BRCA1 expression and improved survival in ovarian cancer patients treated with intraperitoneal cisplatin and paclitaxel: a Gynecologic Oncology Group Study.

abstract：BACKGROUND:Surgery is considered to be the first line treatment for solid tumours. Recently, retrospective studies reported that general anaesthesia was associated with worse long-term cancer-free survival when compared with regional anaesthesia. This has important clinical implications; however, the mechanisms underly...

journal_title：British journal of cancer

authors： Huang H,Benzonana LL,Zhao H,Watts HR,Perry NJ,Bevan C,Brown R,Ma D

更新日期：2014-09-23 00:00:00

abstract：:HuR, a ubiquitously expressed member of the Hu protein family that binds and stabilizes an AU-rich element (ARE)-containing mRNAs, is known to shuttle between the nucleus and the cytoplasm via several export pathways. When normal cells were treated with heat shock, HuR was exported to the cytoplasm in a chromosome mai...

journal_title：British journal of cancer

authors： Hasegawa H,Kakuguchi W,Kuroshima T,Kitamura T,Tanaka S,Kitagawa Y,Totsuka Y,Shindoh M,Higashino F

更新日期：2009-06-16 00:00:00

abstract：:Deletion of chromosome arm 1p and amplification of the MYCN oncogene are well-recognized genetic alterations in neuroblastoma cells. Recently, another alteration has been reported; gain of the distal part of chromosome arm 17q. In this study 48 neuroblastoma tumours were successfully analysed for 17q status in relatio...

journal_title：British journal of cancer

authors： Abel F,Ejeskär K,Kogner P,Martinsson T

更新日期：1999-12-01 00:00:00

abstract：:Heterogeneity of DNA content in multiple hepatocellular carcinomas (HCCs) was investigated by flow cytometry in 62 tumours from 26 patients who had undergone surgical treatment for multiple synchronous HCCs. Heterogeneity of DNA content was defined (a) when tumours had a different DNA ploidy pattern or (b) when the di...

journal_title：British journal of cancer

authors： Hui AM,Kawasaki S,Imamura H,Miyagawa S,Ishii K,Katsuyama T,Makuuchi M

更新日期：1997-01-01 00:00:00

abstract：:KRN 8602 (MX2) is a novel morpholino anthracycline derivative having the chemical structure 3'-deamino-3'-morpholino-13-deoxo-10-hydroxycarminomycin hydrochloride. To investigate the mechanisms of resistance to MX2, we established an MX2-resistant phenotype (K562/MX2) of the human myelogeneous leukaemia cell line (K56...

journal_title：British journal of cancer

authors： Asano T,Nakamura K,Fujii H,Horichi N,Ohmori T,Hasegawa K,Isoe T,Adachi M,Otake N,Fukunaga Y

更新日期：2005-04-25 00:00:00

abstract：:We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, named PTC, is a novel rearranged version of the ret proto-oncogene. In fact PTC is the product of the fusion of the tyrosine kinase domain of the ret proto-oncogene with the 5'-terminal region of another ge...

journal_title：British journal of cancer

authors： Fabien N,Paulin C,Santoro M,Berger N,Grieco M,Galvain D,Barbier Y,Dubois PM,Fusco A

更新日期：1992-12-01 00:00:00

abstract：:No published data are available concerning the activity and tolerability of intramuscularly administered granulocyte colony-stimulating factor (G-CSF) in humans. To fill this gap, 19 patients with advanced ovarian cancer previously treated with at least one first-line chemotherapy cycle received the following myelosup...

journal_title：British journal of cancer

authors： Di Leo A,Bajetta E,Nolè F,Biganzoli L,Ferrari L,Oriana S,Riboldi G,Bohm S,Spatti G,Raspagliesi F

更新日期：1994-05-01 00:00:00

abstract：:Increasingly, treatment choices leading to the same survival outcome can be offered to cancer patients (e.g. mastectomy or conservative surgery in early breast cancer). Two approaches available for post-orchidectomy, stage I patients with non-seminomatous germ cell tumours of the testis (NSGCTT), particularly those at...

journal_title：British journal of cancer

authors： Cullen MH,Billingham LJ,Cook J,Woodroffe CM

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of health-related quality of life (HRQOL) from coBRIM is reported. METHODS:Patients completing the Eur...

journal_title：British journal of cancer

authors： Dréno B,Ascierto PA,Atkinson V,Liszkay G,Maio M,Mandalà M,Demidov L,Stroyakovskiy D,Thomas L,de la Cruz-Merino L,Dutriaux C,Garbe C,Bartley K,Karagiannis T,Chang I,Rooney I,Koralek DO,Larkin J,McArthur GA,Ribas A

更新日期：2018-03-20 00:00:00

abstract：:The serum CA125 level was determined by a one-step immunoradiometric assay method in patients with lung cancer. Increased serum CA125 levels were observed in 37.8% of patients with squamous cell cancer, in 30.0% of those with adenocarcinoma and in 60.0% of those with small call cancer. Most patients with increased ser...

journal_title：British journal of cancer

authors： Kimura Y,Fujii T,Hamamoto K,Miyagawa N,Kataoka M,Iio A

更新日期：1990-10-01 00:00:00

abstract：:Recombinant single-chain fragments (scFv) of the murine anti-MUC1 monoclonal antibody C595 have been produced using the original hybridoma cells as a source of variable heavy (V(H))- and variable light (V(L))-chain-encoding antibody genes. The use of the polymerase chain reaction (PCR), bacteriophage (phage) display t...

journal_title：British journal of cancer

authors： Denton G,Sekowski M,Spencer DI,Hughes OD,Murray A,Denley H,Tendler SJ,Price MR

更新日期：1997-01-01 00:00:00

abstract：:Comparative genomic hybridization (CGH) was used to detect copy number changes of DNA sequences in the Ewing family of tumours (ET). We analysed 20 samples from 17 patients. Fifteen tumours (75%) showed copy number changes. Gains of DNA sequences were much more frequent than losses, the majority of the gains affecting...

journal_title：British journal of cancer

authors： Armengol G,Tarkkanen M,Virolainen M,Forus A,Valle J,Böhling T,Asko-Seljavaara S,Blomqvist C,Elomaa I,Karaharju E,Kivioja AH,Siimes MA,Tukiainen E,Caballín MR,Myklebost O,Knuutila S

更新日期：1997-01-01 00:00:00

abstract：:Previously, we reported that Bcl-2 was frequently expressed in renal cell carcinoma (RCC) specimens, but p53 mutation was a rare event. However, it was unclear whether Bcl-2 positivity was associated with the clinicopathological characteristics and prognosis in RCC. Therefore, we investigated the expression of Bcl-2 p...

journal_title：British journal of cancer

authors： Itoi T,Yamana K,Bilim V,Takahashi K,Tomita F

更新日期：2004-01-12 00:00:00

abstract：BACKGROUND:There is growing evidence that history of allergic or autoimmune disease is associated with reduced risk of glioma, but few prospective studies have explored the biological basis. To assess associations with immune conditions and levels of 14 cytokines in serial prediagnostic serum samples, we conducted a st...

journal_title：British journal of cancer

authors： Brenner AV,Inskip PD,Rusiecki J,Rabkin CS,Engels J,Pfeiffer RM

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Cytosolic deacetylase histone deacetylase 6 (HDAC6) is involved in the autophagy degradation pathway of malformed proteins, an important survival mechanism in cancer cells. We evaluated modulation of autophagy-related proteins and cell death by the HDAC6-selective inhibitor C1A. METHODS:Autophagy substrates...

journal_title：British journal of cancer

authors： Kaliszczak M,van Hechanova E,Li Y,Alsadah H,Parzych K,Auner HW,Aboagye EO

更新日期：2018-11-01 00:00:00

abstract：:Treatment failure in AML is often attributed to P-glycoprotein-associated multidrug resistance. However, the importance of increased DNA repair in resistant cells is becoming more apparent. In order to investigate the ability of the DNA repair inhibitor aphidicolin to modulate drug resistance, we continually exposed b...

journal_title：British journal of cancer

authors： Sargent JM,Elgie AW,Williamson CJ,Lewandowicz GM,Taylor CG

更新日期：2001-03-02 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) has been proposed to guide breast cancer surgery by measuring residual tumour after neoadjuvant chemotherapy. This study-level meta-analysis examines MRI's agreement with pathology, compares MRI with alternative tests and investigates consistency between different measures of...

journal_title：British journal of cancer

authors： Marinovich ML,Macaskill P,Irwig L,Sardanelli F,von Minckwitz G,Mamounas E,Brennan M,Ciatto S,Houssami N

更新日期：2013-09-17 00:00:00

abstract：:The secosteroid hormones, all-trans- and 9-cis-retinoic acid and vitamin D3, have demonstrated significant capacity to control proliferation in vitro of many solid tumour cell lines. Cooperative synergistic effects by these two ligands have been reported, and it is, therefore, possible that greater therapeutic effects...

journal_title：British journal of cancer

authors： Campbell MJ,Park S,Uskokovic MR,Dawson MI,Jong L,Koeffler HP

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:We performed a retrospective nationwide study to explore age as a prognostic factor in synovial sarcoma patients. METHODS:Data on 613 synovial sarcoma patients were obtained from the Netherlands Cancer Registry. The prognostic relevance of age groups (children, adolescent and young adults (AYAs), adults, an...

journal_title：British journal of cancer

authors： Vlenterie M,Ho VK,Kaal SE,Vlenterie R,Haas R,van der Graaf WT

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The 1997 international consensus conference on renal cell cancer (RCC) prognosis suggested erythrocyte sedimentation rate (ESR), alkaline phosphatase (ALP), and anaemia as prognostic biomarkers, but most studies reviewed were limited by small sample sizes. METHODS:The Cox proportional hazards model was used...

journal_title：British journal of cancer

authors： Choi Y,Park B,Kim K,Jeong BC,Seo SI,Jeon SS,Choi HY,Lee JE,Lee HM

更新日期：2013-02-05 00:00:00

abstract：:Chromosome 9p21 gene copy number in Ewing's sarcoma family of tumour (ESFT) cell lines and primary ESFT has been evaluated using Multiplex Ligation-dependent probe amplification, and the clinical significance of CDKN2A loss and p16/p14(ARF) expression investigated. Homozygous deletion of CDKN2A was identified in 4/9 (...

journal_title：British journal of cancer

authors： Brownhill SC,Taylor C,Burchill SA

更新日期：2007-06-18 00:00:00

abstract：:We investigated the feasibility and the anti-tumour activity of weekly cisplatin and the simultaneous application of local hyperthermia in patients with a pelvic recurrence of cervical cancer in previously irradiated area. Dose levels of cisplatin 60 mg m(-2), 70 mg m(-2) and 80 mg m(-2) were studied. Treatment object...

journal_title：British journal of cancer

authors： de Wit R,van der Zee J,van der Burg ME,Kruit WH,Logmans A,van Rhoon GC,Verweij J

更新日期：1999-07-01 00:00:00

abstract：:Fine-needle aspiration cytology, which is well established to be accurate for the diagnosis of thyroid cancer, may be inconclusive for the follicular thyroid neoplasms. As galectin-3 was suggested to be a marker of malignant thyrocytes, we investigated whether this protein might be helpful in the diagnosis of aspirate...

journal_title：British journal of cancer

authors： Collet JF,Hurbain I,Prengel C,Utzmann O,Scetbon F,Bernaudin JF,Fajac A

更新日期：2005-11-14 00:00:00

abstract：BACKGROUND:Inhibitors of the mammalian target of rapamycin (mTOR) might become a novel tool to treat advanced prostate cancer. However, chronic drug exposure may trigger resistance, limiting the utility of mTOR inhibitors. METHODS:Metastatic potential of PC3 prostate cancer cells, susceptible (PC3(par)) or resistant (...

journal_title：British journal of cancer

authors： Tsaur I,Makarević J,Juengel E,Gasser M,Waaga-Gasser AM,Kurosch M,Reiter M,Wedel S,Bartsch G,Haferkamp A,Wiesner C,Blaheta RA

更新日期：2012-08-21 00:00:00

abstract：BACKGROUND:Enzastaurin, an oral serine-threonine kinase inhibitor, was initially developed as an ATP-competitive selective inhibitor against protein kinase Cβ. However, the mechanism by which enzastaurin contributes to tumourigenesis remains unclear. METHODS:We analysed the anti-tumour effects of enzastaurin in 22 lun...

journal_title：British journal of cancer

authors： Shimokawa T,Seike M,Soeno C,Uesaka H,Miyanaga A,Mizutani H,Kitamura K,Minegishi Y,Noro R,Okano T,Yoshimura A,Gemma A

更新日期：2012-02-28 00:00:00

abstract：:The 5-year relative survival rates of women diagnosed with breast cancer between 1992 and 1994 were compared among the 99 Health Authorities (1999 boundaries) of England. Substantial variation, with evidence of geographical clustering was observed. Part of this variation was explained by differences in deprivation bet...

journal_title：British journal of cancer

authors： Mullee MA,De Stavola B,Romanengo M,Coleman MP

更新日期：2004-06-01 00:00:00

abstract：:Monoclonal antibody MUC 2-63 recognises neurogenic tumours and has been used successfully for radioimaging human malignant gliomas. We now show that the MUC 2-63 antigen has the same tissue distribution and molecular weight range as the CD44 antigen and confirm the identity of these two molecules in blocking studies u...

journal_title：British journal of cancer

authors： Romeijn P,Lenthall R,Stavrou D,Melcher D,Ladyman H,Ritter MA

更新日期：1994-11-01 00:00:00

abstract：:In a population-based cohort study of all women aged over 50 years with breast cancer in the Swedish Cancer Register in 1961-2003, those diagnosed before 31 December 1987 were regarded as unexposed to tamoxifen, whereas those diagnosed after that date were considered potentially exposed. Crosslinkages within the Cance...

journal_title：British journal of cancer

authors： Chandanos E,Lindblad M,Jia C,Rubio CA,Ye W,Lagergren J

更新日期：2006-07-03 00:00:00

abstract：:The continuous cell line UCRU BL 17CL was derived from a human invasive bladder cancer and expresses elements of transitional, squamous and glandular differentiation. Nine clones of this line were established by limit dilution and have been extensively characterised. Only six of these clones grew subcutaneously in nud...

journal_title：British journal of cancer

authors： Brown JL,Russell PJ,Philips J,Wotherspoon J,Raghavan D

更新日期：1990-03-01 00:00:00

abstract：:Epidemiologic evidence has recently identified an association between an endemic outbreak of pleural and peritoneal mesothelioma in the Urgup region of Turkey and exposure to zeolite fibres. This malignancy is usually associated with exposure to asbestos dusts whose mineralogical characteristics differ from those of z...

journal_title：British journal of cancer

authors： Kelsey KT,Yano E,Liber HL,Little JB

更新日期：1986-07-01 00:00:00