当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > The impact of vitamin D pathway genetic variation and circulating 25-hydroxyvitamin D on cancer outcome: systematic review and meta-analysis.

The impact of vitamin D pathway genetic variation and circulating 25-hydroxyvitamin D on cancer outcome: systematic review and meta-analysis.

Abstract：

BACKGROUND:Vitamin D has been linked with improved cancer outcome. This systematic review and meta-analysis investigates the relationship between cancer outcomes and both vitamin D-related genetic variation and circulating 25-hydroxyvitamin D (25OHD) concentration. METHODS:A systematic review and meta-analysis of papers until November 2016 on PubMed, EMBASE and Web of Science pertaining to association between circulating vitamin D level, functionally relevant vitamin D receptor genetic variants and variants within vitamin D pathway genes and cancer survival or disease progression was performed. RESULTS:A total of 44 165 cases from 64 studies were included in meta-analyses. Higher 25OHD was associated with better overall survival (hazard ratio (HR=0.74, 95% CI: 0.66-0.82) and progression-free survival (HR=0.84, 95% CI: 0.77-0.91). The rs1544410 (BsmI) variant was associated with overall survival (HR=1.40, 95% CI: 1.05-1.75) and rs7975232 (ApaI) with progression-free survival (HR=1.29, 95% CI: 1.02-1.56). The rs2228570 (FokI) variant was associated with overall survival in lung cancer patients (HR=1.29, 95% CI: 1.0-1.57), with a suggestive association across all cancers (HR=1.26, 95% CI: 0.96-1.56). CONCLUSIONS:Higher 25OHD concentration is associated with better cancer outcome, and the observed association of functional variants in vitamin D pathway genes with outcome supports a causal link. This analysis provides powerful background rationale to instigate clinical trials to investigate the potential beneficial effect of vitamin D in the context of stratification by genotype.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Vaughan-Shaw PG,O'Sullivan F,Farrington SM,Theodoratou E,Campbell H,Dunlop MG,Zgaga L

doi

10.1038/bjc.2017.44

subject

Has Abstract

pub_date

2017-04-11 00:00:00

pages

1092-1110

issue

8

eissn

0007-0920

issn

1532-1827

pii

bjc201744

journal_volume

116

pub_type

杂志文章,meta分析,评审

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Laminin activates the p185HER2 oncoprotein and mediates growth inhibition of breast carcinoma cells.

    abstract：:The interaction between laminin and the oncoprotein encoded by the c-erbB-2 oncogene was studied in vitro and in vivo in human breast carcinomas. In vitro analysis of breast carcinoma cell lines overexpressing p185HER2 revealed that laminin, but not fibronectin, induced tyrosine phosphorylation and down-modulation of ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.560

    authors： Tagliabue E,Ardini E,Pellegrini R,Campiglio M,Bufalino R,Jeschke M,Groner B,Colnaghi MI,Ménard S

    更新日期：1996-11-01 00:00:00

  • High dose melphalan, BCNU and etoposide with autologous bone marrow transplantation for Hodgkin's disease.

    abstract：:Thirty-eight patients with previously treated Hodgkin's disease were given high dose combination chemotherapy using melphalan and BCNU and autologous bone marrow transplantation. In 25 patients etoposide was added in conventional dosage. During the course of the study the dose of melphalan was increased from 80 to 140...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1989.128

    authors： Zulian GB,Selby P,Milan S,Nandi A,Gore M,Forgeson G,Perren TJ,McElwain TJ

    更新日期：1989-04-01 00:00:00

  • Tissue distribution and tumour localization of 99m-technetium-labelled liposomes in cancer patients.

    abstract：:The possible use of liposomes (phospholipid vesicles) to direct cytotoxic drugs to tumours has led us to investigate the tissue localization of i.v. injected 99m-Tc-labelled liposomes in cancer patients. Twenty mg or 300 mg doses of liposomal lipid (7:2:1 molar ratio of phosphatidylcholine : cholesterol : phosphatidic...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1979.138

    authors： Richardson VJ,Ryman BE,Jewkes RF,Jeyasingh K,Tattersall MN,Newlands ES,Kaye SB

    更新日期：1979-07-01 00:00:00

  • Effects of cyclosporin A and a non-immunosuppressive analogue, O-acetyl cyclosporin A, upon the growth of parent and multidrug resistant human lung cancer cells in vitro.

    abstract：:We have studied the ability of cyclosporin A (CsA) and a non-immunosuppressive analogue, O-acetyl cyclosporin A (OACsA, B3-243) to inhibit the growth of human lung cancer cells in vitro. Using continuous drug exposure and the MTT colorimetric assay to determine cell growth we found that CsA produced partial growth inh...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1992.68

    authors： Twentyman PR,Wright KA,Wallace HM

    更新日期：1992-03-01 00:00:00

  • Mechanistic modelling of dynamic MRI data predicts that tumour heterogeneity decreases therapeutic response.

    abstract：BACKGROUND:Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) contains crucial information about tumour heterogeneity and the transport limitations that reduce drug efficacy. Mathematical modelling of drug delivery and cellular responsiveness based on underutilised DCE-MRI data has the unique potential to p...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605773

    authors： Venkatasubramanian R,Arenas RB,Henson MA,Forbes NS

    更新日期：2010-08-10 00:00:00

  • Metallothionein - overexpression as a highly significant prognostic factor in melanoma: a prospective study on 1270 patients.

    abstract：:Metallothioneins (MT) are ubiquitous, intracellular small proteins with high affinity for heavy metal ions. In the last decades, it was shown that MT overexpression in a variety of cancers is associated with resistance to anticancer drugs and is combined with a poor prognosis. In this prospective study, we examined th...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603028

    authors： Weinlich G,Eisendle K,Hassler E,Baltaci M,Fritsch PO,Zelger B

    更新日期：2006-03-27 00:00:00

  • Can cancer cells transform normal host cells into malignant cells?

    abstract：:A human prostate tumour cell line, LNCaP C4-2, when injected into athymic male nude mice, produced tumours containing: (1) only human cancer cells similar to those injected; (2) only murine stromal cells containing abnormal chromosome constitutions; or (3) both human prostate cancer cells similar to those injected and...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.524

    authors： Pathak S,Nemeth MA,Multani AS,Thalmann GN,von Eschenbach AC,Chung LW

    更新日期：1997-01-01 00:00:00

  • Clinical-guide risk prediction of hepatocellular carcinoma development in chronic hepatitis C patients after interferon-based therapy.

    abstract：BACKGROUND:Interferon (IFN)-based therapies could eradicate hepatitis C (HCV) and reduce the risk of hepatocellular carcinoma (HCC). However, HCC could still happen after sustained virological response (SVR). We aimed to develop a simple scoring system to predict the risk of HCC development among HCV patients after ant...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.564

    authors： Chang KC,Wu YY,Hung CH,Lu SN,Lee CM,Chiu KW,Tsai MC,Tseng PL,Huang CM,Cho CL,Chen HH,Hu TH

    更新日期：2013-10-29 00:00:00

  • A randomised phase II study of sialyl-Tn and DETOX-B adjuvant with or without cyclophosphamide pretreatment for the active specific immunotherapy of breast cancer.

    abstract：:Studies in animal models of mouse mammary carcinoma have shown that ovine submaxillary mucin, which carries multiple sialyl-Tn (STn) epitopes, is effective in stimulating an immune response and inhibiting tumour growth. In similar studies using carbohydrate antigens, pretreatment with low-dose cyclophosphamide has bee...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/bjc.1996.532

    authors： Miles DW,Towlson KE,Graham R,Reddish M,Longenecker BM,Taylor-Papadimitriou J,Rubens RD

    更新日期：1996-10-01 00:00:00

  • Epstein-Barr virus expression in Hodgkin's disease in relation to patient characteristics, serum factors and blood lymphocyte function.

    abstract：:Epstein-Barr virus (EBV) expression was investigated by immunohistochemistry (latent membrane protein 1 [LMP-1]) and in situ hybridization (EBV encoded RNA [EBER]) in biopsies from 95 patients with untreated Hodgkin's disease (HD). Tumour EBV status was related to EBV antibody titres, spontaneous and concanavalin A in...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690827

    authors： Axdorph U,Porwit-MacDonald A,Sjöberg J,Grimfors G,Ekman M,Wang W,Biberfeld P,Björkholm M

    更新日期：1999-12-01 00:00:00

  • Cytokeratin 7 and 20 staining for the diagnosis of lung and colorectal adenocarcinoma.

    abstract：:The origin of metastatic adenocarcinoma lesions can sometimes be difficult to diagnose. The objectives of our study were to establish the cytokeratin staining pattern of primary and metastatic lung and colorectal adenocarcinomas, and to determine if this helps to identify the site of origin of metastatic lesions. We r...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600326

    authors： Kummar S,Fogarasi M,Canova A,Mota A,Ciesielski T

    更新日期：2002-06-17 00:00:00

  • Perforin expression in lymphocytes infiltrated to human colorectal cancer.

    abstract：:Perforin (PFP) is a cytotoxic protein released from killer cells. PFP immunoreactivity in human peripheral blood lymphocytes (PBL) and tumour infiltrating lymphocytes (TIL) was investigated immunocytochemically with the aid of an anti-PFP monoclonal antibody. PFP was detected in the cytoplasm of 10% of PBL. We perform...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1991.283

    authors： Nakanishi H,Monden T,Morimoto H,Kobayashi T,Shimano T,Mori T

    更新日期：1991-08-01 00:00:00

  • Indomethacin induces apoptosis via a MRP1-dependent mechanism in doxorubicin-resistant small-cell lung cancer cells overexpressing MRP1.

    abstract：:Small-cell lung cancers (SCLCs) initially respond to chemotherapy, but are often resistant at recurrence. The non-steroidal anti-inflammatory drug indomethacin is an inhibitor of multidrug resistance protein 1 (MRP1) function. The doxorubicin-resistant MRP1-overexpressing human SCLC cell line GLC(4)-Adr was highly sen...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604010

    authors： de Groot DJ,van der Deen M,Le TK,Regeling A,de Jong S,de Vries EG

    更新日期：2007-10-22 00:00:00

  • Cold lymphocytotoxic antibodies in nasopharyngeal carcinoma.

    abstract：:Sera from patients with nasopharyngeal carcinoma (NPC), a disease associated with Epstein-Barr virus (EBV), were found to be cytotoxic at 15% degrees C in the presence of complement for a panel of human lymphocytes, with a higher frequency than those of matched controls. The cold lymphocytotoxic antibodies (LTA) respo...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1977.64

    authors： Lamelin JP,Revillard JP,Chalopin JM,Ho JH,Souissi T,Schwaab G,De-Thé G

    更新日期：1977-04-01 00:00:00

  • Effects of the glucolipid synthase inhibitor, P4, on functional and phenotypic parameters of murine myeloma cells.

    abstract：:This study describes the effects of the glucolipid synthase inhibitor P4, (DL-threo-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol ), on various functional and phenotypic parameters of 5T33 murine myeloma cells. Cell recovery was reduced by >85% following incubation of the cells for 3 days in the presence of 4 mic...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690792

    authors： Manning LS,Radin NS

    更新日期：1999-11-01 00:00:00

  • Maspin is a marker for early recurrence in primary stage III and IV colorectal cancer.

    abstract：BACKGROUND:Little is known about the factors that drive metastasis formation in colorectal cancer (CRC). Here, we set out to identify genes and proteins in patients with colorectal liver metastases that correlate with early disease recurrence. Such factors may predict a propensity for metastasis in earlier stages of CR...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.489

    authors： Snoeren N,Emmink BL,Koerkamp MJ,van Hooff SR,Goos JA,van Houdt WJ,de Wit M,Prins AM,Piersma SR,Pham TV,Belt EJ,Bril H,Stockmann HB,Meijer GA,van Hillegersberg R,Holstege FC,Jimenez CR,Fijneman RJ,Kranenburg OW,Rinke

    更新日期：2013-09-17 00:00:00

  • Induction of myogenic differentiation in human rhabdomyosarcoma cells by ionising radiation, N,N-dimethylformamide and their combination.

    abstract：:Differentiation-inducing ability of gamma-radiation, N,N-dimethylformamide and their combination has been tested on human rhabdomyosarcoma RMZ-RC2 clone cells. Ionising radiation at 2-5 Gy doses induced a more differentiated morphology, with the appearance of an increased proportion of multinuclear myotube-like cells,...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1992.107

    authors： Nicoletti G,De Giovanni C,Landuzzi L,Simone G,Rocchi P,Nanni P,Lollini PL

    更新日期：1992-04-01 00:00:00

  • Indole-3-carbinol synergistically sensitises ovarian cancer cells to bortezomib treatment.

    abstract：BACKGROUND:Bortezomib is a proteasome inhibitor with minimal clinical activity as a monotherapy in solid tumours, but its combination with other targeted therapies is being actively investigated as a way to increase its anticarcinogenic properties. Here, we evaluate the therapeutic potential of co-treatment with bortez...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.546

    authors： Taylor-Harding B,Agadjanian H,Nassanian H,Kwon S,Guo X,Miller C,Karlan BY,Orsulic S,Walsh CS

    更新日期：2012-01-17 00:00:00

  • BRCA1 expression and improved survival in ovarian cancer patients treated with intraperitoneal cisplatin and paclitaxel: a Gynecologic Oncology Group Study.

    abstract：BACKGROUND:Breast cancer 1, early onset (BRCA1) is a tumour-suppressor gene associated with familial epithelial ovarian cancer (EOC). Reduced BRCA1 expression is associated with enhanced sensitivity to platinum-based chemotherapy. We sought to examine the prognostic relevance of BRCA1 expression in EOC patients treated...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1038/bjc.2013.70

    authors： Lesnock JL,Darcy KM,Tian C,Deloia JA,Thrall MM,Zahn C,Armstrong DK,Birrer MJ,Krivak TC

    更新日期：2013-04-02 00:00:00

  • Paediatric germ cell tumours and congenital abnormalities: a Children's Oncology Group study.

    abstract：METHODS:Maternally reported congenital abnormalities (CAs) were examined in a case-control study of 278 cases of paediatric germ cell tumours (GCTs) and 423 controls. RESULTS AND CONCLUSIONS:Germ cell tumours were significantly associated with cryptorchidism in males (OR=10.8, 95% CI: 2.1-55.1), but not with any other...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605169

    authors： Johnson KJ,Ross JA,Poynter JN,Linabery AM,Robison LL,Shu XO

    更新日期：2009-08-04 00:00:00

  • Does deprivation affect breast cancer management?

    abstract：:We evaluated whether social deprivation affected decision-making for breast cancer surgery. Of 3419 patients, 53.6% had mastectomy and this was predicted by deprivation, age, tumour size and hospital, all of which retained significance on multivariate analysis, except deprivation. Pathological characteristics and surg...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602390

    authors： Henley NC,Hole DJ,Kesson E,Burns HJ,George WD,Cooke TG

    更新日期：2005-02-28 00:00:00

  • An immunohistochemical study of altered immunomodulatory molecule expression in head and neck squamous cell carcinoma.

    abstract：:For the presentation of peptide antigens to cytotoxic CD8+ T lymphocytes of the immune system, the expression of human leukocyte antigen (HLA) class I molecules on the cell surface is necessary. There is increasing evidence that surface HLA class I antigen expression is altered in a variety of human tumours by either ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.472

    authors： Vora AR,Rodgers S,Parker AJ,Start R,Rees RC,Murray AK

    更新日期：1997-01-01 00:00:00

  • Cytotoxic antibody in acute myeloblastic leukaemia during immunotherapy: lack of tumour specificity.

    abstract：:Cytotoxic antibodies to antigens specific for leukaemic myeloblasts have been sought in the serum of patients with acute myeloblastic leukaemia treated by immunotherapy with irradiated allogeneic myeloblasts and BCG. Assays of complement- and K-cell-mediated activity were used. Cytotoxicity to allogeneic myeloblasts w...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1977.40

    authors： Gale DG,MacLennan IC

    更新日期：1977-03-01 00:00:00

  • Prognostic significance of Bcl-xL expression and efficacy of Bcl-xL targeting therapy in urothelial carcinoma.

    abstract：BACKGROUND:Bcl-xL has an important role in the control of cell death through its inhibition of apoptosis. The aim of this study was to investigate the clinicopathological significance of Bcl-xL in upper urinary tract urothelial carcinoma (UTUC) and the therapeutic effect of targeting Bcl-xL protein in urothelial carcin...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.216

    authors： Yoshimine S,Kikuchi E,Kosaka T,Mikami S,Miyajima A,Okada Y,Oya M

    更新日期：2013-06-11 00:00:00

  • Cancer mortality by educational level in the city of Barcelona.

    abstract：:The objective of this study was to examine the relationship between educational level and mortality from cancer in the city of Barcelona. The data were derived from a record linkage between the Barcelona Mortality Registry and the Municipal Census. The relative risks (RR) of death and 95% confidence intervals (CIs) ac...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690108

    authors： Fernandez E,Borrell C

    更新日期：1999-02-01 00:00:00

  • Lung tumour markers in oncology practice: a study of TPA and CA125.

    abstract：:Several substances mark the course of lung cancer and may reliably help the clinician in decision-making. This is the first clinical study specifically designed to compare tissue polypeptide antigen and CA 125 tumour associated antigen. Three hundred and eighty-four new lung cancer patients (309 males) were studied at...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600577

    authors： Buccheri G,Ferrigno D

    更新日期：2002-11-04 00:00:00

  • Integrating cytokines and angiogenic factors and tumour bulk with selected clinical criteria improves determination of prognosis in advanced renal cell carcinoma.

    abstract：BACKGROUND:In two clinical trials of the vascular endothelial growth factor (VEGF) receptor inhibitor pazopanib in advanced renal cell carcinoma (mRCC), we found interleukin-6 as predictive of pazopanib benefit. We evaluated the prognostic significance of candidate cytokines and angiogenic factors (CAFs) identified in ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2017.206

    authors： Zurita AJ,Gagnon RC,Liu Y,Tran HT,Figlin RA,Hutson TE,D'Amelio AM Jr,Sternberg CN,Pandite LN,Heymach JV

    更新日期：2017-08-08 00:00:00

  • Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat.

    abstract：:The growth of s.c. Walker 256 carcinoma was found to be independent of secondary growths induced by i.v. injection. Tumour cells injected i.v. lodged mainly in the lungs, with small clusters of cells in the lymph nodes. The rate of cellular proliferation of these secondary growths of Walker carcinoma was significantly...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1978.12

    authors： Bellamy D,Hinsull SM

    更新日期：1978-01-01 00:00:00

  • Evaluation of Angiopoietin-2 as a biomarker in gastric cancer: results from the randomised phase III AVAGAST trial.

    abstract：BACKGROUND:In the phase III AVAGAST trial, the addition of bevacizumab to chemotherapy improved progression-free survival (PFS) but not overall survival (OS) in patients with advanced gastric cancer. We studied the role of Angiopoietin-2 (Ang-2), a key driver of tumour angiogenesis, metastasis and resistance to antiang...

    journal_title：British journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/bjc.2016.30

    authors： Hacker UT,Escalona-Espinosa L,Consalvo N,Goede V,Schiffmann L,Scherer SJ,Hedge P,Van Cutsem E,Coutelle O,Büning H

    更新日期：2016-04-12 00:00:00

  • Association of apolipoprotein E polymorphisms and dietary factors in colorectal cancer.

    abstract：:ApoE single nucleotide polymorphisms (SNPs) Cys112Arg (Epsilon-4), and Arg158Cys (Epsilon-2) have been implicated in cardiovascular and Alzheimer's disease, but their role in colorectal cancer (CRC) has not been extensively studied. We investigated whether ApoE polymorphisms alone or in combination with dietary factor...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605097

    authors： Mrkonjic M,Chappell E,Pethe VV,Manno M,Daftary D,Greenwood CM,Gallinger S,Zanke BW,Knight JA,Bapat B

    更新日期：2009-06-16 00:00:00