Abstract:
:This study describes the effects of the glucolipid synthase inhibitor P4, (DL-threo-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol ), on various functional and phenotypic parameters of 5T33 murine myeloma cells. Cell recovery was reduced by >85% following incubation of the cells for 3 days in the presence of 4 microM P4 (the IC50 concentration). Both cytostatic and cytotoxic inhibition was observed with tumour cell metabolic activity and clonogenic potential reduced to 42% and 14% of controls, respectively, and viability reduced to 52%. A dose-dependent increase in cells undergoing apoptosis (from 7% to 26%) was also found. P4 induced a decrease in the number of cells expressing H-2 Class I and CD44, and a large increase in cells expressing H-2 Class II and the IgG2b paraprotein. It did not affect surface expression of CD45 or CD54 (ICAM-1). Based on these alterations in tumour cell growth, adhesion molecule expression and potential immunogenicity, it is anticipated that P4 will provide a novel therapeutic approach for the treatment of multiple myeloma. In addition, given that essentially all tumours rely heavily on overexpressed or abnormal glucosphingolipids for growth, development and metastasis, glucolipid synthase inhibitors may prove to be universally effective anti-cancer agents.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Manning LS,Radin NSdoi
10.1038/sj.bjc.6690792subject
Has Abstractpub_date
1999-11-01 00:00:00pages
952-8issue
6eissn
0007-0920issn
1532-1827journal_volume
81pub_type
杂志文章abstract::The survival of 64 consecutive patients with disseminated midgut carcinoid tumours was compared in a retrospective study with that of 25 consecutive patients with sporadic malignant endocrine pancreatic tumours treated according to similar surgical principles. The presence of hepatic metastases implied a worse prognos...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690494
更新日期:1999-06-01 00:00:00
abstract::PEP005 is a novel ingenol angelate that modulates protein kinases C (PKC) functions by activating PKC delta and inhibiting PKC alpha. This study assessed the antiproliferative effects of PEP005 alone and in combination with several other anticancer agents in a panel of 10 human cancer cell lines characterised for expr...
journal_title:British journal of cancer
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更新日期:2008-12-02 00:00:00
abstract:BACKGROUND:Uterine serous papillary carcinoma (USPC) is a biologically aggressive variant of endometrial cancer. We investigated the expression of Serum Amyloid A (SAA) and evaluated its potential as a serum biomarker in USPC patients. METHODS:SAA gene and protein expression levels were evaluated in USPC and normal en...
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更新日期:2009-07-21 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Several recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in the plasma/serum. We hypothesised that miR-18a in the plasma is a potential biomarker in patients with pancreatic cancer. METHODS:miR-18a is located in the miR-17-92 cluster and reported to be highly expressed in pancr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.453
更新日期:2011-11-22 00:00:00
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journal_title:British journal of cancer
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更新日期:1974-08-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601884
更新日期:2004-07-05 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.53
更新日期:2014-04-15 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.2102
更新日期:2001-11-02 00:00:00
abstract::Antibodies to the tumour-specific transplantation type antigen (TSTA) of a transplanted methylcholanthrene-induced sarcoma (MC-1) in syngeneic rats were studied using the techniques of indirect membrane immunofluorescence and mixed haemadsorption with a (51)Cr-labelled indicator cell. After tumour excision, anti-TSTA ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1973.4
更新日期:1973-01-01 00:00:00
abstract::There are two main histological groups of testicular germ cell tumours, which may have different risk factors. Some authors have analysed potential risk factors by histological group but few consistent differences have been identified. In this paper we examine risk factors for pure seminoma and other tumours using dat...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690611
更新日期:1999-08-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.278
更新日期:1998-05-01 00:00:00
abstract::The childhood peak of common acute lymphoblastic leukaemia has been proposed as being a rare response to delayed exposure to a common infection. In this context, factors related to the child's immune system are of special interest. Information on such factors was obtained in a recent German case-control study comprisi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690395
更新日期:1999-05-01 00:00:00
abstract::We have determined the methylation status of the CpG island of the oestrogen receptor alpha gene in seven human ovarian cell lines. Cell lines expressing oestrogen receptor alpha showed no evidence of hypermethylation. In three of four cell lines that produced no detectable oestrogen receptor alpha protein, hypermethy...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600028
更新日期:2002-01-21 00:00:00
abstract::Following relapse on endocrine therapy for advanced, hormone receptor-positive breast cancer, it is common for patients to experience responses to alternative endocrine agents. Fulvestrant ('Faslodex') is a new type of endocrine treatment--an oestrogen receptor (ER) antagonist with no agonist effects. Fulvestrant down...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
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更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Eukaryotic translation elongation factor 1A2 (eEF1A2) is a known proto-oncogene. We proposed that stimulation of the eEF1A2 expression in cancer tissues is caused by the loss of miRNA-mediated control. METHODS:Impact of miRNAs on eEF1A2 at the mRNA and protein levels was examined by qPCR and western blot, r...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.243
更新日期:2013-06-11 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603005
更新日期:2006-04-24 00:00:00
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journal_title:British journal of cancer
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更新日期:2012-11-20 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
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更新日期:2013-05-14 00:00:00
abstract::Time trends in therapeutic approaches and in the prognosis of colon cancer for patients aged 75 years and above have been investigated in comparison with corresponding trends for younger patients using a population-based series of 2089 colon cancer patients diagnosed between 1976 and 1990 in the Côte-d'Or area (478,00...
journal_title:British journal of cancer
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更新日期:1997-01-01 00:00:00
abstract::We identified 2384 patients in the Danish Cancer Register in whom cancer had been diagnosed in 1960-1996 before they reached the age of 20 and compared them with 53 143 sex- and age-matched controls identified from the Register of Population Statistics. Complete education records and demographic and socioeconomic info...
journal_title:British journal of cancer
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更新日期:2004-08-31 00:00:00
abstract:BACKGROUND:Little is known about the effect of participating in a colorectal cancer (CRC) screening programme on quality of life (QOL), neither for participants with a negative nor for those with a positive test result. These findings, however, are important to evaluate the impact of CRC screening. METHODS:Participant...
journal_title:British journal of cancer
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更新日期:2012-10-09 00:00:00
abstract::The influence of vascular endothelial growth factor (VEGF) expression and microvessel density (MVD) on prognosis and the relationship between VEGF expression and MVD in ovarian carcinoma are not well defined. We studied VEGF expression in parallel with MVD by immunohistochemistry in 94 ovarian tumours (64 malignant, 1...
journal_title:British journal of cancer
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doi:10.1054/bjoc.2000.1228
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:New prognostic markers are needed to identify patients with Ewing sarcoma (EWS) and osteosarcoma unlikely to benefit from standard therapy. We describe the incidence and association with outcome of circulating tumour DNA (ctDNA) using next-generation sequencing (NGS) assays. METHODS:A NGS hybrid capture ass...
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abstract::DepoCyte is a slow-release formulation of cytarabine designed for intrathecal administration. The goal of this multi-centre cohort study was to determine the safety and efficacy of DepoCyte for the intrathecal treatment of neoplastic meningitis due to breast cancer. DepoCyte 50 mg was injected once every 2 weeks for o...
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2002-07-29 00:00:00