Abstract:
:To clarify the prognostic factors in patients with submucosal carcinoma of the oesophagus, we examined the results of surgical treatment for 78 cases over the last decade. The clinicopathological factors including age, sex, location of the tumour, length of the tumour, histological differentiation, subclassification of depth, lymphatic or blood vessel invasion, intramural metastasis and lymph node metastasis were all analysed. Then the correlation between these factors and prognosis was investigated. As a result, significant differences were observed in the survival rates between the groups regarding lymphatic vessel invasion (P = 0.0003), intramural metastasis (P = 0.0051) and lymph node metastasis (P = 0.0026). According to a multivariate analysis, intramural metastasis (P = 0.0038, relative risk 9.17), vessel invasion (P = 0.0033, relative risk 6.25) and lymph node metastasis (P = 0.0187, relative risk 3.62) were found to be independent prognostic factors. The prognosis of the patients with at least one of these factors was significantly poorer than that without. The five-year survival rate of the patients without these factors was as good as that with mucosal carcinoma of the oesophagus. Based on our findings, vessel invasion, intramural metastasis and lymph node metastasis are thus considered to be significant prognostic factors in patients with submucosal carcinoma of the oesophagus.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Watanabe M,Kuwano H,Araki K,Kawaguchi H,Saeki H,Kitamura K,Ohno S,Sugimachi Kdoi
10.1054/bjoc.2000.1288subject
Has Abstractpub_date
2000-09-01 00:00:00pages
609-13issue
5eissn
0007-0920issn
1532-1827pii
S0007092000912886journal_volume
83pub_type
杂志文章abstract::Pancreatic cancer is a highly lethal malignancy with a dismal 5-year survival of less than 5%. The scarcity of early biomarkers has considerably hindered our ability to launch preventive measures for this malignancy in a timely manner. Neutrophil gelatinase-associated lipocalin (NGAL), a 24-kDa glycoprotein, was repor...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604329
更新日期:2008-05-06 00:00:00
abstract::Primary liver cancer (PLC) incidence trends from Africa are unknown. Using Kampala Cancer Registry data from 1960 to 1980 and 1991 to 2005, we identified 771 PLCs. Although rates were stable among men, PLC incidence among women increased >50%. Investigations of viral hepatitis, aflatoxin, obesity, and human immunodefi...
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journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2010-05-11 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.218
更新日期:1988-09-01 00:00:00
abstract::In the years 1979-1982, 83 patients with malignant teratoma of the testis who had retroperitoneal adenopathy at presentation or after a period of surveillance were treated. Complete radiological resolution of disease was obtained in 34 patients and a residual mass remained in 26, the remainder having progression of th...
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更新日期:1986-05-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1984.230
更新日期:1984-11-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.615
更新日期:1997-01-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.653
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journal_title:British journal of cancer
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6600877
更新日期:2003-04-22 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.729
更新日期:2014-01-21 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6604354
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journal_title:British journal of cancer
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abstract::A sedentary lifestyle, obesity, and a Westernized diet have been implicated in the aetiology of both colorectal cancer and non-insulin dependent diabetes mellitus, leading to the hypothesis that hyperinsulinaemia may promote colorectal cancer. We prospectively examined the association between colorectal cancer risk an...
journal_title:British journal of cancer
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doi:10.1054/bjoc.2000.1582
更新日期:2001-02-02 00:00:00
abstract::Diffuse invasion of the brain, an intrinsic property of gliomas, renders these tumours incurable, and is a principal determinant of their spatial and temporal growth. Knowledge of the invasive potential of gliomas is highly desired in order to understand their behaviour in vivo. Comprehensive ex vivo invasion studies ...
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pub_type: 杂志文章
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更新日期:2004-08-16 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.89
更新日期:1978-04-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.258
更新日期:1994-07-01 00:00:00
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更新日期:2015-03-31 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2010-10-12 00:00:00
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pub_type: 杂志文章
doi:10.1038/bjc.2012.301
更新日期:2012-08-07 00:00:00
abstract:BACKGROUND:In this study, we evaluated the possibility that KRAS mutational status might be predictive of oxaliplatin (OXA) efficacy. We also explored the role of excision repair cross complementing group-1 (ERCC-1). METHODS:Ninety anti-epidermal growth factor receptor-naive advanced colorectal cancer patients were re...
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pub_type: 杂志文章
doi:10.1038/bjc.2012.526
更新日期:2013-01-15 00:00:00