Abstract：
BACKGROUND:Understanding the molecular biology of colorectal cancer (CRC) provides opportunities for effective personalised patient management. We evaluated whether chromosomal aberrations, mutations in the PI(3)K signalling pathway and the CpG-island methylator phenotype (CIMP) in primary colorectal tumours can predict liver metastases. METHODS:Formalin-fixed paraffin-embedded material from primary colorectal tumours of three different groups were investigated: patients with CRC without metastases (M0, n=39), patients who were treated with hyperthermal intraperitoneal chemotherapy for CRC metastases confined to the peritoneum (PM, n=46) and those who had isolated hepatic perfusion for CRC metastases confined to the liver (LM, n=48). RESULTS:All samples were analysed for DNA copy number changes, PIK3CA, KRAS, BRAF mutations, CIMP and microsatellite instability. The primary CRCs of the LM group had significantly higher frequency of amplified chromosome 20q (P=0.003), significantly fewer mutations in the PI(3)K signalling pathway (P=0.003) and fewer CIMP high tumours (P=0.05). There was a strong inverse correlation between 20q and the PI(3)K pathway mutations. CONCLUSION:The development of CRC liver metastases is associated with amplification of chromosome 20q and not driven by mutations in the PI(3)K signalling pathway.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Bruin SC,He Y,Mikolajewska-Hanclich I,Liefers GJ,Klijn C,Vincent A,Verwaal VJ,de Groot KA,Morreau H,van Velthuysen ML,Tollenaar RA,van 't Veer LJdoi
10.1038/bjc.2011.184subject
Has Abstractpub_date
2011-07-12 00:00:00pages
281-7issue
2eissn
0007-0920issn
1532-1827pii
bjc2011184journal_volume
105pub_type
杂志文章abstract：:The objective of the study was to investigate the predictive value of various clinical, biochemical, and histopathological parameters, with special emphasis on the expression of the retinoblastoma protein (pRB), on the radiation response in bladder cancer. In order to obtain a truly objective response measure, patient...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6601063
更新日期：2003-07-21 00:00:00
abstract：:The 5-year relative survival rates of women diagnosed with breast cancer between 1992 and 1994 were compared among the 99 Health Authorities (1999 boundaries) of England. Substantial variation, with evidence of geographical clustering was observed. Part of this variation was explained by differences in deprivation bet...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601812
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:There are currently two million cancer survivors in the United Kingdom, and in recent years this number has grown by 3% per annum. The aim of this paper is to provide long-term projections of cancer prevalence in the United Kingdom. METHODS:National cancer registry data for England were used to estimate can...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.366
更新日期：2012-09-25 00:00:00
abstract：:I.p. administration at several dose levels over periods of up to 12 weeks, or continuous i.v. infusion of high doses of misonidazole (MISO) for 15 h, produced no significant change in peripheral nerve conduction velocity (NCV) and did not prevent the normal increase in NCV as the animals matured from 12 to 24 weeks of...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.94
更新日期：1980-04-01 00:00:00
abstract：:In 1977 a number of patients with soft-tissue sarcomas and previous exposure to phenoxyacetic acids were described. Following from these observations a matched case-control study was made. Exposure to chlorophenols was also included in this study. The results showed that exposure to phenoxyacetic acids or chlorophenol...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.125
更新日期：1979-06-01 00:00:00
abstract：:In a previous report we suggested that the estimation of prothymosin alpha (PTA) levels in primary breast tumours might be used to identify breast cancer patients at high risk for distant metastasis (Dominguez F et al (1993) Eur J Cancer 29A: 893-897). Here the role of tumour PTA levels as predictor was investigated w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.0968
更新日期：2000-02-01 00:00:00
abstract：BACKGROUND:Circulating tumour cells (CTCs) can provide information on patient prognosis and treatment efficacy. However, there is no universal method to detect CTC currently available. Here, we compared the performance of two CTC detection systems based on the expression of the EpCAM antigen (CellSearch assay) or on ce...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.294
更新日期：2011-09-06 00:00:00
abstract：BACKGROUND:Here, we explore the therapeutic potential of dasatinib, a small-molecule inhibitor that targets multiple cytosolic and membrane-bound tyrosine kinases, including members of the Src kinase family, EphA2, and focal adhesion kinase for the treatment of ovarian cancer. METHODS:We examined the effects of dasati...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605381
更新日期：2009-11-17 00:00:00
abstract：BACKGROUND:Stage at diagnosis is a strong predictor of cancer survival. Differences in stage distributions and stage-specific management help explain geographic differences in cancer outcomes. Stage information is thus essential to improve policies for cancer control. Despite recent progress, stage information is often...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.177
更新日期：2016-07-26 00:00:00
abstract：BACKGROUND:Chromosomal instability (CIN) is a common trait of cancer characterised by the continuous gain and loss of chromosomes during mitosis. Excessive levels of CIN can suppress tumour growth, providing a possible therapeutic strategy. The Mps1/TTK kinase has been one of the prime targets to explore this concept, ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0081-2
更新日期：2018-06-01 00:00:00
abstract：:The aim of this work was to test in vitro and in vivo the efficacy of the derivatives of 5-aminolevulinic acid (ALA): hexyl-ALA (He-ALA), undecanoyl-ALA and R,S-2-(hydroximethyl)tetrahydropyranyl-ALA (THP-ALA) as pro-photosensitising agents. The compounds were assayed in a cell line derived from a murine mammary tumou...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601722
更新日期：2004-04-19 00:00:00
abstract：:The present study investigates the role of nitric oxide and the involvement of nitric oxide synthase II isoform on the invasion of human colorectal adenocarcinoma cell lines HRT-18 and HT-29. HRT-18 cells, which constitutively express nitric oxide synthase II mRNA were three-fold more invasive in a Matrigel invasion a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600224
更新日期：2002-04-22 00:00:00
abstract：BACKGROUND:SCALOP, a randomised, phase II trial, tested the activity and safety of gemcitabine (GEM)-based and capecitabine (CAP)-based chemoradiation (CRT) for locally advanced pancreatic cancer (LAPC). Here we present the long-term outcomes. METHODS:Eligibility: histologically proven LAPC ⩽7 cm. Following 12 weeks o...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjc.2017.95
更新日期：2017-05-09 00:00:00
abstract：BACKGROUND:Vismodegib has been used for the treatment of locally advanced basal cell carcinoma (laBCC) and metastatic BCC (mBCC) since 2011. Most efficacy and safety data are provided by clinical trials. This study evaluates the effectiveness of vismodegib for the treatment of laBCC, mBCC and basal cell nevus syndrome ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-01220-w
更新日期：2021-01-19 00:00:00
abstract：:To study the effect of oral supplemental calcium on colonic epithelial proliferation, 17 adenomatous polyp patients received 1.5 g Ca2+ as calcium carbonate daily during 12 weeks, while on a calcium constant diet, based on the patients' habitual diet. Seven subsequently continued calcium supplementation for 9 months w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.93
更新日期：1993-03-01 00:00:00
abstract：BACKGROUND:In metastatic colorectal cancer (mCRC), KRAS is the only validated biomarker used to select patients for administration of epidermal growth factor receptor (EGFR)-targeted therapies. To identify additional predictive markers, we investigated the importance of HER2, the primary EGFR dimerisation partner, in t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.4
更新日期：2013-02-19 00:00:00
abstract：:Cell viability following short (1 h) contact with paclitaxel or docetaxel was assayed using synchronised HeLa cells. Docetaxel proved almost totally lethal against S-phase cells. Its toxicity was only partial against cells in mitosis, and declined to a minimum with progression to G1. For paclitaxel, cytotoxicity incre...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.232
更新日期：1995-06-01 00:00:00
abstract：BACKGROUND:Period analysis is increasingly used to compute long-term cancer survival, as it provides better prediction of survival of newly diagnosed patients than traditional cohort analysis. However, the patient population to which period survival estimates best pertain to and which should be described in a study is ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.14
更新日期：2013-02-19 00:00:00
abstract：:We evaluated animal food intake and cooking methods in relation to endometrial cancer risk in a population-based case-control study in Shanghai, China. A validated food frequency questionnaire was used to collect the usual dietary habits of 1204 cases and 1212 controls aged 30-69 years between 1997 and 2003. Statistic...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603458
更新日期：2006-12-04 00:00:00
abstract：BACKGROUND:Expression of epithelial cell adhesion molecule (EpCAM) is deregulated in epithelial malignancies. Beside its role in cell adhesion, EpCAM acts as signalling molecule with tumour-promoting functions. Thus, EpCAM is part of the molecular network of oncogenic receptors and considered an interesting therapeutic...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.366
更新日期：2014-08-26 00:00:00
abstract：:In small-cell lung cancer cell lines resistance to growth inhibition by transforming growth factor (TGF)-beta 1, was previously shown to correlate with lack of TGF-beta receptor I (RI) and II (RII) proteins. To further investigate the role of these receptors, the expression of mRNA for RI, RII and beta-glycan (RIII) w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.201
更新日期：1996-05-01 00:00:00
abstract：:The incidence of B cell leukaemia in 186 consecutive untreated patients with histologically defined B cell neoplasms is described. The lymphomas were classified by the Kiel convention. B cell leukaemia in the context of this paper refers to the situation where a neoplastic clone of B cells in the blood greatly outnumb...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1983.174
更新日期：1983-08-01 00:00:00
abstract：:Over the past several years, our group has provided considerable evidence that the expression of sigma-2 (sigma2) receptors may serve as a biomarker of tumour cell proliferation. In these in vitro studies, sigma2 receptors were expressed 8-10 times more in proliferative (P) tumour cells than in quiescent (Q) tumour ce...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.1067
更新日期：2000-03-01 00:00:00
abstract：:The ability of the sister chromatid exchange (SCE) assay to detect heterogeneity in intrinsic radiation sensitivity was investigated. In order to identify tumour cell subpopulations, frequency histograms of cis-diamminedichloroplatinum (II) (cPt)-induced SCEs were generated and compared to those from cultures that had...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.11
更新日期：1989-01-01 00:00:00
abstract：:A possible link between protein kinase C (PKC) and P-glycoprotein (P-gp)-mediated-multidrug resistance (MDR) was assumed from studies on MDR cell lines selected in vitro. The functional relevance of PKC for the MDR phenotype remains unclear, and the involvement of a particular PKC isozyme in clinically occurring drug ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.13
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of health-related quality of life (HRQOL) from coBRIM is reported. METHODS:Patients completing the Eur...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.2017.488
更新日期：2018-03-20 00:00:00
abstract：:The p16 protein plays an important role in the transition of cells into the G1 phase of the cell cycle. We have studied the prevalence of p16 protein expression in breast carcinomas in a prospective series of 368 invasive and 52 non-invasive malignancies, as well as in 88 locally recurring tumours and three tumour cel...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.739
更新日期：1998-12-01 00:00:00
abstract：:Hormone concentrations in blood and total 12 h urine values were compared between 40 post-menopausal women with breast cancer and 40 control women in a study which carefully controlled for the possible confounding effects of age, weight and pregnancy history by individually matching cases and controls on these factors...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.56
更新日期：1990-02-01 00:00:00
abstract：BACKGROUND:Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated. METHODS:We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.339
更新日期：2013-07-23 00:00:00
abstract：:The efficacy of photodynamic therapy (PDT) using delta-aminolaevulinic acid (ALA)-induced protoporphyrin IX (PpIX) sensitisation and laser light at 635 nm was investigated in the treatment of experimental hepatic tumours. The model of liver tumours was induced either by local inoculation or by administration of tumour...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.584
更新日期：1996-11-01 00:00:00
