Abstract:
:The efficacy of photodynamic therapy (PDT) using delta-aminolaevulinic acid (ALA)-induced protoporphyrin IX (PpIX) sensitisation and laser light at 635 nm was investigated in the treatment of experimental hepatic tumours. The model of liver tumours was induced either by local inoculation or by administration of tumour cells through the portal vein in rats. ALA at a dose of 60 mg kg(-1) b.w. was intravenously administered 60 min before PDT. PpIX accumulation in tumour, normal liver and abdominal wall muscle was detected by means of laser-induced fluorescence (LIF). Laser Doppler imaging (LDI) was used to determine changes in the superficial blood flow in connection with PDT. Histopathological examinations were performed to evaluate the PDT effects on the tumour and the surrounding liver tissue, including pathological features in the microvascular system. The accumulation of PpIX, as monitored by LIF, showed high fluorescence intensities at about 635 nm in both the hepatic tumour tissue and normal liver and low values in the abdominal wall. LDI demonstrated that the blood flow in the treated tumour and its surrounding normal liver tissue decreased immediately after the PDT, indicating an effect on the vascular system. A large number of thrombi in the irradiated tumour were found microscopically 3 h after the PDT. The tumour growth rate showed a marked decrease when evaluated 3 and 6 days after the treatment. These results show that the ALA-PDT is effective in the inhibition of growth of experimental hepatic tumours.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Svanberg K,Liu DL,Wang I,Andersson-Engels S,Stenram U,Svanberg Sdoi
10.1038/bjc.1996.584subject
Has Abstractpub_date
1996-11-01 00:00:00pages
1526-33issue
10eissn
0007-0920issn
1532-1827journal_volume
74pub_type
杂志文章abstract::The prognostic value of C-reactive protein, compared with ECOG performance status (ECOG-ps), in patients receiving alpha-interferon treatment for advanced renal cancer was assessed in 58 patients. In all, 55 patients died on follow-up. On multivariate analysis with ECOG-ps and C-reactive protein entered as covariates,...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6602152
更新日期:2004-10-04 00:00:00
abstract::The tumour suppressor gene CDKN2A, located on chromosome 9p21, encodes the cell cycle regulatory protein p16. Inactivation of the CDKN2A gene could lead to uncontrolled cell growth. In order to determine the role of CDKN2A in the development of sporadic ovarian cancer, loss of heterozygosity at 9p21-22, homozygous del...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690621
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pub_type: 杂志文章
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更新日期:2003-05-19 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600144
更新日期:2002-03-04 00:00:00
abstract:BACKGROUND:Body mass index (BMI) has been associated with the risk of oesophageal cancer. But the influence of BMI on postoperative complication and prognosis has always been controversial. METHODS:In total, 2031 consecutive patients who underwent oesophagectomy between 1998 and 2008 were classified according to Asian...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析
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更新日期:2013-11-26 00:00:00
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pub_type: 杂志文章
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更新日期:2014-01-07 00:00:00
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pub_type: 杂志文章
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更新日期:2002-10-07 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1038/bjc.2017.44
更新日期:2017-04-11 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2002-07-15 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.466
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:In colorectal cancer (CRC), BRAF mutations influence tumour progression. In mismatch repair-deficient (dMMR) tumours, BRAF mutations are associated with a good prognosis, whereas in MMR-competent tumours, they are detrimental. The differential expression of the downstream MAPK pathway members, which are cons...
journal_title:British journal of cancer
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doi:10.1038/s41416-018-0174-y
更新日期:2018-08-01 00:00:00
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journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:1990-03-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,评审
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更新日期:2011-04-12 00:00:00
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pub_type: 杂志文章
doi:10.1054/bjoc.2000.1288
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-08-07 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2009-09-15 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1977.154
更新日期:1977-07-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.411
更新日期:1996-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/bjc.1995.215
更新日期:1995-05-01 00:00:00
abstract::The bioreductive antitumour agent, mitomycin C (MMC), requires activation by reductive enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1). We used a novel approach to increase MMC efficacy by selectively inducing NQO1 in tumour cells in vivo. CD-1 nude mice were implanted with HCT116 cells, and fed control diet or d...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602171
更新日期:2004-10-18 00:00:00