Risk factors for oral and pharyngeal cancer in women: a study from Italy and Switzerland.

abstract：:The aim of this paper was to provide epidemiological evidence to support the notion that cervical intraepithelial neoplasia (CIN) without human papillomavirus (HPV) is a true entity. If a diagnosis of HPV-negative cervical neoplasia is erroneous, one would not expect there to be any differences in risk factors between...

journal_title：British journal of cancer

authors： Burger MP,Hollema H,Pieters WJ,Schröder FP,Quint WG

更新日期：1996-03-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMCs) were obtained from patients receiving radioactive murine monoclonal antibody (MAb) therapy for malignant epithelial tumours, as well as normal controls, and were tested for the ability of T cells to proliferate in vitro in the presence of the MAb administered for therapy (HMF...

journal_title：British journal of cancer

authors： Kosmas C,Epenetos AA,Courtenay-Luck NS

更新日期：1991-09-01 00:00:00

abstract：:The purpose of the study was to determine the response rates (RR) and duration to second- and third-line chemotherapy programmes in patients with anthracycline-resistant breast cancer, utilizing various definitions of anthracycline resistance. This was a retrospective analysis performed on 1335 patients with metastati...

journal_title：British journal of cancer

authors： Pivot X,Asmar L,Buzdar AU,Valero V,Hortobagyi G

更新日期：2000-02-01 00:00:00

abstract：:BNP7787 (disodium 2,2'-dithio-bis-ethane sulphonate; Tavocept) is a novel agent developed to protect against cisplatin (cis-diammine-dichloroplatinum(II))-associated chronic toxicities. In this study, we determined the recommended dose of BNP7787 when preceding a fixed dose of cisplatin, the pharmacokinetics (PKs) and...

journal_title：British journal of cancer

authors： Boven E,Westerman M,van Groeningen CJ,Verschraagen M,Ruijter R,Zegers I,van der Vijgh WJ,Giaccone G

更新日期：2005-05-09 00:00:00

abstract：:Four human melanoma xenograft lines (A-07, D-12, R-18, U-25) grown orthotopically in Balb/c nu/nu mice were characterized with respect to the fraction of radiobiologically hypoxic cells. The purpose of the study was to establish a firm radiobiological basis for future use of the lines in the development and evaluation...

journal_title：British journal of cancer

authors： Rofstad EK,Måseide K

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:When tumour tissue is unavailable, cell-free DNA (cfDNA)can serve as a surrogate for genetic analyses. Because mutated alleles in cfDNA are usually below 1%, next-generation sequencing (NGS)must be narrowed to target only clinically relevant genes. In this proof-of-concept study, we developed a panel to use ...

journal_title：British journal of cancer

authors： Malapelle U,Mayo de-Las-Casas C,Rocco D,Garzon M,Pisapia P,Jordana-Ariza N,Russo M,Sgariglia R,De Luca C,Pepe F,Martinez-Bueno A,Morales-Espinosa D,González-Cao M,Karachaliou N,Viteri Ramirez S,Bellevicine C,Molina-Vila M

更新日期：2017-03-14 00:00:00

abstract：BACKGROUND:Locally advanced oesophageal cancer (LAEC) is associated with poor survival and more effective treatments are needed. The aim of this phase I trial was to assess the maximum tolerated dose (MTD) of a novel weekly docetaxel and cisplatin regimen concurrent with radical radiotherapy. METHODS:Patients with unr...

journal_title：British journal of cancer

authors： Day FL,Leong T,Ngan S,Thomas R,Jefford M,Zalcberg JR,Rischin D,McKendick J,Milner AD,Di Iulio J,Matera A,Michael M

更新日期：2011-01-18 00:00:00

abstract：BACKGROUND:The germline BRCA2 mutation is associated with increased prostate cancer (PrCa) risk. We have assessed survival in young PrCa cases with a germline mutation in BRCA2 and investigated loss of heterozygosity at BRCA2 in their tumours. METHODS:Two cohorts were compared: one was a group with young-onset PrCa, t...

journal_title：British journal of cancer

authors： Edwards SM,Evans DG,Hope Q,Norman AR,Barbachano Y,Bullock S,Kote-Jarai Z,Meitz J,Falconer A,Osin P,Fisher C,Guy M,Jhavar SG,Hall AL,O'Brien LT,Gehr-Swain BN,Wilkinson RA,Forrest MS,Dearnaley DP,Ardern-Jones AT,Pag

更新日期：2010-09-07 00:00:00

abstract：:The multivariate lognormal survival model can be used to determine the relationship of prognostic covariates to two important parameters of malignancy. Cured fraction and median survival time among uncured patients. Analysis with this model revealed that cured fraction is primarily a function of histologic type and no...

journal_title：British journal of cancer

authors： Gamel JW,Jones AS

更新日期：1993-05-01 00:00:00

abstract：:In a longitudinal study of the evolution of serum beta 2-microglobulin (beta 2-m) levels in 37 patients with myelomatosis, those patients with a level of < 4 mg/l at first presentation had a median survival of 46 months, whereas those with an initial level of > mg/l had a median survival of 15 months. THe beta 2-m app...

journal_title：British journal of cancer

authors： Norfolk D,Child JA,Cooper EH,Kerruish S,Ward AM

更新日期：1980-10-01 00:00:00

abstract：BACKGROUND:Combined oral contraceptive (COC) use reduces epithelial ovarian cancer (EOC) risk. However, little is known about risk with COC use before the first full-term pregnancy (FFTP). METHODS:This Canadian population-based case-control study (2001-2012) included 854 invasive cases/2139 controls aged ⩾40 years who...

journal_title：British journal of cancer

authors： Cook LS,Pestak CR,Leung AC,Steed H,Nation J,Swenerton K,Gallagher R,Magliocco A,Köbel M,Brooks-Wilson A,Le N

更新日期：2017-01-17 00:00:00

abstract：:Besides its cardiotoxic effect, doxorubicin also elicits inflammatory effects in vivo. 7-Monohydroxyethylrutoside (monoHER) has recently been used as a protector against doxorubicin-induced cardiotoxicity in vivo. It is not known yet whether monoHER can also protect against doxorubicin-induced inflammatory effects. Th...

journal_title：British journal of cancer

authors： Abou El Hassan MA,Verheul HM,Jorna AS,Schalkwijk C,van Bezu J,van der Vijgh WJ,Bast A

更新日期：2003-07-21 00:00:00

abstract：BACKGROUND:Few studies have investigated the relationship between physician and patient-assessed performance status (PS) in blood cancers. METHODS:Retrospective analysis among 1418 patients with haematologic malignancies seen at Dana-Farber Cancer Institute between 2007 and 2014. We analysed physician-patient agreemen...

journal_title：British journal of cancer

authors： Liu MA,Hshieh T,Condron N,Wadleigh M,Abel GA,Driver JA

更新日期：2016-09-27 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the safety of neoadjuvant chemoradiation using radiotherapy (RT) combined with concurrent capecitabine and irinotecan for locally advanced rectal cancer before surgery. METHODS:Forty-six patients were recruited and treated on the basis that MRI scanning had shown poo...

journal_title：British journal of cancer

authors： Gollins SW,Myint S,Susnerwala S,Haylock B,Wise M,Topham C,Samuel L,Swindell R,Morris J,Mason L,Levine E

更新日期：2009-09-15 00:00:00

abstract：:Pancreatic cancer is the fifth most common cause of cancer death. Identification of defined patient groups based on a prognostic index may improve the prediction of survival and selection of therapy. Many prognostic factors have been identified often based on retrospective, underpowered studies with unclear analyses. ...

journal_title：British journal of cancer

authors： Stocken DD,Hassan AB,Altman DG,Billingham LJ,Bramhall SR,Johnson PJ,Freemantle N

更新日期：2008-09-16 00:00:00

abstract：:Matched pair analysis relating to 3376 mothers of children who died of cancer 1972-1981 and of healthy control children from the Oxford Survey of Childhood Cancers showed no evidence of protection from breastfeeding for acute lymphocytic leukaemia (OR 1.04, 95% CI 0.86-1.26), for all cancers combined (OR 1.04, 95% CI ...

journal_title：British journal of cancer

authors： Lancashire RJ,Sorahan T,OSCC.

更新日期：2003-04-07 00:00:00

abstract：BACKGROUND:Lithium accumulates in the colon and inhibits the enzyme GSK-3β that possesses anti-carcinogenic effects. We therefore examined the association between lithium use and colorectal cancer risk in a nationwide study. METHODS:We used the Danish Cancer Registry to identify all patients diagnosed with incident co...

journal_title：British journal of cancer

authors： Pottegård A,Ennis ZN,Hallas J,Jensen BL,Madsen K,Friis S

更新日期：2016-03-01 00:00:00

abstract：:Swedish population-based incidence and mortality rates for cancer of the uterine cervix, both in situ and invasive, during the period 1958 to 1981 were determined by means of a dynamic model. This new approach describes without any preconceptions the development of the disease as a sequential process over the stages c...

journal_title：British journal of cancer

authors： Gustafsson L,Adami HO

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:MYCN amplification with subsequent MYCN protein overexpression is a powerful indicator of poor prognosis of neuroblastoma patients. Little is known regarding the prognostic significance of the homologous MYC protein expression in neuroblastoma. METHODS:Immunostaining for MYCN and MYC protein was performed o...

journal_title：British journal of cancer

authors： Wang LL,Teshiba R,Ikegaki N,Tang XX,Naranjo A,London WB,Hogarty MD,Gastier-Foster JM,Look AT,Park JR,Maris JM,Cohn SL,Seeger RC,Asgharzadeh S,Shimada H

更新日期：2015-06-30 00:00:00

abstract：:Doxorubicin- and paclitaxel-selected variants of an in vitro invasive clonal population of the human breast cancer cell line, MDA-MB-435S, were established by pulse selection, and exhibited a novel 'superinvasive' phenotype. This phenotype is characterised by an ability to relocate to another surface following invasio...

journal_title：British journal of cancer

authors： Glynn SA,Gammell P,Heenan M,O'Connor R,Liang Y,Keenan J,Clynes M

更新日期：2004-11-15 00:00:00

abstract：:The reactivation of U.V.-irradiated adenovirus 2 in HeLa cells is enhanced 8-9 fold if the cells are given a brief hyperthermic shock before infection. Maximum reactivation is achieved by heating for 10 min at 45.5 degrees C and with a delay of 36 h between heating and infection. The induction process requires protein...

journal_title：British journal of cancer

authors： Piperakis SM,McLennan AG

更新日期：1984-02-01 00:00:00

abstract：:Previously, we reported that Bcl-2 was frequently expressed in renal cell carcinoma (RCC) specimens, but p53 mutation was a rare event. However, it was unclear whether Bcl-2 positivity was associated with the clinicopathological characteristics and prognosis in RCC. Therefore, we investigated the expression of Bcl-2 p...

journal_title：British journal of cancer

authors： Itoi T,Yamana K,Bilim V,Takahashi K,Tomita F

更新日期：2004-01-12 00:00:00

abstract：:The UK National Case-Control Study Group has examined the relationship between smoking (both own smoking and passive), alcohol consumption and caffeine consumption and the risk of breast cancer. A total of 755 women with breast cancer diagnosed before the age of 36, each with an age-matched general population control,...

journal_title：British journal of cancer

authors： Smith SJ,Deacon JM,Chilvers CE

更新日期：1994-07-01 00:00:00

abstract：:In order to elucidate the clinical significance of the erbB family, epidermal growth factor receptor (EGF-R), c-erbB-2, c-erbB-3 and c-erbB-4 in hepatocellular carcinoma (HCC), we investigated the expression of these proteins by means of immunohistochemistry for HCC as well as adjacent noncancerous lesions. EGF-R was ...

journal_title：British journal of cancer

authors： Ito Y,Takeda T,Sakon M,Tsujimoto M,Higashiyama S,Noda K,Miyoshi E,Monden M,Matsuura N

更新日期：2001-05-18 00:00:00

abstract：:Two human colon cancer xenografts (EC and AC) were established in tissue culture only after long-term passage in nude mice. Earlier attempts to establish cell lines were unsuccessful. The epithelioid cells retain their tumourigenicity after in vitro growth, giving rise to tumours with a take rate of 60-80%. After reim...

journal_title：British journal of cancer

authors： Walton J,Winterbourne D,Fiennes A,Harris P,Hermon-Taylor J,Grant A

更新日期：1985-05-01 00:00:00

abstract：:It remains unclear whether any aspect of quality of life has a role in predicting survival in an unselected cohort of patients with gastro-oesophageal cancer. Therefore the aim of the present study was to examine the relationship between quality of life (EORTC QLQ-C30), clinico-pathological characteristics and surviva...

journal_title：British journal of cancer

authors： McKernan M,McMillan DC,Anderson JR,Angerson WJ,Stuart RC

更新日期：2008-03-11 00:00:00

abstract：BACKGROUND:We previously reported that chaetocin has potent and selective anti-myeloma activity attributable to reactive oxygen species (ROS) induction imposed by inhibition of the redox enzyme thioredoxin reductase; we now detail its effects in solid tumours. METHODS:Cellular assays, transcriptional profiling and the...

journal_title：British journal of cancer

authors： Isham CR,Tibodeau JD,Bossou AR,Merchan JR,Bible KC

更新日期：2012-01-17 00:00:00

abstract：:NK911 is a novel supramolecular nanocarrier designed for the enhanced delivery of doxorubicin (DXR) and is one of the successful polymer micelle systems to exhibit an efficient accumulation in solid tumours in mice. The purpose of this study was to define the maximum-tolerated dose (MTD) and dose-limiting toxicities (...

journal_title：British journal of cancer

authors： Matsumura Y,Hamaguchi T,Ura T,Muro K,Yamada Y,Shimada Y,Shirao K,Okusaka T,Ueno H,Ikeda M,Watanabe N

更新日期：2004-11-15 00:00:00

abstract：:We report observations on the spread by metastasis and infiltration of a transplantable tumour in rats treated by 60Co gamma-irradiation of the primary, irradiation plus parenteral cyclophosphamide, or parenteral cyclophosphamide alone. The proportion of animals with overt disseminated disease and the extent of spread...

journal_title：British journal of cancer

authors： Moore JV,Dixon B

更新日期：1977-08-01 00:00:00

abstract：:The ability of 5-aminolaevulinic acid and some of its esterified derivatives to induce porphyrin accumulation has been examined in CaNT murine mammary carcinoma cells growing in culture and as tumours in vivo. Topical or intravenous administration of 5-aminolaevulinic acid-esters to mice bearing subcutaneous tumours p...

journal_title：British journal of cancer

authors： Tunstall RG,Barnett AA,Schofield J,Griffiths J,Vernon DI,Brown SB,Roberts DJ

更新日期：2002-07-15 00:00:00