Abstract：
BACKGROUND:Several recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in the plasma/serum. We hypothesised that miR-18a in the plasma is a potential biomarker in patients with pancreatic cancer. METHODS:miR-18a is located in the miR-17-92 cluster and reported to be highly expressed in pancreatic cancer tissues. This study was divided into three parts: (1) Confirmation of higher miR-18a levels in primary pancreatic cancer tissues and cell lines than in normal pancreatic tissues and a human fibroblast cell line. (2) Evaluation of the plasma miR-18a assay using quantitative RT-PCR by comparing plasma results obtained from 36 patients with pancreatic cancer and from 30 healthy volunteers. (3) Evaluation of the assay for monitoring tumour dynamics in patients with pancreatic cancer. RESULTS:(1) The expression of miR-18a was significantly higher in pancreatic cancer tissues (P=0.012) and pancreatic cancer cell lines (P=0.015) than in normal tissues and fibroblasts. (2) Plasma concentrations of miR-18a were significantly higher in pancreatic cancer patients than in controls (P<0.0001). The value of the area under the receiver-operating characteristic curve (AUC) was 0.9369. (3) Plasma levels of miR-18a were significantly lower in postoperative samples than in preoperative samples (P=0.0077). CONCLUSION:Circulating miR-18a might provide new complementary tumour markers for pancreatic cancer.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Morimura R,Komatsu S,Ichikawa D,Takeshita H,Tsujiura M,Nagata H,Konishi H,Shiozaki A,Ikoma H,Okamoto K,Ochiai T,Taniguchi H,Otsuji Edoi
10.1038/bjc.2011.453subject
Has Abstractpub_date
2011-11-22 00:00:00pages
1733-40issue
11eissn
0007-0920issn
1532-1827pii
bjc2011453journal_volume
105pub_type
杂志文章abstract：BACKGROUND:We performed a cross-sectional study in Indonesia to evaluate the performance of a single-visit approach of cervical cancer screening, using visual inspection with acetic acid (VIA), histology and cryotherapy in low-resource settings. METHODS:Women having limited access to health-care facilities were screen...
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