Quality of life in participants of a CRC screening program.

abstract：:In small-cell lung cancer cell lines resistance to growth inhibition by transforming growth factor (TGF)-beta 1, was previously shown to correlate with lack of TGF-beta receptor I (RI) and II (RII) proteins. To further investigate the role of these receptors, the expression of mRNA for RI, RII and beta-glycan (RIII) w...

journal_title：British journal of cancer

authors： Nørgaard P,Spang-Thomsen M,Poulsen HS

更新日期：1996-05-01 00:00:00

abstract：:Oestrogen receptor protein (ER) was detected in 9 of 11 samples of malignant breast tissue and 8 of 9 samples of normal breast tissue. Levels of cytosolic ER (ERc) in malignant breast were 21-1102 fmol mg-1 soluble protein (Kd 1.8 X 10(-9)-3.1 X 10(-8) mol l-1) and those of nucleosolic ER (ERn), 13-526 fmol mg-1 solub...

journal_title：British journal of cancer

authors： Iqbal MJ,Colletta AA,Houmayoun-Valyani SD,Baum M

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:Mechanisms that increase resistance to apoptosis help promote cellular transformation. Cancer cells have deregulated apoptotic pathways, where increased expression and stability of anti-apoptotic proteins Mcl-1 and Bcl-2 increases resistance to apoptosis. Pathways that increase the stability of proteins in c...

journal_title：British journal of cancer

authors： Pervin S,Tran A,Tran L,Urman R,Braga M,Chaudhuri G,Singh R

更新日期：2011-07-26 00:00:00

abstract：BACKGROUND:This multicentre, open-label study evaluated the efficacy and safety of SPI-1620, an analogue of endothelin-1, administered in combination with docetaxel as second-line treatment for patients with advanced biliary tract cancer (ABTC). METHODS:Eligible patients received continuous cycles of combination thera...

journal_title：British journal of cancer

authors： Kim R,Chiorean EG,Amin M,Rocha-Lima CMS,Gandhi J,Harris WP,Song T,Portnoy D

更新日期：2017-07-11 00:00:00

abstract：:With few exceptions, the major limit to high-dose chemotherapeutic treatments is the severity and duration of drug-induced myelosuppression. We have recently developed a monoclonal antibody, MAD11, which reacts with the potent anti-tumour antibiotic doxorubicin and other anthracyclines. To protect directly pluripotent...

journal_title：British journal of cancer

authors： Morelli D,Ménard S,Cazzaniga S,Colnaghi MI,Balsari A

更新日期：1997-01-01 00:00:00

abstract：:The syndecans, a family of cell-surface heparan sulphate proteoglycans, have been proposed to mediate cellular interactions with extracellular effector molecules, such as growth factors and components of the extracellular matrix, during critical phases of development. Transcripts of all four syndecans are expressed at...

journal_title：British journal of cancer

authors： Wong ZM,Choo B,Li M,Carey DJ,Cano-Gauci DF,Buick RN

更新日期：1998-03-01 00:00:00

abstract：:Experimental studies indicated that long-chain polyunsaturated fatty acids may increase sensitivity of mammary tumours to several cytotoxic drugs. To evaluate this hypothesis in breast cancer, we have prospectively studied the association between levels of fatty acids stored in breast adipose tissue and the response o...

journal_title：British journal of cancer

authors： Bougnoux P,Germain E,Chajès V,Hubert B,Lhuillery C,Le Floch O,Body G,Calais G

更新日期：1999-04-01 00:00:00

abstract：:Antibodies to the tumour-specific transplantation type antigen (TSTA) of a transplanted methylcholanthrene-induced sarcoma (MC-1) in syngeneic rats were studied using the techniques of indirect membrane immunofluorescence and mixed haemadsorption with a (51)Cr-labelled indicator cell. After tumour excision, anti-TSTA ...

journal_title：British journal of cancer

authors： Thomson DM,Steele K,Alexander P

更新日期：1973-01-01 00:00:00

abstract：:The RNASEL gene on chromosome 1q25 has been identified as a prostate cancer susceptibility gene. We screened for RNASEL germline mutations in familial prostate cancer patients, and performed a case-control study to examine the association of specific variants with prostate cancer risk in the Japanese. Three variants w...

journal_title：British journal of cancer

authors： Nakazato H,Suzuki K,Matsui H,Ohtake N,Nakata S,Yamanaka H

更新日期：2003-08-18 00:00:00

abstract：BACKGROUND:Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. The present study was conducted to investigate the expression of GOLPH3 and its prognostic significance in renal cell carcinoma (RCC). Meanwhile, the function of GOLPH3 in human RCC was further inves...

journal_title：British journal of cancer

authors： Xue Y,Wu G,Liao Y,Xiao G,Ma X,Zou X,Zhang G,Xiao R,Wang X,Liu Q,Long D,Yang J,Xu H,Liu F,Liu M,Xie K,Huang R

更新日期：2014-04-29 00:00:00

abstract：:As regulators of malignant cell behaviour and communication with stroma, cytokines have proved useful in understanding cancer biology and developing novel therapies. In renal cell carcinoma, patients with inflammatory reactions are known to have poor prognosis. In order to elucidate the relation between renal cell car...

journal_title：British journal of cancer

authors： Yoshida N,Ikemoto S,Narita K,Sugimura K,Wada S,Yasumoto R,Kishimoto T,Nakatani T

更新日期：2002-05-06 00:00:00

abstract：:The carcinogenicity of the vegetative tissues of bracken fern (Pteridium) has long been established. More recently, the carcinogenic effects of the spores of bracken have also been recognized. Both vegetative tissues and spores of bracken can induce adducts in DNA in animal tissues, but the possible genotoxic or carci...

journal_title：British journal of cancer

authors： Simán SE,Povey AC,Ward TH,Margison GP,Sheffield E

更新日期：2000-07-01 00:00:00

abstract：:Male and female Swiss strain mice were put on a 0.03% thioacetamide diet at the age of 2 months. Control mice were kept on a stock diet. Control and treated mice were killed at the ages of 6, 9, 13 and 17 months. Progressive morphological, histological and biochemical alterations in the liver and tumour tissue of the ...

journal_title：British journal of cancer

authors： Gothoskar SV,Talwalkar GV,Bhide SV

更新日期：1970-09-01 00:00:00

abstract：:An increasing body of evidence indicates that glutathione S-transferases play a role in the intrinsic and acquired resistance of tumours to anticancer drugs. In view of the wide use of tumour cell lines to understand the factors which confer either sensitivity or resistance to chemotherapeutic agents we have determine...

journal_title：British journal of cancer

authors： Lewis AD,Forrester LM,Hayes JD,Wareing CJ,Carmichael J,Harris AL,Mooghen M,Wolf CR

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:Pancreaticoduodenectomy remains a major undertaking. A preoperative blood test, which could confidently predict the benefits of surgery would improve the selection of pancreatic cancer patients for surgery. This study aimed to identify protein biomarkers prognostic for long-term survival and to validate them...

journal_title：British journal of cancer

authors： Xue A,Chang JW,Chung L,Samra J,Hugh T,Gill A,Butturini G,Baxter RC,Smith RC

更新日期：2012-11-20 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a distinct type of head and neck cancer. Approximately 70% of patients with newly diagnosed NPC present with locally advanced disease. Phase III clinical trials support the addition of chemotherapy to radiotherapy for the initial treatment of these patients. Once metastatic disease de...

journal_title：British journal of cancer

authors： Agulnik M,Siu LL

更新日期：2005-03-14 00:00:00

abstract：BACKGROUND:There remains uncertainty on the need for bone staging in men with intermediate-risk prostate cancer. Current guidelines do not use mpMRI-staging information and rely on historic pathology grading. METHODS:We investigated the ability of mpMRI and the new Grade Group system to better predict bone metastasis ...

journal_title：British journal of cancer

authors： Thurtle D,Hsu RC,Chetan M,Lophatananon A,Hubbard R,Gnanapragasam VJ,Barrett T

更新日期：2016-11-22 00:00:00

abstract：BACKGROUND:Operable non-small cell lung cancer (NSCLC) patients whose tumours have spread to regional or central lymph nodes at the time of diagnosis have dismal prognoses compared with those who have limited disease. The current TNM staging system for NSCLC poorly distinguishes patients with lymph-node metastases who ...

journal_title：British journal of cancer

authors： Kilvaer TK,Paulsen EE,Khanehkenari MR,Al-Saad S,Johansen RM,Al-Shibli K,Bremnes RM,Busund LT,Donnem T

更新日期：2016-05-10 00:00:00

abstract：:To improve our understanding of the relationship and possible associations between human papillomavirus (HPV) infection and the development of cervical malignancies, the presence of multiple types of HPV DNA sequences in cervical carcinoma was determined in Chinese citizens living in two different geographical locatio...

journal_title：British journal of cancer

authors： Pao CC,Kao SM,Tang GC,Lee K,Si J,Ruan S

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:This phase 1 study examined the safety, maximum-tolerated dose (MTD) and antitumour activity of E7449, a novel PARP 1/2 and tankyrase 1/2 inhibitor. METHODS:E7449 was orally administered once daily in 28-day cycles to patients with advanced solid tumours (50-800-mg doses). Archival tumour samples from conse...

journal_title：British journal of cancer

authors： Plummer R,Dua D,Cresti N,Drew Y,Stephens P,Foegh M,Knudsen S,Sachdev P,Mistry BM,Dixit V,McGonigle S,Hall N,Matijevic M,McGrath S,Sarker D

更新日期：2020-08-01 00:00:00

abstract：:Spontaneous and radiation-induced genetic instability of peripheral blood mononuclear cells derived from unselected breast cancer (BC) patients (n=50) was examined using the single-cell gel electrophoresis (Comet) assay and a modified G2 micronucleus (MN) test. Cells from apparently healthy donors (n=16) and from canc...

journal_title：British journal of cancer

authors： Djuzenova CS,Mühl B,Fehn M,Oppitz U,Müller B,Flentje M

更新日期：2006-04-24 00:00:00

abstract：:We conducted a case-control study to investigate the role of early infections in the aetiology of childhood acute leukaemias. The study included 280 incident cases (240 acute lymphoblastic leukaemia and 40 acute non-lymphoblastic leukaemia) and 288 hospital controls, frequency matched by age, gender, hospital, catchme...

journal_title：British journal of cancer

authors： Perrillat F,Clavel J,Auclerc MF,Baruchel A,Leverger G,Nelken B,Philippe N,Schaison G,Sommelet D,Vilmer E,Hémon D

更新日期：2002-04-08 00:00:00

abstract：:Common warts could indicate cervical cancer susceptibility, as both are caused by human papillomavirus (HPV). Eczema was also investigated, as atopic eczema has been negatively associated with warts, but non-atopic eczema may be associated with compromised host defences, as observed in patients with HIV, suggesting in...

journal_title：British journal of cancer

authors： Montgomery SM,Ehlin AG,Sparén P,Björkstén B,Ekbom A

更新日期：2002-10-21 00:00:00

abstract：:Despite expressing both Fas and Fas ligand, DU145 and LNCaP prostate cancer cells were resistant to anti-Fas-induced cell death. Resistance to Fas-mediated cytotoxicity could be overcome in DU145, but not in LNCaP, cells by pretreating cells with sublethal doses of cytotoxic drugs, such as camptothecin. Activated casp...

journal_title：British journal of cancer

authors： Costa-Pereira AP,Cotter TG

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:The addition of breast magnetic resonance imaging (MRI) to screening mammography for women with BRCA mutations significantly increases sensitivity, but there is little data on clinical outcomes. We report screening performance, cancer stage, distant recurrence rate, and breast cancer-specific mortality in ou...

journal_title：British journal of cancer

authors： Passaperuma K,Warner E,Causer PA,Hill KA,Messner S,Wong JW,Jong RA,Wright FC,Yaffe MJ,Ramsay EA,Balasingham S,Verity L,Eisen A,Curpen B,Shumak R,Plewes DB,Narod SA

更新日期：2012-06-26 00:00:00

abstract：:Testicular germ cell tumour (GCT) is not an AIDS-defining illness despite an increased incidence in men with HIV infection. We performed a matched case-control study comparing outcomes in HIV-positive men and the general population with GCT, using three age and stage matched controls for each case. There was no differ...

journal_title：British journal of cancer

authors： Powles T,Bower M,Shamash J,Stebbing J,Ong J,Daugaard G,De Ruiter A,Johnson M,Fisher M,Anderson J,Nelson M,Gazzard B,Oliver T

更新日期：2004-04-19 00:00:00

abstract：:On the basis of preclinical data suggesting the possibility of maximising the efficacy of 5-fluorouracil and cisplatin by interferon, a pilot clinical trial was initiated in recurrent and/or metastatic head and neck cancer. Thirty-four patients were treated with cisplatin at 100 mg m-2, followed by 5-fluorouracil at 1...

journal_title：British journal of cancer

authors： Cascinu S,Fedeli A,Luzi Fedeli S,Catalano G

更新日期：1994-02-01 00:00:00

abstract：:EWS-Fli-1, a fusion gene found in Ewing's sarcoma and primitive neuro-ectodermal tumour (PNET), encodes a transcriptional activator and promotes cellular transformation. We have made stable Ewing's sarcoma cells expressing antisense EWS-Fli-1 transcripts by transfecting the antisense EWS-Fli-1 expression plasmid. Thes...

journal_title：British journal of cancer

authors： Dohjima T,Ohno T,Banno Y,Nozawa Y,Wen-yi Y,Shimizu K

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Cancer stem cells (CSCs) are responsible for tumour initiation, metastasis and recurrence. However, the mechanism of CSC formation, maintenance and expansion in colorectal cancer (CRC) remains poorly characterised. METHODS:The role of COP9 signalosome subunit 6 (CSN6) in regulating cancer stemness was evalu...

journal_title：British journal of cancer

authors： Qin B,Zou S,Li K,Wang H,Wei W,Zhang B,Xiao L,Choi HH,Tang Q,Huang D,Liu Q,Pan Q,Meng M,Fang L,Lee MH

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:While current chemotherapy has increased cure rates for children with acute lymphoblastic leukaemia (ALL), the largest number of relapsing patients are still stratified as medium risk (MR) at diagnosis (50-60%). This highlights an opportunity to develop improved relapse-prediction models for MR patients. We ...

journal_title：British journal of cancer

authors： Alruwetei AM,Bendak K,Yadav BD,Carol H,Evans K,Mayoh C,Sutton R,Marshall GM,Lock RB

更新日期：2020-09-01 00:00:00