Abstract:
:The aim of the study was to investigate whether 99Tc(m)-MIBI (Cardiolite), recently shown to be a substrate for P-glycoprotein, has the potential to be used as a marker for mdr1 gene expression and whether cyclosporin A (CyA) can modify its accumulation in vivo. Leukaemic cells from ten patients with acute myelocytic leukaemia (AML) were used, five with undetectable mdr1 gene expression and five with mdr1 mRNA levels ranging from 1.0 to 3.8 mdr1 mRNA transcripts per cell. Cells were incubated with 99Tc(m)-MIBI, or with daunorubicin (Dnr), with and without 3 microM CyA. The median 99Tc(m)-MIBI accumulation (% of added radioactivity) in mdr1-negative cells was 0.89% and in the mdr1-positive cells 0.34%, P = 0.01. In mdr1-negative cells, the median increase in 99Tc(m)-MIBI accumulation with CyA was 30% compared with the mdr1-positive cells with a median increase of 242%, P = 0.009. CyA had no significant effect on Dnr accumulation in four of the mdr1-negative samples. The median increase of Dnr accumulation in the mdr1-positive cells was 40%. The results show that 99Tc(m)-MIBI with a high sensitivity can detect rather low levels of mdr1 gene expression in clinical samples. Consequently, 99T(c)m-MIBI scintigraphy has the potential to be used for monitoring the effect of resistance modifiers on the accumulation and retention of cytostatic drugs in human tumours in vivo.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Gruber A,Areström I,Xu D,Liliemark J,Larsson SA,Jacobsson Hdoi
10.1038/bjc.1998.290subject
Has Abstractpub_date
1998-06-01 00:00:00pages
1732-6issue
11eissn
0007-0920issn
1532-1827journal_volume
77pub_type
杂志文章abstract::The mechanism of down-regulation of c-myc RNA associated with androgen-induced suppression of the transformed phenotype in the human prostate carcinoma cell line LNCaP was investigated. The synthetic androgen mibolerone (7 alpha-17 alpha-Dimethyl-19-nortestosterone) reversibly inhibits the proliferation of LNCaP cells...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.76
更新日期:1992-03-01 00:00:00
abstract::This study reports on the frequency and disease association pattern of a number of gene rearrangements in a large panel of lymphoid tumours (n = 94). We detected the t(11;14) translocation, involving rearrangement of the BCL-1 locus, in 60% of mantle cell lymphomas. The BCL-2 gene, located at band 18q21, was rearrange...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.279
更新日期:1997-01-01 00:00:00
abstract::We evaluated the risk of bladder cancer in a cohort of 79,280 Swedish men hospitalised for benign prostatic hyperplasia (BPH), identified in the Swedish Inpatient Register between 1964 and 1983 and followed until 1989 via multiple record linkages with nationwide data on cancer registry, death and emigration. Standardi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603730
更新日期:2007-05-07 00:00:00
abstract:BACKGROUND:We previously reported that chaetocin has potent and selective anti-myeloma activity attributable to reactive oxygen species (ROS) induction imposed by inhibition of the redox enzyme thioredoxin reductase; we now detail its effects in solid tumours. METHODS:Cellular assays, transcriptional profiling and the...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.522
更新日期:2012-01-17 00:00:00
abstract:BACKGROUND:This study is to investigate the effects of geserelin+tamoxifen (TAM) on estradiol level, breast density (BD), endometrial thickness (ET), and blood lipids in premenopausal and perimenopausal women with hormone receptor-positive early-stage breast cancer. METHODS:This study recruited 110 premenopausal and p...
journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/bjc.2013.324
更新日期:2013-08-06 00:00:00
abstract::The abilities of chemokines in orchestrating cellular migration are utilised by different (patho-)biological networks including malignancies. However, except for CXCR4/CXCL12, little is known about the relation between tumour-related chemokine expression and the development and progression of solid tumours like breast...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604621
更新日期:2008-09-16 00:00:00
abstract:BACKGROUND:The host immune reaction is represented by immune/inflammatory cell infiltrates. Here we systematically analysed tumour-infiltrating immune/inflammatory cells in pancreatic ductal carcinoma (PDC) and evaluated their clinicopathological impact. METHODS:Using immunohistochemistry, we examined tumour-infiltrat...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.32
更新日期:2013-03-05 00:00:00
abstract::Human papillomavirus (HPV) is thought to cause some vulval squamous cell carcinomas (VSCC) by degrading p53 product. Evidence on whether HPV-negative VSCC results from p53 mutation is conflicting. We performed immunohistochemistry for p53 product on 52 cases of lone vulval intraepithelial neoplasia (VIN), 21 cases of ...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1038/sj.bjc.6600677
更新日期:2003-01-27 00:00:00
abstract::There is increasing evidence that essential fatty acids (EFA) may have a role to play in the aetiology of some types of cancer although their precise mode of action is unknown. Differences in the metabolism of EFA between patients with benign or malignant prostatic disease may help to elucidate their role in the latte...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1991.481
更新日期:1991-12-01 00:00:00
abstract::This study evaluates the overall survival and disease free survival of melanoma patients that were treated with an autologous melanoma cell vaccine, administered as a post-operative adjuvant. Included are 43 patients with totally resected metastatic melanoma (28-AJCC stage III, 15-AJCC stage IV), with a median follow ...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6600251
更新日期:2002-05-20 00:00:00
abstract::Our previous studies showed that carboxymethyl benzylamide dextran (CMDB7) blocks basic fibroblast growth factor (FGF-2)-dependent cell proliferation of a human breast epithelial line (HBL100), suggesting its potential role as a potent antiangiogenic substance. The derived cell line (HH9), which was transformed with t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.451
更新日期:1998-07-01 00:00:00
abstract::We analysed two case-control studies of women from Italy and Switzerland, including 195 cases of oral and pharyngeal cancers and 1113 controls. The multivariate odds ratio was 4.6 for heavy smokers and 2.7 for high alcohol intake. Vegetables, fruit, beta-carotene and wholegrain foods were inversely, butter and retinol...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.0900
更新日期:2000-01-01 00:00:00
abstract::Evidence in the literature suggests that hyperthermia (HT) or inhibitors of calmodulin can increase the sensitivity of rodent cells to bleomycin (BLM) by interfering with DNA repair functions. In an attempt to explore methods of improving the efficacy of thermochemotherapy we have investigated the individual and combi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1986.14
更新日期:1986-01-01 00:00:00
abstract::Members of the public are increasingly consulted over health care and research priorities. Patient involvement in determining cancer research priorities, however, has remained underdeveloped. This paper presents the findings of the first consultation to be conducted with UK cancer patients concerning research prioriti...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603662
更新日期:2007-03-26 00:00:00
abstract::Carcinoembryonic antigen-like substances in the urine of patients with bladder carcinoma and of healthy male subjects occur in a wide range of average molecular sizes. Some of these substances are glycoproteins giving reactions of antigenic identity with carcinoembryonic antigen (CEA) derived from colorectal carcinoma...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1974.93
更新日期:1974-06-01 00:00:00
abstract:BACKGROUND:MiR-125b has critical role in non-small-cell lung cancer (NSCLC) cell migration, and its target genes have not been elucidated. Kinesin-1 light chain (KLC)-2 was predicted as one of miR-125b's targets by bioinformatics analysis. This study is to identify the function of KLC2 and its interaction with miR-125b...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.3
更新日期:2015-03-03 00:00:00
abstract:BACKGROUND:This study explored the association between smoking and colorectal malignant carcinoma (CRC) in the Chinese population at the national level for the first time. METHODS:In the China Nationwide Retrospective Mortality Survey conducted during 1989-1991, 12,942 CRC cases among 1,136,336 all-cause deaths aged ≥...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.9
更新日期:2014-03-04 00:00:00
abstract::We analysed 29 consecutive cases of primary gastric lymphoma (20 men and 9 women) treated in our unit between January 1977 and May 1983. Median age was 55 years. Abdominal pain and weight loss were the main presenting symptoms while there was no palpable disease in the majority of cases. Upper gastrointestinal radiolo...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1985.206
更新日期:1985-09-01 00:00:00
abstract::A clinical trial conducted according to a schedule of interim analyses written into the protocol, and stopped according to a predetermined rule, is known to statisticians as a sequential clinical trial. This methodology is becoming more widely used in trials concerning life-threatening diseases because of its ability ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.500
更新日期:1993-12-01 00:00:00
abstract::Immunoglobulins (Ig) and some complement components (C) were quantified in sera from patients with gastric carcinoma before surgery and at regular intervals during a 5-year follow-up. The preoperative concentrations of C1-INH and C4 were higher (P < 0.0005 and P < 0.005) and IgG lower (P < 0.0005) in 50 patients with ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.376
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:This study had two aims: (a) to test the hypothesis that advanced age is associated with lower levels of tolerability and clinical benefit to experimental Phase I trial agents; (b) to assess the validity of the Royal Marsden Hospital (RMH) prognostic score as a patient selection tool in older patients. METH...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.477
更新日期:2016-02-02 00:00:00
abstract::Preclinical models that can accurately predict outcomes in the clinic are much sought after in the field of cancer drug discovery and development. Existing models such as organoids and patient-derived xenografts have many advantages, but they suffer from the drawback of not contextually preserving human tumour archite...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/s41416-019-0672-6
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:New therapeutic options for metastatic pancreatic cancer are urgently needed. In pancreatic cancer, overexpression of the epidermal growth factor receptor 2 (HER2) has been reported in up to 45%. This multicentre phase II study investigated the efficacy and toxicity of the HER2 antibody trastuzumab combined ...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/bjc.2012.18
更新日期:2012-03-13 00:00:00
abstract:BACKGROUND:For patients with locally advanced rectal cancer (LARC), it is unclear whether neoadjuvant chemoradiotherapy-induced pathologic complete response (pCR) individuals would further benefit from adjuvant chemotherapy (ACT). METHODS:The pCR individuals who received different ACT cycles were paired by propensity ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0989-1
更新日期:2020-10-01 00:00:00
abstract::Although it is generally accepted that proteolytic degradation is an important mechanism used by malignant cells in the process of metastasis, comparatively little is known about the regulation of molecules responsible for proteolysis and how they become de-regulated during human tumour progression. Using a geneticall...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690385
更新日期:1999-05-01 00:00:00
abstract::Capecitabine is an oral prodrug of 5-fluorouracil (FU). Since FU concentrations achieved in malignant lesions are an important determinant of efficacy, we investigated the intratumoral transcapillary transfer of capecitabine and its metabolites in vivo. A total of 10 patients with skin metastases from breast cancer re...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600809
更新日期:2003-03-10 00:00:00
abstract::The toxicity of misonidazole (1-(2-nitroimidazol-1-yl)-3-methoxy-2-propanol) towards mammalian cells in vitro has been determined as a function of O2 tension. Misonidazole under hypoxic conditions (less than 10 Parts/10(6) O2) shows the greatest toxicity. Split-dose experiments indicate that lethal damage can be "repa...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.172
更新日期:1978-07-01 00:00:00
abstract::Lung cancer is the primary cause of cancer mortality in developed countries. First diagnosis only when disease has already reached the metastatic phase is the main reason for failure in treatment. To this regard, although low-dose spiral computed tomography (CT) has proven to be effective in the early detection of lun...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/sj.bjc.6605660
更新日期:2010-06-08 00:00:00
abstract:BACKGROUND:Numerous markers have been evaluated to facilitate the non-invasive diagnostic work-up of mesothelioma. The purpose of this study was to conduct a structured review of the diagnostic performance of non-invasive marker tests for the detection of mesothelioma in patients with suspected mesothelioma. METHODS:S...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.2011.104
更新日期:2011-04-12 00:00:00
abstract::The haemodynamics of the uterine arteries and myometrium were assessed using Doppler ultrasound in forty consecutive patients requiring treatment for invasive mole and choriocarcinoma. The investigations were performed prior to the commencement of chemotherapy and the subjects followed prospectively. The Doppler wavef...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.379
更新日期:1992-11-01 00:00:00