delivery of oxygen is a driving force of angiogenes...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604685
更新日期：2008-10-21 00:00:00
abstract：:We report here a case of a patient affected by endometrial cancer and treated primarily with leuprolide, the surgical approach being unfeasible due to her compromised conditions. The therapy was continued for more than 6 years, and no progression of the disease was observed. During this period, some histological and i...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1900
更新日期：2001-08-03 00:00:00
abstract：BACKGROUND:The Mediterranean diet has been shown to have a beneficial role on various neoplasms, but data are scanty on pancreatic cancer. METHODS:We analysed data from two case-control studies conducted in Italy between 1983 and 2008, including 362 and 326 pancreatic cancer cases and 1552 and 652 hospital-controls, r...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.345
更新日期：2013-09-03 00:00:00
abstract：:The association between Ki-ras mutations and proliferation activity was investigated in a comprehensive series of biliary tract carcinomas (BTCs). We precisely microdissected samples of tissue from paraffin-embedded sections of 77 BTCs including 22 intrahepatic cholangiocarcinomas (ICCs), 36 extrahepatic cholangiocarc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.459
更新日期：1996-09-01 00:00:00
abstract：:Epidemiologic evidence has recently identified an association between an endemic outbreak of pleural and peritoneal mesothelioma in the Urgup region of Turkey and exposure to zeolite fibres. This malignancy is usually associated with exposure to asbestos dusts whose mineralogical characteristics differ from those of z...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.158
更新日期：1986-07-01 00:00:00
abstract：:Our previous studies showed that carboxymethyl benzylamide dextran (CMDB7) blocks basic fibroblast growth factor (FGF-2)-dependent cell proliferation of a human breast epithelial line (HBL100), suggesting its potential role as a potent antiangiogenic substance. The derived cell line (HH9), which was transformed with t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.451
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:Epstein-Barr virus-positive post-transplant lymphoproliferative disease (PTLD) is a potentially lethal complication of iatrogenic immunosupression after transplantation. Predicting the development of PTLD allowing early and effective intervention is therefore of importance. Polymorphisms within cytokine gene...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605278
更新日期：2009-09-15 00:00:00
abstract：:The cisplatin analogue 1R,2R-diaminocyclohexane(trans-diacetato)(dichloro)platinum(IV) (DAP) is a DNA-damaging agent that will be entering clinical trials for its potent cytotoxic effects against cisplatin-resistant tumour cells. This cytotoxicity may reside in its ability to selectively activate G1-phase checkpoint r...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603448
更新日期：2006-12-04 00:00:00
abstract：BACKGROUND:Melanoma is highly resistant to current modalities of therapy, with the extent of pigmentation playing an important role in therapeutic resistance. Nuclear factor-κB (NF-κB) is constitutively activated in melanoma and can serve as a molecular target for cancer therapy and steroid/secosteroid action. METHODS...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.458
更新日期：2011-12-06 00:00:00
abstract：:Malignant melanoma (MM) is thought to arise by sequential accumulation of genetic alterations in normal melanocytes. Previous cytogenetic and molecular studies indicated the 9p21 as the chromosomal region involved in MM pathogenesis. In addition to the CDKN genes (p16/CDKN2A, p15/CDKN2B and p19(ARF), frequently inacti...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1513
更新日期：2000-12-01 00:00:00
abstract：:In a population-based, matched, case-control study from southern Sweden of 571 patients with a first diagnosis of cutaneous malignant melanoma and 913 healthy controls aged 16-80 years, the association between sunbed use and malignant melanoma was evaluated. A total of 250 (44%) cases and 372 (41%) controls reported e...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.1181
更新日期：2000-05-01 00:00:00
abstract：:Resistance to cytotoxic agents may be encountered during the treatment of acute myeloblastic leukaemia (AML). P-glycoprotein encoded by the MDR-1 gene has been implicated as a potential drug resistance mechanism in leukaemic cells. In recent years, many data have been accrued concerning the expression of P-glycoprotei...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.1994.70
更新日期：1994-02-01 00:00:00
abstract：:Three intraperitoneal human ovarian cancer xenografts (OS, HU, and LA) were used to assess the antitumour activity of intraperitoneal therapy with liposome encapsulated MTP-PE. MTP-PE led to significant prolongation of survival in all three xenograft models, but with varying efficacy. In one tumour model (OS), 80% of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.92
更新日期：1991-03-01 00:00:00
abstract：:The purpose of this study was to determine the maximum-tolerated dose of gemcitabine plus mitoxantrone in women with metastatic breast cancer (MBC) and to evaluate activity and toxicity of this combination in a phase II trial. Sixty-three patients with MBC, previously treated with chemotherapy including anthracycline ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6600780
更新日期：2003-02-24 00:00:00
abstract：:Cancer incidence in the Falkland Islands, 1989-2000, was compared with rates in England and Wales, from which most Islanders originate. Colon and rectum cancer incidence was significantly raised 1989-93 but greatly reduced after 1994, when colonoscopic screening in high-risk families and sigmoidoscopic screening in th...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.2099
更新日期：2001-11-02 00:00:00
abstract：BACKGROUND:Twenty to 40% localised RCC patients may experience recurrence after curative surgery. Limited miRNA predictors have been identified for ccRCC recurrence. METHODS:Through a multi-phase study design, we analysed miRNAs in tissues obtained from 203 ccRCC patients. Paired t-test was used for tumour-normal comp...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.392
更新日期：2017-01-03 00:00:00
abstract：:The relationship of cytogenetic changes with the acquisition of an indefinite life span in vitro, the ability of cells to grow in soft agar and their tumourigenicity in syngeneic animals has been studied in control, trans-7,8-dihydrodiolbenzo(a)pyrene and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrah...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1984.159
更新日期：1984-08-01 00:00:00
abstract：:The aim of this study was to determine the correlation between changes in collagen metabolites (ICTP, mature cross-linked carboxy-terminal telopeptide of type I collagen; PINP, the amino-terminal propeptide of type I procollagen) and bone mineral density (BMD) in 206 pre- and post-menopausal breast cancer patients wit...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1998.471
更新日期：1998-07-01 00:00:00
abstract：:Short-term cultures from one synovial chondroma and three cases of synovial chondromatosis, a lesion for which no previous karyotypic information exists, were cytogenetically analysed. Whereas the chondroma displayed the relatively simple karyotype 46,XY,add(12)(q13),der(17)t(12;17)(q13;q21), more complex changes were...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.346
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND:To evaluate the prognostic value of lymph node density (LND) in patients with lymph node-positive cervical cancer. METHODS:A total of 88 consecutive patients were included in our study. Patients were treated with cisplatin-based concomitant chemoradiotherapy after surgical staging was performed at the Medic...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605801
更新日期：2010-08-24 00:00:00
abstract：BACKGROUND:Cancer/testis-antigens (CTAs) are specifically expressed in human malignancies and testis tissue, but their molecular functions are poorly understood. CTAs serve as regulators of gene expression, cell cycle and spermatogenesis, as well as targets for immune-based therapies. The CTA PRAME is expressed in vari...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.187
更新日期：2016-08-09 00:00:00
abstract：:This study describes the effects of the glucolipid synthase inhibitor P4, (DL-threo-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol ), on various functional and phenotypic parameters of 5T33 murine myeloma cells. Cell recovery was reduced by >85% following incubation of the cells for 3 days in the presence of 4 mic...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690792
更新日期：1999-11-01 00:00:00
