Abstract:
:In a population-based cohort study of all women aged over 50 years with breast cancer in the Swedish Cancer Register in 1961-2003, those diagnosed before 31 December 1987 were regarded as unexposed to tamoxifen, whereas those diagnosed after that date were considered potentially exposed. Crosslinkages within the Cancer Register and the Registers of Death and Emigration enabled follow-up. Standardised incidence ratios (SIRs) of oesophageal and gastric cancer represented relative risks. Among 138 885 cohort members contributing with 1 075 724 person-years of follow-up, we found a nonsignificantly increased risk of oesophageal adenocarcinoma during the potential tamoxifen exposure period (SIR 1.60, 95% confidence interval (CI) 0.83-3.08), but the risk estimates decreased with increasing latency interval. No association was observed during the unexposed period. No increased risk of cardia adenocarcinoma was identified in either period. The risk of non-cardia gastric adenocarcinoma was increased in the potential tamoxifen period (SIR 1.27, 1.03-1.57), and almost doubled (SIR 1.86, 95% CI 1.10-3.14) in the period of longest latency (10-14 years). The corresponding overall SIR was increased in the unexposed group also, but here SIR did not increase with longer latency intervals. An increased risk of tobacco-related tumours, that is, oesophageal squamous-cell carcinoma and lung cancer, was limited to the unexposed cohort, indicating that confounding by smoking might explain the increased SIR during the unexposed period. We concluded that there might be a link between tamoxifen and risk of non-cardia gastric adenocarcinoma.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Chandanos E,Lindblad M,Jia C,Rubio CA,Ye W,Lagergren Jdoi
10.1038/sj.bjc.6603214subject
Has Abstractpub_date
2006-07-03 00:00:00pages
118-22issue
1eissn
0007-0920issn
1532-1827pii
6603214journal_volume
95pub_type
杂志文章abstract::Reductions in cell-cell adhesion and stromal and vascular invasion are essential steps in the progression from localized malignancy to metastatic disease. In this study, changes in the expression of the components of the E-cadherin-catenin cell adhesion complex have been investigated using immunohistochemical techniqu...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:British journal of cancer
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更新日期:1994-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1988-05-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1998-08-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1981-10-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1990.140
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1038/bjc.1973.9
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601712
更新日期:2004-03-22 00:00:00
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2006-02-27 00:00:00
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更新日期:2003-05-06 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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