Cellular reaction in trophoblastic tumours.

abstract：:In rats a maximal tolerated dose of carboplatin (60 mg kg-1, i.v.) caused severe anaemia, leucopenia and thrombocytopenia. These indices of haematological toxicity were also observed with a maximal tolerated dose of cis-platin (6.5 mg kg-1, i.v.), but reductions in blood cell counts were less than those observed with ...

journal_title：British journal of cancer

authors： Siddik ZH,Boxall FE,Harrap KR

更新日期：1987-04-01 00:00:00

abstract：:The presence or absence of lymphocytic mucopolysaccharides (MPS) is studied in 223 subjects: 100 normals (controls); 8 cancer patients cured for more than 6 years; 30 cancer patients at the start of their treatment; and 85 relatives of first degree consanguinity of these last patients. The data are studied by statisti...

journal_title：British journal of cancer

authors： Riesco A,Cruz Coke R

更新日期：1973-09-01 00:00:00

abstract：:A total of 152 non-small cell lung cancers (NSCLC) were studied retrospectively to determine the relationship between epidermal growth factor receptor (EGF-R) status and the histological type, tumour size, nodal status and prognosis. EGF-R status was assessed on routinely embedded paraffin sections with an antibody to...

journal_title：British journal of cancer

authors： Dazzi H,Hasleton PS,Thatcher N,Barnes DM,Wilkes S,Swindell R,Lawson RA

更新日期：1989-05-01 00:00:00

abstract：:The incidence of adenocarcinoma of the oesophagus in British women is among the highest in the world. To investigate its aetiology, we conducted a multi-centre, population based case-control study in four regions in England and Scotland. We included 74 incident cases in women with histologically confirmed diagnoses of...

journal_title：British journal of cancer

authors： Cheng KK,Sharp L,McKinney PA,Logan RF,Chilvers CE,Cook-Mozaffari P,Ahmed A,Day NE

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Aberrant choline metabolism has been proposed as a novel cancer hallmark. We recently showed that epithelial ovarian cancer (EOC) possesses an altered MRS-choline profile, characterised by increased phosphocholine (PCho) content to which mainly contribute over-expression and activation of choline kinase-alph...

journal_title：British journal of cancer

authors： Granata A,Nicoletti R,Tinaglia V,De Cecco L,Pisanu ME,Ricci A,Podo F,Canevari S,Iorio E,Bagnoli M,Mezzanzanica D

更新日期：2014-01-21 00:00:00

abstract：:We previously demonstrated a characteristically high sensitivity of pancreatic cancer cells to interferon alpha (IFN-alpha) gene transfer, which induced a more prominent growth suppression and cell death in pancreatic cancer cells than in other types of cancers and normal cells. The IFN-alpha protein can exhibit both ...

journal_title：British journal of cancer

authors： Ohashi M,Yoshida K,Kushida M,Miura Y,Ohnami S,Ikarashi Y,Kitade Y,Yoshida T,Aoki K

更新日期：2005-08-22 00:00:00

abstract：BACKGROUND:Lithium accumulates in the colon and inhibits the enzyme GSK-3β that possesses anti-carcinogenic effects. We therefore examined the association between lithium use and colorectal cancer risk in a nationwide study. METHODS:We used the Danish Cancer Registry to identify all patients diagnosed with incident co...

journal_title：British journal of cancer

authors： Pottegård A,Ennis ZN,Hallas J,Jensen BL,Madsen K,Friis S

更新日期：2016-03-01 00:00:00

abstract：:Pulmonary metastasectomy is widely and increasingly practiced in the belief that this intervention can cure patients with colorectal cancer, and that without it few survive 5 years. No good evidence exists supporting such convictions, indeed recent trial results challenge them. What evidence underpins this acceptance ...

journal_title：British journal of cancer

authors： Macbeth F,Fallowfield L

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:The role of tumour-infiltrating inflammation in the prognosis of patients with colorectal cancer (CRC) has not been fully evaluated. The primary objective of our meta-analysis was to determine the impact of tumour-infiltrating inflammation on survival outcomes. METHODS:Ovid MEDLINE and EMBASE were searched ...

journal_title：British journal of cancer

authors： Mei Z,Liu Y,Liu C,Cui A,Liang Z,Wang G,Peng H,Cui L,Li C

更新日期：2014-03-18 00:00:00

abstract：:Epidemiologic evidence has recently identified an association between an endemic outbreak of pleural and peritoneal mesothelioma in the Urgup region of Turkey and exposure to zeolite fibres. This malignancy is usually associated with exposure to asbestos dusts whose mineralogical characteristics differ from those of z...

journal_title：British journal of cancer

authors： Kelsey KT,Yano E,Liber HL,Little JB

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Although mortality rates are elevated in psychiatric patients relative to their healthy counterparts, little is known about the impact of mental health on survival in people with cancer. METHODS AND RESULTS:Among 16 498 Swedish men with cancer, survival was worse in those with a history of psychiatric hospi...

journal_title：British journal of cancer

authors： Batty GD,Whitley E,Gale CR,Osborn D,Tynelius P,Rasmussen F

更新日期：2012-05-22 00:00:00

abstract：:Prolactin (PRL) has been reported to inhibit apoptosis in various cell types and to serve as a cofactor in the upregulation of CD25 on T cells during activation. We investigated a possible relation between prolactin receptor (PRL-R) or IL-2 receptor alpha (IL-2Ralpha, CD25) expression on circulating T lymphocytes and ...

journal_title：British journal of cancer

authors： Bauernhofer T,Kuss I,Friebe-Hoffmann U,Baum AS,Dworacki G,Vonderhaar BK,Whiteside TL

更新日期：2003-04-22 00:00:00

abstract：BACKGROUND:Overexpression of ErbB2 receptor in breast cancer is associated with disease progression and poor prognosis. Trastuzumab, the only humanised anti-ErbB2 antibody currently used in breast cancer, has proven to be effective; however, a relevant problem for clinical practice is that a high fraction of breast can...

journal_title：British journal of cancer

authors： Gelardi T,Damiano V,Rosa R,Bianco R,Cozzolino R,Tortora G,Laccetti P,D'Alessio G,De Lorenzo C

更新日期：2010-02-02 00:00:00

abstract：:Endocrine therapy is a recognised option in the treatment of chemo-resistant ovarian cancer. We conducted a nonrandomised phase II evaluation of combination endocrine therapy with tamoxifen and goserelin in patients with advanced ovarian cancer that had recurred following chemotherapy. In total, 26 patients entered th...

journal_title：British journal of cancer

authors： Hasan J,Ton N,Mullamitha S,Clamp A,McNeilly A,Marshall E,Jayson GC

更新日期：2005-09-19 00:00:00

abstract：:Use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the risk of gastric or oesophageal adenocarcinomas. We examined the association between self-reported use of aspirin or non-aspirin NSAIDs in the earlier 12 months and gastric non-cardia (N=182), gastric cardia (N=178), and oesophageal a...

journal_title：British journal of cancer

authors： Abnet CC,Freedman ND,Kamangar F,Leitzmann MF,Hollenbeck AR,Schatzkin A

更新日期：2009-02-10 00:00:00

abstract：BACKGROUND:Patients with borderline resectable pancreatic cancer (BRPC) have poor prognosis with upfront surgery. METHODS:This was a single-arm Phase 2 trial for clinical and biomarker analysis. The primary endpoint is 1-year progression-free survival (PFS) rate. Patients received 8 cycles of neoadjuvant modified (m) ...

journal_title：British journal of cancer

authors： Yoo C,Lee SS,Song KB,Jeong JH,Hyung J,Park DH,Song TJ,Seo DW,Lee SK,Kim MH,Lee SS,Kim JH,Jin HS,Park JH,Hwang DW,Lee JH,Lee W,Chang HM,Kim KP,Ryoo BY,Kim SC

更新日期：2020-08-01 00:00:00

abstract：:The modulating effect of 43 degrees C hyperthermia on the induction of oncogenic transformation by the antineoplastic agents, actinomycin D, mitomycin C, and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) was examined using the C3H 10T1/2 cell line. For any given level of cytotoxicity, cells exposed to the three chemothe...

journal_title：British journal of cancer

authors： Komatsu K,Miller RC,Hall EJ

更新日期：1988-01-01 00:00:00

abstract：:We retrospectively analysed neuromuscular toxicity associated with paclitaxel 210 mg m(-2) given by 3-h infusion in 247 patients. The severity correlated significantly with total cumulative dose, but could not be predicted by the pretreatment clinical variables or by pharmacokinetic parameters. The toxicity tended to ...

journal_title：British journal of cancer

authors： Kunitoh H,Saijo N,Furuse K,Noda K,Ogawa M

更新日期：1998-05-01 00:00:00

abstract：:Three intraperitoneal human ovarian cancer xenografts (OS, HU, and LA) were used to assess the antitumour activity of intraperitoneal therapy with liposome encapsulated MTP-PE. MTP-PE led to significant prolongation of survival in all three xenograft models, but with varying efficacy. In one tumour model (OS), 80% of ...

journal_title：British journal of cancer

authors： Malik ST,Martin D,Hart I,Balkwill F

更新日期：1991-03-01 00:00:00

abstract：:In the early period following radical hepatectomy for hepatoma, recurrences in the remaining liver are frequently found. In regenerating liver, implantation and growth of tumour cells released into the portal system during surgical treatment might be promoted. We examined the relationship between liver regeneration an...

journal_title：British journal of cancer

authors： Mizutani J,Hiraoka T,Yamashita R,Miyauchi Y

更新日期：1992-06-01 00:00:00

abstract：:Immunohistochemical localization of chondroitin sulphate and dermatan sulphate proteoglycans (PGs) was observed in 70 tumour tissues, using monoclonal antibodies 9A-2 and 3B-3 raised against core molecules obtained from chondroitin sulphate PG by chondroitinase ABC-treatment. They recognize a stub of delta Di-4S and d...

journal_title：British journal of cancer

authors： Fukatsu T,Sobue M,Nagasaka T,Ohiwa N,Fukata S,Nakashima N,Takeuchi J

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Detection of lymph node involvement in women with IB2-IIB cervical cancer could have a positive effect on survival. We set out to evaluate the incidence of pelvic and/or para-aortic lymph node involvement using the sentinel node (SN) biopsy and its impact on survival. METHODS:From 2002 to 2010, 66 women with...

journal_title：British journal of cancer

authors： Chéreau E,Feron JG,Ballester M,Coutant C,Bezu C,Rouzier R,Touboul E,Daraï E

更新日期：2012-01-03 00:00:00

abstract：:Metastasis of colorectal carcinomas rarely occurs in cirrhotic livers. Our study investigated the influence of activated Kupffer cells from cirrhotic rat livers on hepatic colonization and FasR-mediated apoptosis of colon cancer cells. A rat colon cancer cell line, RCN-9, was used to inoculate rat livers. Treatment wi...

journal_title：British journal of cancer

authors： Song E,Chen J,Ouyang N,Wang M,Exton MS,Heemann U

更新日期：2001-05-04 00:00:00

abstract：BACKGROUND:Cervical cancer screening coverage remains insufficient in most countries. Our objective was to assess whether in-home vaginal self-sampling with a dry swab for high-risk human papillomavirus (HR-HPV) testing is effective and cost-effective in increasing participation in cervical cancer screening. METHODS:I...

journal_title：British journal of cancer

authors： Haguenoer K,Sengchanh S,Gaudy-Graffin C,Boyard J,Fontenay R,Marret H,Goudeau A,Pigneaux de Laroche N,Rusch E,Giraudeau B

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:Systemic failure remains a challenge in rectal cancer. We investigated the possible systemic anti-tumour immune activity invoked within oxaliplatin-based neoadjuvant therapy. METHODS:In two high-risk patient cohorts, we assessed the circulating levels of the fms-like tyrosine kinase 3 ligand (Flt3L), a fact...

journal_title：British journal of cancer

authors： Kalanxhi E,Meltzer S,Schou JV,Larsen FO,Dueland S,Flatmark K,Jensen BV,Hole KH,Seierstad T,Redalen KR,Nielsen DL,Ree AH

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:MSMB, a gene coding for beta-microseminoprotein, has been identified as a candidate susceptibility gene for prostate cancer (PrCa) in two genome-wide association studies (GWAS). SNP rs10993994 is 2 bp upstream of the transcription initiation site of MSMB and was identified as an associated PrCa risk variant....

journal_title：British journal of cancer

authors： Kote-Jarai Z,Leongamornlert D,Tymrakiewicz M,Field H,Guy M,Al Olama AA,Morrison J,O'Brien L,Wilkinson R,Hall A,Sawyer E,Muir K,Hamdy F,Donovan J,Neal D,Easton D,Eeles R

更新日期：2010-01-19 00:00:00

abstract：:The x(c)(-) cystine transporter enhances biosynthesis of glutathione, a tripeptide thiol important in drug resistance and cellular defense against oxidative stress, by enabling cellular uptake of cystine, a rate-limiting precursor. Because it is known to regulate glutathione levels and growth of various cancer cell ty...

journal_title：British journal of cancer

authors： Lo M,Ling V,Wang YZ,Gout PW

更新日期：2008-08-05 00:00:00

abstract：:Acquired drug resistance is a major problem in cancer treatment. To explore the genes involved in chemosensitivity and resistance, 10 human tumour cell lines, including parental cells and resistant subtypes selected for resistance against doxorubicin, melphalan, teniposide and vincristine, were profiled for mRNA expre...

journal_title：British journal of cancer

authors： Rickardson L,Fryknäs M,Dhar S,Lövborg H,Gullbo J,Rydåker M,Nygren P,Gustafsson MG,Larsson R,Isaksson A

更新日期：2005-08-22 00:00:00

abstract：:During the development of indazolylpyrimidines as novel and potent inhibitors of vascular endothelial growth factor (VEGF) receptor-2 (VEGFR2) tyrosine kinase, we observed that some human tumour xenografts are more sensitive to VEGFR2 kinase inhibitors than others. A better understanding of the basis for this differen...

journal_title：British journal of cancer

authors： Dev IK,Dornsife RE,Hopper TM,Onori JA,Miller CG,Harrington LE,Dold KM,Mullin RJ,Johnson JH,Crosby RM,Truesdale AT,Epperly AH,Hinkle KW,Cheung M,Stafford JA,Luttrell DK,Kumar R

更新日期：2004-10-04 00:00:00

abstract：BACKGROUND:Platinum-based doublet chemotherapy is the standard first-line treatment for advanced non-small cell lung cancer (NSCLC), but earlier studies have suggested that non-platinum combinations are equally effective and better tolerated. We conducted a national, randomised study to compare a non-platinum with a pl...

journal_title：British journal of cancer

authors： Fløtten Ø,Grønberg BH,Bremnes R,Amundsen T,Sundstrøm S,Rolke H,Hornslien K,Wentzel-Larsen T,Aasebø U,von Plessen C

更新日期：2012-07-24 00:00:00