Abstract：
:In a population-based cohort study of all women aged over 50 years with breast cancer in the Swedish Cancer Register in 1961-2003, those diagnosed before 31 December 1987 were regarded as unexposed to tamoxifen, whereas those diagnosed after that date were considered potentially exposed. Crosslinkages within the Cancer Register and the Registers of Death and Emigration enabled follow-up. Standardised incidence ratios (SIRs) of oesophageal and gastric cancer represented relative risks. Among 138 885 cohort members contributing with 1 075 724 person-years of follow-up, we found a nonsignificantly increased risk of oesophageal adenocarcinoma during the potential tamoxifen exposure period (SIR 1.60, 95% confidence interval (CI) 0.83-3.08), but the risk estimates decreased with increasing latency interval. No association was observed during the unexposed period. No increased risk of cardia adenocarcinoma was identified in either period. The risk of non-cardia gastric adenocarcinoma was increased in the potential tamoxifen period (SIR 1.27, 1.03-1.57), and almost doubled (SIR 1.86, 95% CI 1.10-3.14) in the period of longest latency (10-14 years). The corresponding overall SIR was increased in the unexposed group also, but here SIR did not increase with longer latency intervals. An increased risk of tobacco-related tumours, that is, oesophageal squamous-cell carcinoma and lung cancer, was limited to the unexposed cohort, indicating that confounding by smoking might explain the increased SIR during the unexposed period. We concluded that there might be a link between tamoxifen and risk of non-cardia gastric adenocarcinoma.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Chandanos E,Lindblad M,Jia C,Rubio CA,Ye W,Lagergren Jdoi
10.1038/sj.bjc.6603214subject
Has Abstractpub_date
2006-07-03 00:00:00pages
118-22issue
1eissn
0007-0920issn
1532-1827pii
6603214journal_volume
95pub_type
杂志文章abstract：:Epidermal growth factor receptor (EGFR) was studied in ovarian tumours with immunohistochemical (IH) and ligand-binding assay (LBA). Two different monoclonal antibodies (MoAbs: 2E9, EGFR1) with respect to detecting EGFR with different ligand-binding affinities (low, high and low) were used. When comparing the IH data ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.403
更新日期：1992-12-01 00:00:00
abstract：:The death certificate only (DCO) index, which quantifies the proportion of patients for whom the death certificate provides the only notification to the registry, is a widely used measure of incompleteness of population-based cancer registration. This paper provides an algebraic assessment and a quantitative illustrat...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.363
更新日期：1995-08-01 00:00:00
abstract：:The growth of s.c. Walker 256 carcinoma was found to be independent of secondary growths induced by i.v. injection. Tumour cells injected i.v. lodged mainly in the lungs, with small clusters of cells in the lymph nodes. The rate of cellular proliferation of these secondary growths of Walker carcinoma was significantly...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.12
更新日期：1978-01-01 00:00:00
abstract：:The radiation response of Epstein-Barr virus (EBV)-immortalised lymphoblastoid cell lines derive from Li-Fraumeni syndrome (LFS) and LFS-like individuals was investigated. Cells from all LFS and LFS-like cases showed an accumulation of p53 protein following 137Cs gamma-irradiation, which was associated with cell cycle...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.424
更新日期：1996-09-01 00:00:00
abstract：BACKGROUND:Alternative treatments are needed for elderly patients with acute myeloid leukaemia, as the disease prognosis is poor and the current treatment is unsuitable for many patients. METHODS:In this study, we investigated whether combining the nucleoside analogue sapacitabine with histone deacetylase (HDAC) inhib...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605922
更新日期：2010-10-26 00:00:00
abstract：BACKGROUND:Tumours are made up of a mixed population of different types of cells that include normal structures as well as ones associated with the malignancy, and there are multiple interactions between the malignant cells and the local microenvironment. These intercellular interactions, modulated by the microenvironm...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.517
更新日期：2012-01-03 00:00:00
abstract：:Endosialin is a transmembrane glycoprotein selectively expressed in blood vessels and stromal fibroblasts of various human tumours. It has been functionally implicated in angiogenesis, but the factors that control its expression have remained unclear. As insufficient delivery of oxygen is a driving force of angiogenes...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604685
更新日期：2008-10-21 00:00:00
abstract：:The present study was designed to examine whether different p53 haplotypes of exon 4-intron 3-intron 6 affect the frequency of mutations and loss of heterozygosity (LOH) of the p53 gene in male oral squamous cell carcinomas (OSCCs) in Taiwan. We found that individuals without two Pro-W-G alleles had significantly high...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602271
更新日期：2005-01-17 00:00:00
abstract：BACKGROUND:This study had two aims: (a) to test the hypothesis that advanced age is associated with lower levels of tolerability and clinical benefit to experimental Phase I trial agents; (b) to assess the validity of the Royal Marsden Hospital (RMH) prognostic score as a patient selection tool in older patients. METH...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.477
更新日期：2016-02-02 00:00:00
abstract：BACKGROUND:Testing for high-risk human papillomavirus (HPV) in primary screening for cervical cancer is considered more sensitive, but less specific, in comparison with Pap-smear cytology. Women with persistent HPV infections have a higher risk of developing cervical intraepithelial neoplasia 2+ (CIN2+) lesions. This s...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.277
更新日期：2011-08-23 00:00:00
abstract：BACKGROUND:The intestinal uptake of the taxanes paclitaxel and docetaxel is seriously hampered by drug efflux through P-glycoprotein (P-gp) and drug metabolism via cytochrome P450 (CYP) 3A. The resulting low oral bioavailability can be boosted by co-administration of P-gp or CYP3A4 inhibitors. METHODS:Paclitaxel or do...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.222
更新日期：2014-05-27 00:00:00
abstract：:When assessing the value of a particular treatment, it is important to consider the impact it may have on the quality of life of those being treated. This is particularly so for cancer patients, whose life expectancy may be short. Patients with advanced colorectal cancer who participated in two international comparati...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.1998.420
更新日期：1998-01-01 00:00:00
abstract：:The topical carcinogenicity to mouse skin of smoke condensates obtained from a tobacco substitute (NSM), alone or in combination with tobacco, has been compared with condensate from tobacco and with acetone, the solvent used. Sixteen different types of cigarette were used to make the condensates, and the age-standardi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.47
更新日期：1977-03-01 00:00:00
abstract：:Iodine-123-labelled tumour associated monoclonal antibody HMFG2 was administered intralymphatically at a time that cannulation of pedal lymphatic vessels was performed for standard lymphangiography in 6 patients with cervical cancer. Gamma camera images were taken at 2 h and 24 h after injection of antibody and at a s...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.125
更新日期：1985-06-01 00:00:00
abstract：:We have investigated the effects of 50 min whole-body hyperthermia (WBH; 15 min equilibration followed by 41 degrees C for 35 min) on the toxicity and pharmacokinetics of the radiosensitizer Ro 03-8799 in mice. WBH markedly reduced Ro 03-8799 LD50/7d from 779 to 259 micrograms g-1 (P less than 0.001). Pharmacokinetics...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.96
更新日期：1987-05-01 00:00:00
abstract：:To clarify the prognostic factors in patients with submucosal carcinoma of the oesophagus, we examined the results of surgical treatment for 78 cases over the last decade. The clinicopathological factors including age, sex, location of the tumour, length of the tumour, histological differentiation, subclassification o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1288
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:Chronic antigenic stimulation may initiate non-Hodgkin (NHL) and Hodgkin lymphoma (HL) development. Antecedent, infection-related conditions have been associated, but evidence by lymphoproliferative subtype is limited. METHODS:From the US SEER-Medicare database, 44,191 NHL, 1832 HL and 200,000 population-ba...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.173
更新日期：2014-05-27 00:00:00
abstract：BACKGROUND:The integrin-binding protein osteopontin is strongly associated with tumour development, yet is an abundant dietary component as a constituent of human and bovine milk. Therefore, we tested the effect of orally administered osteopontin (o-OPN) on the development of subcutaneous tumours in mice. METHODS:Bovi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.10
更新日期：2014-03-04 00:00:00
abstract：BACKGROUND:Renal cell carcinoma (RCC) is highly resistant to chemotherapy because of a high apoptotic threshold. Recent evidences suggest that GSK-3beta positively regulates human pancreatic cancer and leukaemia cell survival in part through regulation of nuclear factor (NF-kappaB)-mediated expression of anti-apoptotic...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605437
更新日期：2009-12-15 00:00:00
abstract：BACKGROUND:Cancer prognostic biomarkers have shown disappointing clinical applicability. The objective of this study was to classify and estimate how study results are overinterpreted and misreported in prognostic factor studies in oncology. METHODS:This systematic review focused on 17 oncology journals with an impact...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0305-5
更新日期：2018-11-01 00:00:00
abstract：:One hundred and one consecutive patients with newly diagnosed stage I Hodgkin's disease (HD) received treatment at St Bartholomew's Hospital, between 1968 and 1987, with a median follow-up of 12 years. Eleven patients have been excluded from detailed analysis because they either received involved field radiotherapy (R...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.285
更新日期：1990-08-01 00:00:00
abstract：BACKGROUND:Progression-free survival (PFS) is a surrogate endpoint widely used for overall survival (OS) in oncology. Validation of PFS as a surrogate must be done for each indication and each intervention. We aimed to identify all studies evaluating the validity of PFS as a surrogate for OS in oncology, and to describ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0805-y
更新日期：2020-05-01 00:00:00
abstract：:We used data from a prospective cohort study of twins to investigate the influence of unmeasured genetic and measured and unmeasured environmental factors on the smoking behaviour of adolescents and young adults. Twins were surveyed in 1988 (aged 11-18 years), 1991, 1996 and 2004 with data from 1409, 1121, 732 and 758...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604250
更新日期：2008-04-22 00:00:00
abstract：:We have studied loss of heterozygosity at the BRCA1 and BRCA2 loci in 992 normal cell clones derived from topographically defined areas of normal tissue in four samples from BRCA1/BRCA2 mutation carriers. The frequency of loss of heterozygosity in the clones was low (1.01%), but it was found in all four samples, wheth...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603298
更新日期：2006-08-21 00:00:00
abstract：:Human monocytes can be induced to synthesize a cytotoxin which affects certain tumour cell lines. The interaction of monocyte cytotoxin with a susceptible cell line (L929) has been studied to obtain clues to the mode of action of the cytotoxin. The cytotoxin acts directly on the cells rather than on the culture medium...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1983.205
更新日期：1983-09-01 00:00:00
abstract：:Differences were seen in the ability of 2 strains of C. parvum to augment cytotoxicity attributable to NK cells towards a rat lymphoma. Furthermore, 2 batches of the same strain of C. parvum prepared by different methods also differed in their ability to augment cytotoxicity. Other factors influencing cytotoxicity wer...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.201
更新日期：1980-07-01 00:00:00
abstract：BACKGROUND:A major molecular pathway of genetic instability in cancer is DNA mismatch repair deficiency. High-level microsatellite instability (MSI-H) is currently the best predictor of responsiveness towards immune checkpoint blockade. Data about the prevalence of high-level microsatellite instability in cholangiocarc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0199-2
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:The prognosis of squamous cell carcinoma of the oral tongue is poor and it would be beneficial to find prognostic markers to better adjust treatment. Bmi-1 controls cell cycle and self-renewal of tissue stem cells, transcription factor c-myc affects cell proliferation and apoptosis, and Snail regulates epith...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605544
更新日期：2010-03-02 00:00:00
abstract：:In the present study organotypic multicellular spheroids (OMS) were used to study the effects of chemotherapeutic agents on malignant gliomas. Compared with the frequently used cell line models, OMS have several advantages with respect to the preservation of the cellular heterogeneity and the structure of the original...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.336
更新日期：1996-07-01 00:00:00
abstract：:A retrospective seroepidemiologic study was performed to examine the association between human papillomaviruses (HPV) 16 infection and carcinomas of the oropharynx, the oesophagus, penis and vagina. Sera were selected from the serum bank from the Antoni van Leeuwenhoek Hospital (Netherlands Cancer Institute) and the S...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600870
更新日期：2003-04-07 00:00:00
