Abstract:
:In a study of 157 patients with lymphoid malignancy, the phenotype of the tumour cells was correlated with the histological classification of the tumour using the Rappaport and the Kiel classifications. The markers used included E, Fc gamma, Fc micron (IgM) and C3d rosetting, estimation of SIg and CyIg, and tests for the expression of HTLA, Ia and ALL. Repeat biopsy specimens were studied in 23 of these patients. The phenotypic features of lymphoblastic malignancy indicated B-cell, T-cell and ALL-positive null-cell tumours in this group. Immunoblastic lymphomas were predominantly of non-capping B-cell type, but T-cell immunoblastic lymphoma occurred in 2 patients. Immunoblastic lymphomas of receptor-silent cells occur, and are ALL- and HTLA-negative. In the category of diffuse, poorly differentiated lymphocytic lymphomas, most cases are of centroblastic and centrocytic tumour of diffuse type, but pure centrocytic tumours and centroblastic tumours occur. The dominant phenotype in this group is of B cells expressing C3d receptors. Nodular poorly differentiated lymphocytic lymphomas (Rappaport) are classified as centroblastic and centrocytic follicular (Kiel) and most express SIg+ C3d+ phenotype. The frequency of this phenotype appeared the same in both diffuse and nodular poorly differentiated lymphocytic neoplasms. The Rappaport group of diffuse well-differentiated lymphocytic lymphoma includes 2 Kiel categories, malignant lymphoma lymphocytic, and malignant lymphoma lymphoplasmacytoid. Cells of the former tumour were considered to be immature B cells resembling those seen in CLL, and characteristically expressing SIg weakly, with a high frequency of single kappa light chain. Cells of the latter tumour are by contrast mature, and are related to the centroblastic and centrocytic follicular tumour by their histogenesis and phenotypic features. Repeat biopsy examinations indicate that T-cell predominance occurs in the prodromal phase of B-cell-predominant tumours of SIg+ C3d+ phenotype. It is concluded that non-Hodgkin lymphoma can be divided into 2 categories: (1) tumours of immature immunologically incompetent cells of lymphoblastic histology and with phenotypic features akin to T, B and Null-cell ALL, and (2) tumours of differentiated lymphocytes expressing the phenotypic features of B lymphocytes, with maturation arrested at one of several stages of an antigen-dependent immune response.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Habeshaw JA,Catley PF,Stansfeld AG,Brearley RLdoi
10.1038/bjc.1979.137subject
Has Abstractpub_date
1979-07-01 00:00:00pages
11-34issue
1eissn
0007-0920issn
1532-1827journal_volume
40pub_type
杂志文章abstract:BACKGROUND:There is no consensus agreement regarding optimal management of locally excised ductal carcinoma in situ (DCIS) or features of greatest assistance in predicting disease behaviour. Cases in the UKCCCR/ANZ DCIS trial have been histologically reviewed to determine the features of prognostic importance. METHOD:...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605718
更新日期:2010-06-29 00:00:00
abstract::The death certificate only (DCO) index, which quantifies the proportion of patients for whom the death certificate provides the only notification to the registry, is a widely used measure of incompleteness of population-based cancer registration. This paper provides an algebraic assessment and a quantitative illustrat...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.363
更新日期:1995-08-01 00:00:00
abstract::The sera from patients with advanced cancer were tested for their specific inhibitory effects on the cytotoxicity of autologous lymphocytes on tumour cells in a microculture assay. By adding a standard volume of the sera to suspensions of well-washed lymphocytes the inhibitory effect was quantitated by comparison with...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1973.67
更新日期:1973-07-01 00:00:00
abstract::Male and female Swiss strain mice were put on a 0.03% thioacetamide diet at the age of 2 months. Control mice were kept on a stock diet. Control and treated mice were killed at the ages of 6, 9, 13 and 17 months. Progressive morphological, histological and biochemical alterations in the liver and tumour tissue of the ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1970.60
更新日期:1970-09-01 00:00:00
abstract::Solid tumours are often highly acidic compared to normal tissue, and tumour extracellular acidosis contributes to multiple aspects of cancer progression. Now, Anemone et al. in this issue of the British Journal of Cancer provide in vivo evidence that the degree to which various breast cancer cell lines acidify their e...
journal_title:British journal of cancer
pub_type: 社论
doi:10.1038/s41416-020-01171-2
更新日期:2021-01-01 00:00:00
abstract::The association between chromosomal radiosensitivity and genetic predisposition to head and neck cancer was investigated in this study. In all, 101 head and neck cancer patients and 75 healthy control individuals were included in the study. The G(2) assay was used to measure chromosomal radiosensitivity. The results d...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604345
更新日期:2008-05-20 00:00:00
abstract::Oestrogen receptor protein (ER) was detected in 9 of 11 samples of malignant breast tissue and 8 of 9 samples of normal breast tissue. Levels of cytosolic ER (ERc) in malignant breast were 21-1102 fmol mg-1 soluble protein (Kd 1.8 X 10(-9)-3.1 X 10(-8) mol l-1) and those of nucleosolic ER (ERn), 13-526 fmol mg-1 solub...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1986.196
更新日期:1986-09-01 00:00:00
abstract::The purpose of this study was to determine the maximum-tolerated dose of gemcitabine plus mitoxantrone in women with metastatic breast cancer (MBC) and to evaluate activity and toxicity of this combination in a phase II trial. Sixty-three patients with MBC, previously treated with chemotherapy including anthracycline ...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6600780
更新日期:2003-02-24 00:00:00
abstract::An increasing body of evidence indicates that glutathione S-transferases play a role in the intrinsic and acquired resistance of tumours to anticancer drugs. In view of the wide use of tumour cell lines to understand the factors which confer either sensitivity or resistance to chemotherapeutic agents we have determine...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.280
更新日期:1989-09-01 00:00:00
abstract::In an Italian case-control study of oral cancer, number of missing teeth and other aspects of dental care were similar, but the general condition of the mouth, as indicated by gum bleeding, tartar deposits and mucosal irritation, was worse among oral cancer cases than controls. No differences were detected in sexual p...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1398
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:Understanding the molecular biology of colorectal cancer (CRC) provides opportunities for effective personalised patient management. We evaluated whether chromosomal aberrations, mutations in the PI(3)K signalling pathway and the CpG-island methylator phenotype (CIMP) in primary colorectal tumours can predic...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.184
更新日期:2011-07-12 00:00:00
abstract::HER2 / neu is a potential antigen candidate for immunotherapy because of its correlation to a poor prognosis and high expressions in many kinds of epithelial tumours. Especially in the colorectal carcinomas, the higher expression of HER2 / neu is recognized in metastatic regions as well as in primary sites. Several CT...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1547
更新日期:2001-01-05 00:00:00
abstract:BACKGROUND:Impaired drug transport is an important factor that reduces the efficacy of anticancer agents against pancreatic cancer. Here, we report a novel combination chemotherapy using gemcitabine (GEM) and internalised-RGD (iRGD) peptide, which enhances tumour-specific drug penetration by binding neuropilin-1 (NRP1)...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.49
更新日期:2014-03-18 00:00:00
abstract:BACKGROUND:The prognosis of squamous cell carcinoma of the oral tongue is poor and it would be beneficial to find prognostic markers to better adjust treatment. Bmi-1 controls cell cycle and self-renewal of tissue stem cells, transcription factor c-myc affects cell proliferation and apoptosis, and Snail regulates epith...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605544
更新日期:2010-03-02 00:00:00
abstract::Despite expressing both Fas and Fas ligand, DU145 and LNCaP prostate cancer cells were resistant to anti-Fas-induced cell death. Resistance to Fas-mediated cytotoxicity could be overcome in DU145, but not in LNCaP, cells by pretreating cells with sublethal doses of cytotoxic drugs, such as camptothecin. Activated casp...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690365
更新日期:1999-05-01 00:00:00
abstract::A brief review is presented of the evidence linking the development of certain types of neoplasms, and of the malignant lymphomas in particular, to chronic immunosuppression in animals and man and to the naturally occurring human immunologic deficiency states. The discussion then focuses on Hodgkin's disease and consi...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.1971.78
更新日期:1971-12-01 00:00:00
abstract::We have established a novel ascites tumour model (MDA435/LCC6) from the oestrogen receptor-negative, invasive and metastatic MDA-MB-435 human breast cancer cell line. MDA435/LCC6 cells grow as both malignant ascites and solid tumours in vivo in nude mice and nude rats, with a tumour incidence of approximately 100%. Un...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.29
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant condition caused by germline FLCN mutations, and characterised by fibrofolliculomas, pneumothorax and renal cancer. The renal cancer risk, cancer phenotype and pneumothorax risk of BHD have not yet been fully clarified. The main focus of this study was t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.463
更新日期:2011-12-06 00:00:00
abstract::DepoCyte is a slow-release formulation of cytarabine designed for intrathecal administration. The goal of this multi-centre cohort study was to determine the safety and efficacy of DepoCyte for the intrathecal treatment of neoplastic meningitis due to breast cancer. DepoCyte 50 mg was injected once every 2 weeks for o...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1054/bjoc.2000.1574
更新日期:2001-01-01 00:00:00
abstract::The efficacy of cisplatin [cis-diamminedichloroplatinum (II); DDP] is hampered by acquired or de novo resistance of malignant cells to its cytotoxic effects. We have previously reported that cisplatin resistance parallels glutathione S-transferase (GST) activity in several human small-cell lung cancer cell lines. In t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.278
更新日期:1994-08-01 00:00:00
abstract::The in vitro deamination, cytotoxicity, cellular drug uptake, distribution and cellular pharmacology in HL-60 cells of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine (NHAC), a lipophilic derivative of arabinofuranosylcytosine (ara-C), were studied. Compared with ara-C, NHAC in liposomal formulations was highly resista...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.185
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:Glioma stem-like cell (GSC) properties are responsible for gliomagenesis and recurrence. GSCs are invasive but its mechanism remains to be elucidated. Here, we attempted to identify the molecules that promote invasion in GSCs. METHODS:Neurospheres and CD133⁺ cells were collected from glioblastoma (GBM) spec...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.218
更新日期:2013-06-25 00:00:00
abstract::Swedish population-based incidence and mortality rates for cancer of the uterine cervix, both in situ and invasive, during the period 1958 to 1981 were determined by means of a dynamic model. This new approach describes without any preconceptions the development of the disease as a sequential process over the stages c...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.236
更新日期:1989-07-01 00:00:00
abstract::The prognostic value of C-reactive protein, compared with ECOG performance status (ECOG-ps), in patients receiving alpha-interferon treatment for advanced renal cancer was assessed in 58 patients. In all, 55 patients died on follow-up. On multivariate analysis with ECOG-ps and C-reactive protein entered as covariates,...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6602152
更新日期:2004-10-04 00:00:00
abstract::Teratomas have been induced in Japanese quail (Coturnix coturnix Japonica) by intra-testicular injections of 3% zinc chloride solution during a period of testicular growth artificially stimulated by increased photoperiod. These tumours resemble those previously induced by similar methods in domestic fow1 and have hist...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1971.40
更新日期:1971-06-01 00:00:00
abstract:BACKGROUND:Global hypomethylation has been suggested to cause genomic instability and lead to an increased risk of cancer. We examined the association between the global methylation level of peripheral blood leukocyte DNA and breast cancer among Japanese women. METHODS:We conducted a hospital-based case-control study ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.223
更新日期:2014-05-27 00:00:00
abstract::Killing of autologous melanoma (auto-Me) was obtained with pooled allostimulated peripheral blood lymphocytes (PBL) in 34/42 cases and found not to be due to a cross-reactivity between melanoma and allogeneic normal antigens. To see whether generation of tumour cytotoxic PBL by allostimulation was due to release of IL...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1985.151
更新日期:1985-07-01 00:00:00
abstract::Four poly(ADP-ribose) polymerase (PADPRP) inhibitors [3-aminobenzamide, benzamide, 3,4-dihydro-5-methoxyisoquinolin-1(2H)-one (PD 128763) and 8-hydroxy-2-methylquinazolin-4(3H)-one (NU1025)] were compared with respect to their effects on a number of biological end points. The following parameters were assessed: their ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.423
更新日期:1995-10-01 00:00:00
abstract::The lymphocyte marker pattern of non-Hodgkin's lymphoma cells was related to current concepts of lymphoma classification. In a series of 28 lymphomas lymphocyte markers indicated that 2 were of histiocytic origin, 2 were unclassifiable, none were derived from T cells and the remainder were B-cell neoplasms. The immuno...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1977.154
更新日期:1977-07-01 00:00:00
abstract::Vascular endothelial growth factor-A (VEGF-A) has been demonstrated to play an important role in tumour angiogenesis and to influence prognosis in many cancers. However its prognostic value in head and neck squamous cell carcinomas (HNSCCs) remains controversial. Therefore, we investigated the clinical relevance of VE...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603108
更新日期:2006-05-22 00:00:00