Split dose cytotoxic experiments with misonidazole.

abstract：:In some clinical situations the endogenous production of glutamine may be insufficient to maintain optimal tissue structure and function such that glutamine becomes a conditionally essential amino acid. Studies in laboratory animals have demonstrated that glutamine supplementation can reduce the incidence and severity...

journal_title：British journal of cancer

authors： Jebb SA,Osborne RJ,Maughan TS,Mohideen N,Mack P,Mort D,Shelley MD,Elia M

更新日期：1994-10-01 00:00:00

abstract：:A risk model for febrile neutropenia (FN) after conventional cytotoxic chemotherapy, based on early (day 5) lymphopenia and the dose of chemotherapy, has been described. A risk index based on parameters available at day 1 would be easier in daily practice. The objectives of this work were (1) to investigate a risk mod...

journal_title：British journal of cancer

authors： Ray-Coquard I,Borg C,Bachelot T,Sebban C,Philip I,Clapisson G,Le Cesne A,Biron P,Chauvin F,Blay JY,ELYPSE study group.

更新日期：2003-01-27 00:00:00

abstract：BACKGROUND:Novel treatment strategies in Ewing sarcoma include targeted cellular therapies. Preclinical in vivo models are needed that reflect their activity against systemic (micro)metastatic disease. METHODS:Whole-body magnetic resonance imaging (WB-MRI) was used to monitor the engraftment and dissemination of human...

journal_title：British journal of cancer

authors： Liebsch L,Kailayangiri S,Beck L,Altvater B,Koch R,Dierkes C,Hotfilder M,Nagelmann N,Faber C,Kooijman H,Ring J,Vieth V,Rossig C

更新日期：2013-08-06 00:00:00

abstract：:The metabolism of serotonin was studied in cancer patients of their first day of their first course of chemotherapeutic drugs either with strongly or moderately emetogenic regimens. It was observed that strongly emetogenic treatments induce greater increases in serotonin release than moderately emetogenic regimens. Hi...

journal_title：British journal of cancer

authors： Cubeddu LX,Hoffmann IS,Fuenmayor NT,Malave JJ

更新日期：1992-07-01 00:00:00

abstract：:The aim of this study was to investigate the expression of the protein tyrosine phosphatases (PTP) PRL-1, PRL-2, and PRL-3 in human breast cancer and to evaluate its clinical and prognostic significance. PRL-PTP mRNA expression was examined in malignant (n = 7) and nonmalignant (n = 7) cryoconserved breast tissue samp...

journal_title：British journal of cancer

authors： Radke I,Götte M,Kersting C,Mattsson B,Kiesel L,Wülfing P

更新日期：2006-08-07 00:00:00

abstract：BACKGROUND:When tumour tissue is unavailable, cell-free DNA (cfDNA)can serve as a surrogate for genetic analyses. Because mutated alleles in cfDNA are usually below 1%, next-generation sequencing (NGS)must be narrowed to target only clinically relevant genes. In this proof-of-concept study, we developed a panel to use ...

journal_title：British journal of cancer

authors： Malapelle U,Mayo de-Las-Casas C,Rocco D,Garzon M,Pisapia P,Jordana-Ariza N,Russo M,Sgariglia R,De Luca C,Pepe F,Martinez-Bueno A,Morales-Espinosa D,González-Cao M,Karachaliou N,Viteri Ramirez S,Bellevicine C,Molina-Vila M

更新日期：2017-03-14 00:00:00

abstract：:Expression of the calcium-dependent cell-cell adhesion molecule E-cadherin has been examined in 187 primary breast carcinomas using an immunohistochemical technique. The pattern and extent of reactivity has been correlated with clinicopathological data including tumour type, grade and lymph node status and with other ...

journal_title：British journal of cancer

authors： Jones JL,Royall JE,Walker RA

更新日期：1996-10-01 00:00:00

abstract：:An initial report suggested that patients homozygous for the arginine allele at codon 72 of P53 were at increased risk for human papillomavirus (HPV)-related cervical cancer, but other groups have not confirmed this finding. Since approximately 18-36% of head and neck cancers are HPV-related, we examined the genotypic...

journal_title：British journal of cancer

authors： Hamel N,Black MJ,Ghadirian P,Foulkes WD

更新日期：2000-02-01 00:00:00

abstract：:In 1977 a number of patients with soft-tissue sarcomas and previous exposure to phenoxyacetic acids were described. Following from these observations a matched case-control study was made. Exposure to chlorophenols was also included in this study. The results showed that exposure to phenoxyacetic acids or chlorophenol...

journal_title：British journal of cancer

authors： Hardell L,Sandström A

更新日期：1979-06-01 00:00:00

abstract：:Increased fibre intake has been shown to reduce serum oestrogen concentrations. We hypothesized that fibre exerts this effect by decreasing the time available for reabsorption of oestrogens in the colon. We tested this in volunteers by measuring changes in serum oestrogen levels in response to manipulation of intestin...

journal_title：British journal of cancer

authors： Lewis SJ,Heaton KW,Oakey RE,McGarrigle HH

更新日期：1997-01-01 00:00:00

abstract：:Follicular-phase (Day 11) plasma prolactin, and plasma and urinary oestrogen levels of 70 nulliparous nuns were compared with those of 80 of their sisters, of whom 62 were parous. The nuns and their nulliparous sisters did not differ significantly in their prolactin and oestrogen levels. No differences in plasma oestr...

journal_title：British journal of cancer

authors： Yu MC,Gerkins VR,Henderson BE,Brown JB,Pike MC

更新日期：1981-06-01 00:00:00

abstract：:Prolactin (PRL) has been reported to inhibit apoptosis in various cell types and to serve as a cofactor in the upregulation of CD25 on T cells during activation. We investigated a possible relation between prolactin receptor (PRL-R) or IL-2 receptor alpha (IL-2Ralpha, CD25) expression on circulating T lymphocytes and ...

journal_title：British journal of cancer

authors： Bauernhofer T,Kuss I,Friebe-Hoffmann U,Baum AS,Dworacki G,Vonderhaar BK,Whiteside TL

更新日期：2003-04-22 00:00:00

abstract：:We have investigated dihydropyrimidine dehydrogenase expression as a prognostic marker in breast cancer. A total of 119 women with breast cancer undergoing surgery between 1985 and 1996 were included in this study. Eighty-seven patients were treated with postoperative chemotherapy including 5-fluorouracil or 5-fluorou...

journal_title：British journal of cancer

authors： Horiguchi J,Takei H,Koibuchi Y,Iijima K,Ninomiya J,Uchida K,Ochiai R,Yoshida M,Yokoe T,Iino Y,Morishita Y

更新日期：2002-01-21 00:00:00

abstract：:Currently, there are no effective biomarkers for ovarian cancer prognosis or prediction of therapeutic response. The objective of this study was to examine a panel of 10 serum biochemical parameters for their ability to predict response to chemotherapy, progression and survival of ovarian cancer patients. Sera from ov...

journal_title：British journal of cancer

authors： Oikonomopoulou K,Li L,Zheng Y,Simon I,Wolfert RL,Valik D,Nekulova M,Simickova M,Frgala T,Diamandis EP

更新日期：2008-10-07 00:00:00

abstract：:To clarify the prognostic factors in patients with submucosal carcinoma of the oesophagus, we examined the results of surgical treatment for 78 cases over the last decade. The clinicopathological factors including age, sex, location of the tumour, length of the tumour, histological differentiation, subclassification o...

journal_title：British journal of cancer

authors： Watanabe M,Kuwano H,Araki K,Kawaguchi H,Saeki H,Kitamura K,Ohno S,Sugimachi K

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:BRCAness is defined as shared tumour characteristics between sporadic and BRCA-mutated cancers. However, how to exactly measure BRCAness and its frequency in breast cancer is not known. Assays to establish BRCAness would be extremely valuable for the clinical management of these tumours. We assessed BRCAness...

journal_title：British journal of cancer

authors： Lips EH,Mulder L,Oonk A,van der Kolk LE,Hogervorst FB,Imholz AL,Wesseling J,Rodenhuis S,Nederlof PM

更新日期：2013-05-28 00:00:00

abstract：:Karyotyping and marker analysis of G- and C-banded metaphases from a metastatic bronchial carcinoma revealed a dominant stemline with five markers and four sidelines with additional markers. One to three minute bodies were noted in the majority of cells and these were classified as markers. On the basis of this analys...

journal_title：British journal of cancer

authors： Pickthall VJ

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND:Metabolomics has shown promise in gastric cancer (GC) detection. This research sought to identify whether GC has a unique urinary metabolomic profile compared with benign gastric disease (BN) and healthy (HE) patients. METHODS:Urine from 43 GC, 40 BN, and 40 matched HE patients was analysed using (1)H nucle...

journal_title：British journal of cancer

authors： Chan AW,Mercier P,Schiller D,Bailey R,Robbins S,Eurich DT,Sawyer MB,Broadhurst D

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:Whether red and processed meat consumption is a risk factor for pancreatic cancer remains unclear. We conducted a meta-analysis to summarise the evidence from prospective studies of red and processed meat consumption and pancreatic cancer risk. METHODS:Relevant studies were identified by searching PubMed an...

journal_title：British journal of cancer

authors： Larsson SC,Wolk A

更新日期：2012-01-31 00:00:00

abstract：:Docetaxel has been reported to show promising anti-tumour activity in pancreatic ductal cancer (PC). This study was conducted to evaluate the activity and toxicity of moderate-dose (60 mg m(-2)) docetaxel in Japanese chemo-naive patients with measurable metastatic PC. The patients had a performance status of 0-2. They...

journal_title：British journal of cancer

authors： Okada S,Sakata Y,Matsuno S,Kurihara M,Sasaki Y,Ohashi Y,Taguchi T

更新日期：1999-05-01 00:00:00

abstract：:There is considerable interest in immunohistochemical markers of proliferation which are suitable for use on routinely fixed clinical material. The novel proliferation-associated antibody Ki-S1 shows promise in this respect. In this study we have: (i) defined the pattern of Ki-S1 labelling relative to the cell cycle p...

journal_title：British journal of cancer

authors： Camplejohn RS,Brock A,Barnes DM,Gillett C,Raikundalia B,Kreipe H,Parwaresch MR

更新日期：1993-04-01 00:00:00

abstract：:Detailed data were provided by the Oxford Survey of Childhood Cancer OSCC on deaths from childhood cancer in Britain after irradiation of the fetus during diagnostic radiology of the mother. In each age group at death, 0-5, 6-9 and 10-15 years, excess cancer deaths decreased suddenly for births in and after 1958. A ma...

journal_title：British journal of cancer

authors： Mole RH

更新日期：1990-07-01 00:00:00

abstract：:The association between breast and endometrial cancer was investigated in a cohort consisting of 60,065 subjects (99% of all women in whom a first breast cancer was diagnosed in Sweden in 1960-63 and 1968-81). Complete follow-up until 1981 revealed a total of 260 endometrial cancers, as against an expected number of 1...

journal_title：British journal of cancer

authors： Adami HO,Krusemo UB,Bergkvist L,Persson I,Pettersson B

更新日期：1987-01-01 00:00:00

abstract：:We analysed 29 consecutive cases of primary gastric lymphoma (20 men and 9 women) treated in our unit between January 1977 and May 1983. Median age was 55 years. Abdominal pain and weight loss were the main presenting symptoms while there was no palpable disease in the majority of cases. Upper gastrointestinal radiolo...

journal_title：British journal of cancer

authors： Economopoulos T,Alexopoulos C,Stathakis N,Styloyannis S,Dervenoulas J,Tsousis S,Raptis S

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:Older women have lower breast cancer surgery rates than younger women. UK policy states that differences in cancer treatment by age can only be justified by patient choice or poor health. METHODS:We investigate whether lack of surgery for older patients is explained by patient choice/poor health in a prospe...

journal_title：British journal of cancer

authors： Lavelle K,Sowerbutts AM,Bundred N,Pilling M,Degner L,Stockton C,Todd C

更新日期：2014-02-04 00:00:00

abstract：:The cytotoxicity of methotrexate (MTX) on representative human tumour cell lines (two cell lines from head and neck carcinomas, two from breast carcinomas, two from osteosarcomas and one lymphoblastoid cell line) was evaluated to: (1) examine the optimal time interval between MTX and folinic acid (FA) administration; ...

journal_title：British journal of cancer

authors： Bernard S,Etienne MC,Fischel JL,Formento P,Milano G

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant condition caused by germline FLCN mutations, and characterised by fibrofolliculomas, pneumothorax and renal cancer. The renal cancer risk, cancer phenotype and pneumothorax risk of BHD have not yet been fully clarified. The main focus of this study was t...

journal_title：British journal of cancer

authors： Houweling AC,Gijezen LM,Jonker MA,van Doorn MB,Oldenburg RA,van Spaendonck-Zwarts KY,Leter EM,van Os TA,van Grieken NC,Jaspars EH,de Jong MM,Bongers EM,Johannesma PC,Postmus PE,van Moorselaar RJ,van Waesberghe JH,Starink

更新日期：2011-12-06 00:00:00

abstract：:Apoptosis plays an important role in tumorigenesis. Tumour growth is determined by the rate of cell proliferation and cell death. We counted the number of apoptotic cells in haematoxylin and eosin (H&E)-stained tumour sections in series of 172 grade I and II invasive breast cancers with long-term follow-up. The number...

journal_title：British journal of cancer

authors： de Jong JS,van Diest PJ,Baak JP

更新日期：2000-01-01 00:00:00

abstract：:It has been reported that the rho genes, which consist of a ras-related small GTPase protein family, regulate cytoskeletal structures and have the potential to transform cultured cells. To investigate the biological relevance of the rho genes in pancreatic carcinogenesis, we examined expressions of the rhoA, B and C g...

journal_title：British journal of cancer

authors： Suwa H,Ohshio G,Imamura T,Watanabe G,Arii S,Imamura M,Narumiya S,Hiai H,Fukumoto M

更新日期：1998-01-01 00:00:00

abstract：:Serum protein induced by vitamin K absence or antagonist II (PIVKAII), hepatoma-specific band of serum gamma-glutamyl transferase (GGTII), and alpha-fetoprotein (AFP) levels were determined in 120 patients with hepatocellular carcinoma (HCC) and 90 patients with cirrhosis. The mean serum concentration of PIVKAII in HC...

journal_title：British journal of cancer

authors： Cui R,He J,Zhang F,Wang B,Ding H,Shen H,Li Y,Chen X

更新日期：2003-06-16 00:00:00