Tamoxifen exposure and risk of oesophageal and gastric adenocarcinoma: a population-based cohort study of breast cancer patients in Sweden.


:In a population-based cohort study of all women aged over 50 years with breast cancer in the Swedish Cancer Register in 1961-2003, those diagnosed before 31 December 1987 were regarded as unexposed to tamoxifen, whereas those diagnosed after that date were considered potentially exposed. Crosslinkages within the Cancer Register and the Registers of Death and Emigration enabled follow-up. Standardised incidence ratios (SIRs) of oesophageal and gastric cancer represented relative risks. Among 138 885 cohort members contributing with 1 075 724 person-years of follow-up, we found a nonsignificantly increased risk of oesophageal adenocarcinoma during the potential tamoxifen exposure period (SIR 1.60, 95% confidence interval (CI) 0.83-3.08), but the risk estimates decreased with increasing latency interval. No association was observed during the unexposed period. No increased risk of cardia adenocarcinoma was identified in either period. The risk of non-cardia gastric adenocarcinoma was increased in the potential tamoxifen period (SIR 1.27, 1.03-1.57), and almost doubled (SIR 1.86, 95% CI 1.10-3.14) in the period of longest latency (10-14 years). The corresponding overall SIR was increased in the unexposed group also, but here SIR did not increase with longer latency intervals. An increased risk of tobacco-related tumours, that is, oesophageal squamous-cell carcinoma and lung cancer, was limited to the unexposed cohort, indicating that confounding by smoking might explain the increased SIR during the unexposed period. We concluded that there might be a link between tamoxifen and risk of non-cardia gastric adenocarcinoma.


Br J Cancer


Chandanos E,Lindblad M,Jia C,Rubio CA,Ye W,Lagergren J




Has Abstract


2006-07-03 00:00:00














  • Immunotherapy of acute myeloid leukaemia. Medical Research Council.

    abstract::Seventy-one patients suffering from acute myeloid leukaemia (AML) who were already in complete remission and had already received one further course of cytotoxic drugs as consolidation therapy were randomised to receive maintenance chemotherapy alone or the same maintenance chemotherapy plus immunotherapy with BCG and...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,随机对照试验



    更新日期:1978-01-01 00:00:00

  • Testicular cancer in twins: a meta-analysis.

    abstract::In a meta-analysis of testicular cancer in twins, twins had a 30% increased risk (estimate 1.31, 95% CI 1.1-1.6), providing indirect support for the hypothesis that in utero hormone variations influence risk of testicular cancer. The summary-estimate for dizygotic twins was 1.3 (1.0-1.7) and for monozygotic or same se...

    journal_title:British journal of cancer

    pub_type: 杂志文章,meta分析


    authors: Neale RE,Carrière P,Murphy MF,Baade PD

    更新日期:2008-01-15 00:00:00

  • Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer.

    abstract:BACKGROUND:MicroRNA (miRNA)-126 (miR-126) is an endothelial-specific miRNA located within intron 7 of epidermal growth factor-like domain 7 (EGFL7). However, the role of miR-126 in cancer is controversial. METHODS:We examined the function of miR-126 in oral squamous cell carcinoma (OSCC) cells. Furthermore, a series o...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Sasahira T,Kurihara M,Bhawal UK,Ueda N,Shimomoto T,Yamamoto K,Kirita T,Kuniyasu H

    更新日期:2012-08-07 00:00:00

  • Phase II trial of raltitrexed ('Tomudex') in advanced small-cell lung cancer.

    abstract::Raltitrexed, a thymidylate synthase inhibitor, was given to 21 patients with advanced small-cell lung cancer, at a dose of 3 mg m(-2) as a 15-min intravenous infusion at 21-day intervals. All of the patients had extensive disease and 17 had received prior therapy. Patients with disease refractory to primary chemothera...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Woll PJ,Basser R,Le Chevalier T,Drings P,Perez Manga G,Adenis A,Seymour L,Smith F,Thatcher N

    更新日期:1997-01-01 00:00:00

  • The frequency of the predominant Jewish mutations in BRCA1 and BRCA2 in unselected Ashkenazi colorectal cancer patients.

    abstract::It is presently unclear whether carriers of BRCA1 mutations have an increased risk for colorectal cancer (CRC). To gain insight into this issue, 225 unselected Ashkenazi Jewish CRC patients were tested for the presence of the three common Jewish BRCA1/2 germline mutations: 185delAG and 5382insC (BRCA1) and 6174delT (B...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Chen-Shtoyerman R,Figer A,Fidder HH,Rath P,Yeremin L,Bar Meir S,Friedman E,Theodor L

    更新日期:2001-02-01 00:00:00

  • Colorectal cancer and consumption of beef and fat.

    abstract::Secular, socioeconomic and urban-rural gradients and geographical differences in beef and fat consumption within the United States of America are compared with corresponding data on colorectal cancer incidence and mortality rates. These results, together with the results of most previous epidemiological studies, appea...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Enstrom JE

    更新日期:1975-10-01 00:00:00

  • Capecitabine and mitomycin C as third-line therapy for patients with metastatic colorectal cancer resistant to fluorouracil and irinotecan.

    abstract::Protracted venous infusion 5-fluorouracil (5FU) combined with mitomycin C (MMC) has demonstrated significant activity against metastatic colorectal cancer. Owing to potential synergy based upon upregulation of thymidine phosphorylase by MMC, the combination of capecitabine and MMC may improve outcomes in irinotecan-re...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Chong G,Dickson JL,Cunningham D,Norman AR,Rao S,Hill ME,Price TJ,Oates J,Tebbutt N

    更新日期:2005-09-05 00:00:00

  • Busulphan is active against neuroblastoma and medulloblastoma xenografts in athymic mice at clinically achievable plasma drug concentrations.

    abstract::High-dose busulphan-containing chemotherapy regimens have shown high response rates in children with relapsed or refractory neuroblastoma, Ewing's sarcoma and medulloblastoma. However, the anti-tumour activity of busulfan as a single agent remains to be defined, and this was evaluated in athymic mice bearing advanced ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Boland I,Vassal G,Morizet J,Terrier-Lacombe MJ,Valteau-Couanet D,Kalifa C,Hartmann O,Gouyette A

    更新日期:1999-02-01 00:00:00

  • Mammography screening in the Netherlands: delay in the diagnosis of breast cancer after breast cancer screening.

    abstract::In a prospective study we determined the frequency and causes of delay in the diagnosis of breast cancer after suspicious screening mammography. We included all women aged 50-75 years who underwent biennial screening mammography in the southern breast cancer screening region of the Netherlands between 1 January 1996 a...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Duijm LE,Groenewoud JH,Jansen FH,Fracheboud J,van Beek M,de Koning HJ

    更新日期:2004-11-15 00:00:00

  • Enhancement of photodynamic therapy by mitomycin C: a preclinical and clinical study.

    abstract::Photodynamic therapy (PDT) using Photofrin was used in combination with a hypoxic toxin (mitomycin C, MMC) to treat four patients with recurrent skin metastasis of a mammary carcinoma. In preclinical experiments an additive effect was found for the combination of MMC and PDT for treating subcutaneous RIF1 tumours in m...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Baas P,van Geel IP,Oppelaar H,Meyer M,Beynen JH,van Zandwijk N,Stewart FA

    更新日期:1996-04-01 00:00:00

  • Review of the distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) in Africa in relation to the incidence of Kaposi's sarcoma.

    abstract::In the years before human immunodeficiency virus (HIV) infection, the incidence of Kaposi's sarcoma varied markedly across the African continent, and it was a disease primarily affecting men. In contrast, the evidence reviewed here shows that the causal virus-Kaposi's sarcoma associated herpesvirus (KSHV)-is prevalent...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审


    authors: Dedicoat M,Newton R

    更新日期:2003-01-13 00:00:00

  • Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder.

    abstract::Recepteur d'Origine Nantais (RON) is a distinct receptor tyrosine kinase in the c-met proto-oncogene family. We examined the mutational and expression patterns of RON in eight human uroepithelial cell lines. Biological effects of RON overexpression on cancer cells were investigated in vitro, and the prognostic signifi...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Cheng HL,Liu HS,Lin YJ,Chen HH,Hsu PY,Chang TY,Ho CL,Tzai TS,Chow NH

    更新日期:2005-05-23 00:00:00

  • Multi-level evidence that circulating CK18 is a biomarker of tumour burden in colorectal cancer.

    abstract:BACKGROUND:Circulating total cytokeratin 18 (tCK18) and/or caspase cleaved cytokeratin 18 (cCK18) (measured by M65 and M30 enzyme-linked immunosorbent assays (ELISAs), respectively) are used as pharmacodynamic (PD) biomarkers of epithelial cell death in clinical trials. Having validated these ELISAs, we assessed their ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Greystoke A,Dean E,Saunders MP,Cummings J,Hughes A,Ranson M,Dive C,Renehan AG

    更新日期:2012-10-23 00:00:00

  • Antibody drug conjugates and bystander killing: is antigen-dependent internalisation required?

    abstract::Antibody drug conjugates (ADCs) employ the exquisite specificity of tumour-specific monoclonal antibodies (mAb) for the targeted delivery of highly potent cytotoxic drugs to the tumour site. The chemistry of the linker, which connects the drug to the mAb, determines how and when the drug is released from the mAb. This...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审


    authors: Staudacher AH,Brown MP

    更新日期:2017-12-05 00:00:00

  • Loss of cyclin-dependent kinase inhibitor genes and chromosome 9 karyotypic abnormalities in human bladder cancer cell lines.

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Southgate J,Proffitt J,Roberts P,Smith B,Selby P

    更新日期:1995-11-01 00:00:00

  • Mapping the HLA-A24-restricted T-cell epitope peptide from a tumour-associated antigen HER2 / neu: possible immunotherapy for colorectal carcinomas.

    abstract::HER2 / neu is a potential antigen candidate for immunotherapy because of its correlation to a poor prognosis and high expressions in many kinds of epithelial tumours. Especially in the colorectal carcinomas, the higher expression of HER2 / neu is recognized in metastatic regions as well as in primary sites. Several CT...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Tanaka H,Tsunoda T,Nukaya I,Sette A,Matsuda K,Umano Y,Yamaue H,Takesako K,Tanimura H

    更新日期:2001-01-05 00:00:00

  • Changes in expression of cellular oncogenes and endogenous retrovirus-like sequences during hepatocarcinogenesis induced by a peroxisome proliferator.

    abstract::Previous studies have demonstrated that BR-931, a hepatic peroxisome proliferator, can induce liver tumours in mice and rats. Since alterations in gene expression may play a critical role in multistage hepatocarcinogenesis, the present studies examined the expression of the c-myc, c-H-ras, epidermal growth factor (EGF...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hsieh LL,Shinozuka H,Weinstein IB

    更新日期:1991-11-01 00:00:00

  • Metabolism of 7,12,-dimethylbenz(a)anthracene by normal and regenerating rat livers.

    abstract::The in vitro metabolisms of [14C]7,12-dimethylbenz(a)anthracene (DMBA) by post-mitochondrial supernates and microsomes from intact and regenerating rat livers were compared. Both cell fractions from regenerating livers at 48, 72, and 96 h after partial hepatectomy metabolized less [14C]DMBA than similar fractions from...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Tomsak RL,Cook RT

    更新日期:1977-06-01 00:00:00

  • Intake of wholegrain products and risk of colorectal cancers in the Diet, Cancer and Health cohort study.

    abstract:BACKGROUND:Consumption of wholegrain (WG) products may protect against colon and rectal cancer. METHODS:The associations between total and individual WG product consumption and colon and rectal cancer risk were prospectively examined using data on 461 incident cases of colon cancer and 283 incident cases of rectal can...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Egeberg R,Olsen A,Loft S,Christensen J,Johnsen NF,Overvad K,Tjønneland A

    更新日期:2010-08-24 00:00:00

  • Elastosis and response to endocrine therapy in human breast cancer.

    abstract::Response to endocrine therapy in 51 patients with advanced breast cancer was compared with the amount of elastosis in histological sections from their primary tumours. There appeared to be an association between elastosis and response: tumours with no elastosis showed a lower rate of response than those with gross ela...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Masters JR,Millis RR,King RJ,Rubens RD

    更新日期:1979-05-01 00:00:00

  • Benign anal lesions, inflammatory bowel disease and risk for high-risk human papillomavirus-positive and -negative anal carcinoma.

    abstract::A central role in anal carcinogenesis of high-risk types of human papillomaviruses (hrHPV) was recently established, but the possible role of benign anal lesions has not been addressed in hrHPV-positive and -negative anal cancers. As part of a population-based case-control study in Denmark and Sweden, we interviewed 4...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Frisch M,Glimelius B,van den Brule AJ,Wohlfahrt J,Meijer CJ,Walboomers JM,Adami HO,Melbye M

    更新日期:1998-12-01 00:00:00

  • Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion.

    abstract:BACKGROUND:Lymph node metastasis is one of the most important adverse prognostic factors for pancreatic cancer. The aim of this study was to identify novel lymphatic metastasis-associated markers and therapeutic targets for pancreatic cancer. METHODS:DNA microarray study was carried out to identify genes differentiall...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Lee JY,Lee KT,Lee JK,Lee KH,Jang KT,Heo JS,Choi SH,Kim Y,Rhee JC

    更新日期:2011-03-15 00:00:00

  • Correction: Protein biomarkers predictive for response to anti-EGFR treatment in RAS wild-type metastatic colorectal carcinoma.

    abstract::Supplementary Table 1 and the Supplementary Figure legends were not included when this manuscript was first published. The files are now available here. ...

    journal_title:British journal of cancer

    pub_type: 已发布勘误


    authors: Lièvre A,Ouine B,Canet J,Cartier A,Amar Y,Cacheux W,Mariani O,Guimbaud R,Selves J,Lecomte T,Guyetant S,Bieche I,Berger F,de Koning L

    更新日期:2018-08-01 00:00:00

  • DNA damage and repair in tumour and non-tumour tissues of mice induced by nicotinamide.

    abstract::In vivo DNA damage and repair was induced by nicotinamide (NAM) in adenotype 12 virus-induced mouse sarcoma A12B3 and sarcoma F inoculated into CBA mice. DNA damage, NAM and NAD concentrations were measured after in vivo exposure to NAM, in tumours and spleens by alkaline elution and by HPLC analysis. Our results indi...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Olsson AR,Sheng Y,Pero RW,Chaplin DJ,Horsman MR

    更新日期:1996-08-01 00:00:00

  • Regulation of cell proliferation under extreme and moderate hypoxia: the role of pyrimidine (deoxy)nucleotides.

    abstract::In the present study we have used flow cytometric DNA measurements on synchronised human NHIK 3025 cells to measure cell cycle progression under various conditions of reduced oxygenation. Our data indicate that addition of 0.1 mM deoxycytidine or uridine has no effect on the oxygen-dependent arrest in late G1 or on th...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Amellem O,Löffler M,Pettersen EO

    更新日期:1994-11-01 00:00:00

  • Effects of inoculation site and Matrigel on growth and metastasis of human breast cancer cells.

    abstract::The co-injection of extracellular matrix components, such as Matrigel, with human tumour cells into nude mice has been reported to facilitate tumour formation and growth, but it is unknown whether such components exert similar effects on tumour progression and metastasis. Metastatic behaviour is known to be enhanced w...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Bao L,Matsumura Y,Baban D,Sun Y,Tarin D

    更新日期:1994-08-01 00:00:00

  • A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours.

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Eskens FA,Mom CH,Planting AS,Gietema JA,Amelsberg A,Huisman H,van Doorn L,Burger H,Stopfer P,Verweij J,de Vries EG

    更新日期:2008-01-15 00:00:00

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Wistuba II,Maitra A,Carrasco R,Tang M,Troncoso P,Minna JD,Gazdar AF

    更新日期:2002-08-12 00:00:00

  • Allelic imbalance at chromosome 17p13.3 (YNZ22) in breast cancer is independent of p53 mutation or p53 overexpression and is associated with poor prognosis at medium-term follow-up.

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Thompson AM,Crichton DN,Elton RA,Clay MF,Chetty U,Steel CM

    更新日期:1998-03-01 00:00:00

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Laderoute KR,Murphy BJ,Short SM,Grant TD,Knapp AM,Sutherland RM

    更新日期:1992-02-01 00:00:00